Comment diagnostiquer une intoxication aux composés benzhydryliques ?

Le diagnostic repose sur l'historique médical et des tests de laboratoire spécifiques.

Quels tests sont utilisés pour évaluer l'exposition ?

Des analyses sanguines et urinaires peuvent détecter la présence de ces composés.

Quels symptômes indiquent une surdose ?

Les symptômes incluent confusion, somnolence et troubles respiratoires.

Comment différencier les effets des composés benzhydryliques ?

Une évaluation clinique complète et l'historique des médicaments sont nécessaires.

Quels signes cliniques sont associés à ces composés ?

Les signes incluent des anomalies neurologiques et des troubles cardiovasculaires.

Quels sont les symptômes courants d'une exposition ?

Les symptômes incluent des nausées, des vertiges et des maux de tête.

Peut-on avoir des réactions cutanées ?

Oui, des éruptions cutanées et des démangeaisons peuvent survenir.

Quels effets neurologiques peuvent se manifester ?

Des troubles de la coordination et des convulsions peuvent se produire.

Y a-t-il des symptômes respiratoires associés ?

Oui, des difficultés respiratoires et une respiration rapide peuvent apparaître.

Les symptômes varient-ils selon la dose ?

Oui, la gravité des symptômes dépend de la dose et de la durée d'exposition.

Comment prévenir l'exposition aux composés benzhydryliques ?

Utiliser des équipements de protection lors de la manipulation de ces substances.

Y a-t-il des formations recommandées ?

Oui, des formations sur la manipulation sécurisée des produits chimiques sont conseillées.

Quels sont les conseils de stockage sécuritaire ?

Stocker dans des contenants étiquetés et dans des zones bien ventilées.

Comment sensibiliser le personnel aux risques ?

Organiser des sessions d'information régulières sur les dangers des composés.

Quelles sont les réglementations à suivre ?

Respecter les réglementations locales et nationales sur la manipulation des produits chimiques.

Quel est le traitement principal en cas d'intoxication ?

Le traitement comprend l'administration de charbon actif et une surveillance médicale.

Des antidotes spécifiques existent-ils ?

Il n'existe pas d'antidote spécifique pour les composés benzhydryliques.

Comment gérer les symptômes neurologiques ?

Des médicaments anticonvulsivants peuvent être administrés pour contrôler les crises.

Quelle est l'importance de l'hydratation ?

L'hydratation est cruciale pour aider à éliminer les toxines du corps.

Quand faut-il envisager une hospitalisation ?

L'hospitalisation est nécessaire en cas de symptômes graves ou de complications.

Quelles complications peuvent survenir après une exposition ?

Des complications neurologiques et respiratoires peuvent se développer.

Les effets à long terme sont-ils possibles ?

Oui, des effets à long terme sur la santé peuvent survenir après une exposition prolongée.

Comment les complications sont-elles gérées ?

La gestion des complications nécessite un suivi médical régulier et des traitements adaptés.

Y a-t-il des risques de cancer associés ?

Certaines études suggèrent un lien potentiel entre l'exposition et le cancer.

Les complications peuvent-elles être évitées ?

Oui, en respectant les mesures de sécurité et en évitant l'exposition.

Quels sont les principaux facteurs de risque d'exposition ?

Les travailleurs en laboratoire et ceux manipulant des produits chimiques sont à risque.

L'âge influence-t-il le risque d'effets ?

Oui, les jeunes enfants et les personnes âgées sont plus vulnérables.

Les antécédents médicaux jouent-ils un rôle ?

Oui, des antécédents de maladies respiratoires augmentent le risque.

Les conditions environnementales affectent-elles le risque ?

Oui, une exposition dans des environnements mal ventilés augmente le risque.

Les habitudes de vie influencent-elles le risque ?

Oui, le tabagisme et l'alcoolisme peuvent exacerber les effets des composés.

Composés benzhydryliques - Informations médicales vérifiées

Targeted lateral pelvic lymph node excision in the setting of total neoadjuvant therapy for rectal cancer.

03 2023

DOI: 10.1111/ans.18149 PMID: 36398435

Targeted lateral pelvic node dissection in the era of total neoadjuvant therapy....

Humans Neoadjuvant Therapy Lymph Node Excision Lymph Nodes Pelvis +3 autres

Prone position thoracoscopic-assisted total mesoesophageal excision: initial experiences and benefits of lymph node dissection.

