Adam Yasgar

Affiliations

National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850 United States.

Publications (20)

Discovery and Structure-Activity Relationship Study of (

Journal of medicinal chemistry

Avec: Theresa D Manz , Sindhu Carmen Sivakumaren , Fleur M Ferguson , Tinghu Zhang , Hyuk-Soo Seo , Scott B Ficarro , Joseph D Card , Hyeseok Shim , Chandrasekhar V Miduturu , Anton Simeonov , Min Shen , Jarrod A Marto , Sirano Dhe-Paganon , Matthew D Hall , Lewis C Cantley , Nathanael S Gray

Small Molecule Inhibitors of Activation-Induced Deaminase Decrease Class Switch Recombination in B Cells.

ACS pharmacology & translational science

Avec: Juan Alvarez-Gonzalez , Robert W Maul , Amanda E Rieffer , Daniel J Crawford , Daniel J Salamango , Dorjbal Dorjsuren , Alexey V Zakharov , Daniel J Jansen , Ganesha Rai , Juan Marugan , Anton Simeonov , Reuben S Harris , Rahul M Kohli , Patricia J Gearhart

Novel Consensus Architecture To Improve Performance of Large-Scale Multitask Deep Learning QSAR Models.

Journal of chemical information and modeling

Avec: Alexey V Zakharov , Tongan Zhao , Dac-Trung Nguyen , Tyler Peryea , Timothy Sheils , Ruili Huang , Noel Southall , Anton Simeonov

Cross-Platform Bayesian Optimization System for Autonomous Biological Assay Development.

SLAS technology

Avec: Sam Elder , Carleen Klumpp-Thomas , Jameson Travers , Shayne Frebert , Kelli M Wilson , Alexey V Zakharov , Jayme L Dahlin , Christoph Kreisbeck , Dennis Sheberla , Gurusingham S Sittampalam , Alexander G Godfrey , Anton Simeonov , Sam Michael

A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model.

PloS one

Avec: Dorjbal Dorjsuren , Richard T Eastman , Min Jae Song , Yuchi Chen , Kapil Bharti , Alexey V Zakharov , Ajit Jadhav , Marc Ferrer , Pei-Yong Shi , Anton Simeonov

Optimization of High-Throughput Methyltransferase Assays for the Discovery of Small Molecule Inhibitors.

ACS combinatorial science

Avec: Guangping Dong , Darrell L Peterson , Alexey Zakharov , Daniel Talley , Ken Chih-Chien Cheng , Ajit Jadhav , Anton Simeonov , Rong Huang

A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.

Cell reports

Avec: Mark J Henderson , Kathleen A Trychta , Shyh-Ming Yang , Susanne Bäck , Emily S Wires , Carina Danchik , Xiaokang Yan , Hideaki Yano , Lei Shi , Kuo-Jen Wu , Amy Q Wang , Dingyin Tao , Gergely Zahoránszky-Kőhalmi , Xin Hu , Xin Xu , David Maloney , Alexey V Zakharov , Ganesha Rai , Fumihiko Urano , Mikko Airavaara , Oksana Gavrilova , Ajit Jadhav , Yun Wang , Anton Simeonov , Brandon K Harvey

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology.

Chemical research in toxicology

Avec: Ann M Richard , Ruili Huang , Suramya Waidyanatha , Paul Shinn , Bradley J Collins , Inthirany Thillainadarajah , Christopher M Grulke , Antony J Williams , Ryan R Lougee , Richard S Judson , Keith A Houck , Mahmoud Shobair , Chihae Yang , James F Rathman , Suzanne C Fitzpatrick , Anton Simeonov , Russell S Thomas , Kevin M Crofton , Richard S Paules , John R Bucher , Christopher P Austin , Robert J Kavlock , Raymond R Tice

SCAM Detective: Accurate Predictor of Small, Colloidally Aggregating Molecules.

Journal of chemical information and modeling

Avec: Vinicius M Alves , Stephen J Capuzzi , Rodolpho C Braga , Daniel Korn , Joshua E Hochuli , Kyle H Bowler , Ganesha Rai , Anton Simeonov , Eugene N Muratov , Alexey V Zakharov , Alexander Tropsha

Applications of Differential Scanning Fluorometry and Related Technologies in Characterization of Protein-Ligand Interactions.

Methods in molecular biology (Clifton, N.J.)

Avec: Bolormaa Baljinnyam , Michael Ronzetti , Anton Simeonov

Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors.

