Hashim M Al-Hashimi

Affiliations

Department of Biochemistry , Duke University School of Medicine , Durham , North Carolina 27710 , United States.
Department of Chemistry , Duke University , Durham , North Carolina 27708 , United States.

Publications (17)

Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically

Biochemistry

Avec: Huiqing Zhou , Bharathwaj Sathyamoorthy , Allison Stelling , Yu Xu , Yi Xue , Ying Zhang Pigli , David A Case , Phoebe A Rice , Hashim M Al-Hashimi

m6A minimally impacts the structure, dynamics, and Rev ARM binding properties of HIV-1 RRE stem IIB.

PloS one

Avec: Chia-Chieh Chu , Bei Liu , Raphael Plangger , Christoph Kreutz , Hashim M Al-Hashimi

Developments in solution-state NMR yield broader and deeper views of the dynamic ensembles of nucleic acids.

Current opinion in structural biology

Avec: Bei Liu , Honglue Shi , Hashim M Al-Hashimi

Understanding the characteristics of nonspecific binding of drug-like compounds to canonical stem-loop RNAs and their implications for functional cellular assays.

RNA (New York, N.Y.)

Avec: Megan L Kelly , Chia-Chieh Chu , Honglue Shi , Laura R Ganser , Hal P Bogerd , Kelly Huynh , Yuze Hou , Bryan R Cullen , Hashim M Al-Hashimi

Structural basis for impaired 5' processing of a mutant tRNA associated with defects in neuronal homeostasis.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Lien B Lai , Stella M Lai , Eric S Szymanski , Mridu Kapur , Edric K Choi , Hashim M Al-Hashimi , Susan L Ackerman , Venkat Gopalan

RBM45 is an m

Cell reports

Avec: Seung H Choi , Mathieu N Flamand , Bei Liu , Huanyu Zhu , Meghan Hu , Melanie Wang , Jonathon Sewell , Christopher L Holley , Hashim M Al-Hashimi , Kate D Meyer

NMR measurements of transient low-populated tautomeric and anionic Watson-Crick-like G·T/U in RNA:DNA hybrids: Implications for the fidelity of transcription and CRISPR/Cas9 gene editing.

bioRxiv : the preprint server for biology

Avec: Or Szekely , Atul Kaushik Rangadurai , Stephanie Gu , Akanksha Manghrani , Serafima Guseva , Hashim M Al-Hashimi

Rapid assessment of Watson-Crick to Hoogsteen exchange in unlabeled DNA duplexes using high-power SELOPE imino

Magnetic resonance (Gottingen, Germany)

Avec: Bei Liu , Atul Rangadurai , Honglue Shi , Hashim M Al-Hashimi

Quantitative and systematic NMR measurements of sequence-dependent A-T Hoogsteen dynamics uncovers unique conformational specificity in the DNA double helix.

bioRxiv : the preprint server for biology

Avec: Akanksha Manghrani , Atul Kaushik Rangadurai , Or Szekely , Bei Liu , Serafima Guseva , Hashim M Al-Hashimi

Insights into the A-C mismatch conformational ensemble in duplex DNA and its role in genetic processes through a structure-based review.

Journal of molecular biology

Avec: Yeongjoon Lee , Stephanie Gu , Hashim M Al-Hashimi

Direct Measurement of 8OG Syn-Anti Flips in Mutagenic 8OG·A and Long-Range Damage-Dependent Hoogsteen Breathing Dynamics Using

The journal of physical chemistry. B

Avec: Stephanie Gu , Hashim M Al-Hashimi

Probing Watson-Crick and Hoogsteen base pairing in duplex DNA using dynamic nuclear polarization solid-state NMR spectroscopy.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Daniel W Conroy , Yu Xu , Honglue Shi , Nicole Gonzalez Salguero , Rudra N Purusottam , Matthew D Shannon , Hashim M Al-Hashimi , Christopher P Jaroniec

mRNA interactions with disordered regions control protein activity.

bioRxiv : the preprint server for biology

Avec: Yang Luo , Supriya Pratihar , Ellen H Horste , Sibylle Mitschka , Antonia S J S Mey , Hashim M Al-Hashimi , Christine Mayr

Environmental Effects on Guanine-Thymine Mispair Tautomerization Explored with Quantum Mechanical/Molecular Mechanical Free Energy Simulations.

