Diederik Moechars

Affiliations

Neuroscience, Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium.

Publications (22)

Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2.

Journal of medicinal chemistry

Avec: Kazuki Fujimoto , Shuhei Yoshida , Genta Tadano , Naoya Asada , Kouki Fuchino , Shinji Suzuki , Eriko Matsuoka , Takahiko Yamamoto , Shiho Yamamoto , Shigeru Ando , Naoki Kanegawa , Yutaka Tonomura , Hisanori Ito , Diederik Moechars , Frederik J R Rombouts , Harrie J M Gijsen , Ken-Ichi Kusakabe

Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads.

ACS medicinal chemistry letters

Avec: Daniel Oehlrich , Aldo Peschiulli , Gary Tresadern , Michiel Van Gool , Juan Antonio Vega , Ana Isabel De Lucas , Sergio A Alonso de Diego , Hana Prokopcova , Nigel Austin , Sven Van Brandt , Michel Surkyn , Michel De Cleyn , Ann Vos , Frederik J R Rombouts , Gregor Macdonald , Dieder Moechars , Harrie J M Gijsen , Andrés A Trabanco

A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo.

ACS medicinal chemistry letters

Avec: Aldo Peschiulli , Daniel Oehlrich , Michiel Van Gool , Nigel Austin , Sven Van Brandt , Michel Surkyn , Michel De Cleyn , Ann Vos , Gary Tresadern , Frederik J R Rombouts , Gregor J Macdonald , Diederik Moechars , Andrés A Trabanco , Harrie J M Gijsen

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.

Nature neuroscience

Avec: Hannah Van Hove , Liesbet Martens , Isabelle Scheyltjens , Karen De Vlaminck , Ana Rita Pombo Antunes , Sofie De Prijck , Niels Vandamme , Sebastiaan De Schepper , Gert Van Isterdael , Charlotte L Scott , Jeroen Aerts , Geert Berx , Guy E Boeckxstaens , Roosmarijn E Vandenbroucke , Lars Vereecke , Diederik Moechars , Martin Guilliams , Jo A Van Ginderachter , Yvan Saeys , Kiavash Movahedi

Passive immunotherapy with a novel antibody against 3pE-modified Aβ demonstrates potential for enhanced efficacy and favorable safety in combination with BACE inhibitor treatment in plaque-depositing mice.

Neurobiology of disease

Avec: Jonathan Janssens , Bart Hermans , Marc Vandermeeren , Erio Barale-Thomas , Marianne Borgers , Roland Willems , Greet Meulders , Cindy Wintmolders , Dries Van den Bulck , Astrid Bottelbergs , Luc Ver Donck , Peter Larsen , Dieder Moechars , Wilson Edwards , Marc Mercken , Bianca Van Broeck

Pathological and neurophysiological outcomes of seeding human-derived tau pathology in the APP-KI NL-G-F and NL-NL mouse models of Alzheimer's Disease.

Acta neuropathologica communications

Avec: S Tok , H Maurin , C Delay , D Crauwels , N V Manyakov , W Van Der Elst , D Moechars , W H I M Drinkenburg

PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding.

The Journal of biological chemistry

Avec: Alberto Carpinteiro Soares , Andreia Ferreira , Jonas Mariën , Charlotte Delay , Edward Lee , John Q Trojanowski , Dieder Moechars , Wim Annaert , Louis De Muynck

JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.

Journal of medicinal chemistry

Avec: Frederik J R Rombouts , Ken-Ichi Kusakabe , Richard Alexander , Nigel Austin , Herman Borghys , Michel De Cleyn , Deborah Dhuyvetter , Harrie J M Gijsen , Brian Hrupka , Tom Jacobs , Soufyan Jerhaoui , Lieve Lammens , Laurent Leclercq , Koichi Tsubone , Tatsuhiko Ueno , Kenji Morimoto , Shunsuke Einaru , Hirokazu Sumiyoshi , An Van den Bergh , Ann Vos , Michel Surkyn , Ard Teisman , Diederik Moechars

Absence of Uptake and Prion-Like Spreading of Alpha-Synuclein and Tau After Intravitreal Injection of Preformed Fibrils.

