David Machalz

Affiliations

Freie Universitaet Berlin, Institute of Pharmacy, Pharmaceutical and Medicinal Chemistry (Computer-Aided Drug Design) Berlin Germany.

ORCID: https://orcid.org/0000-0001-8634-9411

Publications (12)

A benzoxazole derivative as an inhibitor of anaerobic choline metabolism by human gut microbiota.

RSC medicinal chemistry

Avec: Moustafa T Gabr , David Machalz , Szymon Pach , Gerhard Wolber

Comparison of the three SARMs RAD-140, GLPG0492 and GSK-2881078 in two different in vitro bioassays, and in an in silico androgen receptor binding assay.

The Journal of steroid biochemistry and molecular biology

Avec: Oliver Zierau , Annika Kolodziejczyk , Günter Vollmer , David Machalz , Gerhard Wolber , Detlef Thieme , Annekathrin Martina Keiler

Importance of asparagine-381 and arginine-487 for substrate recognition in CYP4Z1.

Biochemical pharmacology

Avec: Wei Du , David Machalz , Qi Yan , Erik J Sorensen , Gerhard Wolber , Matthias Bureik

Metabolism of the antipsychotic drug olanzapine by CYP3A43.

Xenobiotica; the fate of foreign compounds in biological systems

Avec: Jie Zhao , David Machalz , Sijie Liu , Clemens Alexander Wolf , Gerhard Wolber , Maria Kristina Parr , Matthias Bureik

Functional Expression of All Human Sulfotransferases in Fission Yeast, Assay Development, and Structural Models for Isoforms SULT4A1 and SULT6B1.

Biomolecules

Avec: Yanan Sun , David Machalz , Gerhard Wolber , Maria Kristina Parr , Matthias Bureik

Discovery of a novel potent cytochrome P450 CYP4Z1 inhibitor.

European journal of medicinal chemistry

Avec: David Machalz , Hongjie Li , Wei Du , Shishir Sharma , Sijie Liu , Matthias Bureik , Gerhard Wolber

Fine-mapping of the substrate specificity of human steroid 21-hydroxylase (CYP21A2).

The Journal of steroid biochemistry and molecular biology

Avec: Anna Stoll , Steffen Loke , Jan Felix Joseph , David Machalz , Xavier de la Torre , Francesco Botrè , Gerhard Wolber , Matthias Bureik , Maria Kristina Parr

A convenient test system for the identification of CYP4V2 inhibitors.

Molecular vision

Avec: Shishir Sharma , Sijie Liu , Pradeepraj Durairaj , David Machalz , Gerhard Wolber , Matthias Bureik

New Proluciferin Substrates for Human CYP4 Family Enzymes.

Applied biochemistry and biotechnology

Avec: Jingyao Liu , David Machalz , Gerhard Wolber , Erik J Sorensen , Matthias Bureik

Functional characterization and mechanistic modeling of the human cytochrome P450 enzyme CYP4A22.

FEBS letters

Avec: Pradeepraj Durairaj , Linbing Fan , David Machalz , Gerhard Wolber , Matthias Bureik

Structural insights into understudied human cytochrome P450 enzymes.

Drug discovery today

Avec: David Machalz , Szymon Pach , Marcel Bermudez , Matthias Bureik , Gerhard Wolber

Corticosteroid Biosynthesis Revisited: No Direct Hydroxylation of Pregnenolone by Steroid 21-Hydroxylase.

Frontiers in endocrinology

Avec: Steffen Loke , Anna Stoll , David Machalz , Francesco Botrè , Gerhard Wolber , Matthias Bureik , Maria Kristina Parr

Réseau de co-auteurs

Gerhard Wolber 12 collaborations

Matthias Bureik 10 collaborations

Maria Kristina Parr 4 collaborations

Sijie Liu 3 collaborations

Szymon Pach 2 collaborations

Wei Du 2 collaborations

Erik J Sorensen 2 collaborations

Shishir Sharma 2 collaborations

Anna Stoll 2 collaborations

Steffen Loke 2 collaborations

Francesco Botrè 2 collaborations

Pradeepraj Durairaj 2 collaborations

Moustafa T Gabr 1 collaboration

Oliver Zierau 1 collaboration

Annika Kolodziejczyk 1 collaboration

Günter Vollmer 1 collaboration

Detlef Thieme 1 collaboration

Annekathrin Martina Keiler 1 collaboration

Qi Yan 1 collaboration

Jie Zhao 1 collaboration

Clemens Alexander Wolf 1 collaboration

Yanan Sun 1 collaboration

Hongjie Li 1 collaboration

Jan Felix Joseph 1 collaboration

Xavier de la Torre 1 collaboration

Jingyao Liu 1 collaboration

Linbing Fan 1 collaboration

Marcel Bermudez 1 collaboration