Pierre Layrolle

Affiliations

INSERM UMR1238, Bone Sarcoma and remodeling of calcified tissues, Nantes University, 44093 Nantes, France. pierre.layrolle@univ-nantes.fr.

Publications (29)

Rotator Cuff Tenocytes Differentiate into Hypertrophic Chondrocyte-Like Cells to Produce Calcium Deposits in an Alkaline Phosphatase-Dependent Manner.

Journal of clinical medicine

Avec: Christelle Darrieutort-Laffite , Paul Arnolfo , Thomas Garraud , Annie Adrait , Yohann Couté , Guy Louarn , Valérie Trichet , Pierre Layrolle , Benoit Le Goff , Frédéric Blanchard

Biomimetic versus sintered macroporous calcium phosphate scaffolds enhanced bone regeneration and human mesenchymal stromal cell engraftment in calvarial defects.

Acta biomaterialia

Avec: Meadhbh Á Brennan , David S Monahan , Bénédicte Brulin , Sara Gallinetti , Paul Humbert , Christina Tringides , Cristina Canal , Maria Pau Ginebra , Pierre Layrolle

Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells.

Scientific reports

Avec: Salwa Suliman , Hassan R W Ali , Tommy A Karlsen , Jerome Amiaud , Samih Mohamed-Ahmed , Pierre Layrolle , Daniela E Costea , Jan E Brinchmann , Kamal Mustafa

Reconstruction of Large Skeletal Defects: Current Clinical Therapeutic Strategies and Future Directions Using 3D Printing.

Frontiers in bioengineering and biotechnology

Avec: Luciano Vidal , Carina Kampleitner , Meadhbh Á Brennan , Alain Hoornaert , Pierre Layrolle

Chondrogenic and BMP-4 primings confer osteogenesis potential to human cord blood mesenchymal stromal cells delivered with biphasic calcium phosphate ceramics.

Scientific reports

Avec: Meadhbh Á Brennan , Mario Barilani , Francesco Rusconi , Julien de Lima , Luciano Vidal , Cristiana Lavazza , Lorenza Lazzari , Rosaria Giordano , Pierre Layrolle

Apoptotic mesenchymal stromal cells support osteoclastogenesis while inhibiting multinucleated giant cells formation in vitro.

Scientific reports

Avec: Paul Humbert , Meadhbh Á Brennan , Julien De Lima , Régis Brion , Annie Adrait , Céline Charrier , Bénédicte Brulin , Valérie Trichet , Yohann Couté , Frédéric Blanchard , Pierre Layrolle

Message in a Scaffold: Natural Biomaterials for Three-Dimensional (3D) Bioprinting of Human Brain Organoids.

Biomolecules

Avec: Pierre Layrolle , Pierre Payoux , Stéphane Chavanas

Biocompatibility and osseointegration of nanostructured titanium dental implants in minipigs.

Clinical oral implants research

Avec: Alain Hoornaert , Luciano Vidal , Romain Besnier , Jean-Francois Morlock , Guy Louarn , Pierre Layrolle

Epinephrine Infiltration of Adipose Tissue Impacts MCF7 Breast Cancer Cells and Total Lipid Content.

International journal of molecular sciences

Avec: Pierre Avril , Luciano Vidal , Sophie Barille-Nion , Louis-Romée Le Nail , Françoise Redini , Pierre Layrolle , Michelle Pinault , Stéphane Chevalier , Pierre Perrot , Valérie Trichet

Immune Modulation by Transplanted Calcium Phosphate Biomaterials and Human Mesenchymal Stromal Cells in Bone Regeneration.

Frontiers in immunology

Avec: Paul Humbert , Meadhbh Á Brennan , Noel Davison , Philippe Rosset , Valérie Trichet , Frédéric Blanchard , Pierre Layrolle

Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration.

