Tim W Failes

Affiliations

Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.
ACRF Drug Discovery Centre, Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, New South Wales, Australia.

Publications (14)

Anti-cancer potential of synergistic phytochemical combinations is influenced by the genetic profile of prostate cancer cell lines.

Frontiers in nutrition

Avec: Carol A Gano , Shadma Fatima , Timothy W Failes , Gregory M Arndt , Mila Sajinovic , David Mahns , Ahmad Saedisomeolia , Jens R Coorssen , Joseph Bucci , Paul de Souza , Fatemeh Vafaee , Kieran F Scott

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction.

Oncogene

Avec: Klaartje Somers , Victoria W Wen , Shiloh M C Middlemiss , Brenna Osborne , Helen Forgham , MoonSun Jung , Mawar Karsa , Molly Clifton , Angelika Bongers , Jixuan Gao , Chelsea Mayoh , Newsha Raoufi-Rad , Eric P Kusnadi , Kate M Hannan , David A Scott , Alan Kwek , Bing Liu , Claudia Flemming , Daria A Chudakova , Ruby Pandher , Tim W Failes , James Lim , Andrea Angeli , Andrei L Osterman , Toshihiko Imamura , Ursula R Kees , Claudiu T Supuran , Richard B Pearson , Ross D Hannan , Thomas P Davis , Joshua McCarroll , Maria Kavallaris , Nigel Turner , Andrei V Gudkov , Michelle Haber , Murray D Norris , Michelle J Henderson

Contribution of mutant HSC clones to immature and mature cells in MDS and CMML, and variations with AZA therapy.

Blood

Avec: Annatina S Schnegg-Kaufmann , Julie A I Thoms , Golam Sarower Bhuyan , Henry R Hampton , Lachlin Vaughan , Kayleigh Rutherford , Purvi M Kakadia , Hui Mei Lee , Emma M V Johansson , Timothy W Failes , Greg M Arndt , Jason Koval , Robert Lindeman , Pauline Warburton , Alba Rodriguez-Meira , Adam J Mead , Ashwin Unnikrishnan , Sarah Davidson , Mark N Polizzotto , Mark Hertzberg , Elli Papaemmanuil , Stefan K Bohlander , Omid R Faridani , Christopher J Jolly , Fabio Zanini , John E Pimanda

High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer.

Cancer research

Avec: Chelsea Mayoh , Jie Mao , Jinhan Xie , Gabor Tax , Shu-Oi Chow , Roxanne Cadiz , Karina Pazaky , Paulette Barahona , Pamela Ajuyah , Peter Trebilcock , Angela Malquori , Kate Gunther , Anica Avila , Doo Young Yun , Stephanie Alfred , Anjana Gopalakrishnan , Alvin Kamili , Marie Wong , Mark J Cowley , Sophie Jessop , Loretta M S Lau , Toby N Trahair , David S Ziegler , Jamie I Fletcher , Andrew J Gifford , Maria Tsoli , Glenn M Marshall , Michelle Haber , Vanessa Tyrrell , Timothy W Failes , Greg M Arndt , Richard B Lock , Paul G Ekert , M Emmy M Dolman

FDA-approved disulfiram as a novel treatment for aggressive leukemia.

Journal of molecular medicine (Berlin, Germany)

Avec: Mawar Karsa , Lin Xiao , Emma Ronca , Angelika Bongers , Dayna Spurling , Ayu Karsa , Sandra Cantilena , Anna Mariana , Tim W Failes , Greg M Arndt , Laurence C Cheung , Rishi S Kotecha , Rosemary Sutton , Richard B Lock , Owen Williams , Jasper de Boer , Michelle Haber , Murray D Norris , Michelle J Henderson , Klaartje Somers

High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained.

Cell systems

Avec: Nicole S Bryce , Tim W Failes , Justine R Stehn , Karen Baker , Stefan Zahler , Yulia Arzhaeva , Leanne Bischof , Ciaran Lyons , Irina Dedova , Greg M Arndt , Katharina Gaus , Benjamin T Goult , Edna C Hardeman , Peter W Gunning , John G Lock

βIII-tubulin suppression enhances the activity of Amuvatinib to inhibit cell proliferation in c-Met positive non-small cell lung cancer cells.

Cancer medicine

Avec: Simon Brayford , Alastair Duly , Wee Siang Teo , Tanya Dwarte , Estrella Gonzales-Aloy , Zerong Ma , Laura McVeigh , Timothy W Failes , Greg M Arndt , Joshua A McCarroll , Maria Kavallaris

Accelerating development of high-risk neuroblastoma patient-derived xenograft models for preclinical testing and personalised therapy.

