Titre : Méthode en double aveugle

Méthode en double aveugle : Questions médicales fréquentes

Nom anglais: Double-Blind Method

Descriptor UI: D004311

Tree Number: N06.850.520.445.300

Termes MeSH sélectionnés :

Carcinoma, Transitional Cell

Questions fréquentes et termes MeSH associés

Diagnostic 2

#1

Comment la méthode en double aveugle aide-t-elle au diagnostic ?

Elle permet d'évaluer l'efficacité d'un traitement sans biais d'observation.
Méthodes de recherche Biais Évaluation clinique
#2

Quels tests utilisent la méthode en double aveugle ?

Des essais cliniques pour tester des médicaments ou des interventions.
Essais cliniques Médicaments Interventions thérapeutiques

Symptômes 2

#1

Les symptômes sont-ils évalués en double aveugle ?

Oui, cela permet d'éviter que les attentes influencent les rapports de symptômes.
Symptômes Évaluation des symptômes Biais d'observation
#2

Comment les symptômes sont-ils mesurés en double aveugle ?

Par des échelles standardisées, sans que les évaluateurs sachent le traitement reçu.
Échelles d'évaluation Mesure des symptômes Évaluation clinique

Prévention 2

#1

La méthode en double aveugle est-elle utilisée en prévention ?

Oui, pour évaluer l'efficacité des vaccins ou des interventions préventives.
Prévention Vaccins Essais cliniques
#2

Comment la prévention est-elle testée en double aveugle ?

En comparant un groupe recevant le traitement préventif à un groupe placebo.
Interventions préventives Placebo Essais contrôlés

Traitements 2

#1

Quels traitements utilisent souvent la méthode en double aveugle ?

Les essais de nouveaux médicaments, thérapies ou interventions chirurgicales.
Traitements médicaux Essais cliniques Interventions chirurgicales
#2

Pourquoi utiliser la méthode en double aveugle pour les traitements ?

Pour garantir que les résultats ne soient pas influencés par des attentes ou des biais.
Biais Efficacité des traitements Essais contrôlés

Complications 2

#1

Les complications sont-elles prises en compte en double aveugle ?

Oui, pour évaluer les effets indésirables des traitements sans biais.
Complications Effets indésirables Évaluation clinique
#2

Comment les complications sont-elles rapportées ?

Par des rapports standardisés, sans que les évaluateurs sachent le traitement reçu.
Rapports d'effets indésirables Évaluation des complications Essais cliniques

Facteurs de risque 2

#1

La méthode en double aveugle évalue-t-elle les facteurs de risque ?

Indirectement, en contrôlant les variables pour isoler l'effet du traitement.
Facteurs de risque Contrôle des variables Essais cliniques
#2

Comment les facteurs de risque sont-ils pris en compte ?

En randomisant les participants pour équilibrer les caractéristiques entre groupes.
Randomisation Caractéristiques des participants Essais contrôlés
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Dr Olivier Menir

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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale

Validation scientifique effectuée le 08/04/2025

Contenu vérifié selon les dernières recommandations médicales

En savoir plus sur Dr Menir

Auteurs principaux

Hiroyoshi Yajima

2 publications dans cette catégorie

Publications dans "Méthode en double aveugle" :

Miho Takayama

2 publications dans cette catégorie

Publications dans "Méthode en double aveugle" :

Judith M Schlaeger

2 publications dans cette catégorie

Publications dans "Méthode en double aveugle" :

Nobuari Takakura

2 publications dans cette catégorie

Publications dans "Méthode en double aveugle" :

Ted J Kaptchuk

2 publications dans cette catégorie

Affiliations :
  • Program in Placebo Studies, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA.
  • Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA.
Publications dans "Méthode en double aveugle" :

Booil Jo

2 publications dans cette catégorie

Affiliations :
  • Department of Psychiatry and Behavioral Science, Stanford University, Stanford, CA, USA.
Publications dans "Méthode en double aveugle" :

Cody A Cushing

2 publications dans cette catégorie

Publications dans "Méthode en double aveugle" :

Hakwan Lau

2 publications dans cette catégorie

Publications dans "Méthode en double aveugle" :

Mitsuo Kawato

2 publications dans cette catégorie

Publications dans "Méthode en double aveugle" :

Michelle G Craske

2 publications dans cette catégorie

Publications dans "Méthode en double aveugle" :

Vincent Taschereau-Dumouchel

2 publications dans cette catégorie

Publications dans "Méthode en double aveugle" :

Guus A M Kortman

2 publications dans cette catégorie

Affiliations :
  • NIZO Food Research B.V., 6718 ZB Ede, The Netherlands.
Publications dans "Méthode en double aveugle" :

Maartje van den Belt

2 publications dans cette catégorie

Affiliations :
  • NIZO Food Research B.V., 6718 ZB Ede, The Netherlands.
Publications dans "Méthode en double aveugle" :