03 2023

DOI: 10.1007/s00464-022-09704-x PMID: 36289085

Total mesoesophageal excision (TME) is a promising procedure. Prone position thoracoscopic-assisted TME might be a good choice, even without robust evidence yet. Therefore, it is necessary to explore ... We retrospectively analyzed the short-term outcomes regarding intraoperative unplanned events, postoperative complications, and lymphadenectomy in 61 patients who underwent prone position thoracoscopi... Of these sixty-one patients, there were 10, 24 and 27 cases of tumor in the upper, middle, and lower thoracic, respectively. Although there were five cases of unplanned events during surgery, no conve... The prone position thoracoscopic-assisted TME is a safe procedure that is more conducive to thoracic lymph node dissection, especially for middle and lower mediastinum....

Humans Prone Position Retrospective Studies Esophageal Neoplasms Lymph Node Excision +4 autres

Efficacy of octreotide to reduce lymphorrhea and prevent lymphocele after pelvic lymph node excision in gynecological malignancies.

Aug 2023

DOI: 10.1111/jog.15702 PMID: 37254619

To study the efficacy of octreotide to reduce lymphorrhea and prevent lymphocele after pelvic lymph node excision in gynecological malignancies.... Patients with more than 200 mL of lymph drained per day until postoperative day 3 after pelvic lymph node excision were enrolled. Of the 75 patients, 36 were managed by conservative methods without th... The total and mean daily amount of lymph produced per patient was significantly lower in the octreotide-treated group than in the untreated group. The duration of drain placement was shorter in the oc... The injection of octreotide is effective to reduce lymphorrhea and prevent lymphocele after pelvic lymph node excision in gynecological malignancies....

Female Humans Lymphocele Octreotide Genital Neoplasms, Female +2 autres

Lymph node recurrence after right colon resection for cancer: evidence for the utilisation of complete mesocolic excision.

12 May 2022

DOI: 10.1136/bcr-2021-247904 PMID: 35550325

Complete mesocolic excision (CME) of colon cancer is a resection performed along embryological planes to include the completely intact mesentery surrounding the tumour with a high central vascular lig...

Colectomy Colonic Neoplasms Humans Laparoscopy Lymph Node Excision +3 autres

Subcostal lymph nodes: An unusual sentinel lymph node basin in cutaneous melanoma.

Dec 2022

DOI: 10.1002/jso.27022 PMID: 35870116

Lymphatic drainage from subcostal nodes, along the costal groove, have not previously been characterized as sites for melanoma drainage and metastasis. This study reports a series of patients with sub... Patients who presented to our institution between 2005 and 2020 with documented cutaneous melanoma and sentinel lymph node biopsy of a subcostal node (sentinel = S), or metastases to subcostal nodes l... Six patients had subcostal sentinel nodes (SNs). Primary sites included the posterior trunk and lateral chest wall. Subcostal nodes were found under ribs 10-12. Subcostal SNs had at least one dimensio... Melanoma can metastasize to subcostal lymph nodes and be found at the time of SN biopsy or identified at recurrence. These small nodes are fed by lymphatic channels that run in the neurovascular bundl...

Humans Melanoma Skin Neoplasms Sentinel Lymph Node Lymphatic Metastasis +5 autres

Lymph Node Positivity of Axillary Reverse Mapping Lymph Nodes at the Time of Axillary Lymph Node Dissection: Two-Site Prospective Trial.

Oct 2023

DOI: 10.1245/s10434-023-13883-9 PMID: 37466868

Axillary reverse mapping (ARM) was introduced in 2007 to identify and selectively preserve upper-extremity lymphatics during axillary lymph node surgery to decrease the risk of lymphedema. The patient... Patients undergoing ALND with or without immediate lymphatic reconstruction (ILR) were enrolled in a prospective trial at two institutional sites between April 2018 and Decemeber 2022. This report ana... The inclusion criteria were met by 139 patients, who made up the study population (133 with breast cancer and 6 with other disease). Of the breast cancer patients, 99.2% were female, 35.3% (47/133) we... In the contemporary patient population undergoing ALND, the positivity rate of the ARM LN was relatively high, suggesting that leaving ARM LNs in patients undergoing ALND may not be oncologically safe...

Female Humans Male Axilla Breast Neoplasms +5 autres

Sentinel Lymph Node Identification in Post Neoadjuvant Chemotherapy Breast Cancer Patients Undergoing Surgical Excision Using Lymphosonography.

