David F Claxton

Affiliations

Department of Medicine, Penn State College of Medicine, Hershey, PA, USA.
Penn State Cancer Institute, Hershey, PA, USA.

Publications (14)

Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity.

Oncoimmunology

Avec: Kathleen M Kokolus , Jeremy S Haley , Emily J Koubek , Raghavendra Gowda , Saketh S Dinavahi , Arati Sharma , David F Claxton , Klaus F Helm , Joseph J Drabick , Gavin P Robertson , Jeffrey D Neighbors , Raymond J Hohl , Todd D Schell

Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia.

Cancers

Avec: Johnson Ung , Su-Fern Tan , Todd E Fox , Jeremy J P Shaw , Maansi Taori , Bethany J Horton , Upendarrao Golla , Arati Sharma , Zdzislaw M Szulc , Hong-Gang Wang , Charles E Chalfant , Myles C Cabot , David F Claxton , Thomas P Loughran , David J Feith

Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model.

Journal of immunology (Baltimore, Md. : 1950)

Avec: Bei Jia , Chenchen Zhao , Kentaro Minagawa , Hiroko Shike , David F Claxton , W Christopher Ehmann , Witold B Rybka , Shin Mineishi , Ming Wang , Todd D Schell , K Sandeep Prabhu , Robert F Paulson , Yi Zhang , Leonard D Shultz , Hong Zheng

A phase 1 trial of venetoclax in combination with liposomal vincristine in patients with relapsed or refractory B-cell or T-cell acute lymphoblastic leukemia: Results from the ECOG-ACRIN EA9152 protocol.

EJHaem

Avec: Neil D Palmisiano , Ju-Whei Lee , David F Claxton , Elisabeth M Paietta , Hassan Alkhateeb , Jae Park , Nikolai A Podoltsev , Ehab L Atallah , Dale G Schaar , Shira N Dinner , Jonathan A Webster , Selina M Luger , Mark R Litzow

Pentostatin, Cyclophosphamide, and Rituximab Followed by Alemtuzumab for Relapsed or Refractory Chronic Lymphocytic Leukemia: A Phase 2 Trial of the ECOG-Acrin Cancer Research Group (E2903).

Acta haematologica

Avec: Sanford Kempin , Zhuoxin Sun , Neil E Kay , Elisabeth M Paietta , Joseph J Mazza , Rhett P Ketterling , Olga Frankfurt , David F Claxton , Joel N Saltzman , Gordan Srkalovic , Natalie S Callander , Gerald Gross , Martin S Tallman

Phase 1-2 study of vorinostat (SAHA), cladribine and rituximab (SCR) in relapsed B-cell non-Hodgkin lymphoma and previously untreated mantle cell lymphoma.

British journal of haematology

Avec: Stephen E Spurgeon , Kamal Sharma , David F Claxton , Christopher Ehmann , Jeffrey Pu , Sara Shimko , August Stewart , Nan Subbiah , Gundula Palmbach , Francis LeBlanc , Emile Latour , YiYi Chen , Motomi Mori , Zainul Hasanali , Elliot M Epner

Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications.

Stem cell reviews and reports

Avec: Nathaniel A Long , Upendarrao Golla , Arati Sharma , David F Claxton

Harnessing the power of sphingolipids: Prospects for acute myeloid leukemia.

Blood reviews

Avec: Johnson Ung , Su-Fern Tan , Todd E Fox , Jeremy J P Shaw , Luke R Vass , Pedro Costa-Pinheiro , Francine E Garrett-Bakelman , Michael K Keng , Arati Sharma , David F Claxton , Ross L Levine , Martin S Tallman , Myles C Cabot , Mark Kester , David J Feith , Thomas P Loughran

Interleukin-4 treatment reduces leukemia burden in acute myeloid leukemia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Fenghua Qian , Brooke E Arner , Kathleen M Kelly , Charyguly Annageldiyev , Arati Sharma , David F Claxton , Robert F Paulson , K Sandeep Prabhu

Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Kelsey H Fisher-Wellman , James T Hagen , Miki Kassai , Li-Pin Kao , Margaret A M Nelson , Kelsey L McLaughlin , Hannah S Coalson , Todd E Fox , Su-Fern Tan , David J Feith , Mark Kester , Thomas P Loughran , David F Claxton , Myles C Cabot

Ceramide nanoliposomes augment the efficacy of venetoclax and cytarabine in models of acute myeloid leukemia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Andrei V Khokhlatchev , Arati Sharma , Tye G Deering , Jeremy J P Shaw , Pedro Costa-Pinheiro , Upendarrao Golla , Charyguly Annageldiyev , Myles C Cabot , Mark R Conaway , Su-Fern Tan , Johnson Ung , David J Feith , Thomas P Loughran , David F Claxton , Todd E Fox , Mark Kester

The impact of early PEG-asparaginase discontinuation in young adults with ALL: a post hoc analysis of the CALGB 10403 study.

Blood advances

Avec: Ibrahim Aldoss , Jun Yin , Anna Wall , Krzysztof Mrózek , Michaela Liedtke , David F Claxton , Matthew C Foster , Frederick R Appelbaum , Harry P Erba , Mark R Litzow , Martin S Tallman , Richard M Stone , Richard A Larson , Anjali S Advani , Wendy Stock , Selina M Luger

Ceramide Analogue SACLAC Modulates Sphingolipid Levels and

Molecular cancer research : MCR

Avec: Jennifer M Pearson , Su-Fern Tan , Arati Sharma , Charyguly Annageldiyev , Todd E Fox , Jose Luis Abad , Gemma Fabrias , Dhimant Desai , Shantu Amin , Hong-Gang Wang , Myles C Cabot , David F Claxton , Mark Kester , David J Feith , Thomas P Loughran

Lenalidomide-Epoetin Alfa Versus Lenalidomide Monotherapy in Myelodysplastic Syndromes Refractory to Recombinant Erythropoietin.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Avec: Alan F List , Zhuoxin Sun , Amit Verma , John M Bennett , Rami S Komrokji , Kathy McGraw , Jaroslaw Maciejewski , Jessica K Altman , Puneet S Cheema , David F Claxton , Selina M Luger , Ryan J Mattison , Timothy R Wassenaar , Andrew S Artz , Charles A Schiffer , Mark R Litzow , Martin S Tallman

