Oui, l'âge peut affecter l'expression de Wnt-5a et son rôle dans diverses pathologies.
ÂgeExpression génétique
#3
Le tabagisme affecte-t-il Wnt-5a ?
Oui, le tabagisme peut altérer l'expression de Wnt-5a, augmentant le risque de cancer.
TabagismeRisque de cancer
#4
Y a-t-il un lien entre l'alimentation et Wnt-5a ?
Oui, une alimentation riche en graisses peut influencer négativement l'expression de Wnt-5a.
AlimentationGraisses alimentaires
#5
Le stress chronique impacte-t-il Wnt-5a ?
Oui, le stress chronique peut perturber la régulation de Wnt-5a, augmentant les risques de maladies.
Stress chroniqueRégulation hormonale
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"@type": "Question",
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"@type": "Question",
"name": "Wnt-5a affecte-t-il le système nerveux ?",
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"@type": "Question",
"name": "Peut-on prévenir les anomalies de Wnt-5a ?",
"position": 11,
"acceptedAnswer": {
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"text": "La prévention passe par une bonne santé maternelle et des soins prénatals appropriés."
}
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"@type": "Question",
"name": "Y a-t-il des facteurs environnementaux affectant Wnt-5a ?",
"position": 12,
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"@type": "Question",
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"position": 13,
"acceptedAnswer": {
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}
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"@type": "Question",
"name": "Les suppléments nutritionnels aident-ils Wnt-5a ?",
"position": 14,
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"text": "Certains suppléments, comme les acides gras oméga-3, peuvent moduler l'expression de Wnt-5a."
}
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{
"@type": "Question",
"name": "La gestion du stress influence-t-elle Wnt-5a ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la gestion du stress peut avoir un impact positif sur la régulation de Wnt-5a."
}
},
{
"@type": "Question",
"name": "Comment traiter les anomalies de Wnt-5a ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des thérapies ciblées et des traitements immunologiques peuvent être envisagés."
}
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{
"@type": "Question",
"name": "Y a-t-il des médicaments ciblant Wnt-5a ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des inhibiteurs de la voie Wnt sont en développement pour traiter certains cancers."
}
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{
"@type": "Question",
"name": "La thérapie génique peut-elle aider Wnt-5a ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "La thérapie génique est explorée pour corriger les anomalies de Wnt-5a dans certaines conditions."
}
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{
"@type": "Question",
"name": "Quels traitements sont efficaces contre le cancer lié à Wnt-5a ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements combinés de chimiothérapie et d'immunothérapie montrent des résultats prometteurs."
}
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{
"@type": "Question",
"name": "Des essais cliniques existent-ils pour Wnt-5a ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, plusieurs essais cliniques évaluent des traitements ciblant la voie Wnt-5a."
}
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{
"@type": "Question",
"name": "Quelles complications sont liées à Wnt-5a ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des malformations congénitales et des cancers avancés."
}
},
{
"@type": "Question",
"name": "Wnt-5a peut-il causer des troubles métaboliques ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une dysrégulation de Wnt-5a peut contribuer à des troubles métaboliques."
}
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"@type": "Question",
"name": "Y a-t-il des risques de récidive de cancer avec Wnt-5a ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une expression anormale de Wnt-5a est associée à un risque accru de récidive."
}
},
{
"@type": "Question",
"name": "Wnt-5a influence-t-il la réponse immunitaire ?",
"position": 24,
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"@type": "Answer",
"text": "Oui, Wnt-5a peut moduler la réponse immunitaire, affectant la susceptibilité aux infections."
}
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"@type": "Question",
"name": "Des complications neurologiques sont-elles possibles avec Wnt-5a ?",
"position": 25,
"acceptedAnswer": {
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"text": "Oui, des anomalies de Wnt-5a peuvent entraîner des complications neurologiques."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour Wnt-5a ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des prédispositions génétiques et des expositions environnementales."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il Wnt-5a ?",
"position": 27,
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"@type": "Answer",
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}
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{
"@type": "Question",
"name": "Le tabagisme affecte-t-il Wnt-5a ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme peut altérer l'expression de Wnt-5a, augmentant le risque de cancer."
