Leandros Boukas

Affiliations

McKusick-Nathans Institute of Genetic Medicine.
Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland, USA.

Publications (15)

Precocious chondrocyte differentiation disrupts skeletal growth in Kabuki syndrome mice.

JCI insight

Avec: Jill A Fahrner , Wan-Ying Lin , Ryan C Riddle , Leandros Boukas , Valerie B DeLeon , Sheetal Chopra , Susan E Lad , Teresa Romeo Luperchio , Kasper D Hansen , Hans T Bjornsson

Missense variants causing Wiedemann-Steiner syndrome preferentially occur in the KMT2A-CXXC domain and are accurately classified using AlphaFold2.

PLoS genetics

Avec: Tinna Reynisdottir , Kimberley Jade Anderson , Leandros Boukas , Hans Tomas Bjornsson

Novel mouse model of Weaver syndrome displays overgrowth and excess osteogenesis reversible with KDM6A/6B inhibition.

bioRxiv : the preprint server for biology

Avec: Christine W Gao , WanYing Lin , Ryan C Riddle , Priyanka Kushwaha , Leandros Boukas , Hans T Björnsson , Kasper D Hansen , Jill A Fahrner

Growth deficiency in a mouse model of Kabuki syndrome 2 bears mechanistic similarities to Kabuki syndrome 1.

PLoS genetics

Avec: Christine W Gao , WanYing Lin , Ryan C Riddle , Sheetal Chopra , Jiyoung Kim , Leandros Boukas , Kasper D Hansen , Hans T Björnsson , Jill A Fahrner

KMT2D regulates activation, localization, and integrin expression by T-cells.

Frontiers in immunology

Avec: Sarah J Potter , Li Zhang , Michael Kotliar , Yuehong Wu , Caitlin Schafer , Kurtis Stefan , Leandros Boukas , Dima Qu'd , Olaf Bodamer , Brittany N Simpson , Artem Barski , Andrew W Lindsley , Hans T Bjornsson

Promoter CpG Density Predicts Downstream Gene Loss-of-Function Intolerance.

American journal of human genetics

Avec: Leandros Boukas , Hans T Bjornsson , Kasper D Hansen

Coexpression patterns define epigenetic regulators associated with neurological dysfunction.

Genome research

Avec: Leandros Boukas , James M Havrilla , Peter F Hickey , Aaron R Quinlan , Hans T Bjornsson , Kasper D Hansen

Leveraging the Mendelian disorders of the epigenetic machinery to systematically map functional epigenetic variation.

eLife

Avec: Teresa Romeo Luperchio , Leandros Boukas , Li Zhang , Genay Pilarowski , Jenny Jiang , Allison Kalinousky , Kasper D Hansen , Hans T Bjornsson

Deficiency of TET3 leads to a genome-wide DNA hypermethylation episignature in human whole blood.

NPJ genomic medicine

Avec: Michael A Levy , David B Beck , Kay Metcalfe , Sofia Douzgou , Sivagamy Sithambaram , Trudie Cottrell , Muhammad Ansar , Jennifer Kerkhof , Cyril Mignot , Marie-Christine Nougues , Boris Keren , Hannah W Moore , Renske Oegema , Jacques C Giltay , Marleen Simon , Richard H van Jaarsveld , Jessica Bos , Mieke van Haelst , M Mahdi Motazacker , Elles M J Boon , Gijs W E Santen , Claudia A L Ruivenkamp , Marielle Alders , Teresa Romeo Luperchio , Leandros Boukas , Keri Ramsey , Vinodh Narayanan , G Bradley Schaefer , Roberto Bonasio , Kimberly F Doheny , Roger E Stevenson , Siddharth Banka , Bekim Sadikovic , Jill A Fahrner

Neuron-specific chromatin disruption at CpG islands and aging-related regions in Kabuki syndrome mice.

Genome research

Avec: Leandros Boukas , Teresa Romeo Luperchio , Afrooz Razi , Kasper D Hansen , Hans T Bjornsson

A screen of 1,049 schizophrenia and 30 Alzheimer's-associated variants for regulatory potential.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

Avec: Leslie Myint , Ruihua Wang , Leandros Boukas , Kasper D Hansen , Loyal A Goff , Dimitrios Avramopoulos

Neuron-specific chromatin disruption at CpG islands and aging-related regions in Kabuki syndrome mice.

bioRxiv : the preprint server for biology

Avec: Leandros Boukas , Teresa Romeo Luperchio , Afrooz Razi , Kasper D Hansen , Hans T Bjornsson

Precocious neuronal differentiation and disrupted oxygen responses in Kabuki syndrome.