Jul 2023

DOI: 10.1002/jum.16164 PMID: 36591785

This study evaluated the efficacy of lymphosonography in the identification of sentinel lymph nodes (SLNs) in post neoadjuvant chemotherapy patients with breast cancer scheduled to undergo surgical ex... Seventy-nine subjects scheduled for breast cancer surgery with SLN excision completed this IRB-approved study, out of which 18 (23%) underwent neoadjuvant chemotherapy before surgery. Subjects underwe... Seventy-two SLNs were surgically excised from 18 subjects, 29 were positive for blue dye, 63 were positive for radioactive tracer and 57 were positive for Sonazoid. Comparison with blue dye showed tha... Lymphosonography achieved similar accuracy as radioactive tracer and higher accuracy than blue dye for identifying SLNs. The 15 SLNs positive for malignancy were all identified by lymphosonography....

Humans Female Sentinel Lymph Node Breast Neoplasms Sentinel Lymph Node Biopsy +6 autres

Prediction of nonsentinel lymph node metastasis in acral melanoma with positive sentinel lymph nodes.

Dec 2023

DOI: 10.1002/jso.27438 PMID: 37689989

Metastasis in a nonsentinel lymph node (non-SLN) is an unfavorable independent prognostic factor in cutaneous melanoma (CM). Recent data did suggest potential value of completion lymph node dissection... This retrospective study enrolled 656 cases of melanoma who underwent sentinel lymph node biopsy at Fudan University Shanghai Cancer Center from 2009 to 2017. We identified 81 SLN + AM patients who un... Ulceration, Clark level, number of deposits in the SLN (NumDep) and maximum size of deposits (MaxSize) are independent risk factors associated with non-SLN metastases. We developed a scoring system th... A scoring system that included ulceration, Clark level, MaxSize, and NumDep is reliable and effective for predicting non-SLN metastasis in SLN-positive AM....

Humans Melanoma Skin Neoplasms Lymphatic Metastasis Sentinel Lymph Node +7 autres

Prognostic Value of Lymph Node Yield, Lymph Node Density, and pN in Oral Cancer.

08 2023

DOI: 10.1177/01945998221123927 PMID: 36066971

To investigate thresholds for lymph node yield (LNY), lymph node density (LND), and pN in patients with oral squamous cell carcinoma in relation to previous findings in the literature.... Retrospective register-based study.... Copenhagen Oral Cavity Squamous Cell Carcinoma database.... Appropriate thresholds for LNY, LND, and pN were determined by areas under the curve and subsequently subjected to multivariate analysis. Five-year overall survival and 3-year recurrence-free survival... In total, 413 patients diagnosed with oral squamous cell carcinoma were included. In the pN0 cohort, no superior/prognostic LNY cutoff values were detected. In the pN+ cohort, areas under the curve de... Increased nodal yield, decreased LND, and decreasing number of pN were associated with significantly improved survival outcomes. LNY might serve as a prognosticator of survival as well as a surgical q...

Humans Prognosis Carcinoma, Squamous Cell Retrospective Studies Mouth Neoplasms +5 autres

Effect of inguinal lymph node dissection in lymph node negative patients with squamous cell carcinoma of the penis.

Jan 2023

DOI: 10.1007/s00345-022-04184-z PMID: 36239810

The survival benefit of inguinal lymph node dissection (ILND) vs no ILND in patients with squamous cell carcinoma of the penis (SCCP) and the absence of lymph node invasion is unclear. We addressed th... We identified lymph node negative SCCP patients who either underwent ILND (pN0) or clinical examination only (cN0). We tested for the effect of ILND vs no ILND on cancer-specific mortality (CSM) in Ka... Of 2520 SCCP patients, 369 (15%) underwent ILND (pN0) vs 2151 (85%) did not (cN0). The pN0 vs cN0 distribution according to pT stages was as follows: 80 (7%) vs 1092 (93%) in pT1b, and 289 (21%) vs 10... In pT2-3 stage SCCP, a significantly lower CSM was recorded in lymph node negative patients treated with ILND than in their clinical lymph node negative counterparts who did not undergo ILND....

Male Humans Lymph Node Excision Lymph Nodes Proportional Hazards Models +3 autres

Composés benzhydryliques : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Sous-catégories

Diphénhydramine

2,2'-Dichloro-4,4'-méthylènedianiline

Modafinil

Orphénadrine

Auteurs principaux

Sources (8013 au total)