questionsmedicales.fr
Infection
Infections bactériennes et mycoses
Infections bactériennes
Infections bactériennes : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Infections bactériennes
Diagnostic médical
Culture bactérienne
Tests de diagnostic
Symptômes
Infections bactériennes
Sensibilité aux antibiotiques
Infections bactériennes
Imagerie médicale
Infections bactériennes
Symptômes
5
Symptômes
Infections bactériennes
Douleur abdominale
Infections bactériennes
Toux
Infections bactériennes
Symptômes
Infections bactériennes
Infections urinaires
Symptômes
Prévention
5
Prévention
Infections bactériennes
Vaccins
Infections bactériennes
Masques
Infections bactériennes
Nutrition
Prévention des infections
Désinfection
Infections bactériennes
Traitements
5
Antibiotiques
Infections bactériennes
Traitement antibiotique
Infections bactériennes
Infections bactériennes
Antibiotiques
Probiotiques
Infections bactériennes
Résistance aux antibiotiques
Infections bactériennes
Complications
5
Complications
Infections bactériennes
Infections bactériennes
Mortalité
Séquelles
Infections bactériennes
Système immunitaire
Infections bactériennes
Allergies
Infections bactériennes
Facteurs de risque
5
Facteurs de risque
Infections bactériennes
Tabagisme
Infections bactériennes
Personnes âgées
Infections bactériennes
Stress
Infections bactériennes
Maladies chroniques
Infections bactériennes
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"@type": "Question",
"name": "Comment diagnostique-t-on une infection bactérienne ?",
"position": 1,
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"@type": "Answer",
"text": "Le diagnostic repose sur des analyses de sang, cultures et examens cliniques."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour identifier la bactérie ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les cultures microbiologiques et les tests PCR sont couramment utilisés."
}
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{
"@type": "Question",
"name": "Les symptômes aident-ils au diagnostic ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes cliniques orientent le diagnostic vers une infection bactérienne."
}
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{
"@type": "Question",
"name": "Quand faut-il faire un test de sensibilité ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un test de sensibilité est fait pour déterminer l'antibiotique efficace contre la bactérie."
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"@type": "Question",
"name": "Les imageries sont-elles utiles dans le diagnostic ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les imageries comme les radiographies peuvent aider à visualiser des infections."
}
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{
"@type": "Question",
"name": "Quels sont les symptômes courants d'une infection bactérienne ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fièvre, douleur, rougeur, gonflement et fatigue sont des symptômes fréquents."
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"@type": "Question",
"name": "Une infection bactérienne peut-elle causer des douleurs abdominales ?",
"position": 7,
"acceptedAnswer": {
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"text": "Oui, certaines infections comme la gastro-entérite peuvent provoquer des douleurs abdominales."
}
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{
"@type": "Question",
"name": "Les infections bactériennes provoquent-elles de la toux ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des infections comme la pneumonie peuvent entraîner une toux persistante."
}
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{
"@type": "Question",
"name": "Peut-on avoir des symptômes sans fièvre ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines infections peuvent se manifester sans fièvre, mais avec d'autres symptômes."
}
},
{
"@type": "Question",
"name": "Les infections urinaires causent-elles des symptômes spécifiques ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent provoquer des douleurs lors de la miction et des envies fréquentes."
}
},
{
"@type": "Question",
"name": "Comment prévenir les infections bactériennes ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le lavage des mains, la vaccination et une bonne hygiène sont essentiels pour prévenir."
}
},
{
"@type": "Question",
"name": "Les vaccins aident-ils à prévenir certaines infections ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des vaccins existent pour prévenir des infections comme la méningite et la pneumonie."
}
},
{
"@type": "Question",
"name": "Le port de masques est-il efficace contre les infections ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le port de masques peut réduire la transmission des infections respiratoires."
}
},
{
"@type": "Question",
"name": "L'alimentation joue-t-elle un rôle dans la prévention ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée renforce le système immunitaire et aide à prévenir les infections."