Frontiers in aging neuroscience

Avec: Lien Veys , Jessie Van Houcke , Jeroen Aerts , Sophie Van Pottelberge , Michel Mahieu , Audrey Coens , Ronald Melki , Dieder Moechars , Louis De Muynck , Lies De Groef

The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates.

BMC molecular and cell biology

Avec: Andreia Ferreira , Ines Royaux , Jian Liu , Zhangjie Wang , Guowei Su , Diederik Moechars , Nico Callewaert , Louis De Muynck

Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays.

The Journal of biological chemistry

Avec: Alex Crowe , Mark J Henderson , Johnathon Anderson , Steven A Titus , Alexey Zakharov , Anton Simeonov , Arjan Buist , Charlotte Delay , Diederik Moechars , John Q Trojanowski , Virginia M-Y Lee , Kurt R Brunden

Discovery of N-(4-[

Journal of medicinal chemistry

Avec: Frederik J R Rombouts , Lieven Declercq , José-Ignacio Andrés , Astrid Bottelbergs , Lu Chen , Laura Iturrino , Joseph E Leenaerts , Jonas Mariën , Fengbin Song , Cindy Wintmolders , Stijn Wuyts , Chunfang A Xia , Paula Te Riele , Guy Bormans , Rik Vandenberghe , Hartmuth Kolb , Diederik Moechars

Neurophysiological effects of human-derived pathological tau conformers in the APPKM670/671NL.PS1/L166P amyloid mouse model of Alzheimer's disease.

Scientific reports

Avec: S Tok , H Maurin , C Delay , D Crauwels , N V Manyakov , W Van Der Elst , D Moechars , W H I M Drinkenburg

Mutated Toll-like receptor 9 increases Alzheimer's disease risk by compromising innate immunity protection.

Molecular psychiatry

Avec: Rita Cacace , Lujia Zhou , Elisabeth Hendrickx Van de Craen , Arjan Buist , Julie Hoogmartens , Anne Sieben , Patrick Cras , Rik Vandenberghe , Peter P De Deyn , Daniel Oehlrich , An De Bondt , Sebastiaan Engelborghs , Diederik Moechars , Christine Van Broeckhoven

microRNA-132 regulates gene expression programs involved in microglial homeostasis.

iScience

Avec: Hannah Walgrave , Amber Penning , Giorgia Tosoni , Sarah Snoeck , Kristofer Davie , Emma Davis , Leen Wolfs , Annerieke Sierksma , Mayte Mars , Taofeng Bu , Nicola Thrupp , Lujia Zhou , Diederik Moechars , Renzo Mancuso , Mark Fiers , Andrew J M Howden , Bart De Strooper , Evgenia Salta

The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling.

The Journal of clinical investigation

Avec: Andree Schmidt , Brian Hrupka , Frauke van Bebber , Sanjay Sunil Kumar , Xiao Feng , Sarah K Tschirner , Marlene Aßfalg , Stephan A Müller , Laura Sophie Hilger , Laura I Hofmann , Martina Pigoni , Georg Jocher , Iryna Voytyuk , Emily L Self , Mana Ito , Kana Hyakkoku , Akimasa Yoshimura , Naotaka Horiguchi , Regina Feederle , Bart De Strooper , Stefan Schulte-Merker , Eckhard Lammert , Dieder Moechars , Bettina Schmid , Stefan F Lichtenthaler

Clinical evaluation of [

European journal of nuclear medicine and molecular imaging

Avec: Mark E Schmidt , Luc Janssens , Diederik Moechars , Frederik J R Rombouts , Maarten Timmers , Olivier Barret , Cristian C Constantinescu , Jennifer Madonia , David S Russell , Christine M Sandiego , Hartmuth Kolb

Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2.

