Meltem Muftuoglu

Affiliations

Department of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Department of Molecular Biology and Genetics, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.

Publications (20)

Clinical Efficacy and Tumor Microenvironment Influence in a Dose-Escalation Study of Anti-CD19 Chimeric Antigen Receptor T Cells in Refractory B-Cell Non-Hodgkin's Lymphoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Zi-Xun Yan , Li Li , Wen Wang , Bin-Shen OuYang , Shu Cheng , Li Wang , Wen Wu , Peng-Peng Xu , Muharrem Muftuoglu , Ming Hao , Su Yang , Mu-Chen Zhang , Zhong Zheng , James Li , Wei-Li Zhao

Extended live-cell barcoding approach for multiplexed mass cytometry.

Scientific reports

Avec: Muharrem Muftuoglu , Li Li , Shaoheng Liang , Duncan Mak , Angelique J Lin , Junxiang Fang , Jared K Burks , Ken Chen , Michael Andreeff

Leukocyte telomere length as a compensatory mechanism in vitamin D metabolism.

PloS one

Avec: Deniz Agirbasli , Minenur Kalyoncu , Meltem Muftuoglu , Fehime Benli Aksungar , Mehmet Agirbasli

Epichaperome inhibition targets TP53-mutant AML and AML stem/progenitor cells.

Blood

Avec: Bing Z Carter , Po Yee Mak , Muharrem Muftuoglu , Wenjing Tao , Baozhen Ke , Jingqi Pei , Andrea D Bedoy , Lauren B Ostermann , Yuki Nishida , Sevinj Isgandarova , Mary Sobieski , Nghi Nguyen , Reid T Powell , Margarita Martinez-Moczygemba , Clifford Stephan , Mahesh Basyal , Naveen Pemmaraju , Steffen Boettcher , Benjamin L Ebert , Elizabeth J Shpall , Barbara Wallner , Robert A Morgan , Georgios I Karras , Ute M Moll , Michael Andreeff

Mitochondria-Targeted Liposomes for Drug Delivery to Tumor Mitochondria.

Pharmaceutics

Avec: Aysegul Ekmekcioglu , Ozgul Gok , Devrim Oz-Arslan , Meryem Sedef Erdal , Yasemin Yagan Uzuner , Meltem Muftuoglu

Parents of ataxia-telangiectasia patients display a distinct cellular immune phenotype mimicking ATM-mutated patients.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

Avec: Ismail Ogulur , Tugce Ertuzun , Burcu Kocamis , Yasemin Kendir Demirkol , Emel Uyar , Ayca Kiykim , Dilek Baser , Gozde Yesil , Hacer Akturk , Ayper Somer , Ahmet Ozen , Elif Karakoc-Aydiner , Meltem Muftuoglu , Safa Baris

In-depth analysis of SARS-CoV-2-specific T cells reveals diverse differentiation hierarchies in vaccinated individuals.

JCI insight

Avec: Li Li , Muharrem Muftuoglu , Shaoheng Liang , Mahesh Basyal , Jiangxing Lv , Mehmet Emin Akdogan , Ken Chen , Michael Andreeff , Christopher R Flowers , Simrit Parmar

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19 chimeric antigen receptor T therapy.

Frontiers of medicine

Avec: Zixun Yan , Li Li , Di Fu , Wen Wu , Niu Qiao , Yaohui Huang , Lu Jiang , Depei Wu , Yu Hu , Huilai Zhang , Pengpeng Xu , Shu Cheng , Li Wang , Sahin Lacin , Muharrem Muftuoglu , Weili Zhao

Investigation of base excision repair gene variants in late-onset Alzheimer's disease.

PloS one

Avec: Tugce Ertuzun , Asli Semerci , Mehmet Emin Cakir , Aysegul Ekmekcioglu , Mehmet Oguz Gok , Daniela T Soltys , Nadja C de Souza-Pinto , Ugur Sezerman , Meltem Muftuoglu

Ab initio spillover compensation in mass cytometry data.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Avec: Qi Miao , Fang Wang , Jinzhuang Dou , Ramiz Iqbal , Muharrem Muftuoglu , Rafet Basar , Li Li , Katy Rezvani , Ken Chen

A phase 1/2 study of azacitidine, venetoclax and pevonedistat in newly diagnosed secondary AML and in MDS or CMML after failure of hypomethylating agents.

