B Fromenty

Affiliations

Univ Rennes, INSERM, INRA, Institut NuMeCan, CHU Rennes, France.

Publications (31)

Drug-induced liver injury in obesity and nonalcoholic fatty liver disease.

Advances in pharmacology (San Diego, Calif.)

Avec: Julien Allard , Dounia Le Guillou , Karima Begriche , Bernard Fromenty

Maternal and neonatal outcomes and prognostic factors in acute fatty liver of pregnancy.

European journal of obstetrics, gynecology, and reproductive biology

Avec: Y Joueidi , K Peoc'h , M Le Lous , G Bouzille , C Rousseau , E Bardou-Jacquet , C Bendavid , L Damaj , B Fromenty , V Lavoué , C Moreau

Treatments in Covid-19 patients with pre-existing metabolic dysfunction-associated fatty liver disease: A potential threat for drug-induced liver injury?

Biochimie

Avec: Pierre-Jean Ferron , Thomas Gicquel , Bruno Mégarbane , Bruno Clément , Bernard Fromenty

The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds.

International journal of molecular sciences

Avec: Juliette Legler , Daniel Zalko , Fabien Jourdan , Miriam Jacobs , Bernard Fromenty , Patrick Balaguer , William Bourguet , Vesna Munic Kos , Angel Nadal , Claire Beausoleil , Susana Cristobal , Sylvie Remy , Sibylle Ermler , Luigi Margiotta-Casaluci , Julian L Griffin , Bruce Blumberg , Christophe Chesné , Sebastian Hoffmann , Patrik L Andersson , Jorke H Kamstra

Retrodifferentiation of Human Tumor Hepatocytes to Stem Cells Leads to Metabolic Reprogramming and Chemoresistance.

Cancer research

Avec: Karim Fekir , Hélène Dubois-Pot-Schneider , Romain Désert , Yoann Daniel , Denise Glaise , Claudine Rauch , Fabrice Morel , Bernard Fromenty , Orlando Musso , Florian Cabillic , Anne Corlu

Beneficial effects of citrulline enteral administration on sepsis-induced T cell mitochondrial dysfunction.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Florian Reizine , Murielle Grégoire , Mathieu Lesouhaitier , Valentin Coirier , Juliette Gauthier , Céline Delaloy , Elise Dessauge , Florent Creusat , Fabrice Uhel , Arnaud Gacouin , Frédéric Dessauge , Cécile Le Naoures , Caroline Moreau , Claude Bendavid , Yoann Daniel , Kilian Petitjean , Valérie Bordeau , Claire Lamaison , Caroline Piau , Vincent Cattoir , Mikael Roussel , Bernard Fromenty , Christian Michelet , Yves Le Tulzo , Jaroslaw Zmijewski , Ronan Thibault , Michel Cogné , Karin Tarte , Jean-Marc Tadié

3D multi-cell-type liver organoids: A new model of non-alcoholic fatty liver disease for drug safety assessments.

Toxicology in vitro : an international journal published in association with BIBRA

Avec: J Bronsard , C Savary , J Massart , R Viel , L Moutaux , D Catheline , V Rioux , B Clement , A Corlu , B Fromenty , P J Ferron

Moderate chronic ethanol consumption exerts beneficial effects on nonalcoholic fatty liver in mice fed a high-fat diet: possible role of higher formation of triglycerides enriched in monounsaturated fatty acids.

European journal of nutrition

Avec: Simon Bucher , Karima Begriche , Daniel Catheline , Viviane Trak-Smayra , François Tiaho , Cédric Coulouarn , Grégory Pinon , Dominique Lagadic-Gossmann , Vincent Rioux , Bernard Fromenty

Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis.

Clinics and research in hepatology and gastroenterology

Avec: Julie Massart , Karima Begriche , Bernard Fromenty

Mitochondrial alterations in fatty liver diseases.

Journal of hepatology

Avec: Bernard Fromenty , Michael Roden

Mitochondrial remodeling and energy metabolism adaptations in colonic crypts during spontaneous epithelial repair after colitis induction in mice.

Free radical biology & medicine

Avec: Annaïg Lan , Thomas Guerbette , Mireille Andriamihaja , Benjamin Magnin , Martin Bordet , Pierre-Jean Ferron , Agnès Burel , Roselyne Viel , Bernard Fromenty , Anne Corlu , François Blachier , Guillaume Bouguen

Low concentrations of ethylene bisdithiocarbamate pesticides maneb and mancozeb impair manganese and zinc homeostasis to induce oxidative stress and caspase-dependent apoptosis in human hepatocytes.

