Quels facteurs de risque sont étudiés avec les A549 ?
Des facteurs comme le tabagisme, l'exposition à des agents chimiques et la pollution.
Facteurs de risquePollution
#2
Les A549 aident-elles à identifier des facteurs génétiques ?
Elles peuvent être utilisées pour étudier l'expression génique liée à des prédispositions au cancer.
Facteurs génétiquesExpression génique
#3
Comment les A549 sont-elles utilisées pour étudier l'environnement ?
Elles permettent d'évaluer l'impact des toxines environnementales sur les cellules pulmonaires.
Toxines environnementalesImpact environnemental
#4
Peut-on étudier l'alimentation avec les A549 ?
Indirectement, elles peuvent être utilisées pour explorer l'impact des nutriments sur le cancer.
AlimentationNutriments
#5
Les A549 sont-elles utiles pour étudier le stress oxydatif ?
Oui, elles sont souvent utilisées pour examiner les effets du stress oxydatif sur les cellules.
Stress oxydatifCellules
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"position": 6,
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"@type": "Question",
"name": "Les cellules A549 peuvent-elles simuler des symptômes humains ?",
"position": 7,
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"text": "Elles peuvent être utilisées pour étudier des symptômes liés aux maladies pulmonaires."
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"@type": "Question",
"name": "Comment les A549 aident-elles à comprendre les symptômes du cancer ?",
"position": 8,
"acceptedAnswer": {
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"@type": "Question",
"name": "Les cellules A549 montrent-elles des signes de stress cellulaire ?",
"position": 9,
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"name": "Peut-on observer des symptômes de résistance dans les A549 ?",
"position": 10,
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"name": "Les cellules A549 aident-elles à la prévention du cancer ?",
"position": 11,
"acceptedAnswer": {
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"text": "Indirectement, elles sont utilisées pour étudier les mécanismes de la carcinogenèse."
}
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"@type": "Question",
"name": "Comment les A549 contribuent-elles à la recherche préventive ?",
"position": 12,
"acceptedAnswer": {
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"text": "Elles permettent d'identifier des biomarqueurs et des cibles pour la prévention du cancer."
}
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"@type": "Question",
"name": "Peut-on utiliser les A549 pour étudier des facteurs de risque ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles sont utilisées pour étudier l'impact de divers facteurs environnementaux sur le cancer."
}
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"@type": "Question",
"name": "Les A549 sont-elles utiles pour la recherche sur le tabagisme ?",
"position": 14,
"acceptedAnswer": {
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"text": "Oui, elles sont souvent utilisées pour étudier les effets du tabagisme sur les cellules pulmonaires."
}
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"@type": "Question",
"name": "Comment les A549 aident-elles à comprendre la prévention des maladies ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles permettent d'explorer les mécanismes de protection et les interventions préventives."
}
},
{
"@type": "Question",
"name": "Quels traitements sont testés sur les cellules A549 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements anticancéreux et les thérapies ciblées sont souvent testés sur ces cellules."
}
},
{
"@type": "Question",
"name": "Les A549 sont-elles utilisées pour des essais cliniques ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, elles sont utilisées pour des études précliniques et non pour des essais cliniques directs."
}
},
{
"@type": "Question",
"name": "Comment les A549 aident-elles à développer de nouveaux traitements ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles permettent d'évaluer l'efficacité et la toxicité des nouveaux composés thérapeutiques."
}
},
{
"@type": "Question",
"name": "Les cellules A549 peuvent-elles prédire la réponse au traitement ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent fournir des indications sur la réponse aux traitements, mais ne sont pas définitives."
}
},
{
"@type": "Question",
"name": "Quels agents sont souvent testés sur les A549 ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des agents chimiothérapeutiques comme le cisplatine et des inhibiteurs de tyrosine kinase."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent être étudiées avec les A549 ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles permettent d'étudier les complications liées aux traitements du cancer et aux métastases."
}
},
{
"@type": "Question",
"name": "Les A549 peuvent-elles simuler des complications pulmonaires ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles sont utilisées pour modéliser des complications comme la fibrose pulmonaire."