Journal of hematology & oncology

Avec: Nicholas J Short , Muharrem Muftuoglu , Faustine Ong , Lewis Nasr , Walid Macaron , Guillermo Montalban-Bravo , Yesid Alvarado , Mahesh Basyal , Naval Daver , Courtney D Dinardo , Gautam Borthakur , Nitin Jain , Maro Ohanian , Elias Jabbour , Ghayas C Issa , Wei Qiao , Xuelin Huang , Rashmi Kanagal-Shamanna , Keyur P Patel , Prithviraj Bose , Farhad Ravandi , Ricardo Delumpa , Regina Abramova , Guillermo Garcia-Manero , Michael Andreeff , Jorge Cortes , Hagop Kantarjian

Enhanced

Science advances

Avec: Yuki Nishida , Jo Ishizawa , Edward Ayoub , Rafael Heinz Montoya , Lauren B Ostermann , Muharrem Muftuoglu , Vivian R Ruvolo , Tallie Patsilevas , Darah A Scruggs , Shayaun Khazaei , Po Yee Mak , Wenjing Tao , Bing Z Carter , Steffen Boettcher , Benjamin L Ebert , Naval G Daver , Marina Konopleva , Takahiko Seki , Kensuke Kojima , Michael Andreeff

Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy.

Nature medicine

Avec: Irene Ganan-Gomez , Hui Yang , Feiyang Ma , Guillermo Montalban-Bravo , Natthakan Thongon , Valentina Marchica , Guillaume Richard-Carpentier , Kelly Chien , Ganiraju Manyam , Feng Wang , Ana Alfonso , Shuaitong Chen , Caleb Class , Rashmi Kanagal-Shamanna , Justin P Ingram , Yamini Ogoti , Ashley Rose , Sanam Loghavi , Pamela Lockyer , Benedetta Cambo , Muharrem Muftuoglu , Sarah Schneider , Vera Adema , Michael McLellan , John Garza , Matteo Marchesini , Nicola Giuliani , Matteo Pellegrini , Jing Wang , Jason Walker , Ziyi Li , Koichi Takahashi , Joel D Leverson , Carlos Bueso-Ramos , Michael Andreeff , Karen Clise-Dwyer , Guillermo Garcia-Manero , Simona Colla

Targeting mitochondrial DNA polymerase gamma for selective inhibition of MLH1 deficient colon cancer growth.

PloS one

Avec: Berna Somuncu , Aysegul Ekmekcioglu , Fatma Merve Antmen , Tugce Ertuzun , Emre Deniz , Nazli Keskin , Joon Park , Ilgu Ece Yazici , Busra Simsek , Batu Erman , Whitney Yin , Burak Erman , Meltem Muftuoglu

Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics.

Blood cancer journal

Avec: Bing Z Carter , Po Yee Mak , Wenjing Tao , Edward Ayoub , Lauren B Ostermann , Xuelin Huang , Sanam Loghavi , Steffen Boettcher , Yuki Nishida , Vivian Ruvolo , Paul E Hughes , Phuong K Morrow , Torsten Haferlach , Steven Kornblau , Muharrem Muftuoglu , Michael Andreeff

Cosmic Whirl: Navigating the Comet Trail in DNA: H2AX Phosphorylation and the Enigma of Uncertain Significance Variants.

Genes

Avec: Sevdican Ustun Yilmaz , Nihat Bugra Agaoglu , Karin Manto , Meltem Muftuoglu , Ugur Özbek

Non-muscle invasive bladder cancer tissues have increased base excision repair capacity.

Scientific reports

Avec: Berna Somuncu , Selcuk Keskin , Fatma Merve Antmen , Yesim Saglican , Aysegul Ekmekcioglu , Tugce Ertuzun , Mustafa Bilal Tuna , Can Obek , David M Wilson , Umit Ince , Ali Riza Kural , Meltem Muftuoglu

Transgenic Expression of IL15 Retains CD123-Redirected T Cells in a Less Differentiated State Resulting in Improved Anti-AML Activity in Autologous AML PDX Models.

Frontiers in immunology

Avec: Hong Mu-Mosley , Lauren Ostermann , Muharrem Muftuoglu , Abishek Vaidya , Challice L Bonifant , Mireya Paulina Velasquez , Stephen Gottschalk , Michael Andreeff

A Phase I study of Milademetan (DS3032b) in combination with low dose cytarabine with or without venetoclax in acute myeloid leukemia: Clinical safety, efficacy, and correlative analysis.

Blood cancer journal

Avec: Jayastu Senapati , Muharrem Muftuoglu , Jo Ishizawa , Hussein A Abbas , Sanam Loghavi , Gautam Borthakur , Musa Yilmaz , Ghayas C Issa , Samuel I Dara , Mahesh Basyal , Li Li , Kiran Naqvi , Rasoul Pourebrahim , Elias J Jabbour , Steven M Kornblau , Nicholas J Short , Naveen Pemmaraju , Guillermo Garcia-Manero , Farhad Ravandi , Joseph Khoury , Naval Daver , Hagop M Kantarjian , Michael Andreeff , Courtney D DiNardo

Age-specific induction of mutant p53 drives clonal hematopoiesis and acute myeloid leukemia in adult mice.

