Mehdi Layeghifard

Affiliations

Osteoarthritis Research Program, Division of Orthopaedics, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada.
Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Publications (10)

Association of presurgical circulating MicroRNAs with 1-year postsurgical pain reduction in spine facet osteoarthritis patients with lumbar spinal stenosis.

Osteoarthritis and cartilage open

Avec: Starlee Lively , Marie Milliot , Pratibha Potla , Osvaldo Espin-Garcia , Mehdi Layeghifard , Kala Sundararajan , Helal Endisha , Akihiro Nakamura , Anthony V Perruccio , Christian Veillette , Mohit Kapoor , Y Raja Rampersaud

BARD1 germline variants induce haploinsufficiency and DNA repair defects in neuroblastoma.

Journal of the National Cancer Institute

Avec: Michael P Randall , Laura E Egolf , Zalman Vaksman , Minu Samanta , Matthew Tsang , David Groff , J Perry Evans , Jo Lynne Rokita , Mehdi Layeghifard , Adam Shlien , John M Maris , Sharon J Diskin , Kristopher R Bosse

The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations.

Nature cancer

Avec: Anita Villani , Scott Davidson , Nisha Kanwar , Winnie W Lo , Yisu Li , Sarah Cohen-Gogo , Fabio Fuligni , Lisa-Monique Edward , Nicholas Light , Mehdi Layeghifard , Ricardo Harripaul , Larissa Waldman , Bailey Gallinger , Federico Comitani , Ledia Brunga , Reid Hayes , Nathaniel D Anderson , Arun K Ramani , Kyoko E Yuki , Sasha Blay , Brittney Johnstone , Cara Inglese , Rawan Hammad , Catherine Goudie , Andrew Shuen , Jonathan D Wasserman , Rosemarie E Venier , Marianne Eliou , Miranda Lorenti , Carol Ann Ryan , Michael Braga , Meagan Gloven-Brown , Jianan Han , Maria Montero , Famida Spatare , James A Whitlock , Stephen W Scherer , Kathy Chun , Martin J Somerville , Cynthia Hawkins , Mohamed Abdelhaleem , Vijay Ramaswamy , Gino R Somers , Lianna Kyriakopoulou , Johann Hitzler , Mary Shago , Daniel A Morgenstern , Uri Tabori , Stephen Meyn , Meredith S Irwin , David Malkin , Adam Shlien

SHP2 inhibition with TNO155 increases efficacy and overcomes resistance of ALK inhibitors in neuroblastoma.

Cancer research communications

Avec: Ivette Valencia-Sama , Lynn Kee , Gabriella Christopher , Michael Ohh , Mehdi Layeghifard , Adam Shlien , Madeline N Hayes , Meredith S Irwin

A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo.

Nature genetics

Avec: Masayuki Nakamori , Gagan B Panigrahi , Stella Lanni , Terence Gall-Duncan , Hideki Hayakawa , Hana Tanaka , Jennifer Luo , Takahiro Otabe , Jinxing Li , Akihiro Sakata , Marie-Christine Caron , Niraj Joshi , Tanya Prasolava , Karen Chiang , Jean-Yves Masson , Marc S Wold , Xiaoxiao Wang , Marietta Y W T Lee , John Huddleston , Katherine M Munson , Scott Davidson , Mehdi Layeghifard , Lisa-Monique Edward , Richard Gallon , Mauro Santibanez-Koref , Asako Murata , Masanori P Takahashi , Evan E Eichler , Adam Shlien , Kazuhiko Nakatani , Hideki Mochizuki , Christopher E Pearson

Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival.

Nature communications

Avec: Nathaniel D Anderson , Yael Babichev , Fabio Fuligni , Federico Comitani , Mehdi Layeghifard , Rosemarie E Venier , Stefan C Dentro , Anant Maheshwari , Sheena Guram , Claire Wunker , J Drew Thompson , Kyoko E Yuki , Huayun Hou , Matthew Zatzman , Nicholas Light , Marcus Q Bernardini , Jay S Wunder , Irene L Andrulis , Peter Ferguson , Albiruni R Abdul Razak , Carol J Swallow , James J Dowling , Rima S Al-Awar , Richard Marcellus , Marjan Rouzbahman , Moritz Gerstung , Daniel Durocher , Ludmil B Alexandrov , Brendan C Dickson , Rebecca A Gladdy , Adam Shlien

Identification of a differential metabolite-based signature in patients with late-stage knee osteoarthritis.