Chemosphere

Avec: Kilian Petitjean , Yann Verres , Sébastien Bristeau , Catherine Ribault , Caroline Aninat , Christophe Olivier , Patricia Leroyer , Martine Ropert , Olivier Loréal , Olivier Herault , Laurence Amalric , Nicole Baran , Bernard Fromenty , Anne Corlu , Pascal Loyer

Roadmap to DILI research in Europe. A proposal from COST Action ProEuroDILINet.

Pharmacological research

Avec: M I Lucena , M Villanueva-Paz , Alvarez-Alvarez , G P Aithal , E S Björnsson , G Cakan-Akdogan , F J Cubero , F Esteves , J M Falcon-Perez , B Fromenty , C Garcia-Ruiz , J I Grove , O Konu , M Kranendonk , G Kullak-Ublick , J P Miranda , A Remesal-Doblado , P Sancho-Bru , L Nelson , R J Andrade , A K Daly , J C Fernandez-Checa

Non-oxidative ethanol metabolism in human hepatic cells in vitro: Involvement of uridine diphospho-glucuronosyltransferase 1A9 in ethylglucuronide production.

Toxicology in vitro : an international journal published in association with BIBRA

Avec: Chloé Hugbart , Yann Verres , Brendan Le Daré , Simon Bucher , Elise Vène , Aude Bodin , Vincent Lagente , Bernard Fromenty , Renaud Bouvet , Isabelle Morel , Pascal Loyer , Thomas Gicquel

Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity.

Cell biology and toxicology

Avec: Julien Allard , Simon Bucher , Julie Massart , Pierre-Jean Ferron , Dounia Le Guillou , Roxane Loyant , Yoann Daniel , Youenn Launay , Nelly Buron , Karima Begriche , Annie Borgne-Sanchez , Bernard Fromenty

Alteration of mitochondrial DNA homeostasis in drug-induced liver injury.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Avec: Bernard Fromenty

Polycyclic Aromatic Hydrocarbons Can Trigger Hepatocyte Release of Extracellular Vesicles by Various Mechanisms of Action Depending on Their Affinity for the Aryl Hydrocarbon Receptor.

Toxicological sciences : an official journal of the Society of Toxicology

Avec: Nettie van Meteren , Dominique Lagadic-Gossmann , Martine Chevanne , Isabelle Gallais , Dimitri Gobart , Agnès Burel , Simon Bucher , Nathalie Grova , Bernard Fromenty , Brice M R Appenzeller , Soizic Chevance , Fabienne Gauffre , Eric Le Ferrec , Odile Sergent

Role of Mitochondrial Cytochrome P450 2E1 in Healthy and Diseased Liver.

Cells

Avec: Julie Massart , Karima Begriche , Jessica H Hartman , Bernard Fromenty

Acetaminophen (APAP, Paracetamol) Interferes With the First Trimester Human Fetal Ovary Development in an Ex Vivo Model.

The Journal of clinical endocrinology and metabolism

Avec: Laetitia L Lecante , Sabrina Leverrier-Penna , Thomas Gicquel , Frank Giton , Nathalie Costet , Christèle Desdoits-Lethimonier , Laurianne Lesné , Bernard Fromenty , Vincent Lavoué , Antoine D Rolland , Séverine Mazaud-Guittot

Acetaminophen-Induced Hepatotoxicity in Obesity and Nonalcoholic Fatty Liver Disease: A Critical Review.

Livers

Avec: Karima Begriche , Clémence Penhoat , Pénélope Bernabeu-Gentey , Julie Massart , Bernard Fromenty

Weight of evidence evaluation of the metabolism disrupting effects of triphenyl phosphate using an expert knowledge elicitation approach.

Toxicology and applied pharmacology

Avec: Claire Beausoleil , Anne Thébault , Patrik Andersson , Nicolas J Cabaton , Sibylle Ermler , Bernard Fromenty , Clémentine Garoche , Julian L Griffin , Sebastian Hoffmann , Jorke H Kamstra , Barbara Kubickova , Virissa Lenters , Vesna Munic Kos , Nathalie Poupin , Sylvie Remy , Maria Sapounidou , Daniel Zalko , Juliette Legler , Miriam N Jacobs , Christophe Rousselle

Fatal acetaminophen poisoning with hepatic microvesicular steatosis in a child after repeated administration of therapeutic doses.

