Jeremy Schwartzentruber

Affiliations

Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.

Publications (18)

The next-generation Open Targets Platform: reimagined, redesigned, rebuilt.

Nucleic acids research

Avec: David Ochoa , Andrew Hercules , Miguel Carmona , Daniel Suveges , Jarrod Baker , Cinzia Malangone , Irene Lopez , Alfredo Miranda , Carlos Cruz-Castillo , Luca Fumis , Manuel Bernal-Llinares , Kirill Tsukanov , Helena Cornu , Konstantinos Tsirigos , Olesya Razuvayevskaya , Annalisa Buniello , Jeremy Schwartzentruber , Mohd Karim , Bruno Ariano , Ricardo Esteban Martinez Osorio , Javier Ferrer , Xiangyu Ge , Sandra Machlitt-Northen , Asier Gonzalez-Uriarte , Shyamasree Saha , Santosh Tirunagari , Chintan Mehta , Juan María Roldán-Romero , Stuart Horswell , Sarah Young , Maya Ghoussaini , David G Hulcoop , Ian Dunham , Ellen M McDonagh

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance.

eLife

Avec: Mohd Anisul , Jarrod Shilts , Jeremy Schwartzentruber , James Hayhurst , Annalisa Buniello , Elmutaz Shaikho Elhaj Mohammed , Jie Zheng , Michael Holmes , David Ochoa , Miguel Carmona , Joseph Maranville , Tom R Gaunt , Valur Emilsson , Vilmundur Gudnason , Ellen M McDonagh , Gavin J Wright , Maya Ghoussaini , Ian Dunham

Open Targets Platform: supporting systematic drug-target identification and prioritisation.

Nucleic acids research

Avec: David Ochoa , Andrew Hercules , Miguel Carmona , Daniel Suveges , Asier Gonzalez-Uriarte , Cinzia Malangone , Alfredo Miranda , Luca Fumis , Denise Carvalho-Silva , Michaela Spitzer , Jarrod Baker , Javier Ferrer , Arwa Raies , Olesya Razuvayevskaya , Adam Faulconbridge , Eirini Petsalaki , Prudence Mutowo , Sandra Machlitt-Northen , Gareth Peat , Elaine McAuley , Chuang Kee Ong , Edward Mountjoy , Maya Ghoussaini , Andrea Pierleoni , Eliseo Papa , Miguel Pignatelli , Gautier Koscielny , Mohd Karim , Jeremy Schwartzentruber , David G Hulcoop , Ian Dunham , Ellen M McDonagh

Screening for functional regulatory variants in open chromatin using GenIE-ATAC.

Nucleic acids research

Avec: Sarah Cooper , Jeremy Schwartzentruber , Eve L Coomber , Qianxin Wu , Andrew Bassett

Publisher Correction: Molecular and functional variation in iPSC-derived sensory neurons.

Nature genetics

Avec: Jeremy Schwartzentruber , Stefanie Foskolou , Helena Kilpinen , Julia Rodrigues , Kaur Alasoo , Andrew J Knights , Minal Patel , Angela Goncalves , Rita Ferreira , Caroline Louise Benn , Anna Wilbrey , Magda Bictash , Emma Impey , Lishuang Cao , Sergio Lainez , Alexandre Julien Loucif , Paul John Whiting , Auteur inconnu , Alex Gutteridge , Daniel J Gaffney

Biallelic Loss-of-Function Variants in AIMP1 Cause a Rare Neurodegenerative Disease.

Journal of child neurology

Avec: Andrea Accogli , Kether Guerrero , Maria Daniela D'Agostino , Luan Tran , Cécile Cieuta-Walti , Isabelle Thiffault , Sébastien Chénier , Jeremy Schwartzentruber , Jacek Majewski , Auteur inconnu , Geneviève Bernard

Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer's disease risk genes.

Nature genetics

Avec: Jeremy Schwartzentruber , Sarah Cooper , Jimmy Z Liu , Inigo Barrio-Hernandez , Erica Bello , Natsuhiko Kumasaka , Adam M H Young , Robin J M Franklin , Toby Johnson , Karol Estrada , Daniel J Gaffney , Pedro Beltrao , Andrew Bassett

Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells.