Xuan Zhang

2 publications dans cette catégorie

Affiliations :
  • Chinese EQUATOR Centre, Hong Kong Chinese Medicine Clinical Study Centre, Chinese Clinical Trial Registry (Hong Kong), School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong, People's Republic of China.
Publications dans "Méthode en double aveugle" :

Yernar Dauletovich Mamyrov

1 publication dans cette catégorie

Affiliations :
  • Department of Emergency Medicine, Pavlodar Branch of NCJSC Semey Medical University, Pavlodar, Kazakhstan.
Publications dans "Méthode en double aveugle" :

Daulet Urazovich Mamyrov

1 publication dans cette catégorie

Affiliations :
  • Department of Emergency Medicine, Pavlodar Branch of NCJSC Semey Medical University, Pavlodar, Kazakhstan.
Publications dans "Méthode en double aveugle" :

Gulzhanat Ertaevna Jakova

1 publication dans cette catégorie

Affiliations :
  • Department of Surgery, Pavlodar Branch of NCJSC Semey Medical University, Pavlodar, Kazakhstan.
Publications dans "Méthode en double aveugle" :

Yoshihiro Noso

1 publication dans cette catégorie

Affiliations :
  • Department of Health Services Management, Hiroshima International University, Hiroshima, Japan.
Publications dans "Méthode en double aveugle" :

Marat Kelisovich Syzdykbayev

1 publication dans cette catégorie

Affiliations :
  • Department of Surgery, Anesthesiology and Reanimatology, Semey Medical University, Semey, Kazakhstan.
Publications dans "Méthode en double aveugle" :

Tony Bazi

1 publication dans cette catégorie

Affiliations :
  • American University of Beirut, Beirut, Lebanon. tb14@aub.edu.lb.
Publications dans "Méthode en double aveugle" :

Sources (10000 au total)

Promising Response of Paclitaxel in Metastatic Transitional Cell Carcinoma of Distal Ureter Complicated with Hydroureteronephrosis: A Case Report.

01 Mar 2023
DOI: 10.31729/jnma.8072 PMID: 37203948

Ureteric carcinoma is the rarest of all urothelial malignancies, and little attention has been given to it. Palliation in these groups of patients is a dilemma in the clinics. Use of chemotherapeutic ... carcinoma; case reports; metastasis; paclitaxel....

Female Humans Aged Carcinoma, Transitional Cell Ureter +5 autres

Seminal papers in urology: maintenance Bacillus Calmette-Guerin (BCG) immunotherapy for recurrent Ta, T1 and carcinoma in situ transitional cell carcinoma of the bladder: a randomized southwest oncology group study (SWOG-8507).

24 Nov 2023
DOI: 10.1186/s12894-023-01352-0 PMID: 37996890

The South West Oncology Group's 2000 randomised-control trial investigated the addition of maintenance intravesical bacillus Calmette-Guerin (BCG) to non-muscle invasive urothelial carcinoma (NMIUC) t...

Humans Carcinoma, Transitional Cell Urinary Bladder Neoplasms BCG Vaccine Urinary Bladder +6 autres

Tumor stemness score to estimate epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSCs) characterization and to predict the prognosis and immunotherapy response in bladder urothelial carcinoma.

01 02 2023
DOI: 10.1186/s13287-023-03239-1 PMID: 36721217

A growing number of investigations have suggested a close link between cancer stem cells (CSCs), epithelial-to-mesenchymal transition (EMT), and the tumor microenvironment (TME). However, the relation... We first explored biomarkers of tumor stemness (TS) by single-cell sequencing analysis. Then, subtypes of bladder urothelial carcinoma (BLCA) were identified using clustering analysis based on TS biom... Three TS clusters and two TS-related gene clusters were identified with differential EMT activity status, CSC features, and TME characteristics in BLCA. Then, a TS scoring system was established with ... Overall, this research provides a better understanding of tumor invasion and metastasis mechanisms through an analysis of TS patterns with different EMT processes and CSC characteristics. The TS score...

Humans Carcinoma, Transitional Cell Epithelial-Mesenchymal Transition Immunotherapy Neoplastic Stem Cells +3 autres

Detection of Epithelial-Mesenchymal Transition Markers in High Grade Bladder Cancer and Special Variants of Urothelial Carcinoma.

01 Jun 2022
DOI: 10.31557/APJCP.2022.23.6.2079 PMID: 35763651

Transitional cell carcinoma is considered the most predominant type of bladder cancer. Bladder can cer can also be found as squamous cell carcinoma that accounts for 5% of the total bladder cancer due... Using 150 archival tissue blocks from human bladder cancer cases to detect expression of SNAIL/SLUG and Twist2 in relation to loss of E-cadherin by immunohistochemical method.... Our results have revealed that in squamous cell carcinoma 40 specimens showed marked Twist 2 expression, and 30 specimens showed marked snail/slug biomarkers expression while poorly differentiated can... Detection of SNAIL/SLUG and Twist 2 biomarkers in urothelial cancer is an important predictor for the loss of E-cadherin, a cornerstone in urinary bladder cell adhesion and its loss in urothelial carc...