Forensic science international

Avec: Renaud Bouvet , Aurélie Cauchois , Alain Baert , Bernard Fromenty , Isabelle Morel , Bruno Turlin , Thomas Gicquel

Large-Scale Modeling Approach Reveals Functional Metabolic Shifts during Hepatic Differentiation.

Journal of proteome research

Avec: Nathalie Poupin , Anne Corlu , Nicolas J Cabaton , Hélène Dubois-Pot-Schneider , Cécile Canlet , Elodie Person , Sandrine Bruel , Clément Frainay , Florence Vinson , Florence Maurier , Fabrice Morel , Marie-Anne Robin , Bernard Fromenty , Daniel Zalko , Fabien Jourdan

Molecular Networking for Drug Toxicities Studies: The Case of Hydroxychloroquine in COVID-19 Patients.

International journal of molecular sciences

Avec: Pierre-Jean Ferron , Brendan Le Daré , Julie Bronsard , Clara Steichen , Elodie Babina , Romain Pelletier , Thierry Hauet , Isabelle Morel , Karin Tarte , Florian Reizine , Bruno Clément , Bernard Fromenty , Thomas Gicquel

Multikinase inhibitor-induced liver injury in patients with cancer: A review for clinicians.

Critical reviews in oncology/hematology

Avec: Camille Houron , Marie Danielou , Olivier Mir , Bernard Fromenty , Gabriel Perlemuter , Cosmin Sebastian Voican

Xenobiotic-Induced Aggravation of Metabolic-Associated Fatty Liver Disease.

International journal of molecular sciences

Avec: Julie Massart , Karima Begriche , Anne Corlu , Bernard Fromenty

Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a possible key event of NAFLD progression induced by benzo[a]pyrene/ethanol co-exposure.

Cell biology and toxicology

Avec: Muhammad Imran , Frédéric Chalmel , Odile Sergent , Bertrand Evrard , Hélène Le Mentec , Antoine Legrand , Aurélien Dupont , Maëlle Bescher , Simon Bucher , Bernard Fromenty , Laurence Huc , Lydie Sparfel , Dominique Lagadic-Gossmann , Normand Podechard

Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET].

Journal of hepatology

Avec: Jose C Fernandez-Checa , Pierre Bagnaninchi , Hui Ye , Pau Sancho-Bru , Juan M Falcon-Perez , Felix Royo , Carmen Garcia-Ruiz , Ozlen Konu , Joana Miranda , Oleg Lunov , Alexandr Dejneka , Alistair Elfick , Alison McDonald , Gareth J Sullivan , Guruprasad P Aithal , M Isabel Lucena , Raul J Andrade , Bernard Fromenty , Michel Kranendonk , Francisco Javier Cubero , Leonard J Nelson

Busulfan induces steatosis in HepaRG cells but not in primary human hepatocytes: Possible explanations and implication for the prediction of drug-induced liver injury.

Fundamental & clinical pharmacology

Avec: Julien Allard , Simon Bucher , Pierre-Jean Ferron , Youenn Launay , Bernard Fromenty

Drug-induced impairment of mitochondrial fatty acid oxidation and steatosis: assessment of causal relationship with 45 pharmaceuticals.

Toxicological sciences : an official journal of the Society of Toxicology

Avec: Nelly Buron , Mathieu Porceddu , Roxane Loyant , Cécile Martel , Julien A Allard , Bernard Fromenty , Annie Borgne-Sanchez

A strategy to detect metabolic changes induced by exposure to chemicals from large sets of condition-specific metabolic models computed with enumeration techniques.

BMC bioinformatics

Avec: Louison Fresnais , Olivier Perin , Anne Riu , Romain Grall , Alban Ott , Bernard Fromenty , Jean-Clément Gallardo , Maximilian Stingl , Clément Frainay , Fabien Jourdan , Nathalie Poupin

