Julian E Alecu

Affiliations

Department of Neurology, Rosamund Stone Zander Translational Neuroscience Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Publications (12)

Generation and characterization of six human induced pluripotent stem cell lines (iPSC) from three families with AP4M1-associated hereditary spastic paraplegia (SPG50).

Stem cell research

Avec: Kathrin Eberhardt , Hellen Jumo , Angelica D'Amore , Julian E Alecu , Marvin Ziegler , Wardiya Afshar Saber , Mustafa Sahin , Darius Ebrahimi-Fakhari

High-throughput imaging of ATG9A distribution as a diagnostic functional assay for adaptor protein complex 4-associated hereditary spastic paraplegia.

Brain communications

Avec: Darius Ebrahimi-Fakhari , Julian E Alecu , Barbara Brechmann , Marvin Ziegler , Kathrin Eberhardt , Hellen Jumo , Angelica D'Amore , Parham Habibzadeh , Mohammad Ali Faghihi , Jan L De Bleecker , Sandrine Vuillaumier-Barrot , Stéphane Auvin , Filippo M Santorelli , Sonja Neuser , Bernt Popp , Edward Yang , Lee Barrett , Alexandra K Davies , Afshin Saffari , Jennifer Hirst , Mustafa Sahin

AP-4-mediated axonal transport controls endocannabinoid production in neurons.

Nature communications

Avec: Alexandra K Davies , Julian E Alecu , Marvin Ziegler , Catherine G Vasilopoulou , Fabrizio Merciai , Hellen Jumo , Wardiya Afshar-Saber , Mustafa Sahin , Darius Ebrahimi-Fakhari , Georg H H Borner

Novel CAPN1 missense variants in complex hereditary spastic paraplegia with early-onset psychosis.

Annals of clinical and translational neurology

Avec: Julian E Alecu , Afshin Saffari , Hellen Jumo , Marvin Ziegler , Oleksandr Strelko , Catherine A Brownstein , Joseph Gonzalez-Heydrich , Lance H Rodan , Mark P Gorman , Mustafa Sahin , Darius Ebrahimi-Fakhari

High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia.

Nature communications

Avec: Afshin Saffari , Barbara Brechmann , Cedric Böger , Wardiya Afshar Saber , Hellen Jumo , Dosh Whye , Delaney Wood , Lara Wahlster , Julian E Alecu , Marvin Ziegler , Marlene Scheffold , Kellen Winden , Jed Hubbs , Elizabeth D Buttermore , Lee Barrett , Georg H H Borner , Alexandra K Davies , Darius Ebrahimi-Fakhari , Mustafa Sahin

Functional validation of novel variants in B4GALNT1 associated with early-onset complex hereditary spastic paraplegia with impaired ganglioside synthesis.

American journal of medical genetics. Part A

Avec: Julian Emanuel Alecu , Yuhsuke Ohmi , Robiul H Bhuiyan , Kei-Ichiro Inamori , Takahiro Nitta , Afshin Saffari , Hellen Jumo , Marvin Ziegler , Claudio Melo de Gusmao , Nutan Sharma , Shiho Ohno , Noriyoshi Manabe , Yoshiki Yamaguchi , Mariko Kambe , Keiko Furukawa , Mustafa Sahin , Jin-Ichi Inokuchi , Koichi Furakawa , Darius Ebrahimi-Fakhari

Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson's disease.

Human molecular genetics

Avec: Razvan-Marius Brazdis , Julian E Alecu , Daniel Marsch , Annika Dahms , Katrin Simmnacher , Sandra Lörentz , Anna Brendler , Yanni Schneider , Franz Marxreiter , Laurent Roybon , Beate Winner , Wei Xiang , Iryna Prots

Unique signatures of stress-induced senescent human astrocytes.

Experimental neurology

Avec: Katrin Simmnacher , Florian Krach , Yanni Schneider , Julian E Alecu , Lena Mautner , Paulina Klein , Laurent Roybon , Iryna Prots , Wei Xiang , Beate Winner

De novo variants cause complex symptoms in HSP-ATL1 (SPG3A) and uncover genotype-phenotype correlations.

Human molecular genetics

Avec: Julian E Alecu , Afshin Saffari , Catherine Jordan , Siddharth Srivastava , Craig Blackstone , Darius Ebrahimi-Fakhari

Systematic Analysis of Brain MRI Findings in Adaptor Protein Complex 4-Associated Hereditary Spastic Paraplegia.

Neurology

Avec: Darius Ebrahimi-Fakhari , Julian E Alecu , Marvin Ziegler , Gregory Geisel , Catherine Jordan , Angelica D'Amore , Rebecca C Yeh , Shyam K Akula , Afshin Saffari , Sanjay P Prabhu , Mustafa Sahin , Edward Yang , Auteur inconnu

Disease Severity and Motor Impairment Correlate With Health-Related Quality of Life in AP-4-Associated Hereditary Spastic Paraplegia.