Osteoarthritis and cartilage open

Avec: Jason S Rockel , Mehdi Layeghifard , Y Raja Rampersaud , Anthony V Perruccio , Nizar N Mahomed , J Roderick Davey , Khalid Syed , Rajiv Gandhi , Mohit Kapoor

bioRxiv : the preprint server for biology

Avec: Michael P Randall , Laura E Egolf , Zalman Vaksman , Minu Samanta , Matthew Tsang , David Groff , J Perry Evans , Jo Lynne Rokita , Mehdi Layeghifard , Adam Shlien , John M Maris , Sharon J Diskin , Kristopher R Bosse

Microbiome networks and change-point analysis reveal key community changes associated with cystic fibrosis pulmonary exacerbations.

NPJ biofilms and microbiomes

Avec: Mehdi Layeghifard , Hannah Li , Pauline W Wang , Sylva L Donaldson , Bryan Coburn , Shawn T Clark , Julio Diaz Caballero , Yu Zhang , D Elizabeth Tullis , Yvonne C W Yau , Valerie Waters , David M Hwang , David S Guttman

Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis.

Nature communications

Avec: Nicholas Light , Mehdi Layeghifard , Ayush Attery , Vallijah Subasri , Matthew Zatzman , Nathaniel D Anderson , Rupal Hatkar , Sasha Blay , David Chen , Ana Novokmet , Fabio Fuligni , James Tran , Richard de Borja , Himanshi Agarwal , Larissa Waldman , Lisa M Abegglen , Daniel Albertson , Jonathan L Finlay , Jordan R Hansford , Sam Behjati , Anita Villani , Moritz Gerstung , Ludmil B Alexandrov , Gino R Somers , Joshua D Schiffman , Varda Rotter , David Malkin , Adam Shlien

