Sebastien Bolze

Affiliations

Poxel, Lyon, France.

Publications (13)

Deuterium-Stabilized (

Hepatology communications

Avec: Vincent Jacques , Sébastien Bolze , Sophie Hallakou-Bozec , Anthony W Czarnik , Ajit S Divakaruni , Pascale Fouqueray , Anne N Murphy , Lex H T Van der Ploeg , Sheila DeWitt

Imeglimin amplifies glucose-stimulated insulin release from diabetic islets via a distinct mechanism of action.

PloS one

Avec: Sophie Hallakou-Bozec , Micheline Kergoat , Pascale Fouqueray , Sébastien Bolze , David E Moller

Beneficial Effects of the Direct AMP-Kinase Activator PXL770 in In Vitro and In Vivo Models of X-Linked Adrenoleukodystrophy.

The Journal of pharmacology and experimental therapeutics

Avec: Pierre-Axel Monternier , Parveen Parasar , Pierre Theurey , Pascale Gluais Dagorn , Navtej Kaur , Tavarekere N Nagaraja , Pascale Fouqueray , Sébastien Bolze , David E Moller , Jaspreet Singh , Sophie Hallakou-Bozec

Pharmacokinetics of Imeglimin in Caucasian and Japanese Healthy Subjects.

Clinical drug investigation

Avec: Pascale Fouqueray , Clémence Chevalier , Sébastien Bolze

Phase 2 trial with imeglimin in patients with Type 2 diabetes indicates effects on insulin secretion and sensitivity.

Endocrinology, diabetes & metabolism

Avec: Pierre Theurey , Carole Thang , Valdis Pirags , Andrea Mari , Giovanni Pacini , Sébastien Bolze , Sophie Hallakou-Bozec , Pascale Fouqueray

Imeglimin Does Not Induce Clinically Relevant Pharmacokinetic Interactions When Combined with Either Metformin or Sitagliptin in Healthy Subjects.

Clinical pharmacokinetics

Avec: Pascale Fouqueray , Sandrine Perrimond-Dauchy , Sébastien Bolze

Absence of QTc prolongation in a thorough QT study with imeglimin, a first in class oral agent for type 2 diabetes mellitus.

European journal of clinical pharmacology

Avec: Julie Dubourg , Sandrine Perrimond-Dauchy , Mathieu Felices , Sébastien Bolze , Pascal Voiriot , Pascale Fouqueray

Efficacy and safety of PXL770, a direct AMP kinase activator, for the treatment of non-alcoholic fatty liver disease (STAMP-NAFLD): a randomised, double-blind, placebo-controlled, phase 2a study.

The lancet. Gastroenterology & hepatology

Avec: Kenneth Cusi , Naim Alkhouri , Stephen A Harrison , Pascale Fouqueray , David E Moller , Sophie Hallakou-Bozec , Sebastien Bolze , Jean-Marie Grouin , Sophie Jeannin Megnien , Julie Dubourg , Vlad Ratziu

Pharmacokinetics of Imeglimin in Subjects with Moderate Hepatic Impairment.

Clinical pharmacokinetics

Avec: Clémence Chevalier , Julie Dubourg , Sébastien Bolze , Pascale Fouqueray

Mechanism of action of Imeglimin: A novel therapeutic agent for type 2 diabetes.

Diabetes, obesity & metabolism

Avec: Sophie Hallakou-Bozec , Guillaume Vial , Micheline Kergoat , Pascale Fouqueray , Sébastien Bolze , Anne-Laure Borel , Eric Fontaine , David E Moller

Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis.

Hepatology communications

Avec: Pascale Gluais-Dagorn , Marc Foretz , Gregory R Steinberg , Battsetseg Batchuluun , Anna Zawistowska-Deniziak , Joost M Lambooij , Bruno Guigas , David Carling , Pierre-Axel Monternier , David E Moller , Sebastien Bolze , Sophie Hallakou-Bozec

Lack of Drug-Drug Interaction Between Cimetidine, a Renal Transporter Inhibitor, and Imeglimin, a Novel Oral Antidiabetic Drug, in Healthy Volunteers.

European journal of drug metabolism and pharmacokinetics

Avec: Clémence Chevalier , Sandrine Perrimond-Dauchy , Julie Dubourg , Pascale Fouqueray , Sébastien Bolze

Importance of the PD-1/PD-L1 Axis for Malignant Transformation and Risk Assessment of Oral Leukoplakia.

Biomedicines

Avec: Jutta Ries , Abbas Agaimy , Falk Wehrhan , Christoph Baran , Stella Bolze , Eva Danzer , Silke Frey , Jonathan Jantsch , Tobias Möst , Maike Büttner-Herold , Claudia Wickenhauser , Marco Kesting , Manuel Weber

Réseau de co-auteurs

Pascale Fouqueray 11 collaborations

Sébastien Bolze 10 collaborations

Sophie Hallakou-Bozec 7 collaborations

David E Moller 5 collaborations

Julie Dubourg 4 collaborations

Clémence Chevalier 3 collaborations

Sandrine Perrimond-Dauchy 3 collaborations

Micheline Kergoat 2 collaborations

Pierre-Axel Monternier 2 collaborations

Pierre Theurey 2 collaborations

Vincent Jacques 1 collaboration

Anthony W Czarnik 1 collaboration

Ajit S Divakaruni 1 collaboration

Anne N Murphy 1 collaboration

Lex H T Van der Ploeg 1 collaboration

Sheila DeWitt 1 collaboration

Parveen Parasar 1 collaboration

Pascale Gluais Dagorn 1 collaboration

Navtej Kaur 1 collaboration

Tavarekere N Nagaraja 1 collaboration

Jaspreet Singh 1 collaboration

Carole Thang 1 collaboration

Valdis Pirags 1 collaboration

Andrea Mari 1 collaboration

Giovanni Pacini 1 collaboration

Mathieu Felices 1 collaboration

Pascal Voiriot 1 collaboration

Kenneth Cusi 1 collaboration

Naim Alkhouri 1 collaboration

Stephen A Harrison 1 collaboration

Jean-Marie Grouin 1 collaboration

Sophie Jeannin Megnien 1 collaboration

Vlad Ratziu 1 collaboration

Guillaume Vial 1 collaboration

Anne-Laure Borel 1 collaboration

Eric Fontaine 1 collaboration

Pascale Gluais-Dagorn 1 collaboration

Marc Foretz 1 collaboration

Gregory R Steinberg 1 collaboration

Battsetseg Batchuluun 1 collaboration

Anna Zawistowska-Deniziak 1 collaboration

Joost M Lambooij 1 collaboration

Bruno Guigas 1 collaboration

David Carling 1 collaboration

Jutta Ries 1 collaboration

Abbas Agaimy 1 collaboration

Falk Wehrhan 1 collaboration

Christoph Baran 1 collaboration

Stella Bolze 1 collaboration

Eva Danzer 1 collaboration

Silke Frey 1 collaboration

Jonathan Jantsch 1 collaboration

Tobias Möst 1 collaboration

Maike Büttner-Herold 1 collaboration

Claudia Wickenhauser 1 collaboration

Marco Kesting 1 collaboration

Manuel Weber 1 collaboration