Biomarkers Cadherins Carcinoma, Squamous Cell Carcinoma, Transitional Cell Epithelial-Mesenchymal Transition +3 autres

A web-based prognostic nomogram for the cancer specific survival of elderly patients with T1-T3N0M0 renal pelvic transitional cell carcinoma based on the surveillance, epidemiology, and end results database.

24 May 2022
DOI: 10.1186/s12894-022-01028-1 PMID: 35610606

At present, there are few studies on renal pelvic transitional cell carcinoma (RPTCC) in elderly patients in the literature. The study aims to establish a new nomogram of cancer-specific survival (CSS... This study downloaded the data of 1375 elderly patients with T1-T3N0M0 RPTCC in the Surveillance, Epidemiology, and Final Results (SEER) database from 2004 to 2018. Patients were randomly divided into... We found that the risk factors affecting CSS in elderly patients with T1-T3N0M0 RPTCC are surgery, AJCC stage, laterality, tumor size, histological grade, and tumour laterality. Based on these factors... In this study, the SEER database was used for the first time to create and validate a new nomogram prediction model for elderly patients with T1-T3N0M0 RPTCC. Compared with the traditional AJCC stage ...

Aged Carcinoma, Renal Cell Carcinoma, Transitional Cell Humans Internet +5 autres

Prognostic significance and immunoinfiltration analysis of genes associated with epithelial-mesenchymal transition and energy metabolism in bladder urothelial carcinoma.

24 11 2023
DOI: 10.18632/aging.205242 PMID: 38015710

Epithelial-mesenchymal transition (EMT) and aberrant energy metabolism are pivotal biological processes in tumor progression, significantly impacting tumor prognosis. However, the relationship between... Bladder cancer samples from The Cancer Genome Atlas were categorized into two groups via clustering analysis to elucidate disparities in expression, prognostic significance, and immune infiltration of... Cluster analysis revealed significant differences in the expression of genes associated with EMT and energy metabolism between the two groups. Group 2 exhibited significantly improved overall survival... EMT and energy metabolism exert pivotal influences on the immune microenvironment in BLCA. CSPG4 holds promise as a prognostic biomarker for patients with BLCA, offering valuable insights into potenti...

Humans Carcinoma, Transitional Cell Urinary Bladder Neoplasms Urinary Bladder Epithelial-Mesenchymal Transition +3 autres

Tailored immunotherapy approach with nivolumab with or without ipilimumab in patients with advanced transitional cell carcinoma after platinum-based chemotherapy (TITAN-TCC): a multicentre, single-arm, phase 2 trial.

04 2023
DOI: 10.1016/S1470-2045(23)00053-0 PMID: 36868252

Nivolumab is used after platinum-based chemotherapy in patients with metastatic urothelial carcinoma. Studies suggest improved outcomes for dual checkpoint inhibition with high ipilimumab doses. We ai... TITAN-TCC is a multicentre, single-arm, phase 2 trial done at 19 hospitals and cancer centres in Germany and Austria. Adults aged 18 years or older with histologically confirmed metastatic or surgical... Between April 8, 2019, and Feb 15, 2021, 83 patients with metastatic urothelial carcinoma were enrolled and all received nivolumab induction treatment (intention-to-treat population). The median age o... Treatment with nivolumab and nivolumab plus ipilimumab boosts in early non-responders and patients who progress late significantly improved objective response rate after previous platinum-based chemot... Bristol Myers Squibb....

Adult Humans Male Female Middle Aged +8 autres

Pathologic collision of urinary bladder urothelial carcinoma with small cell carcinoma: a case report.

11 Jul 2023
DOI: 10.1186/s13000-023-01369-x PMID: 37434193

Urothelial carcinoma is a major subtype of bladder cancer and small cell carcinoma (SCC) is a rare type of cancer in clinical practice. Pathologic collision of urinary bladder urothelial carcinoma wit... Here, we report a patient with high-grade papillary carcinoma which changed to collision tumor with SCC. The patient underwent radical cystectomy; however, neck and mediastinum lymph nodes metastases ... We hypothesized the mechanism underlying this pathological transformation. For patients with urothelial bladder cancer, pathological analysis should be conducted to allow standardized and persistent t... We recommend that radical cystectomy be performed early enough for patients with non-muscle invasive bladder cancer, who are at a high risk of tumor recurrence. However, this conclusion needs to be va...

Humans Carcinoma, Small Cell Carcinoma, Transitional Cell Urinary Bladder Neoplasms Urinary Bladder +4 autres