Astrocytic pathology in Alpers' syndrome.
Refractory epilepsy is the main neurological manifestation of Alpers' syndrome, a severe childhood-onset mitochondrial disease caused by bi-allelic pathogenic variants in the mitochondrial DNA (mtDNA)...
Sclérose cérébrale diffuse de Schilder : Questions médicales fréquentes
Questions fréquentes et termes MeSH associés
Diagnostic 5
#1
Comment diagnostique-t-on la sclérose de Schilder ?
Le diagnostic repose sur l'imagerie cérébrale, l'examen neurologique et l'analyse du liquide céphalorachidien.
#2
Quels tests sont utilisés pour confirmer le diagnostic ?
Les IRM et les tests neuropsychologiques aident à confirmer la présence de lésions cérébrales.
#3
Les symptômes peuvent-ils être confondus avec d'autres maladies ?
Oui, les symptômes peuvent ressembler à ceux de la sclérose en plaques ou d'autres troubles neurologiques.
#4
Quel rôle joue l'examen neurologique dans le diagnostic ?
L'examen neurologique évalue les fonctions cognitives et motrices, révélant des anomalies.
#5
Peut-on utiliser une biopsie pour le diagnostic ?
Une biopsie cérébrale est rarement utilisée, mais peut aider dans des cas atypiques.
Symptômes 5
#1
Quels sont les symptômes courants de la sclérose de Schilder ?
Les symptômes incluent des troubles cognitifs, des problèmes de coordination et des crises épileptiques.
#2
La fatigue est-elle un symptôme fréquent ?
Oui, la fatigue est un symptôme courant et peut affecter la qualité de vie des patients.
#3
Les troubles de la vision sont-ils possibles ?
Oui, des troubles visuels comme la vision floue peuvent survenir en raison des lésions cérébrales.
#4
Les symptômes varient-ils d'un patient à l'autre ?
Oui, l'intensité et la nature des symptômes peuvent varier considérablement entre les patients.
#5
Les symptômes peuvent-ils s'aggraver avec le temps ?
Oui, la progression des symptômes peut se produire, nécessitant une surveillance régulière.
Prévention 5
#1
Peut-on prévenir la sclérose de Schilder ?
Il n'existe pas de méthode de prévention connue, mais un suivi médical régulier est conseillé.
#2
Les facteurs environnementaux jouent-ils un rôle ?
Des facteurs environnementaux peuvent influencer le développement de la maladie, mais ils ne sont pas clairement définis.
#3
L'alimentation peut-elle aider à prévenir la maladie ?
Une alimentation équilibrée peut soutenir la santé neurologique, mais ne prévient pas spécifiquement la maladie.
#4
Le stress a-t-il un impact sur la maladie ?
Le stress peut aggraver les symptômes, mais son rôle dans la prévention n'est pas établi.
#5
Des vaccinations sont-elles recommandées ?
Les vaccinations standard sont recommandées, mais aucune vaccination spécifique ne prévient la maladie.
Traitements 5
#1
Quels traitements sont disponibles pour la sclérose de Schilder ?
Les traitements incluent des corticostéroïdes, des immunosuppresseurs et des thérapies symptomatiques.
#2
La rééducation est-elle recommandée ?
Oui, la rééducation physique et cognitive est souvent recommandée pour améliorer la fonction.
#3
Les médicaments peuvent-ils réduire les symptômes ?
Oui, certains médicaments peuvent aider à gérer les symptômes comme la douleur et la fatigue.
#4
Y a-t-il des traitements expérimentaux ?
Des traitements expérimentaux, comme les thérapies géniques, sont en cours d'évaluation.
#5
Les traitements sont-ils personnalisés ?
Oui, les traitements sont souvent adaptés en fonction des symptômes et de la progression de la maladie.
Complications 5
#1
Quelles complications peuvent survenir ?
Les complications incluent des troubles cognitifs sévères, des crises fréquentes et des handicaps physiques.
#2
La dépression est-elle une complication possible ?
Oui, la dépression peut survenir en raison des défis liés à la maladie et à ses symptômes.
#3
Les complications peuvent-elles affecter la vie quotidienne ?
Oui, les complications peuvent gravement affecter la qualité de vie et l'autonomie des patients.
#4
Y a-t-il un risque accru d'infections ?
Oui, les patients peuvent avoir un risque accru d'infections en raison de l'immunosuppression.
#5
Les complications sont-elles réversibles ?
Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes.
Facteurs de risque 5
#1
Quels sont les facteurs de risque connus ?
