Phase 1-2 study of vorinostat (SAHA), cladribine and rituximab (SCR) in relapsed B-cell non-Hodgkin lymphoma and previously untreated mantle cell lymphoma.
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
/ administration & dosage
Cladribine
/ administration & dosage
Disease-Free Survival
Female
Humans
Lymphoma, B-Cell
/ drug therapy
Lymphoma, Mantle-Cell
/ drug therapy
Male
Middle Aged
Recurrence
Rituximab
/ administration & dosage
Survival Rate
Vorinostat
/ administration & dosage
epigenetic
mantle cell lymphoma
non-Hodgkin lymphoma
overall response
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
08
02
2019
accepted:
09
04
2019
pubmed:
10
6
2019
medline:
2
6
2020
entrez:
10
6
2019
Statut:
ppublish
Résumé
Altered DNA methylation and histone acetylation in lymphoma provided the rationale for using vorinostat (SAHA), cladribine and rituximab (SCR) in non-Hodgkin lymphomas (NHL) in this phase 1-2 study (NCT00764517). Treatment included cladribine 5 mg/m
Substances chimiques
Cladribine
47M74X9YT5
Rituximab
4F4X42SYQ6
Vorinostat
58IFB293JI
Banques de données
ClinicalTrials.gov
['NCT00764517']
Types de publication
Clinical Trial, Phase I
Clinical Trial, Phase II
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
845-854Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 British Society for Haematology and John Wiley & Sons Ltd.
Références
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