Nature communications

Avec: Mary-Ellen Lynall , Blagoje Soskic , James Hayhurst , Jeremy Schwartzentruber , Daniel F Levey , Gita A Pathak , Renato Polimanti , Joel Gelernter , Murray B Stein , Gosia Trynka , Menna R Clatworthy , Ed Bullmore

Mapping interindividual dynamics of innate immune response at single-cell resolution.

Nature genetics

Avec: Natsuhiko Kumasaka , Raghd Rostom , Ni Huang , Krzysztof Polanski , Kerstin B Meyer , Sharad Patel , Rachel Boyd , Celine Gomez , Sam N Barnett , Nikolaos I Panousis , Jeremy Schwartzentruber , Maya Ghoussaini , Paul A Lyons , Fernando J Calero-Nieto , Berthold Göttgens , Josephine L Barnes , Kaylee B Worlock , Masahiro Yoshida , Marko Z Nikolić , Emily Stephenson , Gary Reynolds , Muzlifah Haniffa , John C Marioni , Oliver Stegle , Tzachi Hagai , Sarah A Teichmann

Integrative GWAS and co-localisation analysis suggests novel genes associated with age-related multimorbidity.

Scientific data

Avec: Clare E West , Mohd Karim , Maria J Falaguera , Leo Speidel , Charlotte J Green , Lisa Logie , Jeremy Schwartzentruber , David Ochoa , Janet M Lord , Michael A J Ferguson , Chas Bountra , Graeme F Wilkinson , Beverley Vaughan , Andrew R Leach , Ian Dunham , Brian D Marsden

A map of transcriptional heterogeneity and regulatory variation in human microglia.

Nature genetics

Avec: Adam M H Young , Natsuhiko Kumasaka , Fiona Calvert , Timothy R Hammond , Andrew Knights , Nikolaos Panousis , Jun Sung Park , Jeremy Schwartzentruber , Jimmy Liu , Kousik Kundu , Michael Segel , Natalia A Murphy , Christopher E McMurran , Harry Bulstrode , Jason Correia , Karol P Budohoski , Alexis Joannides , Mathew R Guilfoyle , Rikin Trivedi , Ramez Kirollos , Robert Morris , Matthew R Garnett , Ivan Timofeev , Ibrahim Jalloh , Katherine Holland , Richard Mannion , Richard Mair , Colin Watts , Stephen J Price , Peter J Kirkpatrick , Thomas Santarius , Edward Mountjoy , Maya Ghoussaini , Nicole Soranzo , Omer A Bayraktar , Beth Stevens , Peter J Hutchinson , Robin J M Franklin , Daniel J Gaffney

Very low-depth whole-genome sequencing in complex trait association studies.

Bioinformatics (Oxford, England)

Avec: Arthur Gilly , Lorraine Southam , Daniel Suveges , Karoline Kuchenbaecker , Rachel Moore , Giorgio E M Melloni , Konstantinos Hatzikotoulas , Aliki-Eleni Farmaki , Graham Ritchie , Jeremy Schwartzentruber , Petr Danecek , Britt Kilian , Martin O Pollard , Xiangyu Ge , Emmanouil Tsafantakis , George Dedoussis , Eleftheria Zeggini

An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci.

Nature genetics

Avec: Edward Mountjoy , Ellen M Schmidt , Miguel Carmona , Jeremy Schwartzentruber , Gareth Peat , Alfredo Miranda , Luca Fumis , James Hayhurst , Annalisa Buniello , Mohd Anisul Karim , Daniel Wright , Andrew Hercules , Eliseo Papa , Eric B Fauman , Jeffrey C Barrett , John A Todd , David Ochoa , Ian Dunham , Maya Ghoussaini

Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severity.

EBioMedicine

Avec: Jie Zheng , Yuemiao Zhang , Huiling Zhao , Yi Liu , Denis Baird , Mohd Anisul Karim , Maya Ghoussaini , Jeremy Schwartzentruber , Ian Dunham , Benjamin Elsworth , Katherine Roberts , Hannah Compton , Felix Miller-Molloy , Xingzi Liu , Lin Wang , Hong Zhang , George Davey Smith , Tom R Gaunt

Screening for functional transcriptional and splicing regulatory variants with GenIE.

