Fibroblastes associés au cancer : Questions médicales fréquentes
Nom anglais: Cancer-Associated Fibroblasts
Descriptor UI:D000072645
Tree Number:A11.329.228.105
Termes MeSH sélectionnés :
Time and Motion Studies
Questions fréquentes et termes MeSH associés
Diagnostic
5
#1
Comment identifier les CAF dans une tumeur ?
Les CAF peuvent être identifiés par des marqueurs spécifiques comme FAP et α-SMA.
FibroblastesCancer
#2
Quels tests sont utilisés pour détecter les CAF ?
L'immunohistochimie et la cytométrie en flux sont couramment utilisés.
ImmunohistochimieCytométrie en flux
#3
Les CAF sont-ils visibles par imagerie ?
Les CAF ne sont pas directement visibles, mais leur effet sur la tumeur peut être évalué par imagerie.
Imagerie médicaleTumeurs
#4
Peut-on quantifier les CAF dans un échantillon ?
Oui, des techniques comme la PCR et l'analyse de l'expression génique permettent leur quantification.
PCRExpression génique
#5
Les CAF peuvent-ils être distingués des fibroblastes normaux ?
Oui, les CAF présentent des caractéristiques morphologiques et fonctionnelles distinctes.
FibroblastesCaractéristiques cellulaires
Symptômes
5
#1
Quels symptômes sont liés aux CAF ?
Les CAF ne causent pas de symptômes directs, mais influencent la progression tumorale.
SymptômesProgression tumorale
#2
Les CAF affectent-ils la douleur tumorale ?
Oui, les CAF peuvent moduler la douleur en influençant l'inflammation et la croissance tumorale.
DouleurInflammation
#3
Les CAF sont-ils impliqués dans la fatigue liée au cancer ?
Indirectement, les CAF peuvent contribuer à la fatigue en favorisant la progression tumorale.
FatigueCancer
#4
Les CAF influencent-ils les symptômes de métastases ?
Oui, les CAF peuvent favoriser la migration des cellules tumorales et donc les symptômes de métastases.
MétastasesMigration cellulaire
#5
Les CAF sont-ils liés à des symptômes spécifiques ?
Ils ne causent pas de symptômes spécifiques, mais leur présence peut aggraver l'état général du patient.
État généralCancer
Prévention
5
#1
Peut-on prévenir la formation de CAF ?
La prévention des CAF est complexe, mais un mode de vie sain peut réduire le risque de cancer.
PréventionMode de vie sain
#2
Les facteurs environnementaux influencent-ils les CAF ?
Oui, des facteurs comme l'inflammation chronique et le tabagisme peuvent favoriser les CAF.
Facteurs environnementauxInflammation chronique
#3
L'alimentation joue-t-elle un rôle dans la prévention des CAF ?
Une alimentation riche en antioxydants peut aider à réduire le risque de cancer et donc de CAF.
AlimentationAntioxydants
#4
L'exercice physique peut-il réduire les CAF ?
Oui, l'exercice régulier peut diminuer l'inflammation et potentiellement réduire les CAF.
Exercice physiqueInflammation
#5
Les dépistages précoces aident-ils à prévenir les CAF ?
Les dépistages précoces peuvent aider à détecter le cancer avant que les CAF ne se développent.
Dépistage précoceCancer
Traitements
5
#1
Comment cibler les CAF dans le traitement du cancer ?
Des thérapies ciblées et des inhibiteurs de signalisation sont en développement pour cibler les CAF.
Thérapies cibléesInhibiteurs de signalisation
#2
Les CAF peuvent-ils être une cible pour l'immunothérapie ?
Oui, les CAF peuvent être ciblés pour améliorer l'efficacité de l'immunothérapie anticancéreuse.
ImmunothérapieCiblage
#3
Quels médicaments affectent les CAF ?
Des médicaments comme les inhibiteurs de TGF-β et les agents anti-fibrotiques peuvent affecter les CAF.
TGF-βAgents anti-fibrotiques
#4
Les CAF peuvent-ils influencer la résistance aux traitements ?
Oui, les CAF peuvent contribuer à la résistance aux traitements en modifiant le microenvironnement tumoral.
Résistance aux traitementsMicroenvironnement tumoral
#5
Y a-t-il des essais cliniques sur les CAF ?
Oui, plusieurs essais cliniques explorent des thérapies ciblant les CAF dans divers cancers.
Essais cliniquesThérapies ciblées
Complications
5
#1
Quels sont les risques associés aux CAF ?
Les CAF peuvent favoriser la progression tumorale et la résistance aux traitements.
RisquesProgression tumorale
#2
Les CAF sont-ils liés à des complications post-chirurgicales ?
