questionsmedicales.fr
Métabolisme
Désalkylation
Déméthylation
Déméthylation : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Déméthylation
Analyse de l'ADN
Marqueurs épigénétiques
5-méthylcytosine
Tests sanguins
ADN circulant
Biopsie
Analyse tissulaire
Troubles neurologiques
Cancers
Symptômes
5
Troubles cognitifs
Anomalies de croissance
Maladies génétiques
Cancer
Changements de comportement
Anomalies physiques
Système immunitaire
Infections
Prévention
5
Alimentation équilibrée
Mode de vie sain
Suppléments
Acide folique
Exercice physique
Santé épigénétique
Toxines environnementales
Perturbation épigénétique
Traitements
5
Thérapie génique
Médicaments ciblés
Thérapies épigénétiques
Cancer
Médecine personnalisée
Profil génétique
Complications
5
Cancers
Maladies auto-immunes
Réversibilité
Modifications épigénétiques
Maladies chroniques
Troubles de développement
Fertilité
Fonction reproductive
Effets à long terme
Prédispositions
Facteurs de risque
5
Facteurs de risque
Toxines
Hérédité
Facteurs génétiques
Maladies chroniques
Risque
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"text": "Des tests génétiques et des analyses de l'ADN peuvent révéler des modifications de méthylation."
}
},
{
"@type": "Question",
"name": "Quels marqueurs sont utilisés pour la déméthylation ?",
"position": 2,
"acceptedAnswer": {
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},
{
"@type": "Question",
"name": "Quels tests sanguins peuvent indiquer une déméthylation ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests de métabolites et d'ADN circulant peuvent fournir des indices."
}
},
{
"@type": "Question",
"name": "La biopsie est-elle nécessaire pour diagnostiquer la déméthylation ?",
"position": 4,
"acceptedAnswer": {
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{
"@type": "Question",
"name": "Quels symptômes peuvent alerter sur une déméthylation ?",
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{
"@type": "Question",
"name": "Quels symptômes sont associés à la déméthylation ?",
"position": 6,
"acceptedAnswer": {
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{
"@type": "Question",
"name": "La déméthylation peut-elle causer des maladies ?",
"position": 7,
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{
"@type": "Question",
"name": "Y a-t-il des signes cliniques de déméthylation ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes cliniques peuvent inclure des changements de comportement et des anomalies physiques."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon l'âge ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes peuvent se manifester différemment selon l'âge et le développement."
}
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{
"@type": "Question",
"name": "La déméthylation affecte-t-elle le système immunitaire ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut altérer la réponse immunitaire, augmentant le risque d'infections."
}
},
{
"@type": "Question",
"name": "Comment prévenir la déméthylation ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et un mode de vie sain peuvent aider à prévenir la déméthylation."
}
},
{
"@type": "Question",
"name": "Les suppléments peuvent-ils aider ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des suppléments comme l'acide folique peuvent soutenir la méthylation."
}
},
{
"@type": "Question",
"name": "Le stress influence-t-il la déméthylation ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut affecter les mécanismes de méthylation."
}
},
{
"@type": "Question",
"name": "L'exercice physique a-t-il un impact ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'exercice régulier peut améliorer la santé épigénétique et la méthylation."
}
},
{
"@type": "Question",
"name": "Les toxines environnementales jouent-elles un rôle ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à certaines toxines peut perturber les mécanismes de méthylation."
}
},
{
"@type": "Question",
"name": "Quels traitements existent pour la déméthylation ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des thérapies géniques et des médicaments ciblés."
}
},
{
"@type": "Question",
"name": "La nutrition peut-elle influencer la déméthylation ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains nutriments comme l'acide folique peuvent moduler la méthylation."
}
},
{
"@type": "Question",
"name": "Les thérapies épigénétiques sont-elles efficaces ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles montrent un potentiel prometteur dans le traitement de certains cancers."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir la déméthylation par des médicaments ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs spécifiques peuvent être utilisés pour prévenir la déméthylation."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils personnalisés ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction du profil génétique du patient."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des cancers, des troubles neurologiques et des maladies auto-immunes."
}
},
{
"@type": "Question",
"name": "La déméthylation est-elle réversible ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines modifications peuvent être réversibles, mais pas toutes."
}
},
{
"@type": "Question",
"name": "Quels risques sont associés à la déméthylation ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les risques incluent des maladies chroniques et des troubles de développement."
}
},
{
"@type": "Question",
"name": "La déméthylation peut-elle affecter la fertilité ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut influencer la fertilité en altérant la fonction reproductive."
}
},
{
"@type": "Question",
"name": "Y a-t-il des effets à long terme ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des effets à long terme peuvent inclure des prédispositions à diverses maladies."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque de déméthylation ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent l'alimentation, le stress, et l'exposition à des toxines."
}
},
{
"@type": "Question",
"name": "L'hérédité joue-t-elle un rôle ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des facteurs génétiques peuvent influencer la déméthylation."
}
},
{
"@type": "Question",
"name": "Les maladies chroniques augmentent-elles le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines maladies chroniques peuvent augmenter le risque de déméthylation."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il la déméthylation ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie malsain peut favoriser la déméthylation."