Advanced functional materials

Avec: Meadhbh Á Brennan , Pierre Layrolle , David J Mooney

Single-cell RNA sequencing of human non-hematopoietic bone marrow cells reveals a unique set of inter-species conserved biomarkers for native mesenchymal stromal cells.

Stem cell research & therapy

Avec: Loïc Fiévet , Nicolas Espagnolle , Daniela Gerovska , David Bernard , Charlotte Syrykh , Camille Laurent , Pierre Layrolle , Julien De Lima , Arthur Justo , Nicolas Reina , Louis Casteilla , Marcos J Araúzo-Bravo , Abderrahim Naji , Jean-Christophe Pagès , Frédéric Deschaseaux

The Optic Nerve at Stake: Update on Environmental Factors Modulating Expression of Leber's Hereditary Optic Neuropathy.

Biomedicines

Avec: Pierre Layrolle , Christophe Orssaud , Maryse Leleu , Pierre Payoux , Stéphane Chavanas

Regeneration of segmental defects in metatarsus of sheep with vascularized and customized 3D-printed calcium phosphate scaffolds.

Scientific reports

Avec: Luciano Vidal , Carina Kampleitner , Stéphanie Krissian , Meadhbh Á Brennan , Oskar Hoffmann , Yago Raymond , Yassine Maazouz , Maria-Pau Ginebra , Philippe Rosset , Pierre Layrolle

Feasibility and safety of treating non-unions in tibia, femur and humerus with autologous, expanded, bone marrow-derived mesenchymal stromal cells associated with biphasic calcium phosphate biomaterials in a multicentric, non-comparative trial.

Biomaterials

Avec: Enrique Gómez-Barrena , Philippe Rosset , Florian Gebhard , Philippe Hernigou , Nicola Baldini , Helène Rouard , Luc Sensebé , Rosa M Gonzalo-Daganzo , Rosaria Giordano , Norma Padilla-Eguiluz , Eduardo García-Rey , José Cordero-Ampuero , Juan Carlos Rubio-Suárez , Julien Stanovici , Christian Ehrnthaller , Markus Huber-Lang , Charles Henri Flouzat-Lachaniette , Nathalie Chevallier , Davide Maria Donati , Gabriela Ciapetti , Sandrine Fleury , Manuel-Nicolás Fernandez , José-Rafael Cabrera , Cristina Avendaño-Solá , Tiziana Montemurro , Carmen Panaitescu , Elena Veronesi , Markus Thomas Rojewski , Ramin Lotfi , Massimo Dominici , Hubert Schrezenmeier , Pierre Layrolle

Biomarkers of bone healing induced by a regenerative approach based on expanded bone marrow-derived mesenchymal stromal cells.

Cytotherapy

Avec: Donatella Granchi , Gabriela Ciapetti , Enrique Gómez-Barrena , Markus Rojewski , Philippe Rosset , Pierre Layrolle , Benedetta Spazzoli , Davide Maria Donati , Nicola Baldini

Translation of a standardized manufacturing protocol for mesenchymal stromal cells: A systematic comparison of validation and manufacturing data.

Cytotherapy

Avec: Markus Thomas Rojewski , Ramin Lotfi , Cecilie Gjerde , Kamal Mustafa , Elena Veronesi , Aymen B Ahmed , Markus Wiesneth , Sixten Körper , Luc Sensebé , Pierre Layrolle , Sølve Hellem , Hubert Schrezenmeier

Low-Dose Pesticide Mixture Induces Accelerated Mesenchymal Stem Cell Aging In Vitro.

Stem cells (Dayton, Ohio)

Avec: Xavier Leveque , Mazene Hochane , Fanny Geraldo , Solene Dumont , Catherine Gratas , Lisa Oliver , Claire Gaignier , Valérie Trichet , Pierre Layrolle , Dominique Heymann , Olivier Herault , François M Vallette , Christophe Olivier

Evaluation of the Chemotherapy Drug Response Using Organotypic Cultures of Osteosarcoma Tumours from Mice Models and Canine Patients.