Les facteurs de risque incluent l'âge jeune, des antécédents familiaux et des infections virales.
#2
Le sexe influence-t-il le risque de la maladie ?
Oui, la maladie est plus fréquente chez les garçons que chez les filles, surtout à un jeune âge.
#3
Les infections virales sont-elles un facteur de risque ?
Certaines infections virales, comme le virus Epstein-Barr, peuvent être associées à un risque accru.
#4
L'exposition à des toxines est-elle un facteur de risque ?
L'exposition à certaines toxines environnementales pourrait augmenter le risque, mais les données sont limitées.
#5
Les antécédents médicaux influencent-ils le risque ?
Oui, des antécédents de maladies auto-immunes peuvent augmenter le risque de sclérose de Schilder.
Contenu validé par Dr Olivier Menir
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 08/02/2026
Contenu vérifié selon les dernières recommandations médicales
Auteurs principaux
Christopher P Denton
3 publications dans cette catégorie
Affiliations :
- Division of Medicine, University College London, London, UK.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
Patient perception of disease burden in diffuse cutaneous systemic sclerosis.
Journal of scleroderma and related disorders 2019-08-21
-
Diffuse cutaneous systemic sclerosis following SARS-Co V-2 vaccination.
Journal of autoimmunity 2022-03-02
-
Clinical trial protocol: PRednisolone in early diffuse cutaneous Systemic Sclerosis (PRedSS).
Journal of scleroderma and related disorders 2020-09-17
Susanne J van Veluw
2 publications dans cette catégorie
Affiliations :
- From the J. Philip Kistler Stroke Research Center, Department of Neurology (S.J.v.V., Y.D.R., A.C., G.A.R., A.V., S.M.G.), and Neuropathology Service, C.S. Kubik Laboratory for Neuropathology (M.P.F.), Massachusetts General Hospital and Harvard Medical School, Boston; MassGeneral Institute for Neurodegenerative Disease (S.J.v.V., B.J.B., M.P.F.), Charlestown Navy Yard, MA; Department of Neurology, Brain Center Rudolf Magnus (Y.D.R.), and Image Sciences Institute (A.L.), University Medical Center Utrecht, Utrecht University, the Netherlands; and Athinoula A. Martinos Center for Biomedical Imaging (A.J.v.d.K.), Department of Radiology, Massachusetts General Hospital, Charlestown. svanveluw@mgh.harvard.edu.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
Histopathology of diffusion imaging abnormalities in cerebral amyloid angiopathy.
Neurology 2019-01-30
-
Histopathology of diffusion-weighted imaging-positive lesions in cerebral amyloid angiopathy.
Acta neuropathologica 2020-02-27
Yael D Reijmer
2 publications dans cette catégorie
Affiliations :
- From the J. Philip Kistler Stroke Research Center, Department of Neurology (S.J.v.V., Y.D.R., A.C., G.A.R., A.V., S.M.G.), and Neuropathology Service, C.S. Kubik Laboratory for Neuropathology (M.P.F.), Massachusetts General Hospital and Harvard Medical School, Boston; MassGeneral Institute for Neurodegenerative Disease (S.J.v.V., B.J.B., M.P.F.), Charlestown Navy Yard, MA; Department of Neurology, Brain Center Rudolf Magnus (Y.D.R.), and Image Sciences Institute (A.L.), University Medical Center Utrecht, Utrecht University, the Netherlands; and Athinoula A. Martinos Center for Biomedical Imaging (A.J.v.d.K.), Department of Radiology, Massachusetts General Hospital, Charlestown.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
Histopathology of diffusion imaging abnormalities in cerebral amyloid angiopathy.
Neurology 2019-01-30
-
Histopathology of diffusion-weighted imaging-positive lesions in cerebral amyloid angiopathy.
Acta neuropathologica 2020-02-27
Andre J van der Kouwe
2 publications dans cette catégorie
Affiliations :
- From the J. Philip Kistler Stroke Research Center, Department of Neurology (S.J.v.V., Y.D.R., A.C., G.A.R., A.V., S.M.G.), and Neuropathology Service, C.S. Kubik Laboratory for Neuropathology (M.P.F.), Massachusetts General Hospital and Harvard Medical School, Boston; MassGeneral Institute for Neurodegenerative Disease (S.J.v.V., B.J.B., M.P.F.), Charlestown Navy Yard, MA; Department of Neurology, Brain Center Rudolf Magnus (Y.D.R.), and Image Sciences Institute (A.L.), University Medical Center Utrecht, Utrecht University, the Netherlands; and Athinoula A. Martinos Center for Biomedical Imaging (A.J.v.d.K.), Department of Radiology, Massachusetts General Hospital, Charlestown.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
Histopathology of diffusion imaging abnormalities in cerebral amyloid angiopathy.
