questionsmedicales.fr
Système nerveux
Système neuroendocrinien
Axe hypothalamohypophysaire
Axe hypothalamohypophysaire : Questions médicales fréquentes
Termes MeSH sélectionnés :
Gene Expression Regulation
Diagnostic
5
Dysfonctionnement hormonal
Imagerie par résonance magnétique
Cortisol
Thyroid Stimulating Hormone
Troubles de l'appétit
Cycles menstruels
Endocrinologie
Symptômes hormonaux
Imagerie par résonance magnétique
Hypophyse
Symptômes
5
Hyperthyroïdisme
Palpitations
Hypopituitarisme
Troubles de croissance
Syndrome de Cushing
Hypertension
Prévention
5
Prévention
Alimentation équilibrée
Bilan hormonal
Détection précoce
Exercice physique
Santé hormonale
Antécédents familiaux
Risque
Traitements
5
Hyperprolactinémie
Cabergoline
Hormone de croissance
Traitement hormonal
Hypothyroïdie
Lévothyroxine
Syndrome de Cushing
Chirurgie
Hypopituitarisme
Hormones de remplacement
Complications
5
Hypopituitarisme
Insuffisance surrénalienne
Traitement inapproprié
Complications
Médicaments hormonaux
Effets secondaires
Facteurs de risque
5
Hypopituitarisme
Tumeurs hypophysaires
Stress
Axe hypothalamohypophysaire
Maladies auto-immunes
Axe hormonal
Obésité
Régulation hormonale
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Axe hypothalamohypophysaire : Questions médicales les plus fréquentes",
"headline": "Axe hypothalamohypophysaire : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Axe hypothalamohypophysaire : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-07-14",
"dateModified": "2025-04-10",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Axe hypothalamohypophysaire"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Système neuroendocrinien",
"url": "https://questionsmedicales.fr/mesh/D009490",
"about": {
"@type": "MedicalCondition",
"name": "Système neuroendocrinien",
"code": {
"@type": "MedicalCode",
"code": "D009490",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "A08.713"
}
}
},
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Axe hypothalamo-hypophyso-gonadique",
"alternateName": "Hypothalamic-Pituitary-Gonadal Axis",
"url": "https://questionsmedicales.fr/mesh/D000094365",
"about": {
"@type": "MedicalCondition",
"name": "Axe hypothalamo-hypophyso-gonadique",
"code": {
"@type": "MedicalCode",
"code": "D000094365",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "A08.713.357.250"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Éminence médiane",
"alternateName": "Median Eminence",
"url": "https://questionsmedicales.fr/mesh/D008473",
"about": {
"@type": "MedicalCondition",
"name": "Éminence médiane",
"code": {
"@type": "MedicalCode",
"code": "D008473",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "A08.713.357.500"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Hypophyse",
"alternateName": "Pituitary Gland",
"url": "https://questionsmedicales.fr/mesh/D010902",
"about": {
"@type": "MedicalCondition",
"name": "Hypophyse",
"code": {
"@type": "MedicalCode",
"code": "D010902",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "A08.713.357.750"
}
},
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Adénohypophyse",
"alternateName": "Pituitary Gland, Anterior",
"url": "https://questionsmedicales.fr/mesh/D010903",
"about": {
"@type": "MedicalCondition",
"name": "Adénohypophyse",
"code": {
"@type": "MedicalCode",
"code": "D010903",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "A08.713.357.750.500"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Hypophyse intermédiaire",
"alternateName": "Pituitary Gland, Intermediate",
"url": "https://questionsmedicales.fr/mesh/D052716",
"about": {
"@type": "MedicalCondition",
"name": "Hypophyse intermédiaire",
"code": {
"@type": "MedicalCode",
"code": "D052716",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "A08.713.357.750.750"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Neurohypophyse",
"alternateName": "Pituitary Gland, Posterior",
"url": "https://questionsmedicales.fr/mesh/D010904",
"about": {
"@type": "MedicalCondition",
"name": "Neurohypophyse",
"code": {
"@type": "MedicalCode",
"code": "D010904",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "A08.713.357.750.875"
}
}
}
]
}
],
"about": {
"@type": "MedicalCondition",
"name": "Axe hypothalamohypophysaire",
"alternateName": "Hypothalamo-Hypophyseal System",
"code": {
"@type": "MedicalCode",
"code": "D007030",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Sabrina Chiloiro",
"url": "https://questionsmedicales.fr/author/Sabrina%20Chiloiro",
"affiliation": {
"@type": "Organization",
"name": "Pituitary Unit, Department of Endocrinology, Fondazione A Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy."