Journal of medicinal chemistry

Avec: Kazuki Fujimoto , Eriko Matsuoka , Naoya Asada , Genta Tadano , Takahiko Yamamoto , Kenji Nakahara , Kouki Fuchino , Hisanori Ito , Naoki Kanegawa , Diederik Moechars , Harrie J M Gijsen , Ken-Ichi Kusakabe

Age- and Intravenous Methotrexate-Associated Leukoencephalopathy and Its Neurological Impact in Pediatric Patients with Lymphoblastic Leukemia.

Cancers

Avec: Ilona Rijmenams , Daan Moechars , Anne Uyttebroeck , Ahmed Radwan , Jeroen Blommaert , Sabine Deprez , Stefan Sunaert , Heidi Segers , Céline R Gillebert , Jurgen Lemiere , Charlotte Sleurs

Discovery of Extremely Selective Fused Pyridine-Derived β-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions.

Journal of medicinal chemistry

Avec: Tatsuhiko Ueno , Eriko Matsuoka , Naoya Asada , Shiho Yamamoto , Naoki Kanegawa , Mana Ito , Hisanori Ito , Diederik Moechars , Frederik J R Rombouts , Harrie J M Gijsen , Ken-Ichi Kusakabe

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's disease.

Cell reports

Avec: Disha Shah , Willy Gsell , Jérôme Wahis , Emma S Luckett , Tarik Jamoulle , Ben Vermaercke , Pranav Preman , Daan Moechars , Véronique Hendrickx , Tom Jaspers , Katleen Craessaerts , Katrien Horré , Leen Wolfs , Mark Fiers , Matthew Holt , Dietmar Rudolf Thal , Zsuzsanna Callaerts-Vegh , Rudi D'Hooge , Rik Vandenberghe , Uwe Himmelreich , Vincent Bonin , Bart De Strooper

Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer's disease mouse model, as revealed by spatial transcriptomics.

Cell reports

Avec: Anna Mallach , Magdalena Zielonka , Veerle van Lieshout , Yanru An , Jia Hui Khoo , Marisa Vanheusden , Wei-Ting Chen , Daan Moechars , I Lorena Arancibia-Carcamo , Mark Fiers , Bart De Strooper

