Association between serum anion gap and 28-day mortality in critically ill patients with infective endocarditis: a retrospective cohort study from MIMIC IV database.
Humans
Male
Retrospective Studies
Middle Aged
Female
Critical Illness
/ mortality
Aged
Risk Factors
Time Factors
Biomarkers
/ blood
Acid-Base Equilibrium
Risk Assessment
Databases, Factual
Prognosis
Endocarditis
/ mortality
Acid-Base Imbalance
/ blood
Adult
Intensive Care Units
Hospital Mortality
Predictive Value of Tests
Anion gap
Critically ill patients
Infective endocarditis
MIMIC-IV
Mortality
Journal
BMC cardiovascular disorders
ISSN: 1471-2261
Titre abrégé: BMC Cardiovasc Disord
Pays: England
ID NLM: 100968539
Informations de publication
Date de publication:
23 Oct 2024
23 Oct 2024
Historique:
received:
19
06
2024
accepted:
14
10
2024
medline:
24
10
2024
pubmed:
24
10
2024
entrez:
24
10
2024
Statut:
epublish
Résumé
The relationship between serum anion gap (AG) and 28-day mortality in critically ill patients with infective endocarditis is currently not well established. This study aims to investigate the impact of serum AG on 28-day mortality in critically ill patients with infective endocarditis. A retrospective cohort study was conducted involving 449 participants diagnosed with infective endocarditis and admitted to intensive care units (ICU). Vital signs, laboratory parameters and comorbidity were collected for all participants to analyze the association between anion gap levels and 28-day mortality. A total of 449 critically ill patients with infective endocarditis (IE) were included in the study. The mean age was 57 years, and 64% were male. The overall 28-day mortality rate was 20%. A greater AG on admission were significantly associated with increased 28-day mortality in unadjusted analysis (hazard ratio [HR] 1.13; 95% confidence interval [CI] 1.09-1.18; p < 0.001). After adjusting for all confounders, the association remained significant (adjusted HR 1.07; 95% CI 1.02-1.13; p = 0.003). When AG was converted into categorial variables (quartiles), the risk of 28-day mortality in the greatest Q4 group was significantly higher compared with that in the lowest Q1 group (model 4: HR = 2.62, 95%CI: 1.17-5.83, p = 0.019). Subgroup analysis showed consistent results across different groups. A greater AG on admission were independently associated with increased 28-day mortality in critically ill patients with IE. These findings suggest that the AG can serve as a prognostic marker in this population, aiding in risk stratification and guiding clinical management.
Sections du résumé
BACKGROUND
BACKGROUND
The relationship between serum anion gap (AG) and 28-day mortality in critically ill patients with infective endocarditis is currently not well established.
OBJECTIVE
OBJECTIVE
This study aims to investigate the impact of serum AG on 28-day mortality in critically ill patients with infective endocarditis.
METHODS
METHODS
A retrospective cohort study was conducted involving 449 participants diagnosed with infective endocarditis and admitted to intensive care units (ICU). Vital signs, laboratory parameters and comorbidity were collected for all participants to analyze the association between anion gap levels and 28-day mortality.
RESULTS
RESULTS
A total of 449 critically ill patients with infective endocarditis (IE) were included in the study. The mean age was 57 years, and 64% were male. The overall 28-day mortality rate was 20%. A greater AG on admission were significantly associated with increased 28-day mortality in unadjusted analysis (hazard ratio [HR] 1.13; 95% confidence interval [CI] 1.09-1.18; p < 0.001). After adjusting for all confounders, the association remained significant (adjusted HR 1.07; 95% CI 1.02-1.13; p = 0.003). When AG was converted into categorial variables (quartiles), the risk of 28-day mortality in the greatest Q4 group was significantly higher compared with that in the lowest Q1 group (model 4: HR = 2.62, 95%CI: 1.17-5.83, p = 0.019). Subgroup analysis showed consistent results across different groups.
CONCLUSION
CONCLUSIONS
A greater AG on admission were independently associated with increased 28-day mortality in critically ill patients with IE. These findings suggest that the AG can serve as a prognostic marker in this population, aiding in risk stratification and guiding clinical management.
Identifiants
pubmed: 39443905
doi: 10.1186/s12872-024-04258-3
pii: 10.1186/s12872-024-04258-3
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
585Informations de copyright
© 2024. The Author(s).
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