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"@type": "Question",
"name": "Comment le zébrage chromosomique est-il réalisé ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il implique la coloration des chromosomes lors de la métaphase pour révéler des bandes."
}
},
{
"@type": "Question",
"name": "Quels types d'anomalies peut-on détecter ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "On peut identifier des délétions, duplications ou translocations chromosomiques."
}
},
{
"@type": "Question",
"name": "Quel est le rôle du zébrage dans le diagnostic prénatal ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il permet de détecter des anomalies chromosomiques chez le fœtus par amniocentèse."
}
},
{
"@type": "Question",
"name": "Le zébrage chromosomique est-il utilisé en oncologie ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il aide à identifier des altérations chromosomiques dans les cellules tumorales."
}
},
{
"@type": "Question",
"name": "Quels échantillons sont nécessaires pour le zébrage ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des échantillons de sang, de moelle osseuse ou de tissus peuvent être utilisés."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer une anomalie chromosomique ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des retards de développement, des malformations congénitales ou des troubles mentaux."
}
},
{
"@type": "Question",
"name": "Les symptômes sont-ils toujours présents avec des anomalies chromosomiques ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, certaines anomalies peuvent être asymptomatiques et découvertes par hasard."
}
},
{
"@type": "Question",
"name": "Comment les anomalies chromosomiques affectent-elles la santé ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent entraîner des maladies génétiques, des troubles de la croissance ou des cancers."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon le type d'anomalie ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, chaque type d'anomalie peut entraîner des symptômes différents et variés."
}
},
{
"@type": "Question",
"name": "Peut-on prédire les symptômes d'une anomalie chromosomique ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Pas toujours, car l'expression des symptômes peut varier d'une personne à l'autre."
}
},
{
"@type": "Question",
"name": "Comment peut-on prévenir les anomalies chromosomiques ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le conseil génétique et les tests prénataux peuvent aider à identifier les risques."
}
},
{
"@type": "Question",
"name": "Les habitudes de vie influencent-elles les anomalies chromosomiques ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines habitudes, comme l'alcool ou le tabac, peuvent augmenter les risques d'anomalies."
}
},
{
"@type": "Question",
"name": "Le dépistage prénatal est-il recommandé ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il est recommandé pour les femmes à risque ou ayant des antécédents familiaux."
}
},
{
"@type": "Question",
"name": "Les vaccinations peuvent-elles prévenir les anomalies chromosomiques ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines vaccinations peuvent prévenir des infections qui pourraient affecter le fœtus."
}
},
{
"@type": "Question",
"name": "Le suivi médical est-il important pour la prévention ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un suivi médical régulier peut aider à détecter des problèmes potentiels tôt."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour les anomalies chromosomiques ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements varient selon l'anomalie, incluant thérapies géniques ou interventions chirurgicales."
}
},
{
"@type": "Question",
"name": "Le zébrage chromosomique guide-t-il les traitements ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il aide à personnaliser les traitements en fonction des anomalies détectées."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements préventifs pour les anomalies chromosomiques ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de traitements préventifs, mais le conseil génétique est utile."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils efficaces pour toutes les anomalies ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, l'efficacité dépend du type d'anomalie et de la gravité des symptômes associés."
}
},
{
"@type": "Question",
"name": "Peut-on guérir une anomalie chromosomique ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines anomalies peuvent être gérées, mais beaucoup ne peuvent pas être complètement guéries."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec des anomalies chromosomiques ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications peuvent inclure des troubles de la croissance, des malformations ou des cancers."
}
},
{
"@type": "Question",
"name": "Les anomalies chromosomiques augmentent-elles le risque de cancer ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines anomalies chromosomiques sont associées à un risque accru de cancers spécifiques."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être gérées, mais beaucoup ne sont pas réversibles."
}
},
{
"@type": "Question",
"name": "Les complications affectent-elles la qualité de vie ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent avoir un impact significatif sur la qualité de vie des individus concernés."
}
},
{
"@type": "Question",
"name": "Les complications varient-elles selon l'anomalie ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, chaque type d'anomalie peut entraîner des complications différentes et spécifiques."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque d'anomalies chromosomiques ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge maternel avancé, des antécédents familiaux et certaines expositions environnementales."
}
},
{
"@type": "Question",
"name": "L'âge des parents influence-t-il les anomalies chromosomiques ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un âge maternel avancé est associé à un risque accru d'anomalies chromosomiques."
}
},
{
"@type": "Question",
"name": "Les infections pendant la grossesse sont-elles un facteur de risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines infections peuvent augmenter le risque d'anomalies chromosomiques chez le fœtus."
}
},
{
"@type": "Question",
"name": "Les habitudes alimentaires influencent-elles les risques ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation déséquilibrée peut affecter la santé reproductive et augmenter les risques."