Nucleic acids research

Avec: Sarah E Cooper , Jeremy Schwartzentruber , Erica Bello , Eve L Coomber , Andrew R Bassett

Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics.

Nucleic acids research

Avec: Maya Ghoussaini , Edward Mountjoy , Miguel Carmona , Gareth Peat , Ellen M Schmidt , Andrew Hercules , Luca Fumis , Alfredo Miranda , Denise Carvalho-Silva , Annalisa Buniello , Tony Burdett , James Hayhurst , Jarrod Baker , Javier Ferrer , Asier Gonzalez-Uriarte , Simon Jupp , Mohd Anisul Karim , Gautier Koscielny , Sandra Machlitt-Northen , Cinzia Malangone , Zoe May Pendlington , Paola Roncaglia , Daniel Suveges , Daniel Wright , Olga Vrousgou , Eliseo Papa , Helen Parkinson , Jacqueline A L MacArthur , John A Todd , Jeffrey C Barrett , Jeremy Schwartzentruber , David G Hulcoop , David Ochoa , Ellen M McDonagh , Ian Dunham

Artificial intelligence for dementia genetics and omics.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Avec: Conceicao Bettencourt , Nathan Skene , Sara Bandres-Ciga , Emma Anderson , Laura M Winchester , Isabelle F Foote , Jeremy Schwartzentruber , Juan A Botia , Mike Nalls , Andrew Singleton , Brian M Schilder , Jack Humphrey , Sarah J Marzi , Christina E Toomey , Ahmad Al Kleifat , Eric L Harshfield , Victoria Garfield , Cynthia Sandor , Samuel Keat , Stefano Tamburin , Carlo Sala Frigerio , Ilianna Lourida , Auteur inconnu , Janice M Ranson , David J Llewellyn

Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature genetics

Avec: Inigo Barrio-Hernandez , Jeremy Schwartzentruber , Anjali Shrivastava , Noemi Del-Toro , Asier Gonzalez , Qian Zhang , Edward Mountjoy , Daniel Suveges , David Ochoa , Maya Ghoussaini , Glyn Bradley , Henning Hermjakob , Sandra Orchard , Ian Dunham , Carl A Anderson , Pablo Porras , Pedro Beltrao