}
},
{
"@type": "Question",
"name": "Comment les A549 aident-elles à comprendre les complications du cancer ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles permettent d'étudier les interactions entre les cellules tumorales et le microenvironnement."
}
},
{
"@type": "Question",
"name": "Peut-on étudier la résistance aux traitements avec les A549 ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles sont souvent utilisées pour comprendre les mécanismes de résistance aux traitements."
}
},
{
"@type": "Question",
"name": "Les A549 sont-elles impliquées dans des complications métaboliques ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent être utilisées pour étudier les effets métaboliques des traitements anticancéreux."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque sont étudiés avec les A549 ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs comme le tabagisme, l'exposition à des agents chimiques et la pollution."
}
},
{
"@type": "Question",
"name": "Les A549 aident-elles à identifier des facteurs génétiques ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent être utilisées pour étudier l'expression génique liée à des prédispositions au cancer."
}
},
{
"@type": "Question",
"name": "Comment les A549 sont-elles utilisées pour étudier l'environnement ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles permettent d'évaluer l'impact des toxines environnementales sur les cellules pulmonaires."
}
},
{
"@type": "Question",
"name": "Peut-on étudier l'alimentation avec les A549 ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Indirectement, elles peuvent être utilisées pour explorer l'impact des nutriments sur le cancer."
}
},
{
"@type": "Question",
"name": "Les A549 sont-elles utiles pour étudier le stress oxydatif ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles sont souvent utilisées pour examiner les effets du stress oxydatif sur les cellules."
}
}
]
}
]
}
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. Electronic address: taolm@ecust.edu.cn.
Will Rogers Institute Pulmonary Research Center and Hastings Center for Pulmonary Research, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Will Rogers Institute Pulmonary Research Center and Hastings Center for Pulmonary Research, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Department of Physiology and Neurosciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA.
Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Sonny Astani Department of Civil and Environmental Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Will Rogers Institute Pulmonary Research Center and Hastings Center for Pulmonary Research, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Mork Family Department of Chemical Engineering and Materials Science, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
This Position Statement on root resorption represents the consensus of an expert committee convened by the European Society of Endodontology (ESE). The statement is based on current clinical and scien...
The current literature on multiple idiopathic cervical root resorption (MICRR), a rare and aggressive form of external root resorption, is limited to case reports and series. Therefore, we performed a...
This study aimed to understand the influence of periodontal fibroblasts (PDLFs) on clastic differentiation of macrophages (Mφ) in different resorptive environments....
PDLF-Mφ direct coculture (juxtacrine) was seeded on dentin, cementum, and polystyrene with/without lipopolysaccharide, macrophage colony-stimulating factor, and receptor activator of nuclear factor ka...
PDLF-Mφ coculture showed a higher number of TRAP-positive multinucleated cells than Mφ monoculture on dentin and polystyrene. No TRAP-positive multinucleated cells were observed in paracrine and cemen...
The study highlights the juxtacrine effect of PDLFs on the clastic differentiation of Mφ with a difference in clastic activity between dentin and cementum. The study also emphasizes the temporal effec...
The literature reports the association of external root resorption (ERR) with orthodontic movement. In cases of premolars extractions, orthodontic movement of anterior teeth is usually quite expressiv...
The aim of this study was to assess the root morphology of maxillary canines and incisors in patients submitted to four premolar extraction and orthodontic retraction of the anterior teeth, by means o...
The sample consisted of six adult patients, five female and one male, with a mean age of 23.5 ± 6.5 years, who underwent orthodontic treatment. All patients presented bimaxillary dental protrusion, wi...
All average differences were close to zero and, even when evaluating the extreme values, the observed changes were always smaller than the accuracy of the CBCT....
A mild resorption trend was observed, although it was not clinically significant, with values lower than the tomography accuracy....
External inflammatory root resorption (EIRR) and external replacement root resorption (ERRR) are the most common adverse outcomes after luxation injuries or dental injuries. They are usually detected ...
