Mouse enteric neurons control intestinal plasmacytoid dendritic cell function via serotonin-HTR7 signaling.
Animals
Dendritic Cells
/ immunology
Serotonin
/ metabolism
Mice
Signal Transduction
Receptors, Serotonin
/ metabolism
Serotonergic Neurons
/ metabolism
Intestinal Mucosa
/ metabolism
Mice, Inbred C57BL
Immunoglobulin A
/ metabolism
B-Lymphocytes
/ immunology
Enteric Nervous System
/ metabolism
Salmonella typhimurium
/ immunology
Intestines
/ immunology
Mice, Knockout
Salmonella Infections
/ immunology
Male
Cell Differentiation
/ immunology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
25 Oct 2024
25 Oct 2024
Historique:
received:
19
03
2024
accepted:
12
10
2024
medline:
26
10
2024
pubmed:
26
10
2024
entrez:
25
10
2024
Statut:
epublish
Résumé
Serotonergic neurons in the central nervous system control behavior and mood, but knowledge of the roles of serotonergic circuits in the regulation of immune homeostasis is limited. Here, we employ mouse genetics to investigate the functions of enteric serotonergic neurons in the control of immune responses and find that these circuits regulate IgA induction and boost host defense against oral, but not systemic Salmonella Typhimurium infection. Enteric serotonergic neurons promote gut-homing, retention and activation of intestinal plasmacytoid dendritic cells (pDC). Mechanistically, this neuro-immune crosstalk is achieved through a serotonin-5-HT receptor 7 (HTR7) signaling axis that ultimately facilitates the pDC-mediated differentiation of IgA
Identifiants
pubmed: 39455564
doi: 10.1038/s41467-024-53545-2
pii: 10.1038/s41467-024-53545-2
doi:
Substances chimiques
Serotonin
333DO1RDJY
Receptors, Serotonin
0
serotonin 7 receptor
0
Immunoglobulin A
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9237Subventions
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
ID : AI-042347
Informations de copyright
© 2024. The Author(s).
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