}
},
{
"@type": "Person",
"name": "Laura De Marinis",
"url": "https://questionsmedicales.fr/author/Laura%20De%20Marinis",
"affiliation": {
"@type": "Organization",
"name": "Pituitary Unit, Department of Endocrinology, Fondazione A Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: Laura.DeMarinis@unicatt.it."
}
},
{
"@type": "Person",
"name": "Tommaso Tartaglione",
"url": "https://questionsmedicales.fr/author/Tommaso%20Tartaglione",
"affiliation": {
"@type": "Organization",
"name": "Department of Radiology, Istituto Dermopatico dell'Immacolata, Rome and Università Cattolica del Sacro Cuore, Rome, Italy."
}
},
{
"@type": "Person",
"name": "Antonella Giampietro",
"url": "https://questionsmedicales.fr/author/Antonella%20Giampietro",
"affiliation": {
"@type": "Organization",
"name": "Pituitary Unit, Department of Endocrinology, Fondazione A Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy."
}
},
{
"@type": "Person",
"name": "Antonio Bianchi",
"url": "https://questionsmedicales.fr/author/Antonio%20Bianchi",
"affiliation": {
"@type": "Organization",
"name": "Pituitary Unit, Department of Endocrinology, Fondazione A Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Regulation of myogenic gene expression.",
"datePublished": "2022-08-01",
"url": "https://questionsmedicales.fr/article/35926660",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.yexcr.2022.113299"
}
},
{
"@type": "ScholarlyArticle",
"name": "Repetitive DNA regulates gene expression.",
"datePublished": "2023-09-21",
"url": "https://questionsmedicales.fr/article/37733865",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1126/science.adk2055"
}
},
{
"@type": "ScholarlyArticle",
"name": "Regulation of Gene Expression in Cancer-An Overview.",
"datePublished": "2022-12-15",
"url": "https://questionsmedicales.fr/article/36552821",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3390/cells11244058"
}
},
{
"@type": "ScholarlyArticle",
"name": "Factors and Methods for the Detection of Gene Expression Regulation.",
"datePublished": "2023-02-06",
"url": "https://questionsmedicales.fr/article/36830673",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3390/biom13020304"
}
},
{
"@type": "ScholarlyArticle",
"name": "Viral miRNA regulation of host gene expression.",
"datePublished": "2022-11-30",
"url": "https://questionsmedicales.fr/article/36463091",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.semcdb.2022.11.007"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Système nerveux",
"item": "https://questionsmedicales.fr/mesh/D009420"
},
{
"@type": "ListItem",
"position": 3,
"name": "Système neuroendocrinien",
"item": "https://questionsmedicales.fr/mesh/D009490"
},
{
"@type": "ListItem",
"position": 4,
"name": "Axe hypothalamohypophysaire",
"item": "https://questionsmedicales.fr/mesh/D007030"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Axe hypothalamohypophysaire - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Axe hypothalamohypophysaire",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-18",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Axe hypothalamohypophysaire",
"description": "Comment diagnostiquer un dysfonctionnement de l'axe ?\nQuels tests hormonaux sont utilisés ?\nQuels symptômes indiquent un problème hypothalamique ?\nQuand consulter un endocrinologue ?\nL'imagerie est-elle nécessaire pour le diagnostic ?",
"url": "https://questionsmedicales.fr/mesh/D007030?mesh_terms=Gene+Expression+Regulation#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Axe hypothalamohypophysaire",
"description": "Quels sont les symptômes d'un excès de prolactine ?\nComment se manifeste un déficit en cortisol ?\nQuels signes indiquent un hyperthyroïdisme ?\nQuels symptômes sont liés à l'hypopituitarisme ?\nComment reconnaître un syndrome de Cushing ?",
"url": "https://questionsmedicales.fr/mesh/D007030?mesh_terms=Gene+Expression+Regulation#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Axe hypothalamohypophysaire",
"description": "Peut-on prévenir les troubles hormonaux ?\nComment éviter le stress sur l'axe hypothalamique ?\nLes examens réguliers sont-ils importants ?\nL'exercice physique aide-t-il l'axe hormonal ?\nFaut-il surveiller les antécédents familiaux ?",
