Salvianolic acids modulate lifespan and gut microbiota composition in amyloid-β-expressing Drosophila melanogaster.
Animals
Gastrointestinal Microbiome
/ drug effects
Drosophila melanogaster
/ drug effects
Amyloid beta-Peptides
/ metabolism
Benzofurans
/ pharmacology
Longevity
/ drug effects
Lactates
/ pharmacology
Caffeic Acids
/ pharmacology
Alzheimer Disease
/ microbiology
Disease Models, Animal
Humans
Salvia miltiorrhiza
/ chemistry
Bacteria
/ classification
Polyphenols
/ pharmacology
Depsides
Drosophila melanogaster
16S ribosomal RNA
Alzheimer’s disease
Gut microbiota
Methylparaben
Salvianolic acid
Journal
World journal of microbiology & biotechnology
ISSN: 1573-0972
Titre abrégé: World J Microbiol Biotechnol
Pays: Germany
ID NLM: 9012472
Informations de publication
Date de publication:
21 Oct 2024
21 Oct 2024
Historique:
received:
25
06
2024
accepted:
08
10
2024
medline:
21
10
2024
pubmed:
21
10
2024
entrez:
20
10
2024
Statut:
epublish
Résumé
Alzheimer's disease (AD), a form of neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ), hyperphosphorylated Tau, and neuroinflammation. The increasing population affected by AD urges for the development of effective treatments. The correlation between AD and gut microbiome remains underexplored, potentially providing a better understanding of the disease. Salvianolic acid A (Sal A) and salvianolic acid B (Sal B) are the active components extracted from Salvia miltiorrhiza (Danshen), and their antioxidant, anti-inflammation and Aβ inhibition activities were shown previously. In this study, these compounds were used to investigate their effects on Aβ toxicity, using Drosophila melanogaster expressing human Aβ42 as the model organism, by examining their lifespan and changes in gut bacterial communities. The study used two batches of flies, reared on food with or without methylparaben (MP) supplementation to evaluate the influence of MP on this animal model during pharmacological studies. MP is a common antimicrobial agent used in flies' food. The treatment of Sal A prolonged the lifespan of Aβ-expressing flies reared on MP-supplemented food significantly (P < 0.001), but not those without MP. The lifespan of Sal B-treated flies did not show a significant difference compared to untreated flies for both groups reared on food with and without MP. Sal A-treated flies in the presence of MP exhibited a lower abundance of Corynebacterium and Enterococcus than the untreated flies, while Lactiplantibacillus was the most dominant taxa. Urea cycle was predicted to be predominant in this group compared to the untreated group. The control group, Aβ-expressing flies treated with Sal A and Sal B on MP-supplemented food had improved lifespan compared to their respective groups reared on food without MP, while untreated Aβ-expressing flies was the exception. The gut microbiota composition of flies reared on MP-supplemented food was also significantly different from those without MP (P < 0.001).
Identifiants
pubmed: 39428437
doi: 10.1007/s11274-024-04163-z
pii: 10.1007/s11274-024-04163-z
doi:
Substances chimiques
Amyloid beta-Peptides
0
Benzofurans
0
Lactates
0
salvianolic acid B
C1GQ844199
salvianolic acid A
51622542XO
Caffeic Acids
0
Polyphenols
0
Depsides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
358Subventions
Organisme : Ministry of Higher Education, Malaysia
ID : FRGS/1/2020/STG03/USM/02/15
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature B.V.
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