}
},
{
"@type": "Question",
"name": "Les surfaces doivent-elles être désinfectées ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, désinfecter les surfaces fréquemment touchées aide à réduire le risque d'infection."
}
},
{
"@type": "Question",
"name": "Quels antibiotiques sont couramment prescrits ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les pénicillines, céphalosporines et macrolides sont souvent utilisés pour traiter les infections."
}
},
{
"@type": "Question",
"name": "Comment se déroule un traitement antibiotique ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement doit être suivi selon la prescription, généralement sur plusieurs jours."
}
},
{
"@type": "Question",
"name": "Les infections bactériennes nécessitent-elles toujours des antibiotiques ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, certaines infections peuvent guérir sans antibiotiques, selon leur gravité."
}
},
{
"@type": "Question",
"name": "Quelles sont les alternatives aux antibiotiques ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des traitements comme les probiotiques et les antiseptiques peuvent être envisagés."
}
},
{
"@type": "Question",
"name": "Comment prévenir la résistance aux antibiotiques ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il est crucial de suivre les prescriptions et de ne pas utiliser d'antibiotiques inutilement."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles d'une infection bactérienne ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications peuvent inclure des septicémies, des infections chroniques ou des défaillances d'organes."
}
},
{
"@type": "Question",
"name": "Une infection non traitée peut-elle être mortelle ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines infections bactériennes peuvent entraîner la mort si elles ne sont pas traitées."
}
},
{
"@type": "Question",
"name": "Les infections peuvent-elles causer des dommages permanents ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines infections peuvent entraîner des séquelles permanentes, comme des lésions tissulaires."
}
},
{
"@type": "Question",
"name": "Comment les infections bactériennes affectent-elles le système immunitaire ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent affaiblir le système immunitaire, rendant l'organisme plus vulnérable à d'autres infections."
}
},
{
"@type": "Question",
"name": "Les infections bactériennes peuvent-elles entraîner des allergies ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines infections peuvent déclencher des réactions allergiques ou des sensibilités."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque d'infections bactériennes ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent un système immunitaire affaibli, le diabète et l'âge avancé."
}
},
{
"@type": "Question",
"name": "Le tabagisme augmente-t-il le risque d'infections ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme affaiblit le système immunitaire et augmente le risque d'infections respiratoires."
}
},
{
"@type": "Question",
"name": "Les personnes âgées sont-elles plus à risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes âgées ont un risque accru d'infections en raison d'un système immunitaire affaibli."
}
},
{
"@type": "Question",
"name": "Le stress peut-il affecter le risque d'infections ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut affaiblir le système immunitaire et augmenter le risque d'infections."
}
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{
"@type": "Question",
"name": "Les maladies chroniques augmentent-elles le risque d'infections ?",
"position": 30,
"acceptedAnswer": {
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"text": "Oui, des maladies comme le diabète ou le VIH augmentent la susceptibilité aux infections."
