Alex Rialdi

Affiliations

Center for Therapeutics Discovery, Department of Oncological Sciences and Pharmacological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Liver Cancer Program, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Center for OncoGenomics and Innovative Therapeutics, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Publications (11)

Discovery of a first-in-class EZH2 selective degrader.

Nature chemical biology

Avec: Anqi Ma , Elias Stratikopoulos , Kwang-Su Park , Jieli Wei , Tiphaine C Martin , Xiaobao Yang , Megan Schwarz , Violetta Leshchenko , Alexander Rialdi , Brandon Dale , Alessandro Lagana , Ernesto Guccione , Samir Parekh , Ramon Parsons , Jian Jin

Dynamic plasticity of prostate cancer intermediate cells during androgen receptor-targeted therapy.

Cell reports

Avec: Harkirat S Sandhu , Kensey L Portman , Xianxiao Zhou , Julia Zhao , Alexander Rialdi , John P Sfakianos , Ernesto Guccione , Natasha Kyprianou , Bin Zhang , David J Mulholland

SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion.

Cell

Avec: Giuseppe Leuzzi , Alessandro Vasciaveo , Angelo Taglialatela , Xiao Chen , Tessa M Firestone , Allison R Hickman , Wendy Mao , Tanay Thakar , Alina Vaitsiankova , Jen-Wei Huang , Raquel Cuella-Martin , Samuel B Hayward , Jordan S Kesner , Ali Ghasemzadeh , Tarun S Nambiar , Patricia Ho , Alexander Rialdi , Maxime Hebrard , Yinglu Li , Jinmei Gao , Saarang Gopinath , Oluwatobi A Adeleke , Bryan J Venters , Charles G Drake , Richard Baer , Benjamin Izar , Ernesto Guccione , Michael-Christopher Keogh , Raphael Guerois , Lu Sun , Chao Lu , Andrea Califano , Alberto Ciccia

Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis.

Nature communications

Avec: Sonal Sinha , Satoka Aizawa , Yasuhiro Nakano , Alexander Rialdi , Hye Yeon Choi , Rajan Shrestha , Stephanie Q Pan , Yibu Chen , Meng Li , Audrey Kapelanski-Lamoureux , Gregory Yochum , Linda Sher , Satdarshan Paul Monga , Anthoula Lazaris , Keigo Machida , Michael Karin , Ernesto Guccione , Hidekazu Tsukamoto

WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma.

Nature cancer

Avec: Alex Rialdi , Mary Duffy , Alex P Scopton , Frank Fonseca , Julia Nanyi Zhao , Megan Schwarz , Pedro Molina-Sanchez , Slim Mzoughi , Elisa Arceci , Jordi Abril-Fornaguera , Austin Meadows , Marina Ruiz de Galarreta , Denis Torre , Kyna Reyes , Yan Ting Lim , Felix Rosemann , Zaigham M Khan , Kevin Mohammed , Xuedi Wang , Xufen Yu , Manikandan Lakshmanan , Ravisankar Rajarethinam , Soo Yong Tan , Jian Jin , Augusto Villanueva , Eleftherios Michailidis , Ype P De Jong , Charles M Rice , Ivan Marazzi , Dan Hasson , Josep M Llovet , Radoslaw M Sobota , Amaia Lujambio , Ernesto Guccione , Arvin C Dar

Phenotype-Based Screens with Conformation-Specific Inhibitors Reveal p38 Gamma and Delta as Targets for HCC Polypharmacology.

Molecular cancer therapeutics

Avec: Jia Xin Yu , Amanda J Craig , Mary E Duffy , Carlos Villacorta-Martin , Verónica Miguela , Marina Ruiz de Galarreta , Alexander P Scopton , Lisa Silber , Andres Y Maldonado , Alexander Rialdi , Ernesto Guccione , Amaia Lujambio , Augusto Villanueva , Arvin C Dar

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.

Cancer cell

Avec: Jia Yi Fong , Luca Pignata , Pierre-Alexis Goy , Kimihito Cojin Kawabata , Stanley Chun-Wei Lee , Cheryl M Koh , Daniele Musiani , Enrico Massignani , Andriana G Kotini , Alex Penson , Cheng Mun Wun , Yudao Shen , Megan Schwarz , Diana Hp Low , Alexander Rialdi , Michelle Ki , Heike Wollmann , Slim Mzoughi , Florence Gay , Christine Thompson , Timothy Hart , Olena Barbash , Genna M Luciani , Magdalena M Szewczyk , Bas J Wouters , Ruud Delwel , Eirini P Papapetrou , Dalia Barsyte-Lovejoy , Cheryl H Arrowsmith , Mark D Minden , Jian Jin , Ari Melnick , Tiziana Bonaldi , Omar Abdel-Wahab , Ernesto Guccione

The portrait of liver cancer is shaped by mitochondrial genetics.