JCI insight

Avec: Giovanni A Carosso , Leandros Boukas , Jonathan J Augustin , Ha Nam Nguyen , Briana L Winer , Gabrielle H Cannon , Johanna D Robertson , Li Zhang , Kasper D Hansen , Loyal A Goff , Hans T Bjornsson

Pumping the brakes on RNA velocity by understanding and interpreting RNA velocity estimates.

Genome biology

Avec: Shijie C Zheng , Genevieve Stein-O'Brien , Leandros Boukas , Loyal A Goff , Kasper D Hansen

A mouse model of Weaver syndrome displays overgrowth and excess osteogenesis reversible with KDM6A/6B inhibition.

JCI insight

Avec: Christine W Gao , WanYing Lin , Ryan C Riddle , Priyanka Kushwaha , Leandros Boukas , Hans T Björnsson , Kasper D Hansen , Jill A Fahrner

Réseau de co-auteurs

Kasper D Hansen 12 collaborations

Hans T Bjornsson 8 collaborations

Jill A Fahrner 5 collaborations

Teresa Romeo Luperchio 5 collaborations

Ryan C Riddle 4 collaborations

Christine W Gao 3 collaborations

WanYing Lin 3 collaborations

Hans T Björnsson 3 collaborations

Li Zhang 3 collaborations

Loyal A Goff 3 collaborations

Sheetal Chopra 2 collaborations

Priyanka Kushwaha 2 collaborations

Afrooz Razi 2 collaborations

Wan-Ying Lin 1 collaboration

Valerie B DeLeon 1 collaboration

Susan E Lad 1 collaboration

Tinna Reynisdottir 1 collaboration

Kimberley Jade Anderson 1 collaboration

Hans Tomas Bjornsson 1 collaboration

Jiyoung Kim 1 collaboration

Sarah J Potter 1 collaboration

Michael Kotliar 1 collaboration

Yuehong Wu 1 collaboration

Caitlin Schafer 1 collaboration

Kurtis Stefan 1 collaboration

Dima Qu'd 1 collaboration

Olaf Bodamer 1 collaboration

Brittany N Simpson 1 collaboration

Artem Barski 1 collaboration

Andrew W Lindsley 1 collaboration

James M Havrilla 1 collaboration

Peter F Hickey 1 collaboration

Aaron R Quinlan 1 collaboration

Genay Pilarowski 1 collaboration

Jenny Jiang 1 collaboration

Allison Kalinousky 1 collaboration

Michael A Levy 1 collaboration

David B Beck 1 collaboration

Kay Metcalfe 1 collaboration

Sofia Douzgou 1 collaboration

Sivagamy Sithambaram 1 collaboration

Trudie Cottrell 1 collaboration

Muhammad Ansar 1 collaboration

Jennifer Kerkhof 1 collaboration

Cyril Mignot 1 collaboration

Marie-Christine Nougues 1 collaboration

Boris Keren 1 collaboration

Hannah W Moore 1 collaboration

Renske Oegema 1 collaboration

Jacques C Giltay 1 collaboration

Marleen Simon 1 collaboration

Richard H van Jaarsveld 1 collaboration

Jessica Bos 1 collaboration

Mieke van Haelst 1 collaboration

M Mahdi Motazacker 1 collaboration

Elles M J Boon 1 collaboration

Gijs W E Santen 1 collaboration

Claudia A L Ruivenkamp 1 collaboration

Marielle Alders 1 collaboration

Keri Ramsey 1 collaboration

Vinodh Narayanan 1 collaboration

G Bradley Schaefer 1 collaboration

Roberto Bonasio 1 collaboration

Kimberly F Doheny 1 collaboration

Roger E Stevenson 1 collaboration

Siddharth Banka 1 collaboration

Bekim Sadikovic 1 collaboration

Leslie Myint 1 collaboration

Ruihua Wang 1 collaboration

Dimitrios Avramopoulos 1 collaboration

Giovanni A Carosso 1 collaboration

Jonathan J Augustin 1 collaboration

Ha Nam Nguyen 1 collaboration

Briana L Winer 1 collaboration

Gabrielle H Cannon 1 collaboration

Johanna D Robertson 1 collaboration

Shijie C Zheng 1 collaboration

Genevieve Stein-O'Brien 1 collaboration