"url": "https://questionsmedicales.fr/mesh/D007030?mesh_terms=Gene+Expression+Regulation#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Axe hypothalamohypophysaire",
"description": "Quels traitements pour l'hyperprolactinémie ?\nComment traiter un déficit en hormone de croissance ?\nQuelles options pour l'hypothyroïdie ?\nComment gérer le syndrome de Cushing ?\nQuels médicaments pour l'hypopituitarisme ?",
"url": "https://questionsmedicales.fr/mesh/D007030?mesh_terms=Gene+Expression+Regulation#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Axe hypothalamohypophysaire",
"description": "Quelles complications peuvent survenir avec l'hypopituitarisme ?\nQuels risques avec un excès de cortisol ?\nComment l'hyperthyroïdie affecte-t-elle le cœur ?\nQuelles sont les conséquences d'un traitement inapproprié ?\nQuels effets secondaires des médicaments hormonaux ?",
"url": "https://questionsmedicales.fr/mesh/D007030?mesh_terms=Gene+Expression+Regulation#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Axe hypothalamohypophysaire",
"description": "Quels facteurs augmentent le risque d'hypopituitarisme ?\nLe stress est-il un facteur de risque ?\nL'âge influence-t-il les troubles hormonaux ?\nLes maladies auto-immunes sont-elles un risque ?\nY a-t-il un lien avec l'obésité ?",
"url": "https://questionsmedicales.fr/mesh/D007030?mesh_terms=Gene+Expression+Regulation#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer un dysfonctionnement de l'axe ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests hormonaux et des IRM peuvent aider à diagnostiquer les troubles."
}
},
{
"@type": "Question",
"name": "Quels tests hormonaux sont utilisés ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les dosages de cortisol, TSH et prolactine sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent un problème hypothalamique ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des troubles de la température, de l'appétit ou des cycles menstruels peuvent indiquer un problème."
}
},
{
"@type": "Question",
"name": "Quand consulter un endocrinologue ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Si des symptômes hormonaux persistants apparaissent, une consultation est recommandée."
}
},
{
"@type": "Question",
"name": "L'imagerie est-elle nécessaire pour le diagnostic ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'IRM peut révéler des anomalies structurelles de l'hypophyse."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'un excès de prolactine ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent galactorrhée, irrégularités menstruelles et infertilité."
}
},
{
"@type": "Question",
"name": "Comment se manifeste un déficit en cortisol ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il se manifeste par fatigue, perte de poids, et hypotension."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent un hyperthyroïdisme ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Perte de poids, nervosité, et palpitations sont des signes d'hyperthyroïdisme."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont liés à l'hypopituitarisme ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fatigue, perte de libido et troubles de croissance peuvent indiquer l'hypopituitarisme."
}
},
{
"@type": "Question",
"name": "Comment reconnaître un syndrome de Cushing ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Obésité centrale, vergetures et hypertension sont des signes du syndrome de Cushing."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les troubles hormonaux ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et un mode de vie sain peuvent aider à prévenir certains troubles."
}
},
{
"@type": "Question",
"name": "Comment éviter le stress sur l'axe hypothalamique ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des techniques de gestion du stress comme la méditation peuvent être bénéfiques."
}
},
{
"@type": "Question",
"name": "Les examens réguliers sont-ils importants ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des bilans hormonaux réguliers peuvent aider à détecter des anomalies précocement."
}
},
{
"@type": "Question",
"name": "L'exercice physique aide-t-il l'axe hormonal ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut améliorer la régulation hormonale et la santé globale."