Oui, les CAF peuvent influencer la cicatrisation et augmenter le risque de récidive.
Complications post-chirurgicalesRécidive
#3
Les CAF peuvent-ils affecter la qualité de vie ?
Oui, leur présence peut aggraver les symptômes et diminuer la qualité de vie des patients.
Qualité de vieSymptômes
#4
Les CAF sont-ils impliqués dans des complications métastatiques ?
Oui, les CAF peuvent faciliter la migration des cellules tumorales vers d'autres organes.
Complications métastatiquesMigration cellulaire
#5
Les CAF peuvent-ils influencer la survie des patients ?
Oui, la présence de CAF est souvent associée à un pronostic défavorable dans plusieurs cancers.
Survie des patientsPronostic
Facteurs de risque
5
#1
Quels facteurs augmentent le risque de CAF ?
L'inflammation chronique, le tabagisme et l'obésité sont des facteurs de risque connus.
Facteurs de risqueInflammation chronique
#2
L'âge influence-t-il le développement des CAF ?
Oui, le risque de développer des CAF augmente avec l'âge en raison de changements cellulaires.
ÂgeChangements cellulaires
#3
Les antécédents familiaux de cancer sont-ils un facteur de risque ?
Oui, des antécédents familiaux peuvent augmenter le risque de développer des CAF.
Antécédents familiauxCancer
#4
Le stress peut-il influencer les CAF ?
Oui, le stress chronique peut affecter le microenvironnement tumoral et favoriser les CAF.
StressMicroenvironnement tumoral
#5
Les infections chroniques sont-elles un facteur de risque ?
Oui, certaines infections chroniques peuvent contribuer à l'inflammation et à la formation de CAF.
Infections chroniquesInflammation
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},
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},
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{
"@type": "Question",
"name": "Les antécédents familiaux de cancer sont-ils un facteur de risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux peuvent augmenter le risque de développer des CAF."
}
},
{
"@type": "Question",
"name": "Le stress peut-il influencer les CAF ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut affecter le microenvironnement tumoral et favoriser les CAF."
}
},
{
"@type": "Question",
"name": "Les infections chroniques sont-elles un facteur de risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines infections chroniques peuvent contribuer à l'inflammation et à la formation de CAF."
}
}
]
}
]
}
Adelaide Medical School, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia. Dan.Worthley@sahmri.com.
Publications dans "Fibroblastes associés au cancer" :
Department of Thoracic Surgery, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing, China.
Publications dans "Fibroblastes associés au cancer" :
Department of Thoracic Surgery, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing, China.
Department of Science and technology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing, China.
Publications dans "Fibroblastes associés au cancer" :
Department of Thoracic Surgery, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing, China. rong_yin@njmu.edu.cn.
Department of Science and technology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing, China. rong_yin@njmu.edu.cn.
Biobank of Lung Cancer, Jiangsu Biobank of Clinical Resources, Nanjing, China. rong_yin@njmu.edu.cn.
Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China. rong_yin@njmu.edu.cn.
Publications dans "Fibroblastes associés au cancer" :
Department of Biochemistry and Molecular Biology, Cancer Immunology, Inflammation & Tolerance Program, Georgia Cancer Center, Augusta University, Augusta, GA, 30912, USA.
Publications dans "Fibroblastes associés au cancer" :
M.V. Lomonosov Moscow State University, Moscow, Russia; Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, Moscow, Russia.
Publications dans "Fibroblastes associés au cancer" :
Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, P.R. China.
Publications dans "Fibroblastes associés au cancer" :
Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, P.R. China.
Publications dans "Fibroblastes associés au cancer" :
This observational-descriptive time and motion study was conducted to determine how heavy home care nurses' workload is and how they allocate their work time to home healthcare. It was carried out in ...
Nurses in psychiatric inpatient care spend less time than desired with patients and investigation of the nature of nursing in this setting is needed. This study explores how nursing activities in psyc...
Efficient planning of the oral health workforce in Primary Health Care (PHC) is paramount to ensure equitable community access to services. This requires a meticulous examination of the population's n...
Calculate the average time parameters for the activities carried out by the oral health team in primary health care....
This is a descriptive observational study using the time-motion method carried out in five Primary Health Care Units in the city of São Paulo, SP, Brazil. Direct and continuous observation of oral hea...
A total of 696.05 h of observation were conducted with 12 Dentists, three Oral Health Assistants, and five Oral Health Technicians. The Dentists' main activity was consultation with an average duratio...
The study establishes time standards for the activities performed by the dental care team and provides support for the application of workforce planning methods that allow for review and optimization ...
