Cosma M Spalluto

Affiliations

Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Sir Henry Wellcome Laboratories, University Hospital Southampton, Southampton SO16 6YD, United Kingdom.
Southampton NIHR Biomedical Research Centre, Southampton General Hospital, Southampton SO16 6YD, United Kingdom.

Publications (16)

Interrelationships Among Small Airways Dysfunction, Neutrophilic Inflammation, and Exacerbation Frequency in COPD.

Chest

Avec: Kerry Day , Kristoffer Ostridge , Joy Conway , Doriana Cellura , Alastair Watson , Cosma Mirella Spalluto , Karl J Staples , Bruce Thompson , Tom Wilkinson

Pulmonary EV miRNA profiles identify disease and distinct inflammatory endotypes in COPD.

Frontiers in medicine

Avec: Hannah Burke , Doriana Cellura , Anna Freeman , Alex Hicks , Kris Ostridge , Alastair Watson , Nicholas P Williams , C Mirella Spalluto , Karl J Staples , Tom M A Wilkinson

Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations.

British journal of pharmacology

Avec: Julia A Tree , Jeremy E Turnbull , Karen R Buttigieg , Michael J Elmore , Naomi Coombes , John Hogwood , Courtney J Mycroft-West , Marcelo A Lima , Mark A Skidmore , Richard Karlsson , Yen-Hsi Chen , Zhang Yang , Cosma Mirella Spalluto , Karl J Staples , Edwin A Yates , Elaine Gray , Dave Singh , Tom Wilkinson , Clive P Page , Miles W Carroll

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction.

ACS central science

Avec: Scott E Guimond , Courtney J Mycroft-West , Neha S Gandhi , Julia A Tree , Thuy T Le , C Mirella Spalluto , Maria V Humbert , Karen R Buttigieg , Naomi Coombes , Michael J Elmore , Matthew Wand , Kristina Nyström , Joanna Said , Yin Xiang Setoh , Alberto A Amarilla , Naphak Modhiran , Julian D J Sng , Mohit Chhabra , Paul R Young , Daniel J Rawle , Marcelo A Lima , Edwin A Yates , Richard Karlsson , Rebecca L Miller , Yen-Hsi Chen , Ieva Bagdonaite , Zhang Yang , James Stewart , Dung Nguyen , Stephen Laidlaw , Edward Hammond , Keith Dredge , Tom M A Wilkinson , Daniel Watterson , Alexander A Khromykh , Andreas Suhrbier , Miles W Carroll , Edward Trybala , Tomas Bergström , Vito Ferro , Mark A Skidmore , Jeremy E Turnbull

Influence of Hypoxia on the Epithelial-Pathogen Interactions in the Lung: Implications for Respiratory Disease.

Frontiers in immunology

Avec: Lee K Page , Karl J Staples , C Mirella Spalluto , Alastair Watson , Tom M A Wilkinson

Mechanisms of SARS-CoV-2 Inactivation Using UVC Laser Radiation.

ACS photonics

Avec: George Devitt , Peter B Johnson , Niall Hanrahan , Simon I R Lane , Magdalena C Vidale , Bhavwanti Sheth , Joel D Allen , Maria V Humbert , Cosma M Spalluto , Rodolphe C Hervé , Karl Staples , Jonathan J West , Robert Forster , Nullin Divecha , Christopher J McCormick , Max Crispin , Nils Hempler , Graeme P A Malcolm , Sumeet Mahajan

Dysregulation of COVID-19 related gene expression in the COPD lung.

Respiratory research

Avec: Alastair Watson , Lisa Öberg , Bastian Angermann , C Mirella Spalluto , Michael Hühn , Hannah Burke , Doriana Cellura , Anna Freeman , Daniel Muthas , Damla Etal , Graham Belfield , Fredrik Karlsson , Karl Nordström , Kris Ostridge , Karl J Staples , Tom Wilkinson , Auteur inconnu

Inflammatory phenotyping predicts clinical outcome in COVID-19.

Respiratory research

Avec: H Burke , A Freeman , D C Cellura , B L Stuart , N J Brendish , S Poole , F Borca , H T T Phan , N Sheard , S Williams , C M Spalluto , K J Staples , T W Clark , T M A Wilkinson , Auteur inconnu

Towards an artificial human lung: modelling organ-like complexity to aid mechanistic understanding.

The European respiratory journal

Avec: Maria Victoria Humbert , Cosma Mirella Spalluto , Joseph Bell , Cornelia Blume , Franco Conforti , Elizabeth R Davies , Lareb S N Dean , Paul Elkington , Hans Michael Haitchi , Claire Jackson , Mark G Jones , Matthew Loxham , Jane S Lucas , Hywel Morgan , Marta Polak , Karl J Staples , Emily J Swindle , Liku Tezera , Alastair Watson , Tom M A Wilkinson

Real-world performance of a single-use, analyser-free, molecular point-of-care test for COVID-19 used in the emergency department: results of a prospective trial (ED-POC).