}
},
{
"@type": "Question",
"name": "Faut-il surveiller les antécédents familiaux ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de troubles hormonaux peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "Quels traitements pour l'hyperprolactinémie ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les agonistes de la dopamine comme la cabergoline sont souvent prescrits."
}
},
{
"@type": "Question",
"name": "Comment traiter un déficit en hormone de croissance ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des injections d'hormone de croissance recombinante sont utilisées pour le traitement."
}
},
{
"@type": "Question",
"name": "Quelles options pour l'hypothyroïdie ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "La lévothyroxine est le traitement standard pour l'hypothyroïdie."
}
},
{
"@type": "Question",
"name": "Comment gérer le syndrome de Cushing ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement peut inclure la chirurgie, la radiothérapie ou des médicaments."
}
},
{
"@type": "Question",
"name": "Quels médicaments pour l'hypopituitarisme ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des hormones de remplacement sont administrées selon les déficits identifiés."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec l'hypopituitarisme ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent l'insuffisance surrénalienne et des troubles métaboliques."
}
},
{
"@type": "Question",
"name": "Quels risques avec un excès de cortisol ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un excès de cortisol peut entraîner le diabète, l'hypertension et des infections."
}
},
{
"@type": "Question",
"name": "Comment l'hyperthyroïdie affecte-t-elle le cœur ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut provoquer des arythmies et une hypertension, augmentant le risque cardiaque."
}
},
{
"@type": "Question",
"name": "Quelles sont les conséquences d'un traitement inapproprié ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un traitement inapproprié peut aggraver les symptômes et entraîner des complications graves."
}
},
{
"@type": "Question",
"name": "Quels effets secondaires des médicaments hormonaux ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets secondaires peuvent inclure des nausées, des maux de tête et des changements d'humeur."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque d'hypopituitarisme ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antécédents de tumeurs hypophysaires ou de radiothérapie augmentent le risque."
}
},
{
"@type": "Question",
"name": "Le stress est-il un facteur de risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut perturber l'axe hypothalamohypophysaire."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il les troubles hormonaux ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque de troubles hormonaux augmente avec l'âge."
}
},
{
"@type": "Question",
"name": "Les maladies auto-immunes sont-elles un risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines maladies auto-immunes peuvent affecter l'axe hormonal."
}
},
{
"@type": "Question",
"name": "Y a-t-il un lien avec l'obésité ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'obésité peut perturber la régulation hormonale et augmenter le risque de troubles."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 10/04/2025
Contenu vérifié selon les dernières recommandations médicales
5 publications dans cette catégorie
Affiliations :
Pituitary Unit, Department of Endocrinology, Fondazione A Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Publications dans "Axe hypothalamohypophysaire" :
5 publications dans cette catégorie
Affiliations :
Pituitary Unit, Department of Endocrinology, Fondazione A Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: Laura.DeMarinis@unicatt.it.
Publications dans "Axe hypothalamohypophysaire" :
4 publications dans cette catégorie
Affiliations :
Department of Radiology, Istituto Dermopatico dell'Immacolata, Rome and Università Cattolica del Sacro Cuore, Rome, Italy.
Publications dans "Axe hypothalamohypophysaire" :
4 publications dans cette catégorie
Affiliations :
Pituitary Unit, Department of Endocrinology, Fondazione A Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Publications dans "Axe hypothalamohypophysaire" :
4 publications dans cette catégorie
Affiliations :
Pituitary Unit, Department of Endocrinology, Fondazione A Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Publications dans "Axe hypothalamohypophysaire" :
4 publications dans cette catégorie
Affiliations :
Pituitary Unit, Department of Endocrinology, Fondazione A Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Publications dans "Axe hypothalamohypophysaire" :
3 publications dans cette catégorie
Affiliations :
Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Publications dans "Axe hypothalamohypophysaire" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopaedics Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Publications dans "Axe hypothalamohypophysaire" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopaedics Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Publications dans "Axe hypothalamohypophysaire" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopaedics Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Publications dans "Axe hypothalamohypophysaire" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopaedics Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Publications dans "Axe hypothalamohypophysaire" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopaedics Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Publications dans "Axe hypothalamohypophysaire" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopaedics Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Publications dans "Axe hypothalamohypophysaire" :
3 publications dans cette catégorie
Affiliations :
Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Publications dans "Axe hypothalamohypophysaire" :
3 publications dans cette catégorie
Affiliations :
Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Publications dans "Axe hypothalamohypophysaire" :
3 publications dans cette catégorie
Affiliations :
Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Publications dans "Axe hypothalamohypophysaire" :
3 publications dans cette catégorie
Affiliations :
Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Publications dans "Axe hypothalamohypophysaire" :
3 publications dans cette catégorie
Affiliations :
Division of Brain and Neurophysiology, Department of Physiology, Jichi Medical University, Shimotsuke, Japan.
