David E Heppner

Affiliations

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.

ORCID: 0000-0002-0722-5160

Publications (15)

Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors.

Journal of medicinal chemistry

Avec: David E Heppner , Marcel Günther , Florian Wittlinger , Stefan A Laufer , Michael J Eck

Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors.

ACS medicinal chemistry letters

Avec: Dries J H De Clercq , David E Heppner , Ciric To , Jaebong Jang , Eunyoung Park , Cai-Hong Yun , Mierzhati Mushajiang , Bo Hee Shin , Thomas W Gero , David A Scott , Pasi A Jänne , Michael J Eck , Nathanael S Gray

Dysregulated Redox Regulation Contributes to Nuclear EGFR Localization and Pathogenicity in Lung Cancer.

Scientific reports

Avec: Andrew C Little , Milena Hristova , Loes van Lith , Caspar Schiffers , Christopher M Dustin , Aida Habibovic , Karamatullah Danyal , David E Heppner , Miao-Chong J Lin , Jos van der Velden , Yvonne M Janssen-Heininger , Albert van der Vliet

Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics.

Redox biology

Avec: Nicolas Chamberlain , Bethany R Korwin-Mihavics , Emily M Nakada , Sierra R Bruno , David E Heppner , David G Chapman , Sidra M Hoffman , Albert van der Vliet , Benjamin T Suratt , Oliver Dienz , John F Alcorn , Vikas Anathy

A driving test for oncogenic mutations.

The Journal of biological chemistry

Avec: David E Heppner , Tyler S Beyett , Michael J Eck

Structural insights into redox-active cysteine residues of the Src family kinases.

Redox biology

Avec: David E Heppner

Architecture of the NADPH oxidase family of enzymes.

Redox biology

Avec: Blessing C Ogboo , Uriy V Grabovyy , Aniket Maini , Scott Scouten , Albert van der Vliet , Andrea Mattevi , David E Heppner

Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC.

Bioorganic & medicinal chemistry letters

Avec: Thomas W Gero , David E Heppner , Tyler S Beyett , Ciric To , Seth C Azevedo , Jaebong Jang , Thomas Bunnell , Frederic Feru , Zhengnian Li , Bo Hee Shin , Kara M Soroko , Prafulla C Gokhale , Nathanael S Gray , Pasi A Jänne , Michael J Eck , David A Scott

A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology.

Molecular pharmacology

Avec: Justin J Kim , Ilse K Schaeffner , David E Heppner , Ciric To , Pasi A Jänne , Tyler S Beyett , Michael J Eck

Structural analysis of the macrocyclic inhibitor BI-4020 binding to EGFR kinase.

ChemMedChem

Avec: Tyler S Beyett , Jaimin K Rana , Ilse K Schaeffner , David E Heppner , Michael Eck

Redox regulation of tyrosine kinase signalling: more than meets the eye.

Journal of biochemistry

Avec: Christopher M Dustin , David E Heppner , Miao-Chong J Lin , Albert van der Vliet

Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor.

Cancer discovery

Avec: Ciric To , Jaebong Jang , Ting Chen , Eunyoung Park , Mierzhati Mushajiang , Dries J H De Clercq , Man Xu , Stephen Wang , Michael D Cameron , David E Heppner , Bo Hee Shin , Thomas W Gero , Annan Yang , Suzanne E Dahlberg , Kwok-Kin Wong , Michael J Eck , Nathanael S Gray , Pasi A Jänne

Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.

Journal of medicinal chemistry

Avec: Florian Wittlinger , David E Heppner , Ciric To , Marcel Günther , Bo Hee Shin , Jaimin K Rana , Anna M Schmoker , Tyler S Beyett , Lena M Berger , Benedict-Tilman Berger , Nicolas Bauer , James D Vasta , Cesear R Corona , Matthew B Robers , Stefan Knapp , Pasi A Jänne , Michael J Eck , Stefan A Laufer

Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).

ACS medicinal chemistry letters

Avec: David E Heppner , Florian Wittlinger , Tyler S Beyett , Tatiana Shaurova , Daniel A Urul , Brian Buckley , Calvin D Pham , Ilse K Schaeffner , Bo Yang , Blessing C Ogboo , Earl W May , Erik M Schaefer , Michael J Eck , Stefan A Laufer , Pamela A Hershberger

An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer.