}
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 23/03/2025
Contenu vérifié selon les dernières recommandations médicales
└─
Infections bactériennes à Gram négatif
Gram-Negative Bacterial Infections
D016905
-
C01.150.252.400
└─
Infections bactériennes à Gram positif
Gram-Positive Bacterial Infections
D016908
-
C01.150.252.410
└─└─
Infections à aliivibrio
Aliivibrio Infections
D059707
-
C01.150.252.400.050
└─└─
Infections à Anaplasmataceae
Anaplasmataceae Infections
D000711
-
C01.150.252.400.054
└─└─
Infections à Bacteroidaceae
Bacteroidaceae Infections
D016866
-
C01.150.252.400.110
└─└─
Infections à Bartonellaceae
Bartonellaceae Infections
D001476
-
C01.150.252.400.126
└─└─
Bordetelloses
Bordetella Infections
D001885
-
C01.150.252.400.143
└─└─
Brucellose
Brucellosis
D002006
-
C01.150.252.400.167
└─└─
Infections à Burkholderia
Burkholderia Infections
D019121
-
C01.150.252.400.170
└─└─
Infections à Campylobacter
Campylobacter Infections
D002169
-
C01.150.252.400.177
└─└─
Infections à Chlamydiaceae
Chlamydiaceae Infections
D002694
-
C01.150.252.400.210
└─└─
Infections à Cytophagaceae
Cytophagaceae Infections
D045827
-
C01.150.252.400.245
└─└─
Infections à Desulfovibrionaceae
Desulfovibrionaceae Infections
D045824
-
C01.150.252.400.260
└─└─
Infections à Enterobacteriaceae
Enterobacteriaceae Infections
D004756
-
C01.150.252.400.310
└─└─
Infections à Flavobacteriaceae
Flavobacteriaceae Infections
D045826
-
C01.150.252.400.349
└─└─
Infections à Fusobacteriaceae
Fusobacteriaceae Infections
D045825
-
C01.150.252.400.388
└─└─
Infections à Helicobacter
Helicobacter Infections
D016481
-
C01.150.252.400.466
└─└─
Infections à Moraxellaceae
Moraxellaceae Infections
D045828
-
C01.150.252.400.560
└─└─
Infections à Mycoplasmatales
Mycoplasmatales Infections
D009180
-
C01.150.252.400.610
└─└─
Infections à Neisseriaceae
Neisseriaceae Infections
D016870
-
C01.150.252.400.625
└─└─
Infections à Pasteurellaceae
Pasteurellaceae Infections
D016871
-
C01.150.252.400.700
└─└─
Infections à Piscirickettsiaceae
Piscirickettsiaceae Infections
D044225
-
C01.150.252.400.719
└─└─
Infections à Pseudomonas
Pseudomonas Infections
D011552
-
C01.150.252.400.739
└─└─
Fièvre Q
Q Fever
D011778
-
C01.150.252.400.755
└─└─
Fièvre par morsure de rat
Rat-Bite Fever
D011906
-
C01.150.252.400.771
└─└─
Infections à Spirochaetales
Spirochaetales Infections
D013145
-
C01.150.252.400.794
└─└─
Tréponématoses
Treponemal Infections
D014211
-
C01.150.252.400.840
└─└─
Infections à Vibrio
Vibrio Infections
D014735
-
C01.150.252.400.959
└─└─
Infections à Actinomycetales
Actinomycetales Infections
D000193
-
C01.150.252.410.040
└─└─
Infections à Bacillaceae
Bacillaceae Infections
D016863
-
C01.150.252.410.090
└─└─
Infections à Bifidobacteriales
Bifidobacteriales Infections
D039941
-
C01.150.252.410.110
└─└─
Infections à Clostridium
Clostridium Infections
D003015
-
C01.150.252.410.222
└─└─
Infections à Listeria
Listeriosis
D008088
-
C01.150.252.410.514
└─└─
Infections à staphylocoques
Staphylococcal Infections
D013203
-
C01.150.252.410.868
└─└─
Infections à streptocoques
Streptococcal Infections
D013290
-
C01.150.252.410.890
└─└─└─
Infections à Bacteroides
Bacteroides Infections
D001442
-
C01.150.252.400.110.109
└─└─└─
Infections à Bartonella
Bartonella Infections
D001474
-
C01.150.252.400.126.100
└─└─└─
Mélioïdose
Melioidosis
D008554
-
C01.150.252.400.170.531
└─└─└─
Infections à Chlamydophila
