questionsmedicales.fr
Métabolisme
Métabolisme glucidique
Glycosylation
Glycosylation : Questions médicales fréquentes
Termes MeSH sélectionnés :
Programmed Cell Death 1 Receptor
Diagnostic
5
Glycosylation
Tests génétiques
Glycoprotéines
Tests sanguins
Anomalies congénitales
Développement
Imagerie médicale
Complications
Symptômes
5
Troubles neurologiques
Infections
Troubles digestifs
Glycosylation
Éruptions cutanées
Anomalies de la peau
Retard de croissance
Glycosylation
Prévention
5
Prévention
Diagnostic précoce
Dépistage génétique
Antécédents familiaux
Alimentation équilibrée
Système immunitaire
Consultations médicales
Surveillance
Traitements
5
Thérapies de soutien
Interventions médicales
Enzymes de remplacement
Maladies métaboliques
Diététique
Gestion des symptômes
Médicaments immunosuppresseurs
Complications immunitaires
Essais cliniques
Thérapies ciblées
Complications
5
Complications
Troubles neurologiques
Infections
Système immunitaire
Cancer
Anomalies de glycosylation
Troubles cardiovasculaires
Glycosylation
Complications psychologiques
Anxiété
Facteurs de risque
5
Antécédents familiaux
Mutations génétiques
Âge
Anomalies congénitales
Facteurs environnementaux
Prédispositions génétiques
Maladies métaboliques
Glycosylation
Sexe
Anomalies de glycosylation
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"description": "Comment diagnostiquer une anomalie de glycosylation ?\nQuels tests sanguins sont utilisés pour la glycosylation ?\nLes biopsies sont-elles utiles pour la glycosylation ?\nQuels symptômes indiquent une anomalie de glycosylation ?\nPeut-on utiliser l'imagerie pour diagnostiquer la glycosylation ?",
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"@type": "Question",
"name": "Quels tests sanguins sont utilisés pour la glycosylation ?",
"position": 2,
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"name": "Les biopsies sont-elles utiles pour la glycosylation ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
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{
"@type": "Question",
"name": "Quels symptômes indiquent une anomalie de glycosylation ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des retards de développement, des problèmes immunitaires et des anomalies neurologiques."
}
},
{
"@type": "Question",
"name": "Peut-on utiliser l'imagerie pour diagnostiquer la glycosylation ?",
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"name": "Quels sont les symptômes d'une glycosylation anormale ?",
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"name": "La fatigue est-elle un symptôme de glycosylation ?",
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"position": 9,
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"name": "Les problèmes de croissance sont-ils fréquents ?",
"position": 10,
"acceptedAnswer": {
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{
"@type": "Question",
"name": "Peut-on prévenir les anomalies de glycosylation ?",
"position": 11,
"acceptedAnswer": {
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"@type": "Question",
"name": "Le dépistage génétique est-il recommandé ?",
"position": 12,
"acceptedAnswer": {
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"text": "Oui, le dépistage génétique peut être utile pour les familles à risque."
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{
"@type": "Question",
"name": "Les vaccinations aident-elles à prévenir les complications ?",
"position": 13,
"acceptedAnswer": {
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"text": "Oui, les vaccinations peuvent réduire le risque d'infections chez ces patients."
}
},
{
"@type": "Question",
"name": "Y a-t-il des conseils diététiques préventifs ?",
"position": 14,
"acceptedAnswer": {
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"text": "Une alimentation équilibrée peut soutenir la santé globale et le système immunitaire."
}
},
{
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"name": "Les consultations médicales régulières sont-elles importantes ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles permettent de surveiller l'évolution et d'ajuster les traitements."
}
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{
"@type": "Question",
"name": "Quels traitements existent pour les anomalies de glycosylation ?",
"position": 16,
"acceptedAnswer": {
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}
},
{
"@type": "Question",
"name": "Les enzymes de remplacement sont-elles efficaces ?",
"position": 17,
"acceptedAnswer": {
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{
"@type": "Question",
"name": "La diététique joue-t-elle un rôle dans le traitement ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des régimes spécifiques peuvent aider à gérer certains symptômes."
}
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{
"@type": "Question",
"name": "Les médicaments immunosuppresseurs sont-ils utilisés ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent être prescrits pour traiter des complications immunitaires."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements expérimentaux disponibles ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des essais cliniques sont en cours pour de nouvelles thérapies ciblées."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles de la glycosylation ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des troubles neurologiques, des infections et des problèmes de croissance."