ACS medicinal chemistry letters

Avec: Theresa D Manz , Sindhu C Sivakumaren , Matthew D Hall , Mindy I Davis , Hyuk-Soo Seo , Joseph D Card , Scott B Ficarro , Hyeseok Shim , Jarrod A Marto , Sirano Dhe-Paganon , Atsuo T Sasaki , Matthew B Boxer , Anton Simeonov , Lewis C Cantley , Min Shen , Tinghu Zhang , Fleur M Ferguson , Nathanael S Gray

Discovery and Optimization of 2

Journal of medicinal chemistry

Avec: Jason M Rohde , Surendra Karavadhi , Rajan Pragani , Li Liu , Yuhong Fang , Weihe Zhang , Andrew McIver , Hongchao Zheng , Qingyang Liu , Mindy I Davis , Daniel J Urban , Tobie D Lee , Dorian M Cheff , Melinda Hollingshead , Mark J Henderson , Natalia J Martinez , Kyle R Brimacombe , Wei Zhao , Carleen Klumpp-Thomas , Sam Michael , Joseph Covey , William J Moore , Gordon M Stott , Zhuyin Li , Anton Simeonov , Ajit Jadhav , Stephen Frye , Matthew D Hall , Min Shen , Xiaodong Wang , Samarjit Patnaik , Matthew B Boxer

Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products.

ACS pharmacology & translational science

Avec: Danielle Bougie , Richard T Eastman , Ruili Huang , Misha Itkin , Jennifer Kouznetsova , Caitlin Lynch , Crystal McKnight , Mitch Miller , Deborah K Ngan , Tyler Peryea , Pranav Shah , Paul Shinn , Menghang Xia , Xin Xu , Alexey V Zakharov , Anton Simeonov

Small-Molecule Disruptors of the Interaction between Calcium- and Integrin-Binding Protein 1 and Integrin α

ACS pharmacology & translational science

Avec: Kalyan Golla , Voddarahally N Manjuprasanna , Meghna U Naik , Bolormaa Baljinnyam , Alexey V Zakharov , Sankalp Jain , Ganesha Rai , Ajit Jadhav , Anton Simeonov , Ulhas P Naik

Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Rachel P M Abrams , Tadahisa Teramoto , Myoung-Hwa Lee , Dorjbal Dorjsuren , Richard T Eastman , Nasir Malik , Alexey V Zakharov , Wenxue Li , Muzna Bachani , Kyle Brimacombe , Joseph P Steiner , Matthew D Hall , Anuradha Balasubramanian , Ajit Jadhav , Radhakrishnan Padmanabhan , Anton Simeonov , Avindra Nath

Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.

Bioorganic & medicinal chemistry

Avec: Wan-Chen Tsai , Nathan C Gilbert , Amanda Ohler , Michelle Armstrong , Steven Perry , Chakrapani Kalyanaraman , Ganesha Rai , Anton Simeonov , Ajit Jadhav , Melissa Standley , Hsiau-Wei Lee , Phillip Crews , Anthony T Iavarone , Matthew P Jacobson , David B Neau , Adam R Offenbacher , Marcia Newcomer , Theodore R Holman

Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner.

Journal of medicinal chemistry

Avec: Guangping Dong , Youchao Deng , Ravi Yadav , Daniel Talley , Alexey V Zakharov , Sankalp Jain , Ganesha Rai , Nicholas Noinaj , Anton Simeonov , Rong Huang

Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Haider H Dar , Karolina Mikulska-Ruminska , Yulia Y Tyurina , Diane K Luci , Svetlana N Samovich , Alexander A Kapralov , Austin B Souryavong , Vladimir A Tyurin , Andrew A Amoscato , Michael W Epperly , Galina V Shurin , Melissa Standley , Theodore R Holman , Claudette M St Croix , Simon C Watkins , Andrew P VanDemark , Sandeep Rana , Alexey V Zakharov , Anton Simeonov , Juan Marugan , Rama K Mallampalli , Sally E Wenzel , Joel S Greenberger , Ganesha Rai , Hülya Bayir , Ivet Bahar , Valerian E Kagan

Lies and Liabilities: Computational Assessment of High-Throughput Screening Hits to Identify Artifact Compounds.

Journal of medicinal chemistry

Avec: Vinicius M Alves , James Wellnitz , Ganesha Rai , Marielle Rath , Rodolpho C Braga , Stephen J Capuzzi , Anton Simeonov , Eugene N Muratov , Alexey V Zakharov , Alexander Tropsha

RALDH1 inhibition shows immunotherapeutic efficacy in hepatocellular carcinoma.