Chlamydophila Infections
D023521
-
C01.150.252.400.210.250
└─└─└─
Infections à Escherichia coli
Escherichia coli Infections
D004927
-
C01.150.252.400.310.330
└─└─└─
Infections à Klebsiella
Klebsiella Infections
D007710
-
C01.150.252.400.310.503
└─└─└─
Infections à Proteus
Proteus Infections
D011512
-
C01.150.252.400.310.708
└─└─└─
Salmonelloses
Salmonella Infections
D012480
-
C01.150.252.400.310.821
└─└─└─
Infections à Serratia
Serratia Infections
D016868
-
C01.150.252.400.310.850
└─└─└─
Yersinioses
Yersinia Infections
D015009
-
C01.150.252.400.310.980
└─└─└─
Infections à Fusobacterium
Fusobacterium Infections
D005674
-
C01.150.252.400.388.350
└─└─└─
Infections à Acinetobacter
Acinetobacter Infections
D000151
-
C01.150.252.400.560.022
└─└─└─
Infections à Mycoplasma
Mycoplasma Infections
D009175
-
C01.150.252.400.610.610
└─└─└─
Infections à Ureaplasma
Ureaplasma Infections
D016869
-
C01.150.252.400.610.850
└─└─└─
Infections à méningocoques
Meningococcal Infections
D008589
-
C01.150.252.400.625.549
└─└─└─
Infections à Actinobacillus
Actinobacillus Infections
D000189
-
C01.150.252.400.700.030
└─└─└─
Infections à Haemophilus
Haemophilus Infections
D006192
-
C01.150.252.400.700.433
└─└─└─
Pasteurelloses
Pasteurella Infections
D010326
-
C01.150.252.400.700.662
└─└─└─
Borrélioses
Borrelia Infections
D001899
-
C01.150.252.400.794.352
└─└─└─
Leptospirose
Leptospirosis
D007922
-
C01.150.252.400.794.511
└─└─└─
Choléra
Cholera
D002771
-
C01.150.252.400.959.347
└─└─└─
Actinomycose
Actinomycosis
D000196
-
C01.150.252.410.040.137
└─└─└─
Infections à Corynebacterium
Corynebacterium Infections
D003354
-
C01.150.252.410.040.246
└─└─└─
Infections à Mycobacterium
Mycobacterium Infections
D009164
-
C01.150.252.410.040.552
└─└─└─
Infections à Nocardia
Nocardia Infections
D009617
-
C01.150.252.410.040.692
└─└─└─
Maladie du charbon
Anthrax
D000881
-
C01.150.252.410.090.072
└─└─└─
Gangrène gazeuse
Gas Gangrene
D005738
-
C01.150.252.410.222.440
└─└─└─
Tétanos
Tetanus
D013742
-
C01.150.252.410.222.864
└─└─└─
Érysipéloïde
Erysipeloid
D004887
-
C01.150.252.410.334.329
└─└─└─
Infections à pneumocoques
Pneumococcal Infections
D011008
-
C01.150.252.410.890.670
└─└─└─
Scarlatine
Scarlet Fever
D012541
-
C01.150.252.410.890.823
└─└─└─└─
Fièvre des tranchées
Trench Fever
D014205
-
C01.150.252.400.126.100.800
└─└─└─└─
Psittacose
Psittacosis
D009956
-
C01.150.252.400.210.250.600
└─└─└─└─
Fièvre paratyphoïde
Paratyphoid Fever
D010284
-
C01.150.252.400.310.821.438
└─└─└─└─
Fièvre typhoïde
Typhoid Fever
D014435
-
C01.150.252.400.310.821.873
└─└─└─└─
Infections à Yersinia pseudotuberculosis
Yersinia pseudotuberculosis Infections
D015012
-
C01.150.252.400.310.980.780
└─└─└─└─
Maladie de Weil
Weil Disease
D014895
-
C01.150.252.400.794.511.739
└─└─└─└─
Chancre syphilitique
Chancre
D002601
-
C01.150.252.400.840.500.500
└─└─└─└─
Diphtérie
Diphtheria
D004165
-
C01.150.252.410.040.246.388
└─└─└─└─
Infections à mycobactéries non tuberculeuses
Mycobacterium Infections, Nontuberculous
D009165
-
C01.150.252.410.040.552.475
└─└─└─└─
Tuberculose
Tuberculosis
D014376
-
C01.150.252.410.040.552.846
└─└─└─└─└─
Lèpre
Leprosy
D007918
-
C01.150.252.410.040.552.475.371
└─└─└─└─└─
Infection due à Mycobacterium avium-intracellulare
Mycobacterium avium-intracellulare Infection
D015270
-
C01.150.252.410.040.552.475.495
└─└─└─└─└─
Tuberculome
Tuberculoma
D014375
-
C01.150.252.410.040.552.846.493
