Titre : Épilepsies myocloniques

Épilepsies myocloniques : Questions médicales fréquentes

Termes MeSH sélectionnés :

Complement Factor D
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"datePublished": "2025-05-10", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur Épilepsies myocloniques", "description": "Comment diagnostiquer une épilepsie myoclonique ?\nQuels tests sont utilisés pour le diagnostic ?\nQuels signes cliniques indiquent une épilepsie myoclonique ?\nL'épilepsie myoclonique est-elle héréditaire ?\nQuel rôle joue l'EEG dans le diagnostic ?", "url": "https://questionsmedicales.fr/mesh/D004831?mesh_terms=Complement+Factor+D&page=3#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Épilepsies myocloniques", "description": "Quels sont les symptômes principaux ?\nLes myoclonies sont-elles douloureuses ?\nPeut-on avoir des crises sans myoclonies ?\nLes symptômes varient-ils d'une personne à l'autre ?\nLes crises peuvent-elles survenir la nuit ?", "url": "https://questionsmedicales.fr/mesh/D004831?mesh_terms=Complement+Factor+D&page=3#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Épilepsies myocloniques", "description": "Peut-on prévenir les crises myocloniques ?\nQuels déclencheurs sont à éviter ?\nL'éducation est-elle importante pour la prévention ?\nLe suivi médical est-il essentiel ?\nLes activités physiques sont-elles sûres ?", "url": "https://questionsmedicales.fr/mesh/D004831?mesh_terms=Complement+Factor+D&page=3#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Épilepsies myocloniques", "description": "Quels médicaments sont utilisés pour traiter ?\nY a-t-il des traitements non médicamenteux ?\nComment évaluer l'efficacité du traitement ?\nLes traitements sont-ils à vie ?\nQuels effets secondaires des médicaments ?", "url": "https://questionsmedicales.fr/mesh/D004831?mesh_terms=Complement+Factor+D&page=3#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Épilepsies myocloniques", "description": "Quelles complications peuvent survenir ?\nL'épilepsie myoclonique peut-elle affecter la vie quotidienne ?\nY a-t-il un risque accru de dépression ?\nLes crises peuvent-elles entraîner des accidents ?\nComment gérer les complications psychologiques ?", "url": "https://questionsmedicales.fr/mesh/D004831?mesh_terms=Complement+Factor+D&page=3#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Épilepsies myocloniques", "description": "Quels sont les facteurs de risque connus ?\nL'âge influence-t-il le risque d'épilepsie myoclonique ?\nLes troubles neurologiques augmentent-ils le risque ?\nLe stress est-il un facteur de risque ?\nLes infections cérébrales sont-elles un risque ?", "url": "https://questionsmedicales.fr/mesh/D004831?mesh_terms=Complement+Factor+D&page=3#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une épilepsie myoclonique ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Le diagnostic repose sur l'historique médical, l'examen neurologique et l'EEG." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour le diagnostic ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "L'EEG, l'IRM cérébrale et des tests sanguins peuvent être utilisés." } }, { "@type": "Question", "name": "Quels signes cliniques indiquent une épilepsie myoclonique ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des secousses musculaires rapides, souvent sans perte de conscience, sont typiques." } }, { "@type": "Question", "name": "L'épilepsie myoclonique est-elle héréditaire ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Certaines formes peuvent être héréditaires, nécessitant une évaluation familiale." } }, { "@type": "Question", "name": "Quel rôle joue l'EEG dans le diagnostic ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "L'EEG aide à détecter les anomalies électriques typiques des épilepsies myocloniques." } }, { "@type": "Question", "name": "Quels sont les symptômes principaux ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent des myoclonies, des crises généralisées et parfois des absences." } }, { "@type": "Question", "name": "Les myoclonies sont-elles douloureuses ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Les myoclonies ne sont généralement pas douloureuses, mais peuvent être gênantes." } }, { "@type": "Question", "name": "Peut-on avoir des crises sans myoclonies ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines personnes peuvent avoir des crises généralisées sans myoclonies." } }, { "@type": "Question", "name": "Les symptômes varient-ils d'une personne à l'autre ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'intensité et la fréquence des symptômes peuvent varier considérablement." } }, { "@type": "Question", "name": "Les crises peuvent-elles survenir la nuit ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des crises myocloniques peuvent survenir pendant le sommeil." } }, { "@type": "Question", "name": "Peut-on prévenir les crises myocloniques ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "La prévention passe par un traitement adéquat et l'évitement des déclencheurs." } }, { "@type": "Question", "name": "Quels déclencheurs sont à éviter ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Le stress, la fatigue, et la consommation d'alcool peuvent déclencher des crises." } }, { "@type": "Question", "name": "L'éducation est-elle importante pour la prévention ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'éducation sur la maladie aide les patients à mieux gérer leur condition." } }, { "@type": "Question", "name": "Le suivi médical est-il essentiel ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Un suivi régulier permet d'ajuster le traitement et de surveiller les symptômes." } }, { "@type": "Question", "name": "Les activités physiques sont-elles sûres ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Certaines activités peuvent être sûres, mais il faut éviter les sports à risque." } }, { "@type": "Question", "name": "Quels médicaments sont utilisés pour traiter ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les anticonvulsivants comme le valproate et le lamotrigine sont couramment prescrits." } }, { "@type": "Question", "name": "Y a-t-il des traitements non médicamenteux ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Des approches comme la thérapie comportementale et la diététique peuvent aider." } }, { "@type": "Question", "name": "Comment évaluer l'efficacité du traitement ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "L'efficacité est évaluée par la réduction des crises et les effets secondaires." } }, { "@type": "Question", "name": "Les traitements sont-ils à vie ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Souvent, le traitement est à long terme, mais certains peuvent réduire ou arrêter." } }, { "@type": "Question", "name": "Quels effets secondaires des médicaments ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Les effets secondaires peuvent inclure fatigue, vertiges et troubles gastro-intestinaux." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent des blessures dues aux crises et des troubles psychologiques." } }, { "@type": "Question", "name": "L'épilepsie myoclonique peut-elle affecter la vie quotidienne ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle peut impacter la vie sociale, professionnelle et la qualité de vie." } }, { "@type": "Question", "name": "Y a-t-il un risque accru de dépression ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les personnes épileptiques ont un risque plus élevé de dépression et d'anxiété." } }, { "@type": "Question", "name": "Les crises peuvent-elles entraîner des accidents ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les crises peuvent provoquer des accidents, notamment lors de la conduite." } }, { "@type": "Question", "name": "Comment gérer les complications psychologiques ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Un soutien psychologique et des thérapies adaptées peuvent aider à gérer ces complications." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque connus ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les antécédents familiaux, les traumatismes crâniens et certaines infections sont des facteurs." } }, { "@type": "Question", "name": "L'âge influence-t-il le risque d'épilepsie myoclonique ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'épilepsie myoclonique peut débuter à tout âge, mais souvent dans l'enfance ou l'adolescence." } }, { "@type": "Question", "name": "Les troubles neurologiques augmentent-ils le risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, d'autres troubles neurologiques peuvent augmenter le risque d'épilepsie myoclonique." } }, { "@type": "Question", "name": "Le stress est-il un facteur de risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress peut déclencher des crises chez les personnes prédisposées." } }, { "@type": "Question", "name": "Les infections cérébrales sont-elles un risque ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Certaines infections, comme la méningite, peuvent augmenter le risque d'épilepsie." } } ] } ] }