}
},
{
"@type": "Question",
"name": "Les traitements médicaux peuvent-ils être des facteurs de risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments ou traitements peuvent augmenter le risque d'anomalies chromosomiques."
}
}
]
}
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}
Nanobody (Nb) has gained significant attention in immunoassays owing to its numerous advantages, particularly its ease of molecular evolution. However, the limited understanding of how high sensitivit...
Ultrasound (US) and computed tomography (CT) are commonly used in the diagnosis of pediatric neck abscesses. The objective of this study is to determine the sensitivity and specificity of US and CT in...
Retrospective review of pediatric patients admitted to a tertiary care center from January 1, 2011, to December 31, 2020, with neck abscesses....
Tertiary care center....
The sensitivity and specificity of US and CT were calculated by comparing imaging performed within 24 h of incision and drainage (I&D). Multiple regression was used to evaluate the association of clin...
There were 171 patients included in this study, with a median age of 1.5 years (interquartile range [IQR]: 1-5 years). I&D was done in 156 patients (91.2%), while 15 (8.8%) were treated with antibioti...
Neck US has a low sensitivity for diagnosing pediatric neck abscesses, when compared to CT, but remains a useful initial investigation given its high PPV. Clinicians should have a low threshold for pu...
Level 4....
Ovarian cancer is usually detected at later stages and no effective screening approach, has been identified. Therefore, sensitive and specific biomarkers for detecting ovarian cancer are urgently need...
This study aimed to investigate the efficacy of six biomarkers for the early clinical diagnosis of ovarian cancer....
The study included 120 patients (benign ovarian tumors and early and late ovarian carcinoma) and 30 control healthy volunteers. MiRNA-204, CA125, CA19.9, hepcidin, microfibril-associated glycoprotein ...
The combined area under the receiver operating characteristic curves for miRNA-204, CA125, and CA19.9 were 0.938, 1.000, and 0.998 for benign tumors and early and late ovarian carcinomas, respectively...
The positive predictivity of miRNA-204, CA125, and CA19.9 for ovarian cancer is high (59.57%, 58.24%, and 61.67%, respectively). Thus, the combination of these three biomarkers is a good diagnostic to...
Reducing the age of first autism diagnosis facilitates access to critical early intervention services. A current "waitlist crisis" for autism diagnostic evaluation thus demands that we consider novel ...
Identifying nonspecific low back pain (LBP) in medico-administrative databases is a major challenge because of the number and heterogeneity of existing diagnostic codes and the absence of standard def...
The objective of this study was to estimate the diagnostic performance (sensitivity, specificity, positive predictive value, and negative predictive value) for recognizing ventriculoperitoneal shunt (...
A prospective cohort study was conducted between 2021 and 2022 including all patients 0-18 years of age who had a VPS and attended the hospital's ER with symptoms that could correspond to VPS blockage...
Ninety-one patients were surveyed, and 59.3% showed evidence of a confirmed VPS blockage. Parental sensitivity was 66.7%, with a specificity of 21.6%. An association was found between parents who coul...
Parents who are more knowledgeable of their child's disease, as well as parents who have good communication with their neurosurgeon, were found to have better diagnostic sensitivity....
To compare four plaque indices used in orthodontics. An objective, quantitative plaque index and three subjective conventional plaque indices were analyzed. The study included n = 50 photographs of n ...
The frequency of bone metastases in individuals increases at advanced stages of cancer, mostly in patients suffering from lung, breast, or prostate cancer. The study aims to evaluate the effectiveness...
Retrospective study design was adopted for the analysis of 120 recruited patients (with the presence of bone metastasis) following a series of examinations and tests....
Better sensitivity (73.33%) and specificity (94.66%) for MRI as compared to SPECT. MRI also proved to be more sensitive (68%) and specific (95.74%), as compared to the findings of the CT scan....
The results conclude that MRI provided favorable diagnostic performance for bone metastasis. It emphasizes that diagnosis using MRI may enable practitioners to devise optimal carcinoma treatment strat...
Preeclampsia is a heterogeneous and multiorgan cardiovascular disorder of pregnancy. Here, we report the development of a novel strip-based lateral flow assay (LFA) using lanthanide-doped upconversion...
Following heat illness, a return to activity may require passing a heat tolerance test (HTT). However, there are several logistical limitations to the widespread use of the HTT. Thus, it would be adva...
Sixty-five subjects visited the lab on 3 separate days. The first visit consisted of completing a maximal oxygen uptake (VO2 max) test to assess cardiovascular fitness. For lab visits 2 and 3, subject...
Forty-eight subjects were classified as heat-intolerant and 17 subjects as heat-tolerant. Using the criterion of a HR ≥130 bpm at 30 min of exercise in the thermoneutral environment, specificity (54%)...
Exercise in a thermoneutral environment had a positive predictive value of 100%, thus, if a subject has a HR ≥130 bpm at 30 min of exercise in a thermoneutral environment, they are very likely to fail...