Réseau de co-auteurs

Adam Shlien 7 collaborations

Fabio Fuligni 3 collaborations

Nicholas Light 3 collaborations

Nathaniel D Anderson 3 collaborations

Anthony V Perruccio 2 collaborations

Mohit Kapoor 2 collaborations

Y Raja Rampersaud 2 collaborations

Michael P Randall 2 collaborations

Laura E Egolf 2 collaborations

Zalman Vaksman 2 collaborations

Minu Samanta 2 collaborations

Matthew Tsang 2 collaborations

David Groff 2 collaborations

J Perry Evans 2 collaborations

Jo Lynne Rokita 2 collaborations

John M Maris 2 collaborations

Sharon J Diskin 2 collaborations

Kristopher R Bosse 2 collaborations

Anita Villani 2 collaborations

Scott Davidson 2 collaborations

Lisa-Monique Edward 2 collaborations

Larissa Waldman 2 collaborations

Federico Comitani 2 collaborations

Kyoko E Yuki 2 collaborations

Sasha Blay 2 collaborations

Rosemarie E Venier 2 collaborations

Gino R Somers 2 collaborations

Meredith S Irwin 2 collaborations

David Malkin 2 collaborations

Matthew Zatzman 2 collaborations

Moritz Gerstung 2 collaborations

Ludmil B Alexandrov 2 collaborations

Starlee Lively 1 collaboration

Marie Milliot 1 collaboration

Pratibha Potla 1 collaboration

Osvaldo Espin-Garcia 1 collaboration

Kala Sundararajan 1 collaboration

Helal Endisha 1 collaboration

Akihiro Nakamura 1 collaboration

Christian Veillette 1 collaboration

Nisha Kanwar 1 collaboration

Winnie W Lo 1 collaboration

Yisu Li 1 collaboration

Sarah Cohen-Gogo 1 collaboration

Ricardo Harripaul 1 collaboration

Bailey Gallinger 1 collaboration

Ledia Brunga 1 collaboration

Reid Hayes 1 collaboration

Arun K Ramani 1 collaboration

Brittney Johnstone 1 collaboration

Cara Inglese 1 collaboration

Rawan Hammad 1 collaboration

Catherine Goudie 1 collaboration

Andrew Shuen 1 collaboration

Jonathan D Wasserman 1 collaboration

Marianne Eliou 1 collaboration

Miranda Lorenti 1 collaboration

Carol Ann Ryan 1 collaboration

Michael Braga 1 collaboration

Meagan Gloven-Brown 1 collaboration

Jianan Han 1 collaboration

Maria Montero 1 collaboration

Famida Spatare 1 collaboration

James A Whitlock 1 collaboration

Stephen W Scherer 1 collaboration

Kathy Chun 1 collaboration

Martin J Somerville 1 collaboration

Cynthia Hawkins 1 collaboration

Mohamed Abdelhaleem 1 collaboration

Vijay Ramaswamy 1 collaboration

Lianna Kyriakopoulou 1 collaboration

Johann Hitzler 1 collaboration

Mary Shago 1 collaboration

Daniel A Morgenstern 1 collaboration

Uri Tabori 1 collaboration

Stephen Meyn 1 collaboration

Ivette Valencia-Sama 1 collaboration

Lynn Kee 1 collaboration

Gabriella Christopher 1 collaboration

Michael Ohh 1 collaboration

Madeline N Hayes 1 collaboration

Masayuki Nakamori 1 collaboration

Gagan B Panigrahi 1 collaboration

Stella Lanni 1 collaboration

Terence Gall-Duncan 1 collaboration

Hideki Hayakawa 1 collaboration

Hana Tanaka 1 collaboration

Jennifer Luo 1 collaboration

Takahiro Otabe 1 collaboration

Jinxing Li 1 collaboration

Akihiro Sakata 1 collaboration

Marie-Christine Caron 1 collaboration

Niraj Joshi 1 collaboration

Tanya Prasolava 1 collaboration

Karen Chiang 1 collaboration

Jean-Yves Masson 1 collaboration

Marc S Wold 1 collaboration

Xiaoxiao Wang 1 collaboration

Marietta Y W T Lee 1 collaboration

John Huddleston 1 collaboration

Katherine M Munson 1 collaboration

Richard Gallon 1 collaboration

Mauro Santibanez-Koref 1 collaboration

Asako Murata 1 collaboration

Masanori P Takahashi 1 collaboration

Evan E Eichler 1 collaboration

Kazuhiko Nakatani 1 collaboration

Hideki Mochizuki 1 collaboration

Christopher E Pearson 1 collaboration

Yael Babichev 1 collaboration

Stefan C Dentro 1 collaboration

Anant Maheshwari 1 collaboration

Sheena Guram 1 collaboration

Claire Wunker 1 collaboration

J Drew Thompson 1 collaboration

Huayun Hou 1 collaboration

Marcus Q Bernardini 1 collaboration

Jay S Wunder 1 collaboration

Irene L Andrulis 1 collaboration

Peter Ferguson 1 collaboration

Albiruni R Abdul Razak 1 collaboration

Carol J Swallow 1 collaboration

James J Dowling 1 collaboration

Rima S Al-Awar 1 collaboration

Richard Marcellus 1 collaboration

Marjan Rouzbahman 1 collaboration

Daniel Durocher 1 collaboration

Brendan C Dickson 1 collaboration

Rebecca A Gladdy 1 collaboration

Jason S Rockel 1 collaboration

Nizar N Mahomed 1 collaboration

J Roderick Davey 1 collaboration

Khalid Syed 1 collaboration

Rajiv Gandhi 1 collaboration

Hannah Li 1 collaboration

Pauline W Wang 1 collaboration

Sylva L Donaldson 1 collaboration

Bryan Coburn 1 collaboration

Shawn T Clark 1 collaboration

Julio Diaz Caballero 1 collaboration

Yu Zhang 1 collaboration

D Elizabeth Tullis 1 collaboration

Yvonne C W Yau 1 collaboration

Valerie Waters 1 collaboration

David M Hwang 1 collaboration

David S Guttman 1 collaboration

Ayush Attery 1 collaboration

Vallijah Subasri 1 collaboration

Rupal Hatkar 1 collaboration

David Chen 1 collaboration

Ana Novokmet 1 collaboration

James Tran 1 collaboration

Richard de Borja 1 collaboration

Himanshi Agarwal 1 collaboration

Lisa M Abegglen 1 collaboration

Daniel Albertson 1 collaboration

Jonathan L Finlay 1 collaboration

Jordan R Hansford 1 collaboration

Sam Behjati 1 collaboration

Joshua D Schiffman 1 collaboration

Varda Rotter 1 collaboration