Sources (10000 au total)

Clinical Significance and Potential Function of Complement Factor D in Acute Myeloid Leukemia.

Acute myeloid leukemia (AML) is a hematologic malignancy characterized by aggressive proliferation and a poor prognosis. The objective of this study is to elucidate the specific role of complement fac... We performed a systematic investigation on clinical significance and potential function of CFD in AML by using the R Programming Language with The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (... The expression of CFD was the highest in AML cells than in other tumor cell lines. The expression of CFD was also higher in AML patients than in the matched normal group. Compared with the low express... CFD could serve as a potential OS prognostic biomarker and guide clinical treatment for AML....

Combinatorial Inhibition of Complement Factor D and BCL2 for Early-Onset Colorectal Cancer.

The tumor immune microenvironment is distinct between early-onset and late-onset colorectal cancer which facilitates tumor progression. We previously identified several genes, including complement fac... This study aimed to assess and validate differential expression of immune genes in early and late-onset colorectal cancer. We also aimed to test known drugs targeting genes increased in early-onset co... Retrospective cohort study with analysis performed using tumor RNA from formalin-fixed paraffin-embedded, cell culture and immunohistochemistry to validate gene expression and gene function. In vivo p... Oregon Colorectal Cancer Registry was queried to find patients with colorectal cancer.... Study included 67 patients with early and 54 patients with late-onset colorectal cancer.... Preclinical animal models using the HCT-116 colon cancer cell line were treated with complement factor D inhibitor danicopan and BCL2 inhibitor venetoclax, or with vehicle controls.... Elevated RNA signatures using NanoString data was evaluated from the retrospective cohort. When inhibiting these markers in the mouse preclinical model, tumor volume and weight were the main outcome m... After updating our sample size from our previously published data, we found that complement factor D and BCL2, genes with known function and small molecule inhibitors, are elevated in patients with ea... This study is limited by small sample size and a subcutaneous tumor model.... Combinatorial inhibition of early-onset associated genes complement factor D and BCL2 slows growth of early-onset colorectal cancer in a mouse preclinical model. See Video Abstract....

Adipocytokines and Insulin Resistance: Their Role as Benign Breast Disease and Breast Cancer Risk Factors in a High-Prevalence Overweight-Obesity Group of Women over 40 Years Old.

Insulin levels, adipocytokines, and inflammatory mediators trigger benign breast disease (BBD) and breast cancer (BC). The relationship between serum adipocytokines levels, overweight-obesity, metabol...

Utility of factor D and other alternative complement factors as biomarkers in systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH).

Activation of the complement cascade is thought to play a role in scleroderma vasculopathy. We previously showed that complement factor D was elevated in patients with limited cutaneous SSc and pulmon... Complement components (n = 14) were measured using multiplex assays in 156 patients with SSc-PAH from a multi-site repository and were compared to 33 patients with SSc without PAH, and 40 healthy cont... We found that factor D was significantly elevated in SSc-PAH compared to SSc without PAH (p < 0.0001) and was highly sensitive and specific for SSc-PAH (AUC=0.82, p < 0.001). In SSc-PAH patients, alte... Our work confirms prior studies demonstrating a role for complement activation in SSc vascular disease and elevations of factor D in a large SSc-PAH population. Further, factor H and other complement ...

Serum proteomic identification and validation of two novel atherosclerotic aortic aneurysm biomarkers, profilin 1 and complement factor D.

Effective diagnostic biomarkers for aortic aneurysm (AA) that are detectable in blood tests are required because early detection and rupture risk assessment of AA can provide insights into medical the... We performed proteome analysis of serum samples from patients with atherosclerotic thoracic AA (TAA) and healthy control (HC) subjects to identify diagnostic biomarkers for AA. Serum samples were sepa... Profilin 1 (PFN1) and complement factor D (CFD) showed the most contrasting profiles in all three fractions between patients with TAA and HC subjects and were selected as biomarker candidates. The PFN... PFN1 and CFD are potential diagnostic biomarkers for TAA and AAA and measurable in blood samples; their diagnostic performance can be augmented by their combination. These biomarkers may facilitate th...

Classical and alternate complement factor overexpression in non-obese weight matched women with polycystic ovary syndrome does not correlate with vitamin D.

Women with polycystic ovary syndrome (PCOS) exhibit complement factor expression changes that may be obesity-driven rather than an intrinsic facet of PCOS; furthermore, complement changes have been as... We measured plasma levels of complement pathway proteins by Slow Off-rate Modified Aptamer (SOMA)-scan plasma protein measurement for the classical (C4, C4a, and C4b) and alternative pathways (C3, C3b... Women with PCOS had a higher free androgen index and anti-Mullerian hormone, though insulin resistance was comparable to controls; likewise, C-reactive protein, a marker of inflammation, was comparabl... In a non-obese PCOS population matched for age, insulin resistance and inflammation, initiating proteins of the classical and alternate complement cascades were increased. However, a positive correlat...