Cancer immunology research

Avec: Pengfei Yu , Shuwen Cao , Shyh-Ming Yang , Ganesha Rai , Natalia J Martinez , Alexey V Zakharov , Anton Simeonov , William A Molina-Arocho , Graham P Lobel , Hesham Mohei , Alexis L Scott , Li Zhai , Emma E Furth , M Celeste Simon , Malay Haldar

Réseau de co-auteurs

Anton Simeonov 20 collaborations

Alexey V Zakharov 13 collaborations

Ganesha Rai 9 collaborations

Ajit Jadhav 7 collaborations

Matthew D Hall 4 collaborations

Min Shen 3 collaborations

Dorjbal Dorjsuren 3 collaborations

Ruili Huang 3 collaborations

Richard T Eastman 3 collaborations

Theresa D Manz 2 collaborations

Fleur M Ferguson 2 collaborations

Tinghu Zhang 2 collaborations

Hyuk-Soo Seo 2 collaborations

Scott B Ficarro 2 collaborations

Joseph D Card 2 collaborations

Hyeseok Shim 2 collaborations

Jarrod A Marto 2 collaborations

Sirano Dhe-Paganon 2 collaborations

Lewis C Cantley 2 collaborations

Nathanael S Gray 2 collaborations

Juan Marugan 2 collaborations

Tyler Peryea 2 collaborations

Carleen Klumpp-Thomas 2 collaborations

Sam Michael 2 collaborations

Guangping Dong 2 collaborations

Daniel Talley 2 collaborations

Rong Huang 2 collaborations

Mark J Henderson 2 collaborations

Shyh-Ming Yang 2 collaborations

Xin Xu 2 collaborations

Paul Shinn 2 collaborations

Vinicius M Alves 2 collaborations

Stephen J Capuzzi 2 collaborations

Rodolpho C Braga 2 collaborations

Eugene N Muratov 2 collaborations

Alexander Tropsha 2 collaborations

Bolormaa Baljinnyam 2 collaborations

Mindy I Davis 2 collaborations

Matthew B Boxer 2 collaborations

Natalia J Martinez 2 collaborations

Sankalp Jain 2 collaborations

Melissa Standley 2 collaborations

Theodore R Holman 2 collaborations

Sindhu Carmen Sivakumaren 1 collaboration

Chandrasekhar V Miduturu 1 collaboration

Juan Alvarez-Gonzalez 1 collaboration

Robert W Maul 1 collaboration

Amanda E Rieffer 1 collaboration

Daniel J Crawford 1 collaboration

Daniel J Salamango 1 collaboration

Daniel J Jansen 1 collaboration

Reuben S Harris 1 collaboration

Rahul M Kohli 1 collaboration

Patricia J Gearhart 1 collaboration

Tongan Zhao 1 collaboration

Dac-Trung Nguyen 1 collaboration

Timothy Sheils 1 collaboration

Noel Southall 1 collaboration

Sam Elder 1 collaboration

Jameson Travers 1 collaboration

Shayne Frebert 1 collaboration

Kelli M Wilson 1 collaboration

Jayme L Dahlin 1 collaboration

Christoph Kreisbeck 1 collaboration

Dennis Sheberla 1 collaboration

Gurusingham S Sittampalam 1 collaboration

Alexander G Godfrey 1 collaboration

Min Jae Song 1 collaboration

Yuchi Chen 1 collaboration

Kapil Bharti 1 collaboration

Marc Ferrer 1 collaboration

Pei-Yong Shi 1 collaboration

Darrell L Peterson 1 collaboration

Alexey Zakharov 1 collaboration

Ken Chih-Chien Cheng 1 collaboration

Kathleen A Trychta 1 collaboration

Susanne Bäck 1 collaboration

Emily S Wires 1 collaboration

Carina Danchik 1 collaboration

Xiaokang Yan 1 collaboration

Hideaki Yano 1 collaboration

Lei Shi 1 collaboration

Kuo-Jen Wu 1 collaboration

Amy Q Wang 1 collaboration

Dingyin Tao 1 collaboration

Gergely Zahoránszky-Kőhalmi 1 collaboration

Xin Hu 1 collaboration

David Maloney 1 collaboration

Fumihiko Urano 1 collaboration

Mikko Airavaara 1 collaboration

Oksana Gavrilova 1 collaboration

Yun Wang 1 collaboration

Brandon K Harvey 1 collaboration

Ann M Richard 1 collaboration

Suramya Waidyanatha 1 collaboration

Bradley J Collins 1 collaboration

Inthirany Thillainadarajah 1 collaboration

Christopher M Grulke 1 collaboration

Antony J Williams 1 collaboration

Ryan R Lougee 1 collaboration

Richard S Judson 1 collaboration

Keith A Houck 1 collaboration