└─└─└─└─└─
Tuberculose extrapulmonaire
Tuberculosis, Extrapulmonary
D000092225
-
C01.150.252.410.040.552.846.617
└─└─└─└─└─
Tuberculose miliaire
Tuberculosis, Miliary
D014391
-
C01.150.252.410.040.552.846.764
└─└─└─└─└─
Tuberculose multirésistante
Tuberculosis, Multidrug-Resistant
D018088
-
C01.150.252.410.040.552.846.775
└─└─└─└─└─└─
Lèpre multibacillaire
Leprosy, Multibacillary
D056006
-
C01.150.252.410.040.552.475.371.775
└─└─└─└─└─└─
Lèpre paucibacillaire
Leprosy, Paucibacillary
D056005
-
C01.150.252.410.040.552.475.371.850
└─└─└─└─└─└─
Tuberculose ganglionnaire
Tuberculosis, Lymph Node
D014388
-
C01.150.252.410.040.552.846.617.475
└─└─└─└─└─└─
Tuberculose ultrarésistante aux médicaments
Extensively Drug-Resistant Tuberculosis
D054908
-
C01.150.252.410.040.552.846.775.500
└─└─└─└─└─└─└─
Lèpre lépromateuse
Leprosy, Lepromatous
D015440
-
C01.150.252.410.040.552.475.371.775.500
└─└─└─└─└─└─└─
Lèpre interpolaire
Leprosy, Borderline
D015439
-
C01.150.252.410.040.552.475.371.850.249
└─└─└─└─└─└─└─
Lèpre tuberculoïde
Leprosy, Tuberculoid
D015441
-
C01.150.252.410.040.552.475.371.850.500
└─└─└─└─└─└─└─
Maladie des écrouelles
King's Evil
D018601
-
C01.150.252.410.040.552.846.617.475.500
2 publications dans cette catégorie
Affiliations :
Clinical Laboratory, Puer Hospital of Traditional Chinese Medicine, Puer, China.
Publications dans "Infections bactériennes" :
2 publications dans cette catégorie
Affiliations :
Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China.
Publications dans "Infections bactériennes" :
2 publications dans cette catégorie
Affiliations :
Department of Pathogen Biology and Immunology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, China.
Publications dans "Infections bactériennes" :
2 publications dans cette catégorie
Affiliations :
VA Nebraska Western Iowa Health Care System, Omaha, NE 68105, USA.
Division of Pulmonary, Critical Care & Sleep, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Publications dans "Infections bactériennes" :
2 publications dans cette catégorie
Affiliations :
Aix-Marseille University, IRD, APHM, MEPHI, Marseille, France.
IHU-Méditerranée Infection, Marseille, France.
Publications dans "Infections bactériennes" :
2 publications dans cette catégorie
Affiliations :
Aix-Marseille University, IRD, APHM, MEPHI, Marseille, France.
IHU-Méditerranée Infection, Marseille, France.
Publications dans "Infections bactériennes" :
2 publications dans cette catégorie
Affiliations :
Division of Emergency Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Publications dans "Infections bactériennes" :
2 publications dans cette catégorie
Affiliations :
Division of Emergency Medicine, Department of Pediatrics, Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Publications dans "Infections bactériennes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA 18015, USA.
Publications dans "Infections bactériennes" :
2 publications dans cette catégorie
Affiliations :
Klinische Abteilung für Infektiologie und Tropenmedizin, Medizinische Universität Wien, Vienna, Austria.
Publications dans "Infections bactériennes" :
1 publication dans cette catégorie
Affiliations :
Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Publications dans "Infections bactériennes" :
1 publication dans cette catégorie
Affiliations :
Institute of Virology, Medical University of Innsbruck, Innsbruck, Austria.
