Rick Lee Tarleton

Affiliations

Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America.

Publications (21)

Chagas Disease Drug Discovery: Multiparametric Lead Optimization against

Journal of medicinal chemistry

Avec: Charlotte Fleau , Angel Padilla , Juan Miguel-Siles , Maria T Quesada-Campos , Isabel Saiz-Nicolas , Ignacio Cotillo , Juan Cantizani Perez , Rick L Tarleton , Maria Marco , Gilles Courtemanche

New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma cruzi: Clinical, Parasitological, and Serological Assessment after Three Years of Follow-Up.

Antimicrobial agents and chemotherapy

Avec: María Gabriela Álvarez , Juan Carlos Ramírez , Graciela Bertocchi , Marisa Fernández , Yolanda Hernández , Bruno Lococo , Constanza Lopez-Albizu , Alejandro Schijman , Carolina Cura , Marcelo Abril , Susana Laucella , Rick L Tarleton , María Ailen Natale , Melisa Castro Eiro , Sergio Sosa-Estani , Rodolfo Viotti

Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease.

PLoS pathogens

Avec: Wei Wang , Duo Peng , Rodrigo P Baptista , Yiran Li , Jessica C Kissinger , Rick L Tarleton

Avoiding Clinical Trial Failures in Neglected Tropical Diseases: The Example of Chagas Disease.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Avec: Rick L Tarleton

Effective drug discovery in Chagas disease.

Trends in parasitology

Avec: Rick L Tarleton

Cutting Edge: Augmenting Muscle MHC Expression Enhances Systemic Pathogen Control at the Expense of T Cell Exhaustion.

Journal of immunology (Baltimore, Md. : 1950)

Avec: Angela D Pack , Rick L Tarleton

Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates.

Nature microbiology

Avec: Angel M Padilla , Wei Wang , Tsutomu Akama , David S Carter , Eric Easom , Yvonne Freund , Jason S Halladay , Yang Liu , Sarah A Hamer , Carolyn L Hodo , Gregory K Wilkerson , Dylan Orr , Brooke White , Arlene George , Huifeng Shen , Yiru Jin , Michael Zhuo Wang , Susanna Tse , Robert T Jacobs , Rick L Tarleton

B-Cell Responses in Chronic Chagas Disease: Waning of Trypanosoma cruzi-Specific Antibody-Secreting Cells Following Successful Etiological Treatment.

The Journal of infectious diseases

Avec: G Cesar , M A Natale , M C Albareda , M G Alvarez , B Lococo , A M De Rissio , M Fernandez , M D Castro Eiro , G Bertocchi , B E White , F Zabaleta , R Viotti , R L Tarleton , S A Laucella

Immune exhaustion in chronic Chagas disease: Pro-inflammatory and immunomodulatory action of IL-27 in vitro.

PLoS neglected tropical diseases

Avec: María Ailén Natale , Todd Minning , María Cecilia Albareda , Melisa Daiana Castro Eiro , María Gabriela Álvarez , Bruno Lococo , Gonzalo Cesar , Graciela Bertocchi , María Josefina Elias , María Belén Caputo , Rick Lee Tarleton , Susana Adriana Laucella

A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease.

Science translational medicine

Avec: Juan M Bustamante , Fernando Sanchez-Valdez , Angel M Padilla , Brooke White , Wei Wang , Rick L Tarleton

Protozoan persister-like cells and drug treatment failure.

Nature reviews. Microbiology

Avec: Michael P Barrett , Dennis E Kyle , L David Sibley , Joshua B Radke , Rick L Tarleton

Drug Discovery for Kinetoplastid Diseases: Future Directions.

ACS infectious diseases

Avec: Srinivasa P S Rao , Michael P Barrett , Glenn Dranoff , Christopher J Faraday , Claudio R Gimpelewicz , Asrat Hailu , Catherine L Jones , John M Kelly , Janis K Lazdins-Helds , Pascal Mäser , Jose Mengel , Jeremy C Mottram , Charles E Mowbray , David L Sacks , Phillip Scott , Gerald F Späth , Rick L Tarleton , Jonathan M Spector , Thierry T Diagana

Frequency Variation and Dose Modification of Benznidazole Administration for the Treatment of Trypanosoma cruzi Infection in Mice, Dogs, and Nonhuman Primates.