Cell reports. Medicine

Avec: Rasoul Pourebrahim , Rafael Heinz Montoya , Hiroki Akiyama , Lauren Ostermann , Shayuan Khazaei , Muharrem Muftuoglu , Natalia Baran , Ran Zhao , Tom Lesluyes , Bin Liu , Joseph D Khoury , Mihai Gagea , Peter Van Loo , Michael Andreeff

Réseau de co-auteurs

Muharrem Muftuoglu 13 collaborations

Michael Andreeff 10 collaborations

Li Li 6 collaborations

Mahesh Basyal 4 collaborations

Aysegul Ekmekcioglu 4 collaborations

Tugce Ertuzun 4 collaborations

Ken Chen 3 collaborations

Bing Z Carter 3 collaborations

Po Yee Mak 3 collaborations

Wenjing Tao 3 collaborations

Lauren B Ostermann 3 collaborations

Yuki Nishida 3 collaborations

Steffen Boettcher 3 collaborations

Guillermo Garcia-Manero 3 collaborations

Sanam Loghavi 3 collaborations

Shu Cheng 2 collaborations

Li Wang 2 collaborations

Wen Wu 2 collaborations

Shaoheng Liang 2 collaborations

Naveen Pemmaraju 2 collaborations

Benjamin L Ebert 2 collaborations

Nicholas J Short 2 collaborations

Guillermo Montalban-Bravo 2 collaborations

Naval Daver 2 collaborations

Gautam Borthakur 2 collaborations

Ghayas C Issa 2 collaborations

Xuelin Huang 2 collaborations

Rashmi Kanagal-Shamanna 2 collaborations

Farhad Ravandi 2 collaborations

Jo Ishizawa 2 collaborations

Edward Ayoub 2 collaborations

Rafael Heinz Montoya 2 collaborations

Berna Somuncu 2 collaborations

Fatma Merve Antmen 2 collaborations

Lauren Ostermann 2 collaborations

Rasoul Pourebrahim 2 collaborations

Zi-Xun Yan 1 collaboration

Wen Wang 1 collaboration

Bin-Shen OuYang 1 collaboration

Peng-Peng Xu 1 collaboration

Ming Hao 1 collaboration

Su Yang 1 collaboration

Mu-Chen Zhang 1 collaboration

Zhong Zheng 1 collaboration

James Li 1 collaboration

Wei-Li Zhao 1 collaboration

Duncan Mak 1 collaboration

Angelique J Lin 1 collaboration

Junxiang Fang 1 collaboration

Jared K Burks 1 collaboration

Deniz Agirbasli 1 collaboration

Minenur Kalyoncu 1 collaboration

Fehime Benli Aksungar 1 collaboration

Mehmet Agirbasli 1 collaboration

Baozhen Ke 1 collaboration

Jingqi Pei 1 collaboration

Andrea D Bedoy 1 collaboration

Sevinj Isgandarova 1 collaboration

Mary Sobieski 1 collaboration

Nghi Nguyen 1 collaboration

Reid T Powell 1 collaboration

Margarita Martinez-Moczygemba 1 collaboration

Clifford Stephan 1 collaboration

Elizabeth J Shpall 1 collaboration

Barbara Wallner 1 collaboration

Robert A Morgan 1 collaboration

Georgios I Karras 1 collaboration

Ute M Moll 1 collaboration

Ozgul Gok 1 collaboration

Devrim Oz-Arslan 1 collaboration

Meryem Sedef Erdal 1 collaboration

Yasemin Yagan Uzuner 1 collaboration

Ismail Ogulur 1 collaboration

Burcu Kocamis 1 collaboration

Yasemin Kendir Demirkol 1 collaboration

Emel Uyar 1 collaboration

Ayca Kiykim 1 collaboration

Dilek Baser 1 collaboration

Gozde Yesil 1 collaboration

Hacer Akturk 1 collaboration

Ayper Somer 1 collaboration

Ahmet Ozen 1 collaboration

Elif Karakoc-Aydiner 1 collaboration

Safa Baris 1 collaboration

Jiangxing Lv 1 collaboration

Mehmet Emin Akdogan 1 collaboration

Christopher R Flowers 1 collaboration

Simrit Parmar 1 collaboration

Zixun Yan 1 collaboration

Di Fu 1 collaboration

Niu Qiao 1 collaboration

Yaohui Huang 1 collaboration

Lu Jiang 1 collaboration

Depei Wu 1 collaboration

Yu Hu 1 collaboration

Huilai Zhang 1 collaboration

Pengpeng Xu 1 collaboration

Sahin Lacin 1 collaboration

Weili Zhao 1 collaboration

Asli Semerci 1 collaboration

Mehmet Emin Cakir 1 collaboration

Mehmet Oguz Gok 1 collaboration