Neurology 2019-01-30
-
Histopathology of diffusion-weighted imaging-positive lesions in cerebral amyloid angiopathy.
Acta neuropathologica 2020-02-27
Brian J Bacskai
2 publications dans cette catégorie
Affiliations :
- From the J. Philip Kistler Stroke Research Center, Department of Neurology (S.J.v.V., Y.D.R., A.C., G.A.R., A.V., S.M.G.), and Neuropathology Service, C.S. Kubik Laboratory for Neuropathology (M.P.F.), Massachusetts General Hospital and Harvard Medical School, Boston; MassGeneral Institute for Neurodegenerative Disease (S.J.v.V., B.J.B., M.P.F.), Charlestown Navy Yard, MA; Department of Neurology, Brain Center Rudolf Magnus (Y.D.R.), and Image Sciences Institute (A.L.), University Medical Center Utrecht, Utrecht University, the Netherlands; and Athinoula A. Martinos Center for Biomedical Imaging (A.J.v.d.K.), Department of Radiology, Massachusetts General Hospital, Charlestown.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
Histopathology of diffusion imaging abnormalities in cerebral amyloid angiopathy.
Neurology 2019-01-30
-
Histopathology of diffusion-weighted imaging-positive lesions in cerebral amyloid angiopathy.
Acta neuropathologica 2020-02-27
Matthew P Frosch
2 publications dans cette catégorie
Affiliations :
- From the J. Philip Kistler Stroke Research Center, Department of Neurology (S.J.v.V., Y.D.R., A.C., G.A.R., A.V., S.M.G.), and Neuropathology Service, C.S. Kubik Laboratory for Neuropathology (M.P.F.), Massachusetts General Hospital and Harvard Medical School, Boston; MassGeneral Institute for Neurodegenerative Disease (S.J.v.V., B.J.B., M.P.F.), Charlestown Navy Yard, MA; Department of Neurology, Brain Center Rudolf Magnus (Y.D.R.), and Image Sciences Institute (A.L.), University Medical Center Utrecht, Utrecht University, the Netherlands; and Athinoula A. Martinos Center for Biomedical Imaging (A.J.v.d.K.), Department of Radiology, Massachusetts General Hospital, Charlestown.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
Histopathology of diffusion imaging abnormalities in cerebral amyloid angiopathy.
Neurology 2019-01-30
-
Histopathology of diffusion-weighted imaging-positive lesions in cerebral amyloid angiopathy.
Acta neuropathologica 2020-02-27
Steven M Greenberg
2 publications dans cette catégorie
Affiliations :
- From the J. Philip Kistler Stroke Research Center, Department of Neurology (S.J.v.V., Y.D.R., A.C., G.A.R., A.V., S.M.G.), and Neuropathology Service, C.S. Kubik Laboratory for Neuropathology (M.P.F.), Massachusetts General Hospital and Harvard Medical School, Boston; MassGeneral Institute for Neurodegenerative Disease (S.J.v.V., B.J.B., M.P.F.), Charlestown Navy Yard, MA; Department of Neurology, Brain Center Rudolf Magnus (Y.D.R.), and Image Sciences Institute (A.L.), University Medical Center Utrecht, Utrecht University, the Netherlands; and Athinoula A. Martinos Center for Biomedical Imaging (A.J.v.d.K.), Department of Radiology, Massachusetts General Hospital, Charlestown.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
Histopathology of diffusion imaging abnormalities in cerebral amyloid angiopathy.
Neurology 2019-01-30
-
Histopathology of diffusion-weighted imaging-positive lesions in cerebral amyloid angiopathy.
Acta neuropathologica 2020-02-27
Arjun G Yodh
2 publications dans cette catégorie
Affiliations :
- Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, USA.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
Dynamic cerebral autoregulation measured by diffuse correlation spectroscopy.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2023-01-26
-
Correlation of Cerebral Microdialysis with Non-Invasive Diffuse Optical Cerebral Hemodynamic Monitoring during Deep Hypothermic Cardiopulmonary Bypass.
Metabolites 2022-08-10
Dinesh Khanna
2 publications dans cette catégorie
Affiliations :
- Division of Rheumatology, Department of Internal Medicine, Scleroderma Program, Clinical Autoimmunity Center of Excellence, University of Michigan, Ann Arbor, MI, USA.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis.