Publications dans "Infections bactériennes" :
1 publication dans cette catégorie
Affiliations :
Institute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria.
Publications dans "Infections bactériennes" :
1 publication dans cette catégorie
Affiliations :
Institute of Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Publications dans "Infections bactériennes" :
1 publication dans cette catégorie
Affiliations :
Translational Cell Genetics, Institute of Pharmacology and Genetics, Medical University of Innsbruck, Innsbruck, Austria.
Publications dans "Infections bactériennes" :
1 publication dans cette catégorie
Affiliations :
Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Philipps-Universität Marburg, Germany.
Publications dans "Infections bactériennes" :
1 publication dans cette catégorie
Affiliations :
Verbund Katholischer Kliniken Düsseldorf, Zentralbereich Hygiene, Infektionsmanagement und ABS, Düsseldorf, Germany.
Publications dans "Infections bactériennes" :
1 publication dans cette catégorie
Affiliations :
Klinik und Poliklinik für Gastroenterologie und Rheumatologie, Universitätsklinikum Leipzig, Germany.
Publications dans "Infections bactériennes" :
1 publication dans cette catégorie
Affiliations :
Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. ycxiao@sibs.ac.cn.
Publications dans "Infections bactériennes" :
1 publication dans cette catégorie
Affiliations :
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Publications dans "Infections bactériennes" :
Pharmacokinetic (PK) boosting is the intentional use of a drug-drug interaction to enhance systemic drug exposure. PK boosting of olaparib, a CYP3A-substrate, has the potential to reduce PK variabilit...
This cross-over, multicentre trial compared olaparib 300 mg twice daily (BID) with olaparib 100 mg BID boosted with the strong CYP3A-inhibitor cobicistat 150 mg BID. Patients were randomised to the st...
Of 15 included patients, 12 were eligible for PK analysis. The GMR of the AUC...
Boosting a 100 mg BID olaparib dose with cobicistat increases olaparib exposure 1.45-fold, compared to the standard dose of 300 mg BID. Equivalence of the boosted olaparib was thus not established. Bo...
The short shelf-life of liquid-stored platelets (LP) at 20-24°C poses shortage and wastage challenges. Cryopreserved platelets have significantly extended shelf-life, and were safe and efficacious for...
We performed a phase 1b/2a randomized cross-over study comparing the safety and efficacy of cryopreserved buffy coat-derived pooled platelets (CP) to LP in the prophylactic transfusions of thrombocyto...
A total of 18 adults were randomly assigned 1:1 to CP and LP for their first thrombocytopenic period (TP) of up to 28-days. A total of 14 crossed over to the other platelet-arm for the second TP. Over...
During shortages, CP may supplement LP in prophylactic transfusions of thrombocytopenic patients....
Diagnosis of heart failure with preserved ejection fraction (HFpEF) can be challenging. This study aimed to evaluate the potential of a webtool to enhance the scoring accuracy when applying the comple...
We developed an online tool, the HFpEF calculator, that enables the automatic calculation of current HFpEF algorithms. We assessed the accuracy of manual vs. automatic scoring, defined as the percenta...
Manual calculation of HFpEF diagnostic algorithms is often inaccurate. Using an automated webtool to calculate HFpEF algorithms significantly improved correct scoring. This new approach may impact the...
Standard haemodialysis (sHD) is associated with a poor survival and marked adverse intradialytic patient-reported outcome measures (ID-PROMs). Whereas physical ID-PROMs (PID-PROMs) are alleviated by c...
To assess whether PID-PROMs and thermal perception differ between sHD, cHD, low volume HDF (lvHDF) and high volume HDF (hvHDF), 40 patients were cross-over randomized to each modality for 2 weeks. Dia...
Except for the item 'feeling cold' during cHD (p = .01), PID-PROMs did not differ between modalities, but varied markedly between patients (11/13 items, p < .05). T...