British journal of cancer

Avec: Alvin Kamili , Andrew J Gifford , Nancy Li , Chelsea Mayoh , Shu-Oi Chow , Timothy W Failes , Georgina L Eden , Roxanne Cadiz , Jinhan Xie , Robyn E Lukeis , Murray D Norris , Michelle Haber , Geoffrey B McCowage , Greg M Arndt , Toby N Trahair , Jamie I Fletcher

In vitro and in vivo drug screens of tumor cells identify novel therapies for high-risk child cancer.

EMBO molecular medicine

Avec: Loretta M S Lau , Chelsea Mayoh , Jinhan Xie , Paulette Barahona , Karen L MacKenzie , Marie Wong , Alvin Kamili , Maria Tsoli , Tim W Failes , Amit Kumar , Emily V A Mould , Andrew Gifford , Shu-Oi Chow , Mark Pinese , Jamie I Fletcher , Greg M Arndt , Dong-Anh Khuong-Quang , Carol Wadham , Daniel Batey , Georgina Eden , Peter Trebilcock , Swapna Joshi , Stephanie Alfred , Anjana Gopalakrishnan , Aaminah Khan , Dylan Grebert Wade , Patrick A Strong , Elodie Manouvrier , Lisa T Morgan , Miriam Span , Jin Yi Lim , Roxanne Cadiz , Caitlin Ung , David M Thomas , Katherine M Tucker , Meera Warby , Geoffrey B McCowage , Luciano Dalla-Pozza , Jennifer A Byrne , Federica Saletta , Andrew Fellowes , Stephen B Fox , Murray D Norris , Vanessa Tyrrell , Toby N Trahair , Richard B Lock , Mark J Cowley , Paul G Ekert , Michelle Haber , David S Ziegler , Glenn M Marshall

Doxorubicin-Loaded Gold Nanoarchitectures as a Therapeutic Strategy against Diffuse Intrinsic Pontine Glioma.

Cancers

Avec: Caitlin Ung , Maria Tsoli , Jie Liu , Domenico Cassano , Salvador Pocoví-Martínez , Dannielle H Upton , Anahid Ehteda , Friederike M Mansfeld , Timothy W Failes , Annafranca Farfalla , Christopher Katsinas , Maria Kavallaris , Greg M Arndt , Orazio Vittorio , Giuseppe Cirillo , Valerio Voliani , David S Ziegler

Systematic

Frontiers in oncology

Avec: Mawar Karsa , Emma Ronca , Angelika Bongers , Anna Mariana , Ernest Moles , Timothy W Failes , Greg M Arndt , Laurence C Cheung , Rishi S Kotecha , Maria Kavallaris , Michelle Haber , Murray D Norris , Michelle J Henderson , Lin Xiao , Klaartje Somers

The important role of routine cytopathology in pediatric precision oncology.

Cancer cytopathology

Avec: Jinhan Xie , Amit Kumar , M Emmy M Dolman , Chelsea Mayoh , Dong-Anh Khuong-Quang , Roxanne Cadiz , Marie Wong-Erasmus , Emily V A Mould , Dylan Grebert-Wade , Paulette Barahona , Alvin Kamili , Maria Tsoli , Timothy W Failes , Shu-Oi Chow , Greg M Arndt , Kanika Bhatia , Glenn M Marshall , David S Ziegler , Michelle Haber , Richard B Lock , Vanessa Tyrrell , Loretta Lau , Penny Athanasatos , Andrew J Gifford

Combination drug screen targeting glioblastoma core vulnerabilities reveals pharmacological synergisms.

EBioMedicine

Avec: Jérémy Ariey-Bonnet , Raphael Berges , Marie-Pierre Montero , Baptiste Mouysset , Patricia Piris , Kevin Muller , Guillaume Pinna , Tim W Failes , Greg M Arndt , Philippe Morando , Nathalie Baeza-Kallee , Carole Colin , Olivier Chinot , Diane Braguer , Xavier Morelli , Nicolas André , Manon Carré , Emeline Tabouret , Dominique Figarella-Branger , Marion Le Grand , Eddy Pasquier

Invasion-Block and S-MARVEL: A high-content screening and image analysis platform identifies ATM kinase as a modulator of melanoma invasion and metastasis.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Dajiang Guo , Russell Jurek , Kimberley A Beaumont , Danae S Sharp , Sioh-Yang Tan , Anna Mariana , Timothy W Failes , Abigail K Grootveld , Nayan D Bhattacharyya , Tri Giang Phan , Greg M Arndt , Rohit Jain , Wolfgang Weninger , Shweta Tikoo