Mahmoud Shobair 1 collaboration

Chihae Yang 1 collaboration

James F Rathman 1 collaboration

Suzanne C Fitzpatrick 1 collaboration

Russell S Thomas 1 collaboration

Kevin M Crofton 1 collaboration

Richard S Paules 1 collaboration

John R Bucher 1 collaboration

Christopher P Austin 1 collaboration

Robert J Kavlock 1 collaboration

Raymond R Tice 1 collaboration

Daniel Korn 1 collaboration

Joshua E Hochuli 1 collaboration

Kyle H Bowler 1 collaboration

Michael Ronzetti 1 collaboration

Sindhu C Sivakumaren 1 collaboration

Atsuo T Sasaki 1 collaboration

Jason M Rohde 1 collaboration

Surendra Karavadhi 1 collaboration

Rajan Pragani 1 collaboration

Li Liu 1 collaboration

Yuhong Fang 1 collaboration

Weihe Zhang 1 collaboration

Andrew McIver 1 collaboration

Hongchao Zheng 1 collaboration

Qingyang Liu 1 collaboration

Daniel J Urban 1 collaboration

Tobie D Lee 1 collaboration

Dorian M Cheff 1 collaboration

Melinda Hollingshead 1 collaboration

Kyle R Brimacombe 1 collaboration

Wei Zhao 1 collaboration

Joseph Covey 1 collaboration

William J Moore 1 collaboration

Gordon M Stott 1 collaboration

Zhuyin Li 1 collaboration

Stephen Frye 1 collaboration

Xiaodong Wang 1 collaboration

Samarjit Patnaik 1 collaboration

Danielle Bougie 1 collaboration

Misha Itkin 1 collaboration

Jennifer Kouznetsova 1 collaboration

Caitlin Lynch 1 collaboration

Crystal McKnight 1 collaboration

Mitch Miller 1 collaboration

Deborah K Ngan 1 collaboration

Pranav Shah 1 collaboration

Menghang Xia 1 collaboration

Kalyan Golla 1 collaboration

Voddarahally N Manjuprasanna 1 collaboration

Meghna U Naik 1 collaboration

Ulhas P Naik 1 collaboration

Rachel P M Abrams 1 collaboration

Tadahisa Teramoto 1 collaboration

Myoung-Hwa Lee 1 collaboration

Nasir Malik 1 collaboration

Wenxue Li 1 collaboration

Muzna Bachani 1 collaboration

Kyle Brimacombe 1 collaboration

Joseph P Steiner 1 collaboration

Anuradha Balasubramanian 1 collaboration

Radhakrishnan Padmanabhan 1 collaboration

Avindra Nath 1 collaboration

Wan-Chen Tsai 1 collaboration

Nathan C Gilbert 1 collaboration

Amanda Ohler 1 collaboration

Michelle Armstrong 1 collaboration

Steven Perry 1 collaboration

Chakrapani Kalyanaraman 1 collaboration

Hsiau-Wei Lee 1 collaboration

Phillip Crews 1 collaboration

Anthony T Iavarone 1 collaboration

Matthew P Jacobson 1 collaboration

David B Neau 1 collaboration

Adam R Offenbacher 1 collaboration

Marcia Newcomer 1 collaboration

Youchao Deng 1 collaboration

Ravi Yadav 1 collaboration

Nicholas Noinaj 1 collaboration

Haider H Dar 1 collaboration

Karolina Mikulska-Ruminska 1 collaboration

Yulia Y Tyurina 1 collaboration

Diane K Luci 1 collaboration

Svetlana N Samovich 1 collaboration

Alexander A Kapralov 1 collaboration

Austin B Souryavong 1 collaboration

Vladimir A Tyurin 1 collaboration

Andrew A Amoscato 1 collaboration

Michael W Epperly 1 collaboration

Galina V Shurin 1 collaboration

Claudette M St Croix 1 collaboration

Simon C Watkins 1 collaboration

Andrew P VanDemark 1 collaboration

Sandeep Rana 1 collaboration

Rama K Mallampalli 1 collaboration

Sally E Wenzel 1 collaboration

Joel S Greenberger 1 collaboration

Hülya Bayir 1 collaboration

Ivet Bahar 1 collaboration

Valerian E Kagan 1 collaboration

James Wellnitz 1 collaboration

Marielle Rath 1 collaboration

Pengfei Yu 1 collaboration

Shuwen Cao 1 collaboration

William A Molina-Arocho 1 collaboration

Graham P Lobel 1 collaboration

Hesham Mohei 1 collaboration

Alexis L Scott 1 collaboration

Li Zhai 1 collaboration

Emma E Furth 1 collaboration

M Celeste Simon 1 collaboration

Malay Haldar 1 collaboration