Journal of the American Chemical Society

Avec: Pengfei Li , Atul Rangadurai , Hashim M Al-Hashimi , Sharon Hammes-Schiffer

Publisher Correction: High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble.

Nature structural & molecular biology

Avec: Laura R Ganser , Janghyun Lee , Atul Rangadurai , Dawn K Merriman , Megan L Kelly , Aman D Kansal , Bharathwaj Sathyamoorthy , Hashim M Al-Hashimi

Demonstration that Small Molecules can Bind and Stabilize Low-abundance Short-lived RNA Excited Conformational States.

Journal of molecular biology

Avec: Laura R Ganser , Megan L Kelly , Neeraj N Patwardhan , Amanda E Hargrove , Hashim M Al-Hashimi

Dynamic ensemble of HIV-1 RRE stem IIB reveals non-native conformations that disrupt the Rev-binding site.

Nucleic acids research

Avec: Chia-Chieh Chu , Raphael Plangger , Christoph Kreutz , Hashim M Al-Hashimi

Réseau de co-auteurs

Bei Liu 5 collaborations

Honglue Shi 4 collaborations

Chia-Chieh Chu 3 collaborations

Megan L Kelly 3 collaborations

Laura R Ganser 3 collaborations

Stephanie Gu 3 collaborations

Atul Rangadurai 3 collaborations

Bharathwaj Sathyamoorthy 2 collaborations

Yu Xu 2 collaborations

Raphael Plangger 2 collaborations

Christoph Kreutz 2 collaborations

Or Szekely 2 collaborations

Atul Kaushik Rangadurai 2 collaborations

Akanksha Manghrani 2 collaborations

Serafima Guseva 2 collaborations

Huiqing Zhou 1 collaboration

Allison Stelling 1 collaboration

Yi Xue 1 collaboration

Ying Zhang Pigli 1 collaboration

David A Case 1 collaboration

Phoebe A Rice 1 collaboration

Hal P Bogerd 1 collaboration

Kelly Huynh 1 collaboration

Yuze Hou 1 collaboration

Bryan R Cullen 1 collaboration

Lien B Lai 1 collaboration

Stella M Lai 1 collaboration

Eric S Szymanski 1 collaboration

Mridu Kapur 1 collaboration

Edric K Choi 1 collaboration

Susan L Ackerman 1 collaboration

Venkat Gopalan 1 collaboration

Seung H Choi 1 collaboration

Mathieu N Flamand 1 collaboration

Huanyu Zhu 1 collaboration

Meghan Hu 1 collaboration

Melanie Wang 1 collaboration

Jonathon Sewell 1 collaboration

Christopher L Holley 1 collaboration

Kate D Meyer 1 collaboration

Yeongjoon Lee 1 collaboration

Daniel W Conroy 1 collaboration

Nicole Gonzalez Salguero 1 collaboration

Rudra N Purusottam 1 collaboration

Matthew D Shannon 1 collaboration

Christopher P Jaroniec 1 collaboration

Yang Luo 1 collaboration

Supriya Pratihar 1 collaboration

Ellen H Horste 1 collaboration

Sibylle Mitschka 1 collaboration

Antonia S J S Mey 1 collaboration

Christine Mayr 1 collaboration

Pengfei Li 1 collaboration

Sharon Hammes-Schiffer 1 collaboration

Janghyun Lee 1 collaboration

Dawn K Merriman 1 collaboration

Aman D Kansal 1 collaboration

Neeraj N Patwardhan 1 collaboration

Amanda E Hargrove 1 collaboration