Cancers

Avec: Bénédicte Brulin , John C Nolan , Tecla Marangon , Milan Kovacevic , Mathias Chatelais , Pierre Meheust , Jérome Abadie , Louis-Romée Le Nail , Philippe Rosset , Meadhbh Á Brennan , Pierre Layrolle

Phase composition of calcium phosphate materials affects bone formation by modulating osteoclastogenesis.

Acta biomaterialia

Avec: Paul Humbert , Carina Kampleitner , Julien De Lima , Meadhbh Á Brennan , Irene Lodoso Torrecilla , Joanna Maria Sadowska , Frédéric Blanchard , Cristina Canal , Maria-Pau Ginebra , Oskar Hoffmann , Pierre Layrolle

Osteoblasts mineralization and collagen matrix are conserved upon specific

Matrix biology plus

Avec: Silvia Maruelli , Roberta Besio , Julie Rousseau , Nadia Garibaldi , Jérôme Amiaud , Bénédicte Brulin , Pierre Layrolle , Virginie Escriou , Antonio Rossi , Valerie Trichet , Antonella Forlino

Early efficacy evaluation of mesenchymal stromal cells (MSC) combined to biomaterials to treat long bone non-unions.

Injury

Avec: Enrique Gómez-Barrena , Norma Padilla-Eguiluz , Philippe Rosset , Florian Gebhard , Philippe Hernigou , Nicola Baldini , Helène Rouard , Luc Sensebé , Rosa-María Gonzalo-Daganzo , Rosaria Giordano , Eduardo García-Rey , José Cordero-Ampuero , Juan Carlos Rubio-Suárez , Marta Dominguez García-Simón , Julien Stanovici , Christian Ehrnthaller , Markus Huber-Lang , Charles Henri Flouzat-Lachaniette , Nathalie Chevallier , Davide Maria Donati , Benedetta Spazzoli , Gabriela Ciapetti , Sandrine Fleury , Manuel-Nicolás Fernandez , José-Rafael Cabrera , Cristina Avendaño-Solá , Tiziana Montemurro , Carmen Panaitescu , Elena Veronesi , Markus Thomas Rojewski , Ramin Lotfi , Massimo Dominici , Hubert Schrezenmeier , Pierre Layrolle

Biomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration.

Journal of clinical periodontology

Avec: Mariano Sanz , Christer Dahlin , Danae Apatzidou , Zvi Artzi , Darko Bozic , Elena Calciolari , Hugo De Bruyn , Henrik Dommisch , Nikos Donos , Peter Eickholz , Jan E Ellingsen , Håvard J Haugen , David Herrera , France Lambert , Pierre Layrolle , Eduardo Montero , Kamal Mustafa , Omar Omar , Henning Schliephake

Vertical Bone Regeneration with Synthetic Biomimetic Calcium Phosphate onto the Calvaria of Rats.

Tissue engineering. Part C, Methods

Avec: Alain Hoornaert , Yassine Maazouz , David Pastorino , Carlos Aparicio , Gonzague de Pinieux , Borhane H Fellah , Maria-Pau Ginebra , Pierre Layrolle

Cold Plasma-Treated Ringer's Saline: A Weapon to Target Osteosarcoma.

Cancers

Avec: Miguel Mateu-Sanz , Juan Tornín , Bénédicte Brulin , Anna Khlyustova , Maria-Pau Ginebra , Pierre Layrolle , Cristina Canal

In situ production of pre-vascularized synthetic bone grafts for regenerating critical-sized defects in rabbits.

Acta biomaterialia

Avec: Luciano Vidal , Meadhbh Á Brennan , Stéphanie Krissian , Julien De Lima , Alain Hoornaert , Philippe Rosset , Borhane H Fellah , Pierre Layrolle

A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect.