Antimicrobial agents and chemotherapy

Avec: Juan M Bustamante , Brooke E White , Gregory K Wilkerson , Carolyn L Hodo , Lisa D Auckland , Wei Wang , Stephanie McCain , Sarah A Hamer , Ashley B Saunders , Rick L Tarleton

High variation in immune responses and parasite phenotypes in naturally acquired Trypanosoma cruzi infection in a captive non-human primate breeding colony in Texas, USA.

PLoS neglected tropical diseases

Avec: Angel M Padilla , Phil Y Yao , Tre J Landry , Gretchen M Cooley , Susan M Mahaney , Isabela Ribeiro , John L VandeBerg , Rick L Tarleton

Reduced Trypanosoma cruzi-specific humoral response and enhanced T cell immunity after treatment interruption with benznidazole in chronic Chagas disease.

The Journal of antimicrobial chemotherapy

Avec: Melisa D Castro Eiro , María A Natale , María G Alvarez , Huifeng Shen , Rodolfo Viotti , Bruno Lococo , Jacqueline Bua , Myriam Nuñez , Graciela L Bertocchi , María C Albareda , Gonzalo Cesar , Rick L Tarleton , Susana A Laucella

A flexible, pan-species, multi-antigen platform for the detection and monitoring of SARS-CoV-2-specific antibody responses.

medRxiv : the preprint server for health sciences

Avec: Huifeng Shen , David Forgacs , Digantkumar Chapla , Kelley W Moremen , Lance Wells , Sarah A Hamer , Stephen M Tompkins , Ted M Ross , Nadine Rouphael , Srilatha Edupuganti , Matthew H Collins , Rick L Tarleton

Quantitative 3D Imaging of Trypanosoma cruzi-Infected Cells, Dormant Amastigotes, and T Cells in Intact Clarified Organs.

Journal of visualized experiments : JoVE

Avec: Fernando Sanchez-Valdez , Ángel M Padilla , Juan M Bustamante , Caleb W D Hawkins , Rick L Tarleton

Delayed Activation of T Cells at the Site of Infection Facilitates the Establishment of Trypanosoma cruzi in Both Naive and Immune Hosts.

mSphere

Avec: Angel M Padilla , Charles Rosenberg , Peter Cook , Fernando Sanchez-Valdez , Caroline McElhannon , Rick L Tarleton

Prophylactic low-dose, bi-weekly benznidazole treatment fails to prevent Trypanosoma cruzi infection in dogs under intense transmission pressure.

PLoS neglected tropical diseases

Avec: Juan M Bustamante , Angel M Padilla , Brooke White , Lisa D Auckland , Rachel E Busselman , Stephanie Collins , Elizabeth L Malcolm , Briana F Wilson , Ashley B Saunders , Sarah A Hamer , Rick L Tarleton

Positive clinical outcome using a modified dosing regimen of benznidazole in dogs at high risk for infection or acutely infected with Trypanosoma cruzi.

Journal of veterinary internal medicine

Avec: Sukjung Lim , Stephanie Collins , Sarah A Hamer , Rick L Tarleton , Ashley B Saunders

cGAS-STING Pathway Activation during Trypanosoma cruzi Infection Leads to Tissue-Dependent Parasite Control.

Journal of immunology (Baltimore, Md. : 1950)