Réseau de co-auteurs

Maya Ghoussaini 9 collaborations

Ian Dunham 8 collaborations

David Ochoa 7 collaborations

Miguel Carmona 5 collaborations

Daniel Suveges 5 collaborations

Edward Mountjoy 5 collaborations

Andrew Hercules 4 collaborations

Alfredo Miranda 4 collaborations

Luca Fumis 4 collaborations

Annalisa Buniello 4 collaborations

Ellen M McDonagh 4 collaborations

James Hayhurst 4 collaborations

Jarrod Baker 3 collaborations

Cinzia Malangone 3 collaborations

Mohd Karim 3 collaborations

Javier Ferrer 3 collaborations

Sandra Machlitt-Northen 3 collaborations

Asier Gonzalez-Uriarte 3 collaborations

David G Hulcoop 3 collaborations

Gareth Peat 3 collaborations

Eliseo Papa 3 collaborations

None None 3 collaborations

Daniel J Gaffney 3 collaborations

Natsuhiko Kumasaka 3 collaborations

Mohd Anisul Karim 3 collaborations

Olesya Razuvayevskaya 2 collaborations

Xiangyu Ge 2 collaborations

Jie Zheng 2 collaborations

Tom R Gaunt 2 collaborations

Denise Carvalho-Silva 2 collaborations

Gautier Koscielny 2 collaborations

Sarah Cooper 2 collaborations

Eve L Coomber 2 collaborations

Andrew Bassett 2 collaborations

Inigo Barrio-Hernandez 2 collaborations

Erica Bello 2 collaborations

Adam M H Young 2 collaborations

Robin J M Franklin 2 collaborations

Pedro Beltrao 2 collaborations

Ellen M Schmidt 2 collaborations

Daniel Wright 2 collaborations

Jeffrey C Barrett 2 collaborations

John A Todd 2 collaborations

Irene Lopez 1 collaboration

Carlos Cruz-Castillo 1 collaboration

Manuel Bernal-Llinares 1 collaboration

Kirill Tsukanov 1 collaboration

Helena Cornu 1 collaboration

Konstantinos Tsirigos 1 collaboration

Bruno Ariano 1 collaboration

Ricardo Esteban Martinez Osorio 1 collaboration

Shyamasree Saha 1 collaboration

Santosh Tirunagari 1 collaboration

Chintan Mehta 1 collaboration

Juan María Roldán-Romero 1 collaboration

Stuart Horswell 1 collaboration

Sarah Young 1 collaboration

Mohd Anisul 1 collaboration

Jarrod Shilts 1 collaboration

Elmutaz Shaikho Elhaj Mohammed 1 collaboration

Michael Holmes 1 collaboration

Joseph Maranville 1 collaboration

Valur Emilsson 1 collaboration

Vilmundur Gudnason 1 collaboration

Gavin J Wright 1 collaboration

Michaela Spitzer 1 collaboration

Arwa Raies 1 collaboration

Adam Faulconbridge 1 collaboration

Eirini Petsalaki 1 collaboration

Prudence Mutowo 1 collaboration

Elaine McAuley 1 collaboration

Chuang Kee Ong 1 collaboration

Andrea Pierleoni 1 collaboration

Miguel Pignatelli 1 collaboration

Qianxin Wu 1 collaboration

Stefanie Foskolou 1 collaboration

Helena Kilpinen 1 collaboration

Julia Rodrigues 1 collaboration

Kaur Alasoo 1 collaboration

Andrew J Knights 1 collaboration

Minal Patel 1 collaboration

Angela Goncalves 1 collaboration

Rita Ferreira 1 collaboration

Caroline Louise Benn 1 collaboration

Anna Wilbrey 1 collaboration

Magda Bictash 1 collaboration

Emma Impey 1 collaboration

Lishuang Cao 1 collaboration

Sergio Lainez 1 collaboration

Alexandre Julien Loucif 1 collaboration

Paul John Whiting 1 collaboration

Alex Gutteridge 1 collaboration

Andrea Accogli 1 collaboration

Kether Guerrero 1 collaboration

Maria Daniela D'Agostino 1 collaboration

Luan Tran 1 collaboration

Cécile Cieuta-Walti 1 collaboration

Isabelle Thiffault 1 collaboration

Sébastien Chénier 1 collaboration

Jacek Majewski 1 collaboration

Geneviève Bernard 1 collaboration

Jimmy Z Liu 1 collaboration

Toby Johnson 1 collaboration

Karol Estrada 1 collaboration

Mary-Ellen Lynall 1 collaboration

Blagoje Soskic 1 collaboration

Daniel F Levey 1 collaboration

Gita A Pathak 1 collaboration

Renato Polimanti 1 collaboration

Joel Gelernter 1 collaboration

Murray B Stein 1 collaboration

Gosia Trynka 1 collaboration

Menna R Clatworthy 1 collaboration

Ed Bullmore 1 collaboration

Raghd Rostom 1 collaboration

Ni Huang 1 collaboration

Krzysztof Polanski 1 collaboration

Kerstin B Meyer 1 collaboration

Sharad Patel 1 collaboration

Rachel Boyd 1 collaboration

Celine Gomez 1 collaboration

Sam N Barnett 1 collaboration

Nikolaos I Panousis 1 collaboration

Paul A Lyons 1 collaboration