Publications dans "Axe hypothalamohypophysaire" :
3 publications dans cette catégorie
Affiliations :
Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Publications dans "Axe hypothalamohypophysaire" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopaedics Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Publications dans "Axe hypothalamohypophysaire" :
Skeletal muscle development and regeneration is governed by the combined action of Myf5, MyoD, Mrf4 and MyoG, also known as the myogenic regulatory factors (MRFs). These transcription factors are expr...
Short tandem repeats affect gene expression by binding regulatory proteins....
Regulation of gene expression takes a central place in normal cells to maintain tissue homeostasis but also in cancer cells to respond to intra- and extra-cellular stimuli, such as therapeutic drugs [...
Gene-expression regulation involves multiple processes and a range of regulatory factors. In this review, we describe the key factors that regulate gene expression, including transcription factors (TF...
Viruses have evolved a multitude of mechanisms to combat barriers to productive infection in the host cell. Virally-encoded miRNAs are one such means to regulate host gene expression in ways that bene...
Cellular functions are regulated by signal transduction pathway networks consisting of protein-modifying enzymes that control the activity of many downstream proteins. Protein kinases and phosphatases...
Variation in DNA methylation (DNAm) in adipose tissue is associated with the pathogenesis of obesity and insulin resistance. The activity of enzymes involved in altering DNAm levels is dependent on se...
To understand the role of metabolites as mechanistic regulators of epigenetic marks, we tested the association between selected plasma metabolites and DNAm levels in the adipose tissue of African Amer...
In the AAGMEx cohort (N = 256), plasma levels of metabolites were measured by untargeted liquid chromatography-mass spectrometry; adipose tissue DNAm and transcript levels were measured by reduced rep...
Among the 21 one-carbon metabolism pathway metabolites evaluated, six were associated with gluco-metabolic traits (P...
Our study suggests that a subset of metabolites modulates the methylation levels of CpG sites in specific loci and, in turn, regulates the expression of transcripts involved in obesity and insulin res...
Coronary artery disease (CAD) is the leading cause of death worldwide. Recent meta-analyses of genome-wide association studies have identified over 175 loci associated with CAD. The majority of these ...
We measured gene expression in SMCs isolated from the ascending aortas of 151 heart transplant donors of various genetic ancestries in quiescent or proliferative conditions and calculated the associat...
We identified 4910 expression and 4412 splicing quantitative trait loci (sQTLs) representing regions of the genome associated with transcript abundance and splicing. A total of 3660 expression quantit...
Collectively, our results provide evidence for the molecular mechanisms of genetic susceptibility to CAD in distinct SMC phenotypes....
Cell type- and differentiation-specific gene expression is precisely controlled by genomic non-coding regulatory elements (NCREs), which include promoters, enhancers, silencers and insulators. It is e...
Although gene-expression (GE) and protein levels are typically strongly genetically regulated, their correlation is known to be low. Here we investigate this phenomenon by focusing on the genetic back...
We performed locus-wide association studies of 92 protein levels measured in whole blood for 2,014 samples of European ancestry and found that 66 are genetically regulated. Three female- and one male-...
While total GE and protein levels are only weakly correlated, we found high correlations between their genetically regulated components across multiple tissues. Of note, strong negative causal effects...