}
},
{
"@type": "Question",
"name": "Les infections sont-elles fréquentes chez ces patients ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les patients peuvent être plus susceptibles aux infections en raison d'un système immunitaire affaibli."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de cancer associés ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines anomalies de glycosylation peuvent augmenter le risque de cancers spécifiques."
}
},
{
"@type": "Question",
"name": "Les troubles cardiovasculaires sont-ils liés ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles cardiovasculaires peuvent survenir chez certains patients."
}
},
{
"@type": "Question",
"name": "Les complications psychologiques sont-elles possibles ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des complications psychologiques comme l'anxiété peuvent être observées."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour les anomalies de glycosylation ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antécédents familiaux et certaines mutations génétiques sont des facteurs de risque."
}
},
{
"@type": "Question",
"name": "L'âge joue-t-il un rôle dans la glycosylation ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines anomalies peuvent se manifester plus tôt dans l'enfance, mais d'autres plus tard."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux influencent-ils la glycosylation ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des facteurs environnementaux peuvent interagir avec des prédispositions génétiques."
}
},
{
"@type": "Question",
"name": "Les maladies métaboliques augmentent-elles le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines maladies métaboliques peuvent être associées à des anomalies de glycosylation."
}
},
{
"@type": "Question",
"name": "Le sexe a-t-il un impact sur la glycosylation ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines anomalies peuvent avoir des manifestations différentes selon le sexe."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 29/04/2025
Contenu vérifié selon les dernières recommandations médicales
3 publications dans cette catégorie
Affiliations :
Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen Ø, Denmark.
Publications dans "Glycosylation" :
3 publications dans cette catégorie
Affiliations :
Department of Emergency, State Key Laboratory of Biotherapy, West China Hospital, and School of Chemical Engineering, Sichuan University, No. 17 Renmin Nan Road, Chengdu, 610041, China.
Publications dans "Glycosylation" :
3 publications dans cette catégorie
Affiliations :
Department of Emergency, State Key Laboratory of Biotherapy, West China Hospital, and School of Chemical Engineering, Sichuan University, No. 17 Renmin Nan Road, Chengdu, 610041, China.
Publications dans "Glycosylation" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen Ø, Denmark.
Publications dans "Glycosylation" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, National University of Singapore, 4 Science Drive 2, Singapore, 117544, Republic of Singapore.
Publications dans "Glycosylation" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, National University of Singapore, 4 Science Drive 2, Singapore, 117544, Republic of Singapore.
Publications dans "Glycosylation" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan.
Core for Medicine and Science Collaborative Research and Education Project Research Center for Fundamental Sciences Graduate School of Science Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan.
Publications dans "Glycosylation" :
2 publications dans cette catégorie
Affiliations :
Radboud University Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands. t.boltje@science.ru.nl.
Publications dans "Glycosylation" :
2 publications dans cette catégorie
Affiliations :
Center for Highly Advanced Integration of Nano and Life Sciences (G-CHAIN), Gifu University, Gifu, Japan. kizuka@gifu-u.ac.jp.
Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan. kizuka@gifu-u.ac.jp.
Publications dans "Glycosylation" :
2 publications dans cette catégorie
Affiliations :
Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Centre, Geert Grooteplein 10, 6525 GA Nijmegen, The Netherlands.
Department of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Center, Geert Grooteplein 10, 6525 GA Nijmegen, The Netherlands.
Publications dans "Glycosylation" :
2 publications dans cette catégorie
Affiliations :
Center for Proteomics and Metabolomics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Publications dans "Glycosylation" :
2 publications dans cette catégorie
Affiliations :
Department of Emergency, State Key Laboratory of Biotherapy, West China Hospital, and School of Chemical Engineering, Sichuan University, No. 17 Renmin Nan Road, Chengdu, 610041, China.
Publications dans "Glycosylation" :
2 publications dans cette catégorie
Affiliations :
Department of Emergency, State Key Laboratory of Biotherapy, West China Hospital, and School of Chemical Engineering, Sichuan University, No. 17 Renmin Nan Road, Chengdu, 610041, China.
Publications dans "Glycosylation" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, 610041, China.