The Journal of infection

Avec: Mary E Chapman , Nathan J Brendish , Matthew Morris , C Mirella Spalluto , Christopher J McCormick , Helen E Moyses , Tristan W Clark

Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD.

ERJ open research

Avec: Ventzislava A Hristova , Alastair Watson , Raghothama Chaerkady , Matthew S Glover , Jodie Ackland , Bastian Angerman , Graham Belfield , Maria G Belvisi , Hannah Burke , Doriana Cellura , Howard W Clark , Damla Etal , Anna Freeman , Ashley I Heinson , Sonja Hess , Michael Hühn , Emily Hall , Alex Mackay , Jens Madsen , Christopher McCrae , Daniel Muthas , Steven Novick , Kristoffer Ostridge , Lisa Öberg , Adam Platt , Anthony D Postle , C Mirella Spalluto , Outi Vaarala , Junmin Wang , Karl J Staples , Tom M A Wilkinson , Auteur inconnu

Exercise Training Induces a Shift in Extracellular Redox Status with Alterations in the Pulmonary and Systemic Redox Landscape in Asthma.

Antioxidants (Basel, Switzerland)

Avec: Anna Freeman , Doriana Cellura , Magdalena Minnion , Bernadette O Fernandez , Cosma Mirella Spalluto , Denny Levett , Andrew Bates , Timothy Wallis , Alastair Watson , Sandy Jack , Karl J Staples , Michael P W Grocott , Martin Feelisch , Tom M A Wilkinson

The Role of Extracellular Vesicles as a Shared Disease Mechanism Contributing to Multimorbidity in Patients With COPD.

Frontiers in immunology

Avec: Laura V Reid , C Mirella Spalluto , Alastair Watson , Karl J Staples , Tom M A Wilkinson

A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection.

Nature genetics

Avec: Cornelia Blume , Claire L Jackson , Cosma Mirella Spalluto , Jelmer Legebeke , Liliya Nazlamova , Franco Conforti , Jeanne-Marie Perotin , Martin Frank , John Butler , Max Crispin , Janice Coles , James Thompson , Robert A Ridley , Lareb S N Dean , Matthew Loxham , Stephanie Reikine , Adnan Azim , Kamran Tariq , David A Johnston , Paul J Skipp , Ratko Djukanovic , Diana Baralle , Christopher J McCormick , Donna E Davies , Jane S Lucas , Gabrielle Wheway , Vito Mennella

The Role of Non-Typeable

Frontiers in cellular and infection microbiology

Avec: Jake R Weeks , Karl J Staples , C Mirella Spalluto , Alastair Watson , Tom M A Wilkinson

SARS-CoV-2 Infection of Human Primary Nasal Multiciliated Epithelial Cells Grown on Air-Liquid Interface Cultures.

Methods in molecular biology (Clifton, N.J.)