}
},
{
"@type": "Question",
"name": "Les infections peuvent-elles affecter la déméthylation ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines infections peuvent perturber les mécanismes de méthylation."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 19/04/2025
Contenu vérifié selon les dernières recommandations médicales
2 publications dans cette catégorie
Affiliations :
Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, Australia.
St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia.
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney 22, Australia.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, Australia.
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney 22, Australia.
Centro Andaluz de Biología del Desarrollo, CSIC-Universidad Pablo de Olavide-Junta de Andalucía, Seville, Spain.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Environmental Sciences, University of California, Riverside, California 92521, United States.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Environmental Sciences, University of California, Riverside, California 92521, United States.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Environmental Sciences, University of California, Riverside, California 92521, United States.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Environmental Sciences, University of California, Riverside, California 92521, United States.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Genetics, Stem Cells, Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, 1983963113, Iran.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Genetics, Stem Cells, Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, 1983963113, Iran. Electronic address: s_farivar@sbu.ac.ir.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, Jiangsu, China.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, Jiangsu, China. liujihua@cpu.edu.cn.
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, Jiangsu, China. liujihua@cpu.edu.cn.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Plant Science, Research Institute for Agriculture and Life Sciences, and Plant Genomics and Breeding Institute, Seoul National University, Seoul 08826, Korea.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Plant Science, Research Institute for Agriculture and Life Sciences, and Plant Genomics and Breeding Institute, Seoul National University, Seoul 08826, Korea huhjh@snu.ac.kr.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115 USA.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115 USA.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Publications dans "Déméthylation" :
Advanced myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematological malignancies in children. A second allograft is recommended if a relapse occurs after hematop...
We conducted a phase I/II multicenter study to evaluate the safety, pharmacokinetics, and activity of azacitidine in children with relapsed MDS/JMML prior to the second hematopoietic stem cell transpl...
Patients enrolled from June 2013 to March 2019 received azacitidine intravenously/subcutaneously once daily on days 1-7 of a 28-day cycle. The MDS and JMML cohorts followed a two-stage design separate...
Six patients with MDS and four patients with JMML received a median of three and five cycles, respectively. Azacitidine 75 mg/m...
Azacitidine 75 mg/m...
EudraCT 2010-022235-10....
Drug-induced pericarditis is an important cause of pericarditis and if unnoticed and unmanaged can lead to constrictive pericarditis, pericardial effusion, and cardiac tamponade....
The objective of this analysis was to determine if a significant signal exists between azacitidine use and pericarditis....
A pharmacovigilance analysis was performed using the FDA Adverse Event Database....
48 reports of azacitidine-induced pericarditis with azacitidine as the suspect drug were identified. The most common indications for azacitidine use in the adverse event reports were myelodysplastic s...
The signal between azacitidine and pericarditis was found to be statistically significant. Clinicians should be aware of the possible risk of pericarditis when prescribing azacitidine. If there is sus...
GA trial is registered under EudraCT#: 2013-001639-38....
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is caused by UBA1 somatic mutations and is characterized by late-onset systemic autoimmune inflammation and blood abnormalitie...
Acute myeloid leukemia (AML) predominantly affects elderly population. This poses challenges in management, as patients are frequently not candidates for intensive therapy given comorbidities or frail...
We review the mechanism of action, pharmacology, clinical efficacy, and safety of AZA. It reviews current combination therapies of AZA with other targeted therapies for the treatment of newly diagnose...
AZA is a cornerstone for the treatment of patients considered ineligible for intensive chemotherapy induction, but better results and therapies are required for these patients. AZA has shown synergist...
Nodular skin lesions in patients with acute myeloid leukemia (AML) raise clinical suspicion for leukemia cutis versus fungal infections. Here, we report a rare case of treatment-related erythema nodos...
Approximately 5 weeks after the initiation of sorafenib and one week after azacitidine initiation, a 32-year-old man with primary refractory AML presented with several painful red nodules on the lower...
Treatment with topical and oral steroids led to complete resolution of the nodules. However, once the dose of steroids was reduced, the lesions rapidly recurred. Higher dose steroids were reinitiated,...
Given the onset of lesions one week after the initiation of azacitidine and 5 weeks after the initiation of sorafenib, azacitidine was considered the more likely culprit. Only 2 cases of EN-like erupt...
Azacitidine (AZA), a demethylating agent, is one of the mainstay treatments for patients with myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) who are ineligible for curative allogene...
We present a retrospective overview of a clinical case of a 71-year-old patient that developed new cytopenias on a background of Chronic Lymphocytic Leukaemia and was diagnosed with therapy-associated...
Arthrocentesis of the knee revealed reactive arthritis with no crystal or organism growth. His symptoms were managed effectively with conservative management including NSAIDs, analgesia and temporary ...
We report a case that points to AZA as a probable cause of arthritis flares in MDS patients. The current limitation of this study is the lack of available data, future reviews and research will aid in...
Myeloproliferative neoplasms in blastic phase (MPN-BP) have a dreadful prognosis. We report the characteristics and outcomes of five MPN-BP patients treated with a never-before-described combination o...
Bone marrow fibrosis in myelodysplastic syndromes (MDS) has been associated with poor outcome. However, these studies were conducted prior to the widespread use of azacitidine in the management of MDS...
Hypomethylating therapies using decitabine or azacitidine are actively investigated to treat acute myeloid leukemia, myelodysplastic syndromes, as maintenance therapy after allogenic stem cell transpl...