Interleukin-4 treatment reduces leukemia burden in acute myeloid leukemia.

Animals Cytokines Humans Interleukin-4 / pharmacology Leukemia, Myeloid, Acute / drug therapy Mice PPAR gamma / metabolism Prostaglandin D2 / metabolism
AML H-PGDS IL-4 PPARγ prostaglandin

Journal

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484

Informations de publication

Date de publication:
05 2022
Historique:
revised: 12 04 2022
received: 14 02 2022
accepted: 15 04 2022
entrez: 26 4 2022
pubmed: 27 4 2022
medline: 29 4 2022
Statut: ppublish

Résumé

Interleukin-4 (IL-4) is a signature cytokine pivotal in Type 2 helper T cell (Th2) immune response, particularly in allergy and hypersensitivity. Interestingly, IL-4 increases endogenous levels of prostaglandin D

Identifiants

DOI: 10.1096/fj.202200251R PMID: 35471732 PMC: PMC9994642
pubmed: 35471732
doi: 10.1096/fj.202200251R
pmc: PMC9994642
mid: NIHMS1876659
doi:

Substances chimiques

Cytokines 0
PPAR gamma 0
Interleukin-4 207137-56-2
Prostaglandin D2 RXY07S6CZ2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e22328

Subventions

Organisme : NCI NIH HHS
ID : P01 CA171983
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA044579
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK077152
Pays : United States

Informations de copyright

© 2022 Federation of American Societies for Experimental Biology.

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Auteurs

Fenghua Qian (F)

Department of Veterinary & Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Center for Molecular Immunology and Infectious Disease and Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania, USA.

Brooke E Arner (BE)

Department of Veterinary & Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Center for Molecular Immunology and Infectious Disease and Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania, USA.

Kathleen M Kelly (KM)

Department of Veterinary & Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Center for Molecular Immunology and Infectious Disease and Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania, USA.
Mammalian Pathology Section, Animal Diagnostic Laboratory, Department of Veterinary & Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.

Charyguly Annageldiyev (C)

Division of Hematology and Oncology, Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.

Arati Sharma (A)

Division of Hematology and Oncology, Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.

David F Claxton (DF)

Division of Hematology and Oncology, Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.

Robert F Paulson (RF)

Department of Veterinary & Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Center for Molecular Immunology and Infectious Disease and Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania, USA.

K Sandeep Prabhu (KS)

Department of Veterinary & Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Center for Molecular Immunology and Infectious Disease and Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Interleukin-4 treatment reduces leukemia...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukin-4 treatment reduces leukemia...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Interleukin-4 treatment reduces leukemia...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-4 › Interleukin-4 treatment reduces leukemia...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › Leucémie myéloïde › Leucémie aigüe myéloïde › Interleukin-4 treatment reduces leukemia...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Interleukin-4 treatment reduces leukemia...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur PPAR gamma › Interleukin-4 treatment reduces leukemia...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Prostaglandines › Prostaglandines D › Prostaglandine D2 › Interleukin-4 treatment reduces leukemia...