Nature cancer

Avec: Ciric To , Tyler S Beyett , Jaebong Jang , William W Feng , Magda Bahcall , Heidi M Haikala , Bo H Shin , David E Heppner , Jaimin K Rana , Brittaney A Leeper , Kara M Soroko , Michael J Poitras , Prafulla C Gokhale , Yoshihisa Kobayashi , Kamal Wahid , Kari J Kurppa , Thomas W Gero , Michael D Cameron , Atsuko Ogino , Mierzhati Mushajiang , Chunxiao Xu , Yanxi Zhang , David A Scott , Michael J Eck , Nathanael S Gray , Pasi A Jänne

Réseau de co-auteurs

Michael J Eck 9 collaborations

Tyler S Beyett 7 collaborations

Ciric To 6 collaborations

Pasi A Jänne 6 collaborations

Jaebong Jang 4 collaborations

Bo Hee Shin 4 collaborations

Thomas W Gero 4 collaborations

Nathanael S Gray 4 collaborations

Albert van der Vliet 4 collaborations

Florian Wittlinger 3 collaborations

Stefan A Laufer 3 collaborations

Mierzhati Mushajiang 3 collaborations

David A Scott 3 collaborations

Ilse K Schaeffner 3 collaborations

Jaimin K Rana 3 collaborations

Marcel Günther 2 collaborations

Dries J H De Clercq 2 collaborations

Eunyoung Park 2 collaborations

Christopher M Dustin 2 collaborations

Miao-Chong J Lin 2 collaborations

Blessing C Ogboo 2 collaborations

Kara M Soroko 2 collaborations

Prafulla C Gokhale 2 collaborations

Michael D Cameron 2 collaborations

Cai-Hong Yun 1 collaboration

Andrew C Little 1 collaboration

Milena Hristova 1 collaboration

Loes van Lith 1 collaboration

Caspar Schiffers 1 collaboration

Aida Habibovic 1 collaboration

Karamatullah Danyal 1 collaboration

Jos van der Velden 1 collaboration

Yvonne M Janssen-Heininger 1 collaboration

Nicolas Chamberlain 1 collaboration

Bethany R Korwin-Mihavics 1 collaboration

Emily M Nakada 1 collaboration

Sierra R Bruno 1 collaboration

David G Chapman 1 collaboration

Sidra M Hoffman 1 collaboration

Benjamin T Suratt 1 collaboration

Oliver Dienz 1 collaboration

John F Alcorn 1 collaboration

Vikas Anathy 1 collaboration

Uriy V Grabovyy 1 collaboration

Aniket Maini 1 collaboration

Scott Scouten 1 collaboration

Andrea Mattevi 1 collaboration

Seth C Azevedo 1 collaboration

Thomas Bunnell 1 collaboration

Frederic Feru 1 collaboration

Zhengnian Li 1 collaboration

Justin J Kim 1 collaboration

Michael Eck 1 collaboration

Ting Chen 1 collaboration

Man Xu 1 collaboration

Stephen Wang 1 collaboration

Annan Yang 1 collaboration

Suzanne E Dahlberg 1 collaboration

Kwok-Kin Wong 1 collaboration

Anna M Schmoker 1 collaboration

Lena M Berger 1 collaboration

Benedict-Tilman Berger 1 collaboration

Nicolas Bauer 1 collaboration

James D Vasta 1 collaboration

Cesear R Corona 1 collaboration

Matthew B Robers 1 collaboration

Stefan Knapp 1 collaboration

Tatiana Shaurova 1 collaboration

Daniel A Urul 1 collaboration

Brian Buckley 1 collaboration

Calvin D Pham 1 collaboration

Bo Yang 1 collaboration

Earl W May 1 collaboration

Erik M Schaefer 1 collaboration

Pamela A Hershberger 1 collaboration

William W Feng 1 collaboration

Magda Bahcall 1 collaboration

Heidi M Haikala 1 collaboration

Bo H Shin 1 collaboration

Brittaney A Leeper 1 collaboration

Michael J Poitras 1 collaboration

Yoshihisa Kobayashi 1 collaboration

Kamal Wahid 1 collaboration

Kari J Kurppa 1 collaboration

Atsuko Ogino 1 collaboration

Chunxiao Xu 1 collaboration

Yanxi Zhang 1 collaboration