Avec: Natasha Perumal , Brooke White , Fernando Sanchez-Valdez , Rick L Tarleton

Réseau de co-auteurs

Rick L Tarleton 19 collaborations

Angel M Padilla 5 collaborations

Sarah A Hamer 5 collaborations

Wei Wang 4 collaborations

Brooke White 4 collaborations

Juan M Bustamante 4 collaborations

Fernando Sanchez-Valdez 4 collaborations

Bruno Lococo 3 collaborations

Huifeng Shen 3 collaborations

Ashley B Saunders 3 collaborations

María Gabriela Álvarez 2 collaborations

Graciela Bertocchi 2 collaborations

Rodolfo Viotti 2 collaborations

Carolyn L Hodo 2 collaborations

Gregory K Wilkerson 2 collaborations

Gonzalo Cesar 2 collaborations

Michael P Barrett 2 collaborations

Lisa D Auckland 2 collaborations

Stephanie Collins 2 collaborations

Charlotte Fleau 1 collaboration

Angel Padilla 1 collaboration

Juan Miguel-Siles 1 collaboration

Maria T Quesada-Campos 1 collaboration

Isabel Saiz-Nicolas 1 collaboration

Ignacio Cotillo 1 collaboration

Juan Cantizani Perez 1 collaboration

Maria Marco 1 collaboration

Gilles Courtemanche 1 collaboration

Juan Carlos Ramírez 1 collaboration

Marisa Fernández 1 collaboration

Yolanda Hernández 1 collaboration

Constanza Lopez-Albizu 1 collaboration

Alejandro Schijman 1 collaboration

Carolina Cura 1 collaboration

Marcelo Abril 1 collaboration

Susana Laucella 1 collaboration

María Ailen Natale 1 collaboration

Melisa Castro Eiro 1 collaboration

Sergio Sosa-Estani 1 collaboration

Duo Peng 1 collaboration

Rodrigo P Baptista 1 collaboration

Yiran Li 1 collaboration

Jessica C Kissinger 1 collaboration

Angela D Pack 1 collaboration

Tsutomu Akama 1 collaboration

David S Carter 1 collaboration

Eric Easom 1 collaboration

Yvonne Freund 1 collaboration

Jason S Halladay 1 collaboration

Yang Liu 1 collaboration

Dylan Orr 1 collaboration

Arlene George 1 collaboration

Yiru Jin 1 collaboration

Michael Zhuo Wang 1 collaboration

Susanna Tse 1 collaboration

Robert T Jacobs 1 collaboration

G Cesar 1 collaboration

M A Natale 1 collaboration

M C Albareda 1 collaboration

M G Alvarez 1 collaboration

B Lococo 1 collaboration

A M De Rissio 1 collaboration

M Fernandez 1 collaboration

M D Castro Eiro 1 collaboration

G Bertocchi 1 collaboration

B E White 1 collaboration

F Zabaleta 1 collaboration

R Viotti 1 collaboration

R L Tarleton 1 collaboration

S A Laucella 1 collaboration

María Ailén Natale 1 collaboration

Todd Minning 1 collaboration

María Cecilia Albareda 1 collaboration

Melisa Daiana Castro Eiro 1 collaboration

María Josefina Elias 1 collaboration

María Belén Caputo 1 collaboration

Susana Adriana Laucella 1 collaboration

Dennis E Kyle 1 collaboration

L David Sibley 1 collaboration

Joshua B Radke 1 collaboration

Srinivasa P S Rao 1 collaboration

Glenn Dranoff 1 collaboration

Christopher J Faraday 1 collaboration

Claudio R Gimpelewicz 1 collaboration

Asrat Hailu 1 collaboration

Catherine L Jones 1 collaboration

John M Kelly 1 collaboration

Janis K Lazdins-Helds 1 collaboration

Pascal Mäser 1 collaboration

Jose Mengel 1 collaboration

Jeremy C Mottram 1 collaboration

Charles E Mowbray 1 collaboration

David L Sacks 1 collaboration

Phillip Scott 1 collaboration

Gerald F Späth 1 collaboration

Jonathan M Spector 1 collaboration

Thierry T Diagana 1 collaboration

Brooke E White 1 collaboration

Stephanie McCain 1 collaboration

Phil Y Yao 1 collaboration

Tre J Landry 1 collaboration

Gretchen M Cooley 1 collaboration

Susan M Mahaney 1 collaboration

Isabela Ribeiro 1 collaboration

John L VandeBerg 1 collaboration

Melisa D Castro Eiro 1 collaboration

María A Natale 1 collaboration

María G Alvarez 1 collaboration

Jacqueline Bua 1 collaboration

Myriam Nuñez 1 collaboration

Graciela L Bertocchi 1 collaboration

María C Albareda 1 collaboration

Susana A Laucella 1 collaboration

David Forgacs 1 collaboration

Digantkumar Chapla 1 collaboration

Kelley W Moremen 1 collaboration

Lance Wells 1 collaboration

Stephen M Tompkins 1 collaboration

Ted M Ross 1 collaboration

Nadine Rouphael 1 collaboration

Srilatha Edupuganti 1 collaboration

Matthew H Collins 1 collaboration

Ángel M Padilla 1 collaboration

Caleb W D Hawkins 1 collaboration

Charles Rosenberg 1 collaboration

Peter Cook 1 collaboration

Caroline McElhannon 1 collaboration

Rachel E Busselman 1 collaboration

Elizabeth L Malcolm 1 collaboration

Briana F Wilson 1 collaboration

Sukjung Lim 1 collaboration

Natasha Perumal 1 collaboration