Réseau de co-auteurs

Arati Sharma 7 collaborations

Su-Fern Tan 5 collaborations

Todd E Fox 5 collaborations

Myles C Cabot 5 collaborations

Thomas P Loughran 5 collaborations

David J Feith 5 collaborations

Martin S Tallman 4 collaborations

Mark Kester 4 collaborations

Johnson Ung 3 collaborations

Jeremy J P Shaw 3 collaborations

Upendarrao Golla 3 collaborations

Selina M Luger 3 collaborations

Mark R Litzow 3 collaborations

Charyguly Annageldiyev 3 collaborations

Todd D Schell 2 collaborations

Hong-Gang Wang 2 collaborations

K Sandeep Prabhu 2 collaborations

Robert F Paulson 2 collaborations

Elisabeth M Paietta 2 collaborations

Zhuoxin Sun 2 collaborations

Pedro Costa-Pinheiro 2 collaborations

Kathleen M Kokolus 1 collaboration

Jeremy S Haley 1 collaboration

Emily J Koubek 1 collaboration

Raghavendra Gowda 1 collaboration

Saketh S Dinavahi 1 collaboration

Klaus F Helm 1 collaboration

Joseph J Drabick 1 collaboration

Gavin P Robertson 1 collaboration

Jeffrey D Neighbors 1 collaboration

Raymond J Hohl 1 collaboration

Maansi Taori 1 collaboration

Bethany J Horton 1 collaboration

Zdzislaw M Szulc 1 collaboration

Charles E Chalfant 1 collaboration

Bei Jia 1 collaboration

Chenchen Zhao 1 collaboration

Kentaro Minagawa 1 collaboration

Hiroko Shike 1 collaboration

W Christopher Ehmann 1 collaboration

Witold B Rybka 1 collaboration

Shin Mineishi 1 collaboration

Ming Wang 1 collaboration

Yi Zhang 1 collaboration

Leonard D Shultz 1 collaboration

Hong Zheng 1 collaboration

Neil D Palmisiano 1 collaboration

Ju-Whei Lee 1 collaboration

Hassan Alkhateeb 1 collaboration

Jae Park 1 collaboration

Nikolai A Podoltsev 1 collaboration

Ehab L Atallah 1 collaboration

Dale G Schaar 1 collaboration

Shira N Dinner 1 collaboration

Jonathan A Webster 1 collaboration

Sanford Kempin 1 collaboration

Neil E Kay 1 collaboration

Joseph J Mazza 1 collaboration

Rhett P Ketterling 1 collaboration

Olga Frankfurt 1 collaboration

Joel N Saltzman 1 collaboration

Gordan Srkalovic 1 collaboration

Natalie S Callander 1 collaboration

Gerald Gross 1 collaboration

Stephen E Spurgeon 1 collaboration

Kamal Sharma 1 collaboration

Christopher Ehmann 1 collaboration

Jeffrey Pu 1 collaboration

Sara Shimko 1 collaboration

August Stewart 1 collaboration

Nan Subbiah 1 collaboration

Gundula Palmbach 1 collaboration

Francis LeBlanc 1 collaboration

Emile Latour 1 collaboration

YiYi Chen 1 collaboration

Motomi Mori 1 collaboration

Zainul Hasanali 1 collaboration

Elliot M Epner 1 collaboration

Nathaniel A Long 1 collaboration

Luke R Vass 1 collaboration

Francine E Garrett-Bakelman 1 collaboration

Michael K Keng 1 collaboration

Ross L Levine 1 collaboration

Fenghua Qian 1 collaboration

Brooke E Arner 1 collaboration

Kathleen M Kelly 1 collaboration

Kelsey H Fisher-Wellman 1 collaboration

James T Hagen 1 collaboration

Miki Kassai 1 collaboration

Li-Pin Kao 1 collaboration

Margaret A M Nelson 1 collaboration

Kelsey L McLaughlin 1 collaboration

Hannah S Coalson 1 collaboration

Andrei V Khokhlatchev 1 collaboration

Tye G Deering 1 collaboration

Mark R Conaway 1 collaboration

Ibrahim Aldoss 1 collaboration

Jun Yin 1 collaboration

Anna Wall 1 collaboration

Krzysztof Mrózek 1 collaboration

Michaela Liedtke 1 collaboration

Matthew C Foster 1 collaboration

Frederick R Appelbaum 1 collaboration

Harry P Erba 1 collaboration

Richard M Stone 1 collaboration

Richard A Larson 1 collaboration

Anjali S Advani 1 collaboration

Wendy Stock 1 collaboration

Jennifer M Pearson 1 collaboration

Jose Luis Abad 1 collaboration

Gemma Fabrias 1 collaboration

Dhimant Desai 1 collaboration

Shantu Amin 1 collaboration

Alan F List 1 collaboration

Amit Verma 1 collaboration

John M Bennett 1 collaboration

Rami S Komrokji 1 collaboration

Kathy McGraw 1 collaboration

Jaroslaw Maciejewski 1 collaboration

Jessica K Altman 1 collaboration

Puneet S Cheema 1 collaboration

Ryan J Mattison 1 collaboration

Timothy R Wassenaar 1 collaboration

Andrew S Artz 1 collaboration

Charles A Schiffer 1 collaboration