Réseau de co-auteurs

Greg M Arndt 12 collaborations

Timothy W Failes 9 collaborations

Michelle Haber 7 collaborations

Chelsea Mayoh 5 collaborations

Murray D Norris 5 collaborations

Maria Kavallaris 4 collaborations

Jinhan Xie 4 collaborations

Shu-Oi Chow 4 collaborations

Roxanne Cadiz 4 collaborations

Alvin Kamili 4 collaborations

David S Ziegler 4 collaborations

Maria Tsoli 4 collaborations

Richard B Lock 4 collaborations

Klaartje Somers 3 collaborations

Mawar Karsa 3 collaborations

Angelika Bongers 3 collaborations

Michelle J Henderson 3 collaborations

Paulette Barahona 3 collaborations

Toby N Trahair 3 collaborations

Jamie I Fletcher 3 collaborations

Andrew J Gifford 3 collaborations

Glenn M Marshall 3 collaborations

Vanessa Tyrrell 3 collaborations

Anna Mariana 3 collaborations

Peter Trebilcock 2 collaborations

Stephanie Alfred 2 collaborations

Anjana Gopalakrishnan 2 collaborations

Marie Wong 2 collaborations

Mark J Cowley 2 collaborations

Loretta M S Lau 2 collaborations

Paul G Ekert 2 collaborations

M Emmy M Dolman 2 collaborations

Lin Xiao 2 collaborations

Emma Ronca 2 collaborations

Laurence C Cheung 2 collaborations

Rishi S Kotecha 2 collaborations

Geoffrey B McCowage 2 collaborations

Amit Kumar 2 collaborations

Emily V A Mould 2 collaborations

Dong-Anh Khuong-Quang 2 collaborations

Caitlin Ung 2 collaborations

Carol A Gano 1 collaboration

Shadma Fatima 1 collaboration

Gregory M Arndt 1 collaboration

Mila Sajinovic 1 collaboration

David Mahns 1 collaboration

Ahmad Saedisomeolia 1 collaboration

Jens R Coorssen 1 collaboration

Joseph Bucci 1 collaboration

Paul de Souza 1 collaboration

Fatemeh Vafaee 1 collaboration

Kieran F Scott 1 collaboration

Victoria W Wen 1 collaboration

Shiloh M C Middlemiss 1 collaboration

Brenna Osborne 1 collaboration

Helen Forgham 1 collaboration

MoonSun Jung 1 collaboration

Molly Clifton 1 collaboration

Jixuan Gao 1 collaboration

Newsha Raoufi-Rad 1 collaboration

Eric P Kusnadi 1 collaboration

Kate M Hannan 1 collaboration

David A Scott 1 collaboration

Alan Kwek 1 collaboration

Bing Liu 1 collaboration

Claudia Flemming 1 collaboration

Daria A Chudakova 1 collaboration

Ruby Pandher 1 collaboration

James Lim 1 collaboration

Andrea Angeli 1 collaboration

Andrei L Osterman 1 collaboration

Toshihiko Imamura 1 collaboration

Ursula R Kees 1 collaboration

Claudiu T Supuran 1 collaboration

Richard B Pearson 1 collaboration

Ross D Hannan 1 collaboration

Thomas P Davis 1 collaboration

Joshua McCarroll 1 collaboration

Nigel Turner 1 collaboration

Andrei V Gudkov 1 collaboration

Annatina S Schnegg-Kaufmann 1 collaboration

Julie A I Thoms 1 collaboration

Golam Sarower Bhuyan 1 collaboration

Henry R Hampton 1 collaboration

Lachlin Vaughan 1 collaboration

Kayleigh Rutherford 1 collaboration

Purvi M Kakadia 1 collaboration

Hui Mei Lee 1 collaboration

Emma M V Johansson 1 collaboration

Jason Koval 1 collaboration

Robert Lindeman 1 collaboration

Pauline Warburton 1 collaboration

Alba Rodriguez-Meira 1 collaboration

Adam J Mead 1 collaboration

Ashwin Unnikrishnan 1 collaboration

Sarah Davidson 1 collaboration

Mark N Polizzotto 1 collaboration

Mark Hertzberg 1 collaboration

Elli Papaemmanuil 1 collaboration

Stefan K Bohlander 1 collaboration

Omid R Faridani 1 collaboration

Christopher J Jolly 1 collaboration

Fabio Zanini 1 collaboration

John E Pimanda 1 collaboration

Jie Mao 1 collaboration

