Follicular cell-derived thyroid carcinomas harboring novel genetic
BRAFV600E
Thyroid cancer
mutation
next-generation sequencing
papillary thyroid carcinoma
Journal
Archives of endocrinology and metabolism
ISSN: 2359-4292
Titre abrégé: Arch Endocrinol Metab
Pays: Brazil
ID NLM: 101652058
Informations de publication
Date de publication:
2024
2024
Historique:
received:
26
02
2024
accepted:
08
05
2024
medline:
18
10
2024
pubmed:
18
10
2024
entrez:
18
10
2024
Statut:
epublish
Résumé
To assess the molecular profile of follicular cell-derived thyroid carcinomas (FCDTCs) and correlate the identified mutations with the clinical and pathological features of the affected patients. Cross-sectional study of tumor samples from 100 adult patients diagnosed with FCDTC between 2010 and 2019. The patients' clinical and pathological data were collected. Genomic DNA was extracted from formalin-fixed, paraffin-embedded (FFPE) tumors using the ReliaPrep FFPE gDNA Miniprep System. Genotyping of target genomic regions ( The patients' mean age was 39 years. In all, 82% of the tumors were classic papillary thyroid carcinomas. Overall, 54 (54%) tumor samples yielded satisfactory results on next-generation sequencing (NGS), of which 31 harbored mutations. We described herein seven non-hotspot/novel variants in the
Identifiants
pubmed: 39420942
doi: 10.20945/2359-4292-2024-0067
pmc: PMC11460960
doi:
Substances chimiques
Proto-Oncogene Proteins B-raf
EC 2.7.11.1
BRAF protein, human
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e240067Déclaration de conflit d'intérêts
Disclosure: no potential conflict of interest relevant to this article was reported.