Réseau de co-auteurs

Bernard Fromenty 28 collaborations

Karima Begriche 7 collaborations

Simon Bucher 6 collaborations

Pierre-Jean Ferron 5 collaborations

Thomas Gicquel 5 collaborations

Anne Corlu 5 collaborations

Julie Massart 5 collaborations

Julien Allard 3 collaborations

Daniel Zalko 3 collaborations

Fabien Jourdan 3 collaborations

Yoann Daniel 3 collaborations

Dominique Lagadic-Gossmann 3 collaborations

Isabelle Morel 3 collaborations

Nathalie Poupin 3 collaborations

Dounia Le Guillou 2 collaborations

Bruno Clément 2 collaborations

Juliette Legler 2 collaborations

Vesna Munic Kos 2 collaborations

Claire Beausoleil 2 collaborations

Sylvie Remy 2 collaborations

Sibylle Ermler 2 collaborations

Julian L Griffin 2 collaborations

Sebastian Hoffmann 2 collaborations

Jorke H Kamstra 2 collaborations

Hélène Dubois-Pot-Schneider 2 collaborations

Fabrice Morel 2 collaborations

Florian Reizine 2 collaborations

Kilian Petitjean 2 collaborations

Karin Tarte 2 collaborations

Agnès Burel 2 collaborations

Yann Verres 2 collaborations

Pascal Loyer 2 collaborations

Brendan Le Daré 2 collaborations

Renaud Bouvet 2 collaborations

Roxane Loyant 2 collaborations

Youenn Launay 2 collaborations

Nelly Buron 2 collaborations

Annie Borgne-Sanchez 2 collaborations

Odile Sergent 2 collaborations

Nicolas J Cabaton 2 collaborations

Clément Frainay 2 collaborations

Y Joueidi 1 collaboration

K Peoc'h 1 collaboration

M Le Lous 1 collaboration

G Bouzille 1 collaboration

C Rousseau 1 collaboration

E Bardou-Jacquet 1 collaboration

C Bendavid 1 collaboration

L Damaj 1 collaboration

V Lavoué 1 collaboration

C Moreau 1 collaboration

Bruno Mégarbane 1 collaboration

Miriam Jacobs 1 collaboration

Patrick Balaguer 1 collaboration

William Bourguet 1 collaboration

Angel Nadal 1 collaboration

Susana Cristobal 1 collaboration

Luigi Margiotta-Casaluci 1 collaboration

Bruce Blumberg 1 collaboration

Christophe Chesné 1 collaboration

Patrik L Andersson 1 collaboration

Karim Fekir 1 collaboration

Romain Désert 1 collaboration

Denise Glaise 1 collaboration

Claudine Rauch 1 collaboration

Orlando Musso 1 collaboration

Florian Cabillic 1 collaboration

Murielle Grégoire 1 collaboration

Mathieu Lesouhaitier 1 collaboration

Valentin Coirier 1 collaboration

Juliette Gauthier 1 collaboration

Céline Delaloy 1 collaboration

Elise Dessauge 1 collaboration

Florent Creusat 1 collaboration

Fabrice Uhel 1 collaboration

Arnaud Gacouin 1 collaboration

Frédéric Dessauge 1 collaboration

Cécile Le Naoures 1 collaboration

Caroline Moreau 1 collaboration

Claude Bendavid 1 collaboration

Valérie Bordeau 1 collaboration

Claire Lamaison 1 collaboration

Caroline Piau 1 collaboration

Vincent Cattoir 1 collaboration

Mikael Roussel 1 collaboration

Christian Michelet 1 collaboration

Yves Le Tulzo 1 collaboration

Jaroslaw Zmijewski 1 collaboration

Ronan Thibault 1 collaboration

Michel Cogné 1 collaboration

Jean-Marc Tadié 1 collaboration

J Bronsard 1 collaboration

C Savary 1 collaboration

J Massart 1 collaboration

R Viel 1 collaboration

L Moutaux 1 collaboration

D Catheline 1 collaboration

V Rioux 1 collaboration

B Clement 1 collaboration

A Corlu 1 collaboration

P J Ferron 1 collaboration

Daniel Catheline 1 collaboration

Viviane Trak-Smayra 1 collaboration

François Tiaho 1 collaboration

Cédric Coulouarn 1 collaboration

Grégory Pinon 1 collaboration

Vincent Rioux 1 collaboration

Michael Roden 1 collaboration

Annaïg Lan 1 collaboration

Thomas Guerbette 1 collaboration

Mireille Andriamihaja 1 collaboration

Benjamin Magnin 1 collaboration

Martin Bordet 1 collaboration

Roselyne Viel 1 collaboration

François Blachier 1 collaboration

Guillaume Bouguen 1 collaboration

Sébastien Bristeau 1 collaboration

Catherine Ribault 1 collaboration

Caroline Aninat 1 collaboration

Christophe Olivier 1 collaboration