Arthritis research & therapy 2021-01-06
-
Patient perception of disease burden in diffuse cutaneous systemic sclerosis.
Journal of scleroderma and related disorders 2019-08-21
Gautam Adusumilli
2 publications dans cette catégorie
Affiliations :
- Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
Diffusion basis spectrum imaging and diffusion tensor imaging predict persistent black hole formation in multiple sclerosis.
Multiple sclerosis and related disorders 2024-02-11
-
Deep learning with diffusion basis spectrum imaging for classification of multiple sclerosis lesions.
Annals of clinical and translational neurology 2020-04-18
Peng Sun
2 publications dans cette catégorie
Affiliations :
- Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
Diffusion basis spectrum imaging and diffusion tensor imaging predict persistent black hole formation in multiple sclerosis.
Multiple sclerosis and related disorders 2024-02-11
-
Deep learning with diffusion basis spectrum imaging for classification of multiple sclerosis lesions.
Annals of clinical and translational neurology 2020-04-18
Robert T Naismith
2 publications dans cette catégorie
Affiliations :
- Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
Diffusion basis spectrum imaging and diffusion tensor imaging predict persistent black hole formation in multiple sclerosis.
Multiple sclerosis and related disorders 2024-02-11
-
Deep learning with diffusion basis spectrum imaging for classification of multiple sclerosis lesions.
Annals of clinical and translational neurology 2020-04-18
Sheng-Kwei Song
2 publications dans cette catégorie
Affiliations :
- Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
Diffusion basis spectrum imaging and diffusion tensor imaging predict persistent black hole formation in multiple sclerosis.
Multiple sclerosis and related disorders 2024-02-11
-
Deep learning with diffusion basis spectrum imaging for classification of multiple sclerosis lesions.
Annals of clinical and translational neurology 2020-04-18
Anne H Cross
2 publications dans cette catégorie
Affiliations :
- Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
Diffusion basis spectrum imaging and diffusion tensor imaging predict persistent black hole formation in multiple sclerosis.
Multiple sclerosis and related disorders 2024-02-11
-
Deep learning with diffusion basis spectrum imaging for classification of multiple sclerosis lesions.
Annals of clinical and translational neurology 2020-04-18
Steven O'Reilly
2 publications dans cette catégorie
Affiliations :
- Durham University, Stockton Road, DH1 3LE, United Kingdom. Electronic address: stevenoreilly@hotmail.com.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
Jurriaan M Peters
2 publications dans cette catégorie
Affiliations :
- Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
- Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
White matter mean diffusivity correlates with myelination in tuberous sclerosis complex.
Annals of clinical and translational neurology 2019-06-23
-
Longitudinal Effects of Everolimus on White Matter Diffusion in Tuberous Sclerosis Complex.
Pediatric neurology 2018-10-18
Benoit Scherrer
2 publications dans cette catégorie
Affiliations :
- Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
White matter mean diffusivity correlates with myelination in tuberous sclerosis complex.
Annals of clinical and translational neurology 2019-06-23
-
Longitudinal Effects of Everolimus on White Matter Diffusion in Tuberous Sclerosis Complex.
Pediatric neurology 2018-10-18
Sanjay P Prabhu
2 publications dans cette catégorie
Affiliations :
- Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
White matter mean diffusivity correlates with myelination in tuberous sclerosis complex.
Annals of clinical and translational neurology 2019-06-23
-
Longitudinal Effects of Everolimus on White Matter Diffusion in Tuberous Sclerosis Complex.
Pediatric neurology 2018-10-18
Mustafa Sahin
2 publications dans cette catégorie
Affiliations :
- Translational Neuroscience Center, Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
White matter mean diffusivity correlates with myelination in tuberous sclerosis complex.
Annals of clinical and translational neurology 2019-06-23
-
Longitudinal Effects of Everolimus on White Matter Diffusion in Tuberous Sclerosis Complex.
Pediatric neurology 2018-10-18
Simon K Warfield
2 publications dans cette catégorie
Affiliations :
- Computational Radiology Laboratory, Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Publications dans "Sclérose cérébrale diffuse de Schilder" :
-
White matter mean diffusivity correlates with myelination in tuberous sclerosis complex.
Annals of clinical and translational neurology 2019-06-23
-
Longitudinal Effects of Everolimus on White Matter Diffusion in Tuberous Sclerosis Complex.
Pediatric neurology 2018-10-18
Sources (10000 au total)
Multiple Sclerosis Is Associated With Achalasia and Diffuse Esophageal Spasm.