Fernando J Calero-Nieto 1 collaboration

Berthold Göttgens 1 collaboration

Josephine L Barnes 1 collaboration

Kaylee B Worlock 1 collaboration

Masahiro Yoshida 1 collaboration

Marko Z Nikolić 1 collaboration

Emily Stephenson 1 collaboration

Gary Reynolds 1 collaboration

Muzlifah Haniffa 1 collaboration

John C Marioni 1 collaboration

Oliver Stegle 1 collaboration

Tzachi Hagai 1 collaboration

Sarah A Teichmann 1 collaboration

Clare E West 1 collaboration

Maria J Falaguera 1 collaboration

Leo Speidel 1 collaboration

Charlotte J Green 1 collaboration

Lisa Logie 1 collaboration

Janet M Lord 1 collaboration

Michael A J Ferguson 1 collaboration

Chas Bountra 1 collaboration

Graeme F Wilkinson 1 collaboration

Beverley Vaughan 1 collaboration

Andrew R Leach 1 collaboration

Brian D Marsden 1 collaboration

Fiona Calvert 1 collaboration

Timothy R Hammond 1 collaboration

Andrew Knights 1 collaboration

Nikolaos Panousis 1 collaboration

Jun Sung Park 1 collaboration

Jimmy Liu 1 collaboration

Kousik Kundu 1 collaboration

Michael Segel 1 collaboration

Natalia A Murphy 1 collaboration

Christopher E McMurran 1 collaboration

Harry Bulstrode 1 collaboration

Jason Correia 1 collaboration

Karol P Budohoski 1 collaboration

Alexis Joannides 1 collaboration

Mathew R Guilfoyle 1 collaboration

Rikin Trivedi 1 collaboration

Ramez Kirollos 1 collaboration

Robert Morris 1 collaboration

Matthew R Garnett 1 collaboration

Ivan Timofeev 1 collaboration

Ibrahim Jalloh 1 collaboration

Katherine Holland 1 collaboration

Richard Mannion 1 collaboration

Richard Mair 1 collaboration

Colin Watts 1 collaboration

Stephen J Price 1 collaboration

Peter J Kirkpatrick 1 collaboration

Thomas Santarius 1 collaboration

Nicole Soranzo 1 collaboration

Omer A Bayraktar 1 collaboration

Beth Stevens 1 collaboration

Peter J Hutchinson 1 collaboration

Arthur Gilly 1 collaboration

Lorraine Southam 1 collaboration

Karoline Kuchenbaecker 1 collaboration

Rachel Moore 1 collaboration

Giorgio E M Melloni 1 collaboration

Konstantinos Hatzikotoulas 1 collaboration

Aliki-Eleni Farmaki 1 collaboration

Graham Ritchie 1 collaboration

Petr Danecek 1 collaboration

Britt Kilian 1 collaboration

Martin O Pollard 1 collaboration

Emmanouil Tsafantakis 1 collaboration

George Dedoussis 1 collaboration

Eleftheria Zeggini 1 collaboration

Eric B Fauman 1 collaboration

Yuemiao Zhang 1 collaboration

Huiling Zhao 1 collaboration

Yi Liu 1 collaboration

Denis Baird 1 collaboration

Benjamin Elsworth 1 collaboration

Katherine Roberts 1 collaboration

Hannah Compton 1 collaboration

Felix Miller-Molloy 1 collaboration

Xingzi Liu 1 collaboration

Lin Wang 1 collaboration

Hong Zhang 1 collaboration

George Davey Smith 1 collaboration

Sarah E Cooper 1 collaboration

Andrew R Bassett 1 collaboration

Tony Burdett 1 collaboration

Simon Jupp 1 collaboration

Zoe May Pendlington 1 collaboration

Paola Roncaglia 1 collaboration

Olga Vrousgou 1 collaboration

Helen Parkinson 1 collaboration

Jacqueline A L MacArthur 1 collaboration

Conceicao Bettencourt 1 collaboration

Nathan Skene 1 collaboration

Sara Bandres-Ciga 1 collaboration

Emma Anderson 1 collaboration

Laura M Winchester 1 collaboration

Isabelle F Foote 1 collaboration

Juan A Botia 1 collaboration

Mike Nalls 1 collaboration

Andrew Singleton 1 collaboration

Brian M Schilder 1 collaboration

Jack Humphrey 1 collaboration

Sarah J Marzi 1 collaboration

Christina E Toomey 1 collaboration

Ahmad Al Kleifat 1 collaboration

Eric L Harshfield 1 collaboration

Victoria Garfield 1 collaboration

Cynthia Sandor 1 collaboration

Samuel Keat 1 collaboration

Stefano Tamburin 1 collaboration

Carlo Sala Frigerio 1 collaboration

Ilianna Lourida 1 collaboration

Janice M Ranson 1 collaboration

David J Llewellyn 1 collaboration

Anjali Shrivastava 1 collaboration

Noemi Del-Toro 1 collaboration

Asier Gonzalez 1 collaboration

Qian Zhang 1 collaboration

Glyn Bradley 1 collaboration

Henning Hermjakob 1 collaboration

Sandra Orchard 1 collaboration

Carl A Anderson 1 collaboration

Pablo Porras 1 collaboration