An a priori protocol was prepared by a multidisciplinary expert group, as per the Cochrane handbook and PRISMA guidelines. The systematic search was conducted in six databases and grey-literature sour...
Eight studies were included in the systematic review and could be categorized as per the source of biomarkers, namely epithelial cells from mucosa, gingival crevicular fluid and extracted teeth. The s...
Among the three sources, the inflammatory gingival crevicular fluid appeared to be the most non-invasive source of biomarkers for predicting trauma-induced root resorption, although the evidence about...
Class II malocclusion treatment efficiency with maxillary premolar extractions has been reported. However, no study evaluated the root resorption associated with this protocol. Therefore, this study a...
The sample consisted of 56 patients with complete Class II malocclusion, divided into 2 groups. Group 1 comprised 28 patients (10 female, 18 male) treated with maxillary first premolar extractions, an...
Overjet, overbite, inclination, vertical positional changes, and vertical and horizontal apical displacements of maxillary incisors were similar between groups. There was no statistically significant ...
Treating complete Class II malocclusion with 2 maxillary premolar extractions resulted in a similar root resorption as treating without maxillary premolar extractions. An individualized evaluation of ...
External apical root resorption (EARR) is a common undesirable outcome of orthodontic treatment, this study aimed to identify genetic polymorphisms associated with the susceptibility to extreme orthod...
Genomic DNA was isolated from the saliva of 77 patients who underwent orthodontic treatment involving two maxillary premolar extractions. The patients were divided into two groups based on EARR values...
SNPs related to genes TNFSF11, TNFRSF11B, WNT3A, SFRP2, LRP6, P2RX7, and LRP1 were found to be significantly associated with severe EARR (p < 0.05, pre-Bonferroni correction p-values). Additionally, t...
Extreme phenotype analysis has identified eleven SNPs related to genes TNFSF11, TNFRSF11B, WNT3A, SFRP2, LRP6, P2RX7, and LRP1 that are associated with severe root resorption in the Korean population....
The aim of this study was to estimate the prevalence and severity of external root resorption (RR) caused by retained third molars (M3), to compare the sensitivity of panoramic radiography (PAN) and c...
In a retrospective cross-sectional analysis, we included patients (N = 367) who underwent PAN and CBCT imaging between December 2017 and July 2019. Previous orthodontic treatment, age, gender, superim...
While less than 5% of PANs suggested RR associated with M3, CBCT showed RR in 20% of all M2 with adjacent retained M3. The angle of inclination of M3, patient age and vertical level of molar contact e...
Within the limitations of our study, these data confirm the poor performance of PAN in the diagnosis of RR. CBCT may be helpful in detecting RR in mesioangulated and deeply retained M3 in elderly pati...
Our study may help to decide whether CBCT should be considered prior to M3 surgery....
This study aimed to analyze the scientific production of genetic polymorphisms and external apical root resorption (EARR) to establish main findings, geographic trends, and research gaps for possible ...
Unrestricted publications were searched using the Scopus database (March 2023) to include studies that addressed the association between genetic polymorphisms and EARR. Case-control, cohort, cross-sec...
Of the 44 studies analyzed, "Iglesias-Linares A" was the most cited author. The University of Seville (Spain) conducted the most research on this topic. Brazil, Spain, and the USA were the leading cou...
Endodontics is an area of research that should focus more on root resorption and genetic polymorphisms, as it still underexplored, compared to orthodontics. Polymorphisms have been studied as possible...
External root resorption (ERR) has a multifactorial etiology and is difficult to diagnose, which means that is continues to be of research interest. This work mainly aims to determine whether external...
The Checklist for Reporting In-vitro Studies (CRIS) guidelines were followed throughout this study. This experiment highlights the preparation and generation of standardized synthetic teeth measured o...
ICC values for intra- and inter-examiner agreement were appropriate. DPR overestimated ERR detection compared to the actual and CBCT measurements [Mean diff = 0.765 and 0.768, respectively]. CBCT diag...
The results of this study highlight that both CBCT and DPR are good diagnostic methods for ERR. Nevertheless, root canal filling material influences diagnostic capability in ERR. The clinical signific...