Réseau de co-auteurs

Frederik J R Rombouts 7 collaborations

Harrie J M Gijsen 6 collaborations

Dieder Moechars 5 collaborations

Ken-Ichi Kusakabe 4 collaborations

Bart De Strooper 4 collaborations

Naoya Asada 3 collaborations

Eriko Matsuoka 3 collaborations

Naoki Kanegawa 3 collaborations

Hisanori Ito 3 collaborations

Daniel Oehlrich 3 collaborations

Nigel Austin 3 collaborations

Michel Surkyn 3 collaborations

Michel De Cleyn 3 collaborations

Ann Vos 3 collaborations

Louis De Muynck 3 collaborations

Rik Vandenberghe 3 collaborations

Mark Fiers 3 collaborations

Daan Moechars 3 collaborations

Kazuki Fujimoto 2 collaborations

Genta Tadano 2 collaborations

Kouki Fuchino 2 collaborations

Takahiko Yamamoto 2 collaborations

Shiho Yamamoto 2 collaborations

Aldo Peschiulli 2 collaborations

Gary Tresadern 2 collaborations

Michiel Van Gool 2 collaborations

Sven Van Brandt 2 collaborations

Andrés A Trabanco 2 collaborations

Jeroen Aerts 2 collaborations

Cindy Wintmolders 2 collaborations

Astrid Bottelbergs 2 collaborations

S Tok 2 collaborations

H Maurin 2 collaborations

C Delay 2 collaborations

D Crauwels 2 collaborations

N V Manyakov 2 collaborations

W Van Der Elst 2 collaborations

D Moechars 2 collaborations

W H I M Drinkenburg 2 collaborations

Andreia Ferreira 2 collaborations

Jonas Mariën 2 collaborations

Charlotte Delay 2 collaborations

John Q Trojanowski 2 collaborations

Brian Hrupka 2 collaborations

Tatsuhiko Ueno 2 collaborations

Arjan Buist 2 collaborations

Hartmuth Kolb 2 collaborations

Lujia Zhou 2 collaborations

Leen Wolfs 2 collaborations

Mana Ito 2 collaborations

Shuhei Yoshida 1 collaboration

Shinji Suzuki 1 collaboration

Shigeru Ando 1 collaboration

Yutaka Tonomura 1 collaboration

Juan Antonio Vega 1 collaboration

Ana Isabel De Lucas 1 collaboration

Sergio A Alonso de Diego 1 collaboration

Hana Prokopcova 1 collaboration

Gregor Macdonald 1 collaboration

Gregor J Macdonald 1 collaboration

Hannah Van Hove 1 collaboration

Liesbet Martens 1 collaboration

Isabelle Scheyltjens 1 collaboration

Karen De Vlaminck 1 collaboration

Ana Rita Pombo Antunes 1 collaboration

Sofie De Prijck 1 collaboration

Niels Vandamme 1 collaboration

Sebastiaan De Schepper 1 collaboration

Gert Van Isterdael 1 collaboration

Charlotte L Scott 1 collaboration

Geert Berx 1 collaboration

Guy E Boeckxstaens 1 collaboration

Roosmarijn E Vandenbroucke 1 collaboration

Lars Vereecke 1 collaboration

Martin Guilliams 1 collaboration

Jo A Van Ginderachter 1 collaboration

Yvan Saeys 1 collaboration

Kiavash Movahedi 1 collaboration

Jonathan Janssens 1 collaboration

Bart Hermans 1 collaboration

Marc Vandermeeren 1 collaboration

Erio Barale-Thomas 1 collaboration

Marianne Borgers 1 collaboration

Roland Willems 1 collaboration

Greet Meulders 1 collaboration

Dries Van den Bulck 1 collaboration

Luc Ver Donck 1 collaboration

Peter Larsen 1 collaboration

Wilson Edwards 1 collaboration

Marc Mercken 1 collaboration

Bianca Van Broeck 1 collaboration

Alberto Carpinteiro Soares 1 collaboration

Edward Lee 1 collaboration

Wim Annaert 1 collaboration

Richard Alexander 1 collaboration

Herman Borghys 1 collaboration

Deborah Dhuyvetter 1 collaboration

Tom Jacobs 1 collaboration

Soufyan Jerhaoui 1 collaboration

Lieve Lammens 1 collaboration

Laurent Leclercq 1 collaboration

Koichi Tsubone 1 collaboration

Kenji Morimoto 1 collaboration

Shunsuke Einaru 1 collaboration

Hirokazu Sumiyoshi 1 collaboration

An Van den Bergh 1 collaboration

Ard Teisman 1 collaboration

Lien Veys 1 collaboration

Jessie Van Houcke 1 collaboration

Sophie Van Pottelberge 1 collaboration

Michel Mahieu 1 collaboration