Avec: Maria Victoria Humbert , Christopher J McCormick , Cosma Mirella Spalluto

Réseau de co-auteurs

Karl J Staples 10 collaborations

Alastair Watson 9 collaborations

C Mirella Spalluto 8 collaborations

Tom M A Wilkinson 8 collaborations

Cosma Mirella Spalluto 6 collaborations

Doriana Cellura 5 collaborations

Anna Freeman 4 collaborations

Christopher J McCormick 4 collaborations

Tom Wilkinson 3 collaborations

Hannah Burke 3 collaborations

None None 3 collaborations

Kristoffer Ostridge 2 collaborations

Kris Ostridge 2 collaborations

Julia A Tree 2 collaborations

Jeremy E Turnbull 2 collaborations

Karen R Buttigieg 2 collaborations

Michael J Elmore 2 collaborations

Naomi Coombes 2 collaborations

Courtney J Mycroft-West 2 collaborations

Marcelo A Lima 2 collaborations

Mark A Skidmore 2 collaborations

Richard Karlsson 2 collaborations

Yen-Hsi Chen 2 collaborations

Zhang Yang 2 collaborations

Edwin A Yates 2 collaborations

Miles W Carroll 2 collaborations

Maria V Humbert 2 collaborations

Max Crispin 2 collaborations

Lisa Öberg 2 collaborations

Michael Hühn 2 collaborations

Daniel Muthas 2 collaborations

Damla Etal 2 collaborations

Graham Belfield 2 collaborations

Maria Victoria Humbert 2 collaborations

Cornelia Blume 2 collaborations

Franco Conforti 2 collaborations

Lareb S N Dean 2 collaborations

Matthew Loxham 2 collaborations

Jane S Lucas 2 collaborations

Kerry Day 1 collaboration

Joy Conway 1 collaboration

Bruce Thompson 1 collaboration

Alex Hicks 1 collaboration

Nicholas P Williams 1 collaboration

John Hogwood 1 collaboration

Elaine Gray 1 collaboration

Dave Singh 1 collaboration

Clive P Page 1 collaboration

Scott E Guimond 1 collaboration

Neha S Gandhi 1 collaboration

Thuy T Le 1 collaboration

Matthew Wand 1 collaboration

Kristina Nyström 1 collaboration

Joanna Said 1 collaboration

Yin Xiang Setoh 1 collaboration

Alberto A Amarilla 1 collaboration

Naphak Modhiran 1 collaboration

Julian D J Sng 1 collaboration

Mohit Chhabra 1 collaboration

Paul R Young 1 collaboration

Daniel J Rawle 1 collaboration

Rebecca L Miller 1 collaboration

Ieva Bagdonaite 1 collaboration

James Stewart 1 collaboration

Dung Nguyen 1 collaboration

Stephen Laidlaw 1 collaboration

Edward Hammond 1 collaboration

Keith Dredge 1 collaboration

Daniel Watterson 1 collaboration

Alexander A Khromykh 1 collaboration

Andreas Suhrbier 1 collaboration

Edward Trybala 1 collaboration

Tomas Bergström 1 collaboration

Vito Ferro 1 collaboration

Lee K Page 1 collaboration

George Devitt 1 collaboration

Peter B Johnson 1 collaboration

Niall Hanrahan 1 collaboration

Simon I R Lane 1 collaboration

Magdalena C Vidale 1 collaboration

Bhavwanti Sheth 1 collaboration

Joel D Allen 1 collaboration

Rodolphe C Hervé 1 collaboration

Karl Staples 1 collaboration

Jonathan J West 1 collaboration

Robert Forster 1 collaboration

Nullin Divecha 1 collaboration

Nils Hempler 1 collaboration

Graeme P A Malcolm 1 collaboration

Sumeet Mahajan 1 collaboration

Bastian Angermann 1 collaboration

Fredrik Karlsson 1 collaboration

Karl Nordström 1 collaboration

H Burke 1 collaboration

A Freeman 1 collaboration

D C Cellura 1 collaboration

B L Stuart 1 collaboration

N J Brendish 1 collaboration

S Poole 1 collaboration

F Borca 1 collaboration

H T T Phan 1 collaboration

N Sheard 1 collaboration

S Williams 1 collaboration

C M Spalluto 1 collaboration

K J Staples 1 collaboration

T W Clark 1 collaboration

T M A Wilkinson 1 collaboration

Joseph Bell 1 collaboration

Elizabeth R Davies 1 collaboration

Paul Elkington 1 collaboration

Hans Michael Haitchi 1 collaboration

Claire Jackson 1 collaboration

Mark G Jones 1 collaboration

Hywel Morgan 1 collaboration

Marta Polak 1 collaboration

Emily J Swindle 1 collaboration

Liku Tezera 1 collaboration

Mary E Chapman 1 collaboration

Nathan J Brendish 1 collaboration

Matthew Morris 1 collaboration

Helen E Moyses 1 collaboration

Tristan W Clark 1 collaboration

Ventzislava A Hristova 1 collaboration

Raghothama Chaerkady 1 collaboration

Matthew S Glover 1 collaboration

Jodie Ackland 1 collaboration

Bastian Angerman 1 collaboration

Maria G Belvisi 1 collaboration

Howard W Clark 1 collaboration

Ashley I Heinson 1 collaboration

Sonja Hess 1 collaboration

Emily Hall 1 collaboration

Alex Mackay 1 collaboration

Jens Madsen 1 collaboration

Christopher McCrae 1 collaboration

Steven Novick 1 collaboration

Adam Platt 1 collaboration

Anthony D Postle 1 collaboration

Outi Vaarala 1 collaboration

Junmin Wang 1 collaboration

Magdalena Minnion 1 collaboration

Bernadette O Fernandez 1 collaboration

Denny Levett 1 collaboration

Andrew Bates 1 collaboration

Timothy Wallis 1 collaboration

Sandy Jack 1 collaboration

Michael P W Grocott 1 collaboration

Martin Feelisch 1 collaboration

Laura V Reid 1 collaboration

Claire L Jackson 1 collaboration

Jelmer Legebeke 1 collaboration

Liliya Nazlamova 1 collaboration

Jeanne-Marie Perotin 1 collaboration

Martin Frank 1 collaboration

John Butler 1 collaboration

Janice Coles 1 collaboration

James Thompson 1 collaboration

Robert A Ridley 1 collaboration

Stephanie Reikine 1 collaboration

Adnan Azim 1 collaboration

Kamran Tariq 1 collaboration

David A Johnston 1 collaboration

Paul J Skipp 1 collaboration

Ratko Djukanovic 1 collaboration

Diana Baralle 1 collaboration

Donna E Davies 1 collaboration

Gabrielle Wheway 1 collaboration

Vito Mennella 1 collaboration

Jake R Weeks 1 collaboration