Jason M Sheltzer

Affiliations

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. sheltzer@cshl.edu.

ORCID: http://orcid.org/0000-0003-1381-1323

Publications (24)

Discovering and validating cancer genetic dependencies: approaches and pitfalls.

Nature reviews. Genetics

Avec: Ann Lin , Jason M Sheltzer

Chromosomal instability and aneuploidy as causes of cancer drug resistance.

Trends in cancer

Avec: Devon A Lukow , Jason M Sheltzer

Understanding the impact of an after-school music program with engaged underserved youth.

Journal of community psychology

Avec: Joshua M Sheltzer , Andrés J Consoli

Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies.

Developmental cell

Avec: Devon A Lukow , Erin L Sausville , Pavit Suri , Narendra Kumar Chunduri , Angela Wieland , Justin Leu , Joan C Smith , Vishruth Girish , Ankith A Kumar , Jude Kendall , Zihua Wang , Zuzana Storchova , Jason M Sheltzer

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity.

bioRxiv : the preprint server for biology

Avec: Markus Hoffmann , Heike Hofmann-Winkler , Joan C Smith , Nadine Krüger , Lambert K Sørensen , Ole S Søgaard , Jørgen Bo Hasselstrøm , Michael Winkler , Tim Hempel , Lluís Raich , Simon Olsson , Takashi Yamazoe , Katsura Yamatsuta , Hirotaka Mizuno , Stephan Ludwig , Frank Noé , Jason M Sheltzer , Mads Kjolby , Stefan Pöhlmann

Generating Single Cell-Derived Knockout Clones in Mammalian Cells with CRISPR/Cas9.

Current protocols in molecular biology

Avec: Christopher J Giuliano , Ann Lin , Vishruth Girish , Jason M Sheltzer

Synthesis and Structure-Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold.

European journal of medicinal chemistry

Avec: Zhengnian Li , Ryosuke Ishida , Yan Liu , Jinhua Wang , Yina Li , Yang Gao , Jie Jiang , Jianwei Che , Jason M Sheltzer , Matthew B Robers , Tinghu Zhang , Kenneth D Westover , Behnam Nabet , Nathanael S Gray

Oncogene-like addiction to aneuploidy in human cancers.

bioRxiv : the preprint server for biology

Avec: Vishruth Girish , Asad A Lakhani , Christine M Scaduto , Sarah L Thompson , Leanne M Brown , Ryan A Hagenson , Erin L Sausville , Brianna E Mendelson , Devon A Lukow , Monet Lou Yuan , Pranav K Kandikuppa , Eric C Stevens , Sophia N Lee , Barbora Salovska , Wenxue Li , Joan C Smith , Alison M Taylor , Robert A Martienssen , Yansheng Liu , Ruping Sun , Jason M Sheltzer

An elevated rate of whole-genome duplications in cancers from Black patients.

Nature communications

Avec: Leanne M Brown , Ryan A Hagenson , Tilen Koklič , Iztok Urbančič , Lu Qiao , Janez Strancar , Jason M Sheltzer

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity.

EBioMedicine

Avec: Markus Hoffmann , Heike Hofmann-Winkler , Joan C Smith , Nadine Krüger , Prerna Arora , Lambert K Sørensen , Ole S Søgaard , Jørgen Bo Hasselstrøm , Michael Winkler , Tim Hempel , Lluís Raich , Simon Olsson , Olga Danov , Danny Jonigk , Takashi Yamazoe , Katsura Yamatsuta , Hirotaka Mizuno , Stephan Ludwig , Frank Noé , Mads Kjolby , Armin Braun , Jason M Sheltzer , Stefan Pöhlmann

Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials.

Science translational medicine

Avec: Ann Lin , Christopher J Giuliano , Ann Palladino , Kristen M John , Connor Abramowicz , Monet Lou Yuan , Erin L Sausville , Devon A Lukow , Luwei Liu , Alexander R Chait , Zachary C Galluzzo , Clara Tucker , Jason M Sheltzer

Field-theoretic density estimation for biological sequence space with applications to 5' splice site diversity and aneuploidy in cancer.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Wei-Chia Chen , Juannan Zhou , Jason M Sheltzer , Justin B Kinney , David M McCandlish

Genome-wide identification and analysis of prognostic features in human cancers.