Cell reports

Avec: Mrittika Chattopadhyay , Edmund Charles Jenkins , Ana Victoria Lechuga-Vieco , Kai Nie , Maria Isabel Fiel , Alexander Rialdi , Ernesto Guccione , Jose Antonio Enriquez , Daniela Sia , Amaia Lujambio , Doris Germain

Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition.

Cell

Avec: Bram Priem , Mandy M T van Leent , Abraham J P Teunissen , Alexandros Marios Sofias , Vera P Mourits , Lisa Willemsen , Emma D Klein , Roderick S Oosterwijk , Anu E Meerwaldt , Jazz Munitz , Geoffrey Prévot , Anna Vera Verschuur , Sheqouia A Nauta , Esther M van Leeuwen , Elizabeth L Fisher , Karen A M de Jong , Yiming Zhao , Yohana C Toner , Georgios Soultanidis , Claudia Calcagno , Paul H H Bomans , Heiner Friedrich , Nico Sommerdijk , Thomas Reiner , Raphaël Duivenvoorden , Eva Zupančič , Julie S Di Martino , Ewelina Kluza , Mohammad Rashidian , Hidde L Ploegh , Rick M Dijkhuizen , Sjoerd Hak , Carlos Pérez-Medina , Jose Javier Bravo-Cordero , Menno P J de Winther , Leo A B Joosten , Andrea van Elsas , Zahi A Fayad , Alexander Rialdi , Denis Torre , Ernesto Guccione , Jordi Ochando , Mihai G Netea , Arjan W Griffioen , Willem J M Mulder

Novel microenvironment-based classification of intrahepatic cholangiocarcinoma with therapeutic implications.

Gut

Avec: Miguel A Martin-Serrano , Benjamin Kepecs , Miguel Torres-Martin , Emily R Bramel , Philipp K Haber , Elliot Merritt , Alexander Rialdi , Nesteene Joy Param , Miho Maeda , Katherine E Lindblad , James K Carter , Marina Barcena-Varela , Vincenzo Mazzaferro , Myron Schwartz , Silvia Affo , Robert F Schwabe , Augusto Villanueva , Ernesto Guccione , Scott L Friedman , Amaia Lujambio , Anna Tocheva , Josep M Llovet , Swan N Thung , Alexander M Tsankov , Daniela Sia

Identification of IGF2 as Genomic Driver and Actionable Therapeutic Target in Hepatoblastoma.

Molecular cancer therapeutics

Avec: Jordi Abril-Fornaguera , Laura Torrens , Carmen Andreu-Oller , Juan Carrillo-Reixach , Alex Rialdi , Ugne Balaseviciute , Roser Pinyol , Carla Montironi , Philipp K Haber , Álvaro Del Río-Álvarez , Montserrat Domingo-Sàbat , Laura Royo , Nicholas K Akers , Catherine E Willoughby , Judit Peix , Miguel Torres-Martin , Marc Puigvehi , Stefano Cairo , Margaret Childs , Rudolf Maibach , Rita Alaggio , Piotr Czauderna , Bruce Morland , Bojan Losic , Vincenzo Mazzaferro , Ernesto Guccione , Daniela Sia , Carolina Armengol , Josep M Llovet