(1) PID-PROMs did not differ between modalities, but varied markedly between patients. Hence, PID-PROMs are largely patient-dependent. (2) While T...
To intrinsically motivate students in the long term, longitudinal e-learning systems combined with repeated testing and competitive gamification seem promising. The effects of this approach have never...
Participants were 5.-9. semester medical students (n = 48), recruited in an elective evidence-based medicine subject and randomly distributed to two groups (group 1: n = 23; group 2: n = 25). Both acc...
Students' improvements in e-test scores after training with the corresponding topics in the learning application can be attributed to chance. Even though the majority enjoyed playing and felt motivate...
The authors found no evidence for benefits of the investigated learning programme on students' risk competence or on their internal motivation. The majority disapproved the competitive concept, indica...
Physical exertion is a high-risk activity for aerosol emission of respiratory pathogens. We aimed to determine the safety and tolerability of healthy young adults wearing different types of face mask ...
Cross-over randomised controlled study, completed between June 2021 and January 2022....
Volunteers aged 18-35 years, who exercised regularly and had no significant pre-existing health conditions....
Comparison of wearing a surgical, cloth and filtering face piece (FFP3) mask to no mask during 4×15 min bouts of exercise. Exercise was running outdoors or indoor rowing at moderate-to-high intensity,...
The primary outcome was change in oxygen saturations. Secondary outcomes were change in heart rate, perceived impact of face mask wearing during exercise and willingness to wear a face mask for future...
All 72 volunteers (mean age 23.9) completed the study. Changes in oxygen saturations did not exceed the prespecified non-inferiority margin (2% difference) with any mask type compared with no mask. At...
This study adds to previous findings (mostly from non-randomised studies) that exercising at moderate-to-high intensity wearing a face mask appears to be safe in healthy, young adults....
NCT04932226....
Vegetables are an essential component of a healthy dietary pattern in children; however, their consumption is often insufficient due to lack of preference. To address this, the influence of combining ...
Current research suggests that pre-competition sexual intercourse does not influence athletes' performance. Yet, high quality studies in this field are scarce....
We aimed to investigate whether sexual activity negatively influences physiological performance. We conducted a prospective cross over study, which enrolled active players from the first team of a foo...
We enrolled 14 participants who participated in 88 football matches. The mean age was 29.7 (±3.8) years and the majority were in permanent relationships for longer than 6 months (78.6%). We identified...
To the best of our knowledge, this study is the first to show that sexual intercourse the night before a football match may have a negative influence on players' performance....
To characterise applied force on the face and head during simulated mask ventilation with varying mask, device and expertise level....
Randomised cross-over simulation study....
A quiet, empty room in the children's hospital....
Neonatal healthcare providers, categorised as novices and experts in positive pressure ventilation (PPV)....
PPV for 2 min each in a 2×2 within-subjects design with two masks (round and anatomic) and two ventilation devices (T-piece and self-inflating bag (SIB))....
Applied force (Newton (N)) measured under the head and at four locations on the manikin's face (nasal bridge, mentum, left and right zygomatic arches) and symmetry of force applied around the mask rim...
For the 51 participants, force applied to the head was greater with the SIB than the T-piece (mean (SD): 16.03 (6.96) N vs 14.31 (5.16) N) and greater with the anatomic mask than the round mask (mean ...
We characterised an initial dataset of applied forces on the face and head during simulated PPV and described differences in force when considering mask type, device type and expertise....
To assess the effect of the toothbrush handle on video-observed toothbrushing behaviour and toothbrushing effectiveness....
This is a randomized counterbalanced cross-over study. N = 50 university students and employees brushed their teeth at two occasions, one week apart, using either a commercial ergonomically designed m...
The study participants found the BV1 significantly more cumbersome than the M1 or their brush at home. (p < 0.05). However, correlation analyses revealed a strong consistency of brushing behavior with...
The results of the study indicate that the brushing handle does not play a major role in brushing behavior or brushing effectiveness....