Mechanisms of epigenomic and functional convergence between glucocorticoid- and IL4-driven macrophage programming.

Animals Kruppel-Like Factor 4 Macrophages / metabolism Glucocorticoids / pharmacology Mice Kruppel-Like Transcription Factors / metabolism Receptors, Glucocorticoid / metabolism Interleukin-4 / metabolism Mice, Inbred C57BL Epigenomics Colitis / genetics Nerve Tissue Proteins / metabolism Transcriptome Mice, Knockout Homeostasis Male Phagocytosis Adaptor Proteins, Signal Transducing

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
18 Oct 2024
Historique:
received: 10 01 2024
accepted: 24 09 2024
medline: 19 10 2024
pubmed: 19 10 2024
entrez: 18 10 2024
Statut: epublish

Résumé

Macrophages adopt distinct phenotypes in response to environmental cues, with type-2 cytokine interleukin-4 promoting a tissue-repair homeostatic state (M2

Identifiants

DOI: 10.1038/s41467-024-52942-x PMID: 39424780
pubmed: 39424780
doi: 10.1038/s41467-024-52942-x
pii: 10.1038/s41467-024-52942-x
doi:

Substances chimiques

Kruppel-Like Factor 4 0
Klf4 protein, mouse 0
Glucocorticoids 0
Kruppel-Like Transcription Factors 0
Receptors, Glucocorticoid 0
Interleukin-4 207137-56-2
Grip1 protein, mouse 0
Nerve Tissue Proteins 0
Il4 protein, mouse 0
Adaptor Proteins, Signal Transducing 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

9000

Subventions

Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : NIH R01DK099087
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : NIH R01AI148129
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : F31 HL152706-01A1
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : NIH R01AI148416

Informations de copyright

© 2024. The Author(s).

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Auteurs

Dinesh K Deochand (DK)

Hospital for Special Surgery Research Institute, David Z. Rosensweig Genomics Center, New York, NY, USA.
Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-7395-9250

Marija Dacic (M)

Hospital for Special Surgery Research Institute, David Z. Rosensweig Genomics Center, New York, NY, USA.
Graduate Program in Physiology, Biophysics and Systems Biology, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.

Michael J Bale (MJ)

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.
ORCID: 0000-0002-6899-1459

Andrew W Daman (AW)

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.
ORCID: 0000-0001-8144-0574

Vidyanath Chaudhary (V)

Hospital for Special Surgery Research Institute, David Z. Rosensweig Genomics Center, New York, NY, USA.
Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA.

Steven Z Josefowicz (SZ)

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.
ORCID: 0000-0001-7453-779X

David Oliver (D)

Hospital for Special Surgery Research Institute, David Z. Rosensweig Genomics Center, New York, NY, USA.

Yurii Chinenov (Y)

Hospital for Special Surgery Research Institute, David Z. Rosensweig Genomics Center, New York, NY, USA.

Inez Rogatsky (I)

Hospital for Special Surgery Research Institute, David Z. Rosensweig Genomics Center, New York, NY, USA. rogatskyi@hss.edu.
Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA. rogatskyi@hss.edu.
Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA. rogatskyi@hss.edu.
ORCID: 0000-0003-3514-5077

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mechanisms of epigenomic and functional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription Krüppel-like › Facteur-4 de type Kruppel › Mechanisms of epigenomic and functional...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Mechanisms of epigenomic and functional...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Glucocorticoïdes › Mechanisms of epigenomic and functional...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mechanisms of epigenomic and functional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription Krüppel-like › Mechanisms of epigenomic and functional...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs aux glucocorticoïdes › Mechanisms of epigenomic and functional...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-4 › Mechanisms of epigenomic and functional...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Mechanisms of epigenomic and functional...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Épigénomique › Mechanisms of epigenomic and functional...
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