Gabor Tax 1 collaboration

Karina Pazaky 1 collaboration

Pamela Ajuyah 1 collaboration

Angela Malquori 1 collaboration

Kate Gunther 1 collaboration

Anica Avila 1 collaboration

Doo Young Yun 1 collaboration

Sophie Jessop 1 collaboration

Dayna Spurling 1 collaboration

Ayu Karsa 1 collaboration

Sandra Cantilena 1 collaboration

Rosemary Sutton 1 collaboration

Owen Williams 1 collaboration

Jasper de Boer 1 collaboration

Nicole S Bryce 1 collaboration

Justine R Stehn 1 collaboration

Karen Baker 1 collaboration

Stefan Zahler 1 collaboration

Yulia Arzhaeva 1 collaboration

Leanne Bischof 1 collaboration

Ciaran Lyons 1 collaboration

Irina Dedova 1 collaboration

Katharina Gaus 1 collaboration

Benjamin T Goult 1 collaboration

Edna C Hardeman 1 collaboration

Peter W Gunning 1 collaboration

John G Lock 1 collaboration

Simon Brayford 1 collaboration

Alastair Duly 1 collaboration

Wee Siang Teo 1 collaboration

Tanya Dwarte 1 collaboration

Estrella Gonzales-Aloy 1 collaboration

Zerong Ma 1 collaboration

Laura McVeigh 1 collaboration

Joshua A McCarroll 1 collaboration

Nancy Li 1 collaboration

Georgina L Eden 1 collaboration

Robyn E Lukeis 1 collaboration

Karen L MacKenzie 1 collaboration

Andrew Gifford 1 collaboration

Mark Pinese 1 collaboration

Carol Wadham 1 collaboration

Daniel Batey 1 collaboration

Georgina Eden 1 collaboration

Swapna Joshi 1 collaboration

Aaminah Khan 1 collaboration

Dylan Grebert Wade 1 collaboration

Patrick A Strong 1 collaboration

Elodie Manouvrier 1 collaboration

Lisa T Morgan 1 collaboration

Miriam Span 1 collaboration

Jin Yi Lim 1 collaboration

David M Thomas 1 collaboration

Katherine M Tucker 1 collaboration

Meera Warby 1 collaboration

Luciano Dalla-Pozza 1 collaboration

Jennifer A Byrne 1 collaboration

Federica Saletta 1 collaboration

Andrew Fellowes 1 collaboration

Stephen B Fox 1 collaboration

Jie Liu 1 collaboration

Domenico Cassano 1 collaboration

Salvador Pocoví-Martínez 1 collaboration

Dannielle H Upton 1 collaboration

Anahid Ehteda 1 collaboration

Friederike M Mansfeld 1 collaboration

Annafranca Farfalla 1 collaboration

Christopher Katsinas 1 collaboration

Orazio Vittorio 1 collaboration

Giuseppe Cirillo 1 collaboration

Valerio Voliani 1 collaboration

Ernest Moles 1 collaboration

Marie Wong-Erasmus 1 collaboration

Dylan Grebert-Wade 1 collaboration

Kanika Bhatia 1 collaboration

Loretta Lau 1 collaboration

Penny Athanasatos 1 collaboration

Jérémy Ariey-Bonnet 1 collaboration

Raphael Berges 1 collaboration

Marie-Pierre Montero 1 collaboration

Baptiste Mouysset 1 collaboration

Patricia Piris 1 collaboration

Kevin Muller 1 collaboration

Guillaume Pinna 1 collaboration

Philippe Morando 1 collaboration

Nathalie Baeza-Kallee 1 collaboration

Carole Colin 1 collaboration

Olivier Chinot 1 collaboration

Diane Braguer 1 collaboration

Xavier Morelli 1 collaboration

Nicolas André 1 collaboration

Manon Carré 1 collaboration

Emeline Tabouret 1 collaboration

Dominique Figarella-Branger 1 collaboration

Marion Le Grand 1 collaboration

Eddy Pasquier 1 collaboration

Dajiang Guo 1 collaboration

Russell Jurek 1 collaboration

Kimberley A Beaumont 1 collaboration

Danae S Sharp 1 collaboration

Sioh-Yang Tan 1 collaboration

Abigail K Grootveld 1 collaboration

Nayan D Bhattacharyya 1 collaboration

Tri Giang Phan 1 collaboration

Rohit Jain 1 collaboration

Wolfgang Weninger 1 collaboration

Shweta Tikoo 1 collaboration