Audrey Coens 1 collaboration

Ronald Melki 1 collaboration

Lies De Groef 1 collaboration

Ines Royaux 1 collaboration

Jian Liu 1 collaboration

Zhangjie Wang 1 collaboration

Guowei Su 1 collaboration

Nico Callewaert 1 collaboration

Alex Crowe 1 collaboration

Mark J Henderson 1 collaboration

Johnathon Anderson 1 collaboration

Steven A Titus 1 collaboration

Alexey Zakharov 1 collaboration

Anton Simeonov 1 collaboration

Virginia M-Y Lee 1 collaboration

Kurt R Brunden 1 collaboration

Lieven Declercq 1 collaboration

José-Ignacio Andrés 1 collaboration

Lu Chen 1 collaboration

Laura Iturrino 1 collaboration

Joseph E Leenaerts 1 collaboration

Fengbin Song 1 collaboration

Stijn Wuyts 1 collaboration

Chunfang A Xia 1 collaboration

Paula Te Riele 1 collaboration

Guy Bormans 1 collaboration

Rita Cacace 1 collaboration

Elisabeth Hendrickx Van de Craen 1 collaboration

Julie Hoogmartens 1 collaboration

Anne Sieben 1 collaboration

Patrick Cras 1 collaboration

Peter P De Deyn 1 collaboration

An De Bondt 1 collaboration

Sebastiaan Engelborghs 1 collaboration

Christine Van Broeckhoven 1 collaboration

Hannah Walgrave 1 collaboration

Amber Penning 1 collaboration

Giorgia Tosoni 1 collaboration

Sarah Snoeck 1 collaboration

Kristofer Davie 1 collaboration

Emma Davis 1 collaboration

Annerieke Sierksma 1 collaboration

Mayte Mars 1 collaboration

Taofeng Bu 1 collaboration

Nicola Thrupp 1 collaboration

Renzo Mancuso 1 collaboration

Andrew J M Howden 1 collaboration

Evgenia Salta 1 collaboration

Andree Schmidt 1 collaboration

Frauke van Bebber 1 collaboration

Sanjay Sunil Kumar 1 collaboration

Xiao Feng 1 collaboration

Sarah K Tschirner 1 collaboration

Marlene Aßfalg 1 collaboration

Stephan A Müller 1 collaboration

Laura Sophie Hilger 1 collaboration

Laura I Hofmann 1 collaboration

Martina Pigoni 1 collaboration

Georg Jocher 1 collaboration

Iryna Voytyuk 1 collaboration

Emily L Self 1 collaboration

Kana Hyakkoku 1 collaboration

Akimasa Yoshimura 1 collaboration

Naotaka Horiguchi 1 collaboration

Regina Feederle 1 collaboration

Stefan Schulte-Merker 1 collaboration

Eckhard Lammert 1 collaboration

Bettina Schmid 1 collaboration

Stefan F Lichtenthaler 1 collaboration

Mark E Schmidt 1 collaboration

Luc Janssens 1 collaboration

Maarten Timmers 1 collaboration

Olivier Barret 1 collaboration

Cristian C Constantinescu 1 collaboration

Jennifer Madonia 1 collaboration

David S Russell 1 collaboration

Christine M Sandiego 1 collaboration

Kenji Nakahara 1 collaboration

Ilona Rijmenams 1 collaboration

Anne Uyttebroeck 1 collaboration

Ahmed Radwan 1 collaboration

Jeroen Blommaert 1 collaboration

Sabine Deprez 1 collaboration

Stefan Sunaert 1 collaboration

Heidi Segers 1 collaboration

Céline R Gillebert 1 collaboration

Jurgen Lemiere 1 collaboration

Charlotte Sleurs 1 collaboration

Disha Shah 1 collaboration

Willy Gsell 1 collaboration

Jérôme Wahis 1 collaboration

Emma S Luckett 1 collaboration

Tarik Jamoulle 1 collaboration

Ben Vermaercke 1 collaboration

Pranav Preman 1 collaboration

Véronique Hendrickx 1 collaboration

Tom Jaspers 1 collaboration

Katleen Craessaerts 1 collaboration

Katrien Horré 1 collaboration

Matthew Holt 1 collaboration

Dietmar Rudolf Thal 1 collaboration

Zsuzsanna Callaerts-Vegh 1 collaboration

Rudi D'Hooge 1 collaboration

Uwe Himmelreich 1 collaboration

Vincent Bonin 1 collaboration

Anna Mallach 1 collaboration

Magdalena Zielonka 1 collaboration

Veerle van Lieshout 1 collaboration

Yanru An 1 collaboration

Jia Hui Khoo 1 collaboration

Marisa Vanheusden 1 collaboration

Wei-Ting Chen 1 collaboration

I Lorena Arancibia-Carcamo 1 collaboration