Patricia Leroyer 1 collaboration

Martine Ropert 1 collaboration

Olivier Loréal 1 collaboration

Olivier Herault 1 collaboration

Laurence Amalric 1 collaboration

Nicole Baran 1 collaboration

M I Lucena 1 collaboration

M Villanueva-Paz 1 collaboration

None Alvarez-Alvarez 1 collaboration

G P Aithal 1 collaboration

E S Björnsson 1 collaboration

G Cakan-Akdogan 1 collaboration

F J Cubero 1 collaboration

F Esteves 1 collaboration

J M Falcon-Perez 1 collaboration

C Garcia-Ruiz 1 collaboration

J I Grove 1 collaboration

O Konu 1 collaboration

M Kranendonk 1 collaboration

G Kullak-Ublick 1 collaboration

J P Miranda 1 collaboration

A Remesal-Doblado 1 collaboration

P Sancho-Bru 1 collaboration

L Nelson 1 collaboration

R J Andrade 1 collaboration

A K Daly 1 collaboration

J C Fernandez-Checa 1 collaboration

Chloé Hugbart 1 collaboration

Elise Vène 1 collaboration

Aude Bodin 1 collaboration

Vincent Lagente 1 collaboration

Nettie van Meteren 1 collaboration

Martine Chevanne 1 collaboration

Isabelle Gallais 1 collaboration

Dimitri Gobart 1 collaboration

Nathalie Grova 1 collaboration

Brice M R Appenzeller 1 collaboration

Soizic Chevance 1 collaboration

Fabienne Gauffre 1 collaboration

Eric Le Ferrec 1 collaboration

Jessica H Hartman 1 collaboration

Laetitia L Lecante 1 collaboration

Sabrina Leverrier-Penna 1 collaboration

Frank Giton 1 collaboration

Nathalie Costet 1 collaboration

Christèle Desdoits-Lethimonier 1 collaboration

Laurianne Lesné 1 collaboration

Vincent Lavoué 1 collaboration

Antoine D Rolland 1 collaboration

Séverine Mazaud-Guittot 1 collaboration

Clémence Penhoat 1 collaboration

Pénélope Bernabeu-Gentey 1 collaboration

Anne Thébault 1 collaboration

Patrik Andersson 1 collaboration

Clémentine Garoche 1 collaboration

Barbara Kubickova 1 collaboration

Virissa Lenters 1 collaboration

Maria Sapounidou 1 collaboration

Miriam N Jacobs 1 collaboration

Christophe Rousselle 1 collaboration

Aurélie Cauchois 1 collaboration

Alain Baert 1 collaboration

Bruno Turlin 1 collaboration

Cécile Canlet 1 collaboration

Elodie Person 1 collaboration

Sandrine Bruel 1 collaboration

Florence Vinson 1 collaboration

Florence Maurier 1 collaboration

Marie-Anne Robin 1 collaboration

Julie Bronsard 1 collaboration

Clara Steichen 1 collaboration

Elodie Babina 1 collaboration

Romain Pelletier 1 collaboration

Thierry Hauet 1 collaboration

Camille Houron 1 collaboration

Marie Danielou 1 collaboration

Olivier Mir 1 collaboration

Gabriel Perlemuter 1 collaboration

Cosmin Sebastian Voican 1 collaboration

Muhammad Imran 1 collaboration

Frédéric Chalmel 1 collaboration

Bertrand Evrard 1 collaboration

Hélène Le Mentec 1 collaboration

Antoine Legrand 1 collaboration

Aurélien Dupont 1 collaboration

Maëlle Bescher 1 collaboration

Laurence Huc 1 collaboration

Lydie Sparfel 1 collaboration

Normand Podechard 1 collaboration

Jose C Fernandez-Checa 1 collaboration

Pierre Bagnaninchi 1 collaboration

Hui Ye 1 collaboration

Pau Sancho-Bru 1 collaboration

Juan M Falcon-Perez 1 collaboration

Felix Royo 1 collaboration

Carmen Garcia-Ruiz 1 collaboration

Ozlen Konu 1 collaboration

Joana Miranda 1 collaboration

Oleg Lunov 1 collaboration

Alexandr Dejneka 1 collaboration

Alistair Elfick 1 collaboration

Alison McDonald 1 collaboration

Gareth J Sullivan 1 collaboration

Guruprasad P Aithal 1 collaboration

M Isabel Lucena 1 collaboration

Raul J Andrade 1 collaboration

Michel Kranendonk 1 collaboration

Francisco Javier Cubero 1 collaboration

Leonard J Nelson 1 collaboration

Mathieu Porceddu 1 collaboration

Cécile Martel 1 collaboration

Julien A Allard 1 collaboration

Louison Fresnais 1 collaboration

Olivier Perin 1 collaboration

Anne Riu 1 collaboration

Romain Grall 1 collaboration

Alban Ott 1 collaboration

Jean-Clément Gallardo 1 collaboration

Maximilian Stingl 1 collaboration