Réseau de co-auteurs

Ernesto Guccione 11 collaborations

Alexander Rialdi 9 collaborations

Amaia Lujambio 4 collaborations

Megan Schwarz 3 collaborations

Jian Jin 3 collaborations

Augusto Villanueva 3 collaborations

Josep M Llovet 3 collaborations

Daniela Sia 3 collaborations

Slim Mzoughi 2 collaborations

Jordi Abril-Fornaguera 2 collaborations

Marina Ruiz de Galarreta 2 collaborations

Denis Torre 2 collaborations

Arvin C Dar 2 collaborations

Miguel Torres-Martin 2 collaborations

Philipp K Haber 2 collaborations

Vincenzo Mazzaferro 2 collaborations

Anqi Ma 1 collaboration

Elias Stratikopoulos 1 collaboration

Kwang-Su Park 1 collaboration

Jieli Wei 1 collaboration

Tiphaine C Martin 1 collaboration

Xiaobao Yang 1 collaboration

Violetta Leshchenko 1 collaboration

Brandon Dale 1 collaboration

Alessandro Lagana 1 collaboration

Samir Parekh 1 collaboration

Ramon Parsons 1 collaboration

Harkirat S Sandhu 1 collaboration

Kensey L Portman 1 collaboration

Xianxiao Zhou 1 collaboration

Julia Zhao 1 collaboration

John P Sfakianos 1 collaboration

Natasha Kyprianou 1 collaboration

Bin Zhang 1 collaboration

David J Mulholland 1 collaboration

Giuseppe Leuzzi 1 collaboration

Alessandro Vasciaveo 1 collaboration

Angelo Taglialatela 1 collaboration

Xiao Chen 1 collaboration

Tessa M Firestone 1 collaboration

Allison R Hickman 1 collaboration

Wendy Mao 1 collaboration

Tanay Thakar 1 collaboration

Alina Vaitsiankova 1 collaboration

Jen-Wei Huang 1 collaboration

Raquel Cuella-Martin 1 collaboration

Samuel B Hayward 1 collaboration

Jordan S Kesner 1 collaboration

Ali Ghasemzadeh 1 collaboration

Tarun S Nambiar 1 collaboration

Patricia Ho 1 collaboration

Maxime Hebrard 1 collaboration

Yinglu Li 1 collaboration

Jinmei Gao 1 collaboration

Saarang Gopinath 1 collaboration

Oluwatobi A Adeleke 1 collaboration

Bryan J Venters 1 collaboration

Charles G Drake 1 collaboration

Richard Baer 1 collaboration

Benjamin Izar 1 collaboration

Michael-Christopher Keogh 1 collaboration

Raphael Guerois 1 collaboration

Lu Sun 1 collaboration

Chao Lu 1 collaboration

Andrea Califano 1 collaboration

Alberto Ciccia 1 collaboration

Sonal Sinha 1 collaboration

Satoka Aizawa 1 collaboration

Yasuhiro Nakano 1 collaboration

Hye Yeon Choi 1 collaboration

Rajan Shrestha 1 collaboration

Stephanie Q Pan 1 collaboration

Yibu Chen 1 collaboration

Meng Li 1 collaboration

Audrey Kapelanski-Lamoureux 1 collaboration

Gregory Yochum 1 collaboration

Linda Sher 1 collaboration

Satdarshan Paul Monga 1 collaboration

Anthoula Lazaris 1 collaboration

Keigo Machida 1 collaboration

Michael Karin 1 collaboration

Hidekazu Tsukamoto 1 collaboration

Mary Duffy 1 collaboration

Alex P Scopton 1 collaboration

Frank Fonseca 1 collaboration

Julia Nanyi Zhao 1 collaboration

Pedro Molina-Sanchez 1 collaboration

Elisa Arceci 1 collaboration

Austin Meadows 1 collaboration

Kyna Reyes 1 collaboration

Yan Ting Lim 1 collaboration

Felix Rosemann 1 collaboration

Zaigham M Khan 1 collaboration

Kevin Mohammed 1 collaboration

Xuedi Wang 1 collaboration

Xufen Yu 1 collaboration

Manikandan Lakshmanan 1 collaboration

Ravisankar Rajarethinam 1 collaboration

Soo Yong Tan 1 collaboration

Eleftherios Michailidis 1 collaboration

Ype P De Jong 1 collaboration

Charles M Rice 1 collaboration

Ivan Marazzi 1 collaboration

Dan Hasson 1 collaboration

Radoslaw M Sobota 1 collaboration

Jia Xin Yu 1 collaboration

Amanda J Craig 1 collaboration

Mary E Duffy 1 collaboration

Carlos Villacorta-Martin 1 collaboration

Verónica Miguela 1 collaboration

Alexander P Scopton 1 collaboration

Lisa Silber 1 collaboration

Andres Y Maldonado 1 collaboration

Jia Yi Fong 1 collaboration

Luca Pignata 1 collaboration

Pierre-Alexis Goy 1 collaboration