Publications dans "Glycosylation" :
2 publications dans cette catégorie
Affiliations :
Department of Emergency, State Key Laboratory of Biotherapy, West China Hospital, and School of Chemical Engineering, Sichuan University, No. 17 Renmin Nan Road, Chengdu, 610041, China.
Publications dans "Glycosylation" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, National University of Singapore, 4 Science Drive 2, Singapore, 117544, Republic of Singapore.
Publications dans "Glycosylation" :
2 publications dans cette catégorie
Affiliations :
School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia.
Publications dans "Glycosylation" :
2 publications dans cette catégorie
Affiliations :
University of Natural Resources and Life Sciences Vienna, Vienna, Austria. richard.strasser@boku.ac.at.
Publications dans "Glycosylation" :
1 publication dans cette catégorie
Affiliations :
Key Laboratory of Agriculture Biological Functional Gene of Heilongjiang Provincial Education Committee, Northeast Agricultural University, No. 600 Changjiang Road, Xiangfang District, Harbin, 150030, PR China.
Publications dans "Glycosylation" :
1 publication dans cette catégorie
Affiliations :
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, PR China. Electronic address: 459856454@qq.com.
Publications dans "Glycosylation" :
Programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) plays an important role in negative regulating immunity. The search for effective PD-1/PD-L1 inhibitors has been a...
Current research proves that immune dysregulation is a common feature of coronavirus disease 2019 (COVID-19), and immune exhaustion is associated with increased disease mortality. Immune checkpoint mo...
Natural Killer cells (NKs) represent the innate counterpart of TCRαβ lymphocytes and are characterized by a high anti-tumor and an anti-viral cytotoxic activity. Recently, it has been demonstrated tha...
In this study, we analyzed the expression and function of PD-1 on Cord Blood derived NKs (CB-NKs) on a large cohort of newborns through multiparametric cytofluorimetric analysis....
We identified PD-1 on CB-NKs in more than of half the newborns analyzed. PD-1 was present on CD56...
To our understanding, this study is the first to report PD-1 expression on CB derived NKs and its features in perinatal conditions. These data may prove important in selecting the most suitable CB der...
New biphenyl-based chimeric compounds containing pomalidomide were developed and evaluated for their activity to inhibit and degrade the programmed cell death-1/programmed cell death- ligand 1 (PD-1/P...
An influx of systematic reviews (SRs) of programmed cell death 1 (PD-1) and programmed death ligand-1 (PD-L1) checkpoint inhibitors in cancer treatment with or without meta-analysis and with different...
A comprehensive search of SRs, which included meta-analyses of PD-(L)1 inhibitors on cancer, was performed on eight databases with a cutoff date of 1 January 2022. Two authors independently identified...
A total of 172 SRs with meta-analysis met the inclusion criteria. The report quality of included SRs was quite good, with 128 (74.42%) SRs of high quality and 44 (25.58%) of moderate quality. The meth...
PD-(L)1 inhibitors appeared to be effective and safe for cancer treatment, except for gastrointestinal tumors; however, the quality of the evidence is not convincing. Future studies should improve met...
http://www.crd.york.ac.uk/prospero, identifier CRD42020194260....
Programmed death receptor 1 (PD-1) is an inhibitory receptor on T cells shown to restrain T-cell proliferation. PD-1 immune checkpoint blockade has emerged as a highly promising approach in cancer tre...
A series of novel compounds bearing a cyclopropyl linkage were designed, synthesized, and evaluated as programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) inhibitors. An optimized co...
Multiple clinical studies have indicated that the gut microbiota influences the effects of immune checkpoint blockade (ICB) therapy comprising PD-1/PD-L1 inhibitors, but the causal relationship is unc...
We used bidirectional two-sample Mendelian randomization with two different thresholds to explore the potential causal relationship between the microbiota and PD-1/PD-L1 and species-level microbiota G...
In the primary forward analysis, genus_Holdemanella showed a negative correlation with PD-1 [βIVW = -0.25; 95% CI (-0.43 to -0.07); P...
Checkpoint blockade of the immunoreceptor programmed cell death-1 (PD1) with its ligand-1 (PDL1) by monoclonal antibodies such as pembrolizumab provided compelling clinical results in various cancer t...
Preeclampsia is a pregnancy-specific disease which is characterized by abnormal placentation, endothelial dysfunction, systemic inflammation and disruption of the immune system. The goal of this study...