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},
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"@type": "Question",
"name": "Y a-t-il un lien entre l'alimentation et Wnt-5a ?",
"position": 29,
"acceptedAnswer": {
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"text": "Oui, une alimentation riche en graisses peut influencer négativement l'expression de Wnt-5a."
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"@type": "Question",
"name": "Le stress chronique impacte-t-il Wnt-5a ?",
"position": 30,
"acceptedAnswer": {
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}
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Group of Cell Motility and Muscle Contraction, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Group of Cell Motility and Muscle Contraction, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China lixd@ioz.ac.cn.
University of Chinese Academy of Sciences, Beijing 100049, China.
Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile; Centro de Excelencia en Biomedicina de Magallanes (CEBIMA), Escuela de Medicina, Universidad de Magallanes, Punta Arenas, Chile. Electronic address: ninestrosa@bio.puc.cl.
Group of Cell Motility and Muscle Contraction, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Group of Cell Motility and Muscle Contraction, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Group of Cell Motility and Muscle Contraction, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Group of Cell Motility and Muscle Contraction, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.
During an immune response to microbial infection, CD8+ T cells give rise to short-lived effector cells and memory cells that provide sustained protection. Although the transcriptional programs regulat...
Despite many advances in treatment over the past few years, the poor 5-year survival rate and high recurrence rate of gastric cancer (GC) remain unsatisfactory. As the most abundant epigenetic modific...
Dysregulated epigenetic and transcriptional programming due to abnormalities of transcription factors (TFs) contributes to and sustains the oncogenicity of cancer cells. Here, we unveiled the role of ...
Protein arginine methyltransferase 6 (PRMT6) is a type I arginine methyltransferase that asymmetrically dimethylates histone H3 arginine 2 (H3R2me2a). However, the biological roles and underlying mole...
PRMT6 expression in CRC tissue was examined using immunohistochemistry. The effect of PRMT6 on CRC cells was investigated in vitro and in vivo. Mass spectrometry, co-immunoprecipitation and GST pulldo...
PRMT6 is significantly upregulated in CRC tissues and facilitates cell proliferation of CRC cells in vitro and in vivo. Through RNA-seq analysis, CDKN2B (p15...
PRMT6 functionally associates with PRMT5 to promote CRC progression through epigenetically repressing the expression of CDKN2B and CCNG1. These insights raise the possibility that combinational interv...
Diabetes is associated with epigenetic modifications including DNA methylation and miRNA changes. Diabetic complications in the cornea can cause persistent epithelial defects and impaired wound healin...
Human LEC were isolated, or organ-cultured corneas were obtained, from autopsy eyes from non-diabetic (59.87±20.89 years) and diabetic (71.93±9.29 years) donors. The groups were not statistically diff...
There was significant differential DNA methylation between diabetic and non-diabetic LEC. WNT5A promoter was hypermethylated in diabetic LEC accompanied with markedly decreased Wnt-5a protein. Treatme...
We provide the first account of epigenetic changes in diabetic corneas including dual inhibition of WNT5A by DNA methylation and miRNA action. Overall, Wnt-5a is a new corneal epithelial wound healing...
The DNA methylation dataset is available from the public GEO repository under accession no. GSE229328 ( https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE229328 )....
Epigenetic regulation of heart development remains incompletely understood. Here we show that LSD1, a histone demethylase, plays a crucial role in regulating cardiomyocyte proliferation during heart d...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades the innate immune machinery through multiple viral proteins, including nonstructural protein 1 (NSP1). While NSP1 is known to su...
Epigenetics plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Some studies have reported that YAP is involved in inflammatory response and can regulate target genes thro...
YAP expression was significantly increased in both in vitro and in vivo colitis models as well as in patients with IBD. Epithelial-specific knockout of YAP aggravates disease progression in dextran so...
Our findings elucidate an epigenetic mechanism by which YAP inhibits the inflammatory response in colitis through epigenetic silencing of JMJD3 by recruiting EZH2....