Neurology. Genetics

Avec: Catherine Jordan , Gregory Geisel , Julian E Alecu , Bo Zhang , Mustafa Sahin , Darius Ebrahimi-Fakhari

Plasma Neurofilament Light Chain Is Elevated in Adaptor Protein Complex 4-Related Hereditary Spastic Paraplegia.

Movement disorders : official journal of the Movement Disorder Society

Avec: Julian E Alecu , Afshin Saffari , Marvin Ziegler , Catherine Jordan , Amy Tam , Soyoung Kim , Edward Leung , Krzysztof Szczaluba , Hanna Mierzewska , Staci D King , Filippo M Santorelli , Grace Yoon , Bianca Trombetta , Pia Kivisäkk , Bo Zhang , Mustafa Sahin , Darius Ebrahimi-Fakhari

Réseau de co-auteurs

Darius Ebrahimi-Fakhari 10 collaborations

Mustafa Sahin 9 collaborations

Marvin Ziegler 8 collaborations

Afshin Saffari 7 collaborations

Hellen Jumo 6 collaborations

Catherine Jordan 4 collaborations

Angelica D'Amore 3 collaborations

Alexandra K Davies 3 collaborations

Kathrin Eberhardt 2 collaborations

Wardiya Afshar Saber 2 collaborations

Barbara Brechmann 2 collaborations

Filippo M Santorelli 2 collaborations

Edward Yang 2 collaborations

Lee Barrett 2 collaborations

Georg H H Borner 2 collaborations

Katrin Simmnacher 2 collaborations

Yanni Schneider 2 collaborations

Laurent Roybon 2 collaborations

Beate Winner 2 collaborations

Wei Xiang 2 collaborations

Iryna Prots 2 collaborations

Gregory Geisel 2 collaborations

Bo Zhang 2 collaborations

Parham Habibzadeh 1 collaboration

Mohammad Ali Faghihi 1 collaboration

Jan L De Bleecker 1 collaboration

Sandrine Vuillaumier-Barrot 1 collaboration

Stéphane Auvin 1 collaboration

Sonja Neuser 1 collaboration

Bernt Popp 1 collaboration

Jennifer Hirst 1 collaboration

Catherine G Vasilopoulou 1 collaboration

Fabrizio Merciai 1 collaboration

Wardiya Afshar-Saber 1 collaboration

Oleksandr Strelko 1 collaboration

Catherine A Brownstein 1 collaboration

Joseph Gonzalez-Heydrich 1 collaboration

Lance H Rodan 1 collaboration

Mark P Gorman 1 collaboration

Cedric Böger 1 collaboration

Dosh Whye 1 collaboration

Delaney Wood 1 collaboration

Lara Wahlster 1 collaboration

Marlene Scheffold 1 collaboration

Kellen Winden 1 collaboration

Jed Hubbs 1 collaboration

Elizabeth D Buttermore 1 collaboration

Julian Emanuel Alecu 1 collaboration

Yuhsuke Ohmi 1 collaboration

Robiul H Bhuiyan 1 collaboration

Kei-Ichiro Inamori 1 collaboration

Takahiro Nitta 1 collaboration

Claudio Melo de Gusmao 1 collaboration

Nutan Sharma 1 collaboration

Shiho Ohno 1 collaboration

Noriyoshi Manabe 1 collaboration

Yoshiki Yamaguchi 1 collaboration

Mariko Kambe 1 collaboration

Keiko Furukawa 1 collaboration

Jin-Ichi Inokuchi 1 collaboration

Koichi Furakawa 1 collaboration

Razvan-Marius Brazdis 1 collaboration

Daniel Marsch 1 collaboration

Annika Dahms 1 collaboration

Sandra Lörentz 1 collaboration

Anna Brendler 1 collaboration

Franz Marxreiter 1 collaboration

Florian Krach 1 collaboration

Lena Mautner 1 collaboration

Paulina Klein 1 collaboration

Siddharth Srivastava 1 collaboration

Craig Blackstone 1 collaboration

Rebecca C Yeh 1 collaboration

Shyam K Akula 1 collaboration

Sanjay P Prabhu 1 collaboration

None None 1 collaboration

Amy Tam 1 collaboration

Soyoung Kim 1 collaboration

Edward Leung 1 collaboration

Krzysztof Szczaluba 1 collaboration

Hanna Mierzewska 1 collaboration

Staci D King 1 collaboration

Grace Yoon 1 collaboration

Bianca Trombetta 1 collaboration

Pia Kivisäkk 1 collaboration