The aim of this study was to determine how much time nurses spend on direct and indirect patient care in acute and subacute hospital settings....
Quantifying direct and indirect nursing care provided during inpatient stay is vital to optimise the quality of care and manage resources....
Time and motion cross-sectional observational study and reported the study according to the STROBE guideline....
Nurses working in an acute or subacute medical wards of a single health service participated. Nurses were observed twice for 2 h on the same day with an observer break in between sessions. Real-time t...
Twenty-one nurses (acute n = 12, subacute n = 9) were observed during shifts between 7 AM and 9 PM in May-July 2021. A total of 7240 tasks were recorded. Nurses spent a third of their time on direct p...
Time spent on tasks was similar regardless of the setting and was consistent with previous research. We found differences in the distribution of tasks throughout the day between settings, which could ...
This time-motion study explored the amount of time clinicians spent on wound assessments in a real-world environment using wound assessment digital application utilizing Artificial Intelligence (AI) v...
Clinicians practicing at Valley Wound Center who agreed to join the study were asked to record the time needed to complete wound assessment activities for patients with active wounds referred for a ro...
A total of 91 patients with 115 wounds were assessed. The average time to capture and access wound image with the AI digital tool was significantly faster than a standard digital camera with an averag...
Using the digital assessment tool saved significant time for clinicians in assessing wounds. It also successfully captured quality wound images at the first attempt....
School-based health (SBH) programmes that are contingent on primary school teachers are options to increase access to malaria treatment among learners. However, perceptions that provision of healthcar...
A time and motion study was conducted in 10 primary schools in rural Malawi. Teachers who had been trained to diagnose and treat uncomplicated malaria were continuously observed in real time during sc...
Seventy-four teachers, trained to use LTK, were observed. Their mean age and years of teaching experience were 34.7 and 8.7, respectively. Overall, 739.8 h of teacher observations took place. The aver...
School-based health (SBH) programmes are not detrimental to teaching activities. Teachers manage their time to ensure additional time required for SBH services is not at the expense of teaching duties...
Community health workers (CHWs) are essential field-based personnel and increasingly used to deliver priority interventions to achieve universal health coverage. Existing literature allude to the pote...
A time and motion study was conducted in 7 health facilities in Malawi. Data was collected at baseline between October-July 2019, and 12 months after CCSPT implementation between July and August 2021....
Thirty-seven (n = 37) CHWs were observed. Their mean age and years of experience were 42 and 17, respectively. Overall, CHWs were observed for 323 hours (inter quartile range: 2.8-5.5). Compared with ...
Introduction of CCSPT was not very detrimental to pre-existing community services. CHWs managed their time ensuring additional efforts required for CCSPT were not at the expense of essential activitie...
Ageing populations and care workforce shortages across Europe are causing challenges for care services for older people. Therefore, it is paramount that limited care resources are allocated optimally,...
Cross-sectional observational study design with data from time and motion study, registers, and surveys was used. In total, 1477 home care clients and 1538 residents from assisted living facilities wi...
Physical functioning was the strongest predictor of received care time in both care settings. In home care, greater pain, more unstable health, and higher team autonomy were associated with increased ...
Physical functioning was the main driver of received care time. Interventions that maintain or improve physical functioning can help restrain the growing need of care resources, although it is importa...
The aim of the present study was to determine the time-motion structure of high-level taekwondo matches during the Tokyo 2020 Olympic Games in relation to sex, match outcome, weight category and match...
Overall, 7007 actions were recorded during the analysis of 134 performances (67 rounds of 24 matches: four rounds of 16, eight quarterfinals, eight semifinals and four finals) in male and female flywe...
The AT/ST ratio was ~1:1.5. Male athletes performed significantly longer (P<0.001) sum PT than female athletes. Flyweight athletes differed significantly from their heavyweight counterparts by having ...
The rule changes and the implementation of the electronic score recording system had a major impact on the time-motion structure of combat by generating a considerably higher AT/ST ratio than in the p...
Early childhood caries (ECC) is a major global health issue affecting millions of children. Mitigating this problem requires up-to-date information from reliable surveillance systems. This enables evi...
The DHIS2 Server was configured for the DHIS2 Tracker Android Capture App to allow individual-level data entry. The EOHSS indicators were selected in line with the WHO Action Plan 2030. Two modalities...
The pilot team reported positive feedback on the structure of the EOHSS. Workflow adaptations were made to prioritize surveillance tasks by collecting data from caregivers before acquiring clinical da...
The DHIS2 provides a feasible solution for developing electronic, oral health surveillance systems. The one-minute difference in data capture time in telemodality compared to face-to-face indicates th...