Cell reports

Avec: Joan C Smith , Jason M Sheltzer

Extensive protein dosage compensation in aneuploid human cancers.

Genome research

Avec: Klaske M Schukken , Jason M Sheltzer

Evolving copy number gains promote tumor expansion and bolster mutational diversification.

Nature communications

Avec: Zicheng Wang , Yunong Xia , Lauren Mills , Athanasios N Nikolakopoulos , Nicole Maeser , Scott M Dehm , Jason M Sheltzer , Ruping Sun

Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor.

Cell chemical biology

Avec: Debanjan Bhattacharjee , Jaweria Bakar , Surbhi P Chitnis , Erin L Sausville , Kumar Dilip Ashtekar , Brianna E Mendelson , Kaitlin Long , Joan C Smith , David E Heppner , Jason M Sheltzer

Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract.

Developmental cell

Avec: Joan C Smith , Erin L Sausville , Vishruth Girish , Monet Lou Yuan , Anand Vasudevan , Kristen M John , Jason M Sheltzer

Micronuclei-based model system reveals functional consequences of chromothripsis in human cells.

eLife

Avec: Maja Kneissig , Kristina Keuper , Mirjam S de Pagter , Markus J van Roosmalen , Jana Martin , Hannah Otto , Verena Passerini , Aline Campos Sparr , Ivo Renkens , Fenna Kropveld , Anand Vasudevan , Jason M Sheltzer , Wigard P Kloosterman , Zuzana Storchova

Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer.

Developmental cell

Avec: Anand Vasudevan , Prasamit S Baruah , Joan C Smith , Zihua Wang , Nicole M Sayles , Peter Andrews , Jude Kendall , Justin Leu , Narendra Kumar Chunduri , Dan Levy , Michael Wigler , Zuzana Storchová , Jason M Sheltzer

A CRISPR Competition Assay to Identify Cancer Genetic Dependencies.

Bio-protocol

Avec: Vishruth Girish , Jason M Sheltzer

Aneuploidy as a promoter and suppressor of malignant growth.

Nature reviews. Cancer

Avec: Anand Vasudevan , Klaske M Schukken , Erin L Sausville , Vishruth Girish , Oluwadamilare A Adebambo , Jason M Sheltzer

Oncogene-like addiction to aneuploidy in human cancers.

Science (New York, N.Y.)

Avec: Vishruth Girish , Asad A Lakhani , Sarah L Thompson , Christine M Scaduto , Leanne M Brown , Ryan A Hagenson , Erin L Sausville , Brianna E Mendelson , Pranav K Kandikuppa , Devon A Lukow , Monet Lou Yuan , Eric C Stevens , Sophia N Lee , Klaske M Schukken , Saron M Akalu , Anand Vasudevan , Charles Zou , Barbora Salovska , Wenxue Li , Joan C Smith , Alison M Taylor , Robert A Martienssen , Yansheng Liu , Ruping Sun , Jason M Sheltzer

Aneuploidy in human cancer: new tools and perspectives.

Trends in genetics : TIG

Avec: Asad A Lakhani , Sarah L Thompson , Jason M Sheltzer

The next Nobel Prize in chemistry or in physiology or medicine.