Multiple sclerosis (MS) is an inflammatory disease characterized by the demyelination of primarily the central nervous system. Diffuse esophageal spasm (DES) and achalasia are both disorders of esopha... Cohort analysis was done using the Explorys database. Univariate logistic regression was performed to determine the odds MS confers to each motility disorder studied. Comparison of proportions of dysa... Odds of MS patients developing achalasia or DES were (OR, 2.09; 95% CI, 1.73-2.52;... Patients with MS have higher odds of developing achalasia or DES compared to patients without MS. MS patients with achalasia or DES have higher rates of dysautonomia comorbidities. This suggests that ...
Multiple Ring-Enhancing Brain Lesions: Fulminant Diffuse Cerebral Toxoplasmosis or Cerebral Metastases?
In this case report, we describe a 76-year-old woman, presenting with dizziness for the past 2 months, without other focal neurological signs. A magnetic resonance imaging of the brain was ordered by ...
Volumetric and diffusion MRI abnormalities associated with dysarthria in multiple sclerosis.
Up to half of all people with multiple sclerosis experience communication difficulties due to dysarthria, a disorder that impacts the motor aspects of speech production. Dysarthria in multiple scleros...
Diffusion-based structural connectivity patterns of multiple sclerosis phenotypes.
We aimed to describe the severity of the changes in brain diffusion-based connectivity as multiple sclerosis (MS) progresses and the microstructural characteristics of these networks that are associat... Clinical information and brain MRIs were collected from 221 healthy individuals and 823 people with MS at 8 MAGNIMS centres. The patients were divided into four clinical phenotypes: clinically isolate... Clinically isolated syndrome and relapsing-remitting patients shared similar network changes relative to controls. However, most global and local network properties differed in secondary progressive p... In conclusion, brain connectivity is disrupted in MS and has differential patterns according to the phenotype. Secondary progressive is associated with more widespread changes in connectivity. Additio...
Age-related decline in cerebral oxygen consumption in multiple sclerosis.
Cerebral oxygen metabolism is altered in relapsing-remitting multiple sclerosis (RRMS), possibly a result of disease related cerebral atrophy with subsequent decreased oxygen demand. However, MS infla...
Diffusion basis spectrum imaging and diffusion tensor imaging predict persistent black hole formation in multiple sclerosis.
Diffusion basis spectrum imaging (DBSI) extracts multiple anisotropic and isotropic diffusion tensors, providing greater histopathologic specificity than diffusion tensor imaging (DTI). Persistent bla... In this prospective cohort study, relapsing MS patients with ≥1 CEL(s) underwent monthly MRI scans for 4 to 6 months until gadolinium resolution. DBSI and DTI metrics were quantified when the CEL was ... The cohort included 20 MS participants (median age 33 years; 13 women) with 164 CELs. Of these, 59 (36 %) CELs evolved into PBHs. At Gd-max, DTI RD and AD of all CELs increased, and both metrics were ... Our findings suggest that greater degree of edema/extracellular space in a CEL is a predictor of tissue destruction, as evidenced by PBH evolution....
Rapid Progression of Skin Sclerosis Following Surgery for Carpal Tunnel Syndrome: A Case of Diffuse Cutaneous Systemic Sclerosis.
Carpal tunnel syndrome (CTS) is a frequently encountered compressive neuropathy that is often treated surgically. Here, we present an unusual case of a 74-year-old female who developed a rapid emergen...
Diffuse systemic sclerosis managed with ayurvedic treatment modalities - A case report.
Diffuse systemic sclerosis or scleroderma is a chronic connective tissue disorder involving many systems and visceral organs. The association of interstitial lung disease carries high mortality risk. ...
Diffuse optical tomography for mapping cerebral hemodynamics and functional connectivity in delirium.
Delirium is associated with mortality and new onset dementia, yet the underlying pathophysiology remains poorly understood. Development of imaging biomarkers has been difficult given the challenging n... Twenty-five delirious and matched non-delirious patients (n = 50) were examined using DOT, comparing cerebral oxygenation and functional connectivity in the prefrontal cortex during and after an episo... Total hemoglobin values were significantly decreased in the delirium group, even after delirium resolution. Functional connectivity between the dorsolateral prefrontal cortex and dorsomedial prefronta... These findings highlight DOT's potential as an imaging biomarker to measure impaired cerebral oxygenation and functional dysconnectivity during and after delirium. Future studies should focus on the r... We developed a portable diffuse optical tomography (DOT) system for bedside three-dimensional functional neuroimaging to study delirium in the hospital. We implemented a novel DOT task-focused seed-ba...