Daniela T Soltys 1 collaboration

Nadja C de Souza-Pinto 1 collaboration

Ugur Sezerman 1 collaboration

Qi Miao 1 collaboration

Fang Wang 1 collaboration

Jinzhuang Dou 1 collaboration

Ramiz Iqbal 1 collaboration

Rafet Basar 1 collaboration

Katy Rezvani 1 collaboration

Faustine Ong 1 collaboration

Lewis Nasr 1 collaboration

Walid Macaron 1 collaboration

Yesid Alvarado 1 collaboration

Courtney D Dinardo 1 collaboration

Nitin Jain 1 collaboration

Maro Ohanian 1 collaboration

Elias Jabbour 1 collaboration

Wei Qiao 1 collaboration

Keyur P Patel 1 collaboration

Prithviraj Bose 1 collaboration

Ricardo Delumpa 1 collaboration

Regina Abramova 1 collaboration

Jorge Cortes 1 collaboration

Hagop Kantarjian 1 collaboration

Vivian R Ruvolo 1 collaboration

Tallie Patsilevas 1 collaboration

Darah A Scruggs 1 collaboration

Shayaun Khazaei 1 collaboration

Naval G Daver 1 collaboration

Marina Konopleva 1 collaboration

Takahiko Seki 1 collaboration

Kensuke Kojima 1 collaboration

Irene Ganan-Gomez 1 collaboration

Hui Yang 1 collaboration

Feiyang Ma 1 collaboration

Natthakan Thongon 1 collaboration

Valentina Marchica 1 collaboration

Guillaume Richard-Carpentier 1 collaboration

Kelly Chien 1 collaboration

Ganiraju Manyam 1 collaboration

Feng Wang 1 collaboration

Ana Alfonso 1 collaboration

Shuaitong Chen 1 collaboration

Caleb Class 1 collaboration

Justin P Ingram 1 collaboration

Yamini Ogoti 1 collaboration

Ashley Rose 1 collaboration

Pamela Lockyer 1 collaboration

Benedetta Cambo 1 collaboration

Sarah Schneider 1 collaboration

Vera Adema 1 collaboration

Michael McLellan 1 collaboration

John Garza 1 collaboration

Matteo Marchesini 1 collaboration

Nicola Giuliani 1 collaboration

Matteo Pellegrini 1 collaboration

Jing Wang 1 collaboration

Jason Walker 1 collaboration

Ziyi Li 1 collaboration

Koichi Takahashi 1 collaboration

Joel D Leverson 1 collaboration

Carlos Bueso-Ramos 1 collaboration

Karen Clise-Dwyer 1 collaboration

Simona Colla 1 collaboration

Emre Deniz 1 collaboration

Nazli Keskin 1 collaboration

Joon Park 1 collaboration

Ilgu Ece Yazici 1 collaboration

Busra Simsek 1 collaboration

Batu Erman 1 collaboration

Whitney Yin 1 collaboration

Burak Erman 1 collaboration

Vivian Ruvolo 1 collaboration

Paul E Hughes 1 collaboration

Phuong K Morrow 1 collaboration

Torsten Haferlach 1 collaboration

Steven Kornblau 1 collaboration

Sevdican Ustun Yilmaz 1 collaboration

Nihat Bugra Agaoglu 1 collaboration

Karin Manto 1 collaboration

Ugur Özbek 1 collaboration

Selcuk Keskin 1 collaboration

Yesim Saglican 1 collaboration

Mustafa Bilal Tuna 1 collaboration

Can Obek 1 collaboration

David M Wilson 1 collaboration

Umit Ince 1 collaboration

Ali Riza Kural 1 collaboration

Hong Mu-Mosley 1 collaboration

Abishek Vaidya 1 collaboration

Challice L Bonifant 1 collaboration

Mireya Paulina Velasquez 1 collaboration

Stephen Gottschalk 1 collaboration

Jayastu Senapati 1 collaboration

Hussein A Abbas 1 collaboration

Musa Yilmaz 1 collaboration

Samuel I Dara 1 collaboration

Kiran Naqvi 1 collaboration

Elias J Jabbour 1 collaboration

Steven M Kornblau 1 collaboration

Joseph Khoury 1 collaboration

Hagop M Kantarjian 1 collaboration

Courtney D DiNardo 1 collaboration

Hiroki Akiyama 1 collaboration

Shayuan Khazaei 1 collaboration

Natalia Baran 1 collaboration

Ran Zhao 1 collaboration

Tom Lesluyes 1 collaboration

Bin Liu 1 collaboration

Joseph D Khoury 1 collaboration

Mihai Gagea 1 collaboration

Peter Van Loo 1 collaboration