Cell chemical biology

Avec: Cigall Kadoch , Jason M Sheltzer , Hang Yin

Réseau de co-auteurs

Joan C Smith 9 collaborations

Erin L Sausville 7 collaborations

Vishruth Girish 7 collaborations

Devon A Lukow 5 collaborations

Anand Vasudevan 5 collaborations

Monet Lou Yuan 4 collaborations

Ann Lin 3 collaborations

Asad A Lakhani 3 collaborations

Sarah L Thompson 3 collaborations

Leanne M Brown 3 collaborations

Ryan A Hagenson 3 collaborations

Brianna E Mendelson 3 collaborations

Ruping Sun 3 collaborations

Klaske M Schukken 3 collaborations

Narendra Kumar Chunduri 2 collaborations

Justin Leu 2 collaborations

Jude Kendall 2 collaborations

Zihua Wang 2 collaborations

Zuzana Storchova 2 collaborations

Markus Hoffmann 2 collaborations

Heike Hofmann-Winkler 2 collaborations

Nadine Krüger 2 collaborations

Lambert K Sørensen 2 collaborations

Ole S Søgaard 2 collaborations

Jørgen Bo Hasselstrøm 2 collaborations

Michael Winkler 2 collaborations

Tim Hempel 2 collaborations

Lluís Raich 2 collaborations

Simon Olsson 2 collaborations

Takashi Yamazoe 2 collaborations

Katsura Yamatsuta 2 collaborations

Hirotaka Mizuno 2 collaborations

Stephan Ludwig 2 collaborations

Frank Noé 2 collaborations

Mads Kjolby 2 collaborations

Stefan Pöhlmann 2 collaborations

Christopher J Giuliano 2 collaborations

Christine M Scaduto 2 collaborations

Pranav K Kandikuppa 2 collaborations

Eric C Stevens 2 collaborations

Sophia N Lee 2 collaborations

Barbora Salovska 2 collaborations

Wenxue Li 2 collaborations

Alison M Taylor 2 collaborations

Robert A Martienssen 2 collaborations

Yansheng Liu 2 collaborations

Kristen M John 2 collaborations

Joshua M Sheltzer 1 collaboration

Andrés J Consoli 1 collaboration

Pavit Suri 1 collaboration

Angela Wieland 1 collaboration

Ankith A Kumar 1 collaboration

Zhengnian Li 1 collaboration

Ryosuke Ishida 1 collaboration

Yan Liu 1 collaboration

Jinhua Wang 1 collaboration

Yina Li 1 collaboration

Yang Gao 1 collaboration

Jie Jiang 1 collaboration

Jianwei Che 1 collaboration

Matthew B Robers 1 collaboration

Tinghu Zhang 1 collaboration

Kenneth D Westover 1 collaboration

Behnam Nabet 1 collaboration

Nathanael S Gray 1 collaboration

Tilen Koklič 1 collaboration

Iztok Urbančič 1 collaboration

Lu Qiao 1 collaboration

Janez Strancar 1 collaboration

Prerna Arora 1 collaboration

Olga Danov 1 collaboration

Danny Jonigk 1 collaboration

Armin Braun 1 collaboration

Ann Palladino 1 collaboration

Connor Abramowicz 1 collaboration

Luwei Liu 1 collaboration

Alexander R Chait 1 collaboration

Zachary C Galluzzo 1 collaboration

Clara Tucker 1 collaboration

Wei-Chia Chen 1 collaboration

Juannan Zhou 1 collaboration

Justin B Kinney 1 collaboration

David M McCandlish 1 collaboration

Zicheng Wang 1 collaboration

Yunong Xia 1 collaboration

Lauren Mills 1 collaboration

Athanasios N Nikolakopoulos 1 collaboration

Nicole Maeser 1 collaboration

Scott M Dehm 1 collaboration

Debanjan Bhattacharjee 1 collaboration

Jaweria Bakar 1 collaboration

Surbhi P Chitnis 1 collaboration

Kumar Dilip Ashtekar 1 collaboration

Kaitlin Long 1 collaboration

David E Heppner 1 collaboration

Maja Kneissig 1 collaboration

Kristina Keuper 1 collaboration

Mirjam S de Pagter 1 collaboration

Markus J van Roosmalen 1 collaboration

Jana Martin 1 collaboration

Hannah Otto 1 collaboration

Verena Passerini 1 collaboration

Aline Campos Sparr 1 collaboration

Ivo Renkens 1 collaboration

Fenna Kropveld 1 collaboration

Wigard P Kloosterman 1 collaboration

Prasamit S Baruah 1 collaboration

Nicole M Sayles 1 collaboration

Peter Andrews 1 collaboration

Dan Levy 1 collaboration

Michael Wigler 1 collaboration

Zuzana Storchová 1 collaboration

Oluwadamilare A Adebambo 1 collaboration

Saron M Akalu 1 collaboration

Charles Zou 1 collaboration

Cigall Kadoch 1 collaboration

Hang Yin 1 collaboration