Kimihito Cojin Kawabata 1 collaboration

Stanley Chun-Wei Lee 1 collaboration

Cheryl M Koh 1 collaboration

Daniele Musiani 1 collaboration

Enrico Massignani 1 collaboration

Andriana G Kotini 1 collaboration

Alex Penson 1 collaboration

Cheng Mun Wun 1 collaboration

Yudao Shen 1 collaboration

Diana Hp Low 1 collaboration

Michelle Ki 1 collaboration

Heike Wollmann 1 collaboration

Florence Gay 1 collaboration

Christine Thompson 1 collaboration

Timothy Hart 1 collaboration

Olena Barbash 1 collaboration

Genna M Luciani 1 collaboration

Magdalena M Szewczyk 1 collaboration

Bas J Wouters 1 collaboration

Ruud Delwel 1 collaboration

Eirini P Papapetrou 1 collaboration

Dalia Barsyte-Lovejoy 1 collaboration

Cheryl H Arrowsmith 1 collaboration

Mark D Minden 1 collaboration

Ari Melnick 1 collaboration

Tiziana Bonaldi 1 collaboration

Omar Abdel-Wahab 1 collaboration

Mrittika Chattopadhyay 1 collaboration

Edmund Charles Jenkins 1 collaboration

Ana Victoria Lechuga-Vieco 1 collaboration

Kai Nie 1 collaboration

Maria Isabel Fiel 1 collaboration

Jose Antonio Enriquez 1 collaboration

Doris Germain 1 collaboration

Bram Priem 1 collaboration

Mandy M T van Leent 1 collaboration

Abraham J P Teunissen 1 collaboration

Alexandros Marios Sofias 1 collaboration

Vera P Mourits 1 collaboration

Lisa Willemsen 1 collaboration

Emma D Klein 1 collaboration

Roderick S Oosterwijk 1 collaboration

Anu E Meerwaldt 1 collaboration

Jazz Munitz 1 collaboration

Geoffrey Prévot 1 collaboration

Anna Vera Verschuur 1 collaboration

Sheqouia A Nauta 1 collaboration

Esther M van Leeuwen 1 collaboration

Elizabeth L Fisher 1 collaboration

Karen A M de Jong 1 collaboration

Yiming Zhao 1 collaboration

Yohana C Toner 1 collaboration

Georgios Soultanidis 1 collaboration

Claudia Calcagno 1 collaboration

Paul H H Bomans 1 collaboration

Heiner Friedrich 1 collaboration

Nico Sommerdijk 1 collaboration

Thomas Reiner 1 collaboration

Raphaël Duivenvoorden 1 collaboration

Eva Zupančič 1 collaboration

Julie S Di Martino 1 collaboration

Ewelina Kluza 1 collaboration

Mohammad Rashidian 1 collaboration

Hidde L Ploegh 1 collaboration

Rick M Dijkhuizen 1 collaboration

Sjoerd Hak 1 collaboration

Carlos Pérez-Medina 1 collaboration

Jose Javier Bravo-Cordero 1 collaboration

Menno P J de Winther 1 collaboration

Leo A B Joosten 1 collaboration

Andrea van Elsas 1 collaboration

Zahi A Fayad 1 collaboration

Jordi Ochando 1 collaboration

Mihai G Netea 1 collaboration

Arjan W Griffioen 1 collaboration

Willem J M Mulder 1 collaboration

Miguel A Martin-Serrano 1 collaboration

Benjamin Kepecs 1 collaboration

Emily R Bramel 1 collaboration

Elliot Merritt 1 collaboration

Nesteene Joy Param 1 collaboration

Miho Maeda 1 collaboration

Katherine E Lindblad 1 collaboration

James K Carter 1 collaboration

Marina Barcena-Varela 1 collaboration

Myron Schwartz 1 collaboration

Silvia Affo 1 collaboration

Robert F Schwabe 1 collaboration

Scott L Friedman 1 collaboration

Anna Tocheva 1 collaboration

Swan N Thung 1 collaboration

Alexander M Tsankov 1 collaboration

Laura Torrens 1 collaboration

Carmen Andreu-Oller 1 collaboration

Juan Carrillo-Reixach 1 collaboration

Ugne Balaseviciute 1 collaboration

Roser Pinyol 1 collaboration

Carla Montironi 1 collaboration

Álvaro Del Río-Álvarez 1 collaboration

Montserrat Domingo-Sàbat 1 collaboration

Laura Royo 1 collaboration

Nicholas K Akers 1 collaboration

Catherine E Willoughby 1 collaboration

Judit Peix 1 collaboration

Marc Puigvehi 1 collaboration

Stefano Cairo 1 collaboration

Margaret Childs 1 collaboration

Rudolf Maibach 1 collaboration

Rita Alaggio 1 collaboration

Piotr Czauderna 1 collaboration

Bruce Morland 1 collaboration

Bojan Losic 1 collaboration

Carolina Armengol 1 collaboration