Frontiers in bioengineering and biotechnology

Avec: Fiona E Freeman , Meadhbh Á Brennan , David C Browe , Audrey Renaud , Julien De Lima , Daniel J Kelly , Laoise M McNamara , Pierre Layrolle

PPAR Gamma and Viral Infections of the Brain.

International journal of molecular sciences

Avec: Pierre Layrolle , Pierre Payoux , Stéphane Chavanas

Microbial-stem cell interactions in periodontal disease.

Journal of medical microbiology

Avec: Jordan M Iliopoulos , Pierre Layrolle , Danae A Apatzidou

Réseau de co-auteurs

Meadhbh Á Brennan 11 collaborations

Philippe Rosset 7 collaborations

Luciano Vidal 6 collaborations

Valérie Trichet 5 collaborations

Bénédicte Brulin 5 collaborations

Julien De Lima 5 collaborations

Frédéric Blanchard 4 collaborations

Paul Humbert 4 collaborations

Alain Hoornaert 4 collaborations

Maria-Pau Ginebra 4 collaborations

Cristina Canal 3 collaborations

Kamal Mustafa 3 collaborations

Carina Kampleitner 3 collaborations

Rosaria Giordano 3 collaborations

Pierre Payoux 3 collaborations

Stéphane Chavanas 3 collaborations

Enrique Gómez-Barrena 3 collaborations

Nicola Baldini 3 collaborations

Luc Sensebé 3 collaborations

Davide Maria Donati 3 collaborations

Gabriela Ciapetti 3 collaborations

Elena Veronesi 3 collaborations

Markus Thomas Rojewski 3 collaborations

Ramin Lotfi 3 collaborations

Hubert Schrezenmeier 3 collaborations

Annie Adrait 2 collaborations

Yohann Couté 2 collaborations

Guy Louarn 2 collaborations

Louis-Romée Le Nail 2 collaborations

Stéphanie Krissian 2 collaborations

Oskar Hoffmann 2 collaborations

Yassine Maazouz 2 collaborations

Florian Gebhard 2 collaborations

Philippe Hernigou 2 collaborations

Helène Rouard 2 collaborations

Norma Padilla-Eguiluz 2 collaborations

Eduardo García-Rey 2 collaborations

José Cordero-Ampuero 2 collaborations

Juan Carlos Rubio-Suárez 2 collaborations

Julien Stanovici 2 collaborations

Christian Ehrnthaller 2 collaborations

Markus Huber-Lang 2 collaborations

Charles Henri Flouzat-Lachaniette 2 collaborations

Nathalie Chevallier 2 collaborations

Sandrine Fleury 2 collaborations

Manuel-Nicolás Fernandez 2 collaborations

José-Rafael Cabrera 2 collaborations

Cristina Avendaño-Solá 2 collaborations

Tiziana Montemurro 2 collaborations

Carmen Panaitescu 2 collaborations

Massimo Dominici 2 collaborations

Benedetta Spazzoli 2 collaborations

Borhane H Fellah 2 collaborations

Christelle Darrieutort-Laffite 1 collaboration

Paul Arnolfo 1 collaboration

Thomas Garraud 1 collaboration

Benoit Le Goff 1 collaboration

David S Monahan 1 collaboration

Sara Gallinetti 1 collaboration

Christina Tringides 1 collaboration

Maria Pau Ginebra 1 collaboration

Salwa Suliman 1 collaboration

Hassan R W Ali 1 collaboration

Tommy A Karlsen 1 collaboration

Jerome Amiaud 1 collaboration

Samih Mohamed-Ahmed 1 collaboration

Daniela E Costea 1 collaboration

Jan E Brinchmann 1 collaboration

Mario Barilani 1 collaboration

Francesco Rusconi 1 collaboration

Julien de Lima 1 collaboration

Cristiana Lavazza 1 collaboration

Lorenza Lazzari 1 collaboration

Régis Brion 1 collaboration

Céline Charrier 1 collaboration

Romain Besnier 1 collaboration

Jean-Francois Morlock 1 collaboration

Pierre Avril 1 collaboration

Sophie Barille-Nion 1 collaboration

Françoise Redini 1 collaboration

Michelle Pinault 1 collaboration

Stéphane Chevalier 1 collaboration

Pierre Perrot 1 collaboration

Noel Davison 1 collaboration

David J Mooney 1 collaboration

Loïc Fiévet 1 collaboration

Nicolas Espagnolle 1 collaboration

Daniela Gerovska 1 collaboration

David Bernard 1 collaboration

Charlotte Syrykh 1 collaboration

Camille Laurent 1 collaboration

Arthur Justo 1 collaboration

Nicolas Reina 1 collaboration

Louis Casteilla 1 collaboration

Marcos J Araúzo-Bravo 1 collaboration

Abderrahim Naji 1 collaboration

Jean-Christophe Pagès 1 collaboration

Frédéric Deschaseaux 1 collaboration

Christophe Orssaud 1 collaboration

Maryse Leleu 1 collaboration

Yago Raymond 1 collaboration

Rosa M Gonzalo-Daganzo 1 collaboration

Donatella Granchi 1 collaboration

Markus Rojewski 1 collaboration

Cecilie Gjerde 1 collaboration

Aymen B Ahmed 1 collaboration

Markus Wiesneth 1 collaboration

Sixten Körper 1 collaboration

Sølve Hellem 1 collaboration

Xavier Leveque 1 collaboration

Mazene Hochane 1 collaboration

Fanny Geraldo 1 collaboration

Solene Dumont 1 collaboration

Catherine Gratas 1 collaboration

Lisa Oliver 1 collaboration

Claire Gaignier 1 collaboration

Dominique Heymann 1 collaboration

Olivier Herault 1 collaboration

François M Vallette 1 collaboration

Christophe Olivier 1 collaboration

John C Nolan 1 collaboration

Tecla Marangon 1 collaboration

Milan Kovacevic 1 collaboration

Mathias Chatelais 1 collaboration

Pierre Meheust 1 collaboration

Jérome Abadie 1 collaboration

Irene Lodoso Torrecilla 1 collaboration

Joanna Maria Sadowska 1 collaboration

Silvia Maruelli 1 collaboration

Roberta Besio 1 collaboration

Julie Rousseau 1 collaboration

Nadia Garibaldi 1 collaboration

Jérôme Amiaud 1 collaboration

Virginie Escriou 1 collaboration

Antonio Rossi 1 collaboration

Valerie Trichet 1 collaboration

Antonella Forlino 1 collaboration

Rosa-María Gonzalo-Daganzo 1 collaboration

Marta Dominguez García-Simón 1 collaboration

Mariano Sanz 1 collaboration

Christer Dahlin 1 collaboration

Danae Apatzidou 1 collaboration

Zvi Artzi 1 collaboration

Darko Bozic 1 collaboration

Elena Calciolari 1 collaboration

Hugo De Bruyn 1 collaboration

Henrik Dommisch 1 collaboration

Nikos Donos 1 collaboration

Peter Eickholz 1 collaboration

Jan E Ellingsen 1 collaboration

Håvard J Haugen 1 collaboration

David Herrera 1 collaboration

France Lambert 1 collaboration

Eduardo Montero 1 collaboration

Omar Omar 1 collaboration

Henning Schliephake 1 collaboration

David Pastorino 1 collaboration

Carlos Aparicio 1 collaboration

Gonzague de Pinieux 1 collaboration

Miguel Mateu-Sanz 1 collaboration

Juan Tornín 1 collaboration

Anna Khlyustova 1 collaboration

Fiona E Freeman 1 collaboration

David C Browe 1 collaboration

Audrey Renaud 1 collaboration

Daniel J Kelly 1 collaboration

Laoise M McNamara 1 collaboration

Jordan M Iliopoulos 1 collaboration

Danae A Apatzidou 1 collaboration