Titre : Maladie de Leigh

Maladie de Leigh : Questions médicales fréquentes

Termes MeSH sélectionnés :

Attention Deficit and Disruptive Behavior Disorders
{ "@context": "https://schema.org", "@graph": [ { "@type": "MedicalWebPage", "name": "Maladie de Leigh : Questions médicales les plus fréquentes", "headline": "Maladie de Leigh : Comprendre les symptômes, diagnostics et traitements", "description": "Guide complet et accessible sur les Maladie de Leigh : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.", "datePublished": "2024-02-22", "dateModified": "2025-02-16", "inLanguage": "fr", "medicalAudience": [ { "@type": "MedicalAudience", "name": "Grand public", "audienceType": "Patient", "healthCondition": { "@type": "MedicalCondition", "name": "Maladie de Leigh" }, "suggestedMinAge": 18, "suggestedGender": "unisex" }, { "@type": "MedicalAudience", "name": "Médecins", "audienceType": "Physician", "geographicArea": { "@type": "AdministrativeArea", "name": "France" } }, { "@type": "MedicalAudience", "name": "Chercheurs", "audienceType": "Researcher", "geographicArea": { "@type": "AdministrativeArea", "name": "International" } } ], "reviewedBy": { "@type": "Person", "name": "Dr Olivier Menir", "jobTitle": "Expert en Médecine", "description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale", "url": "/static/pages/docteur-olivier-menir.html", "alumniOf": { "@type": "EducationalOrganization", "name": "Université Paris Descartes" } }, "isPartOf": { "@type": "MedicalWebPage", "name": "Maladies mitochondriales", "url": "https://questionsmedicales.fr/mesh/D028361", "about": { "@type": "MedicalCondition", "name": "Maladies mitochondriales", "code": { "@type": "MedicalCode", "code": "D028361", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "C18.452.660" } } }, "about": { "@type": "MedicalCondition", "name": "Maladie de Leigh", "alternateName": "Leigh Disease", "code": { "@type": "MedicalCode", "code": "D007888", "codingSystem": "MeSH" } }, "author": [ { "@type": "Person", "name": "Simon C Johnson", "url": "https://questionsmedicales.fr/author/Simon%20C%20Johnson", "affiliation": { "@type": "Organization", "name": "Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA; Department of Anesthesiology and Pain Medicine, Seattle, WA, USA; Department of Applied Sciences, Translational Bioscience, Northumbria University, Newcastle, UK; Department of Laboratory Medicine and Pathology, Seattle, WA, USA; Department of Neurology, University of Washington, Seattle, WA, USA. Electronic address: simon.c.johnson@northumbria.ac.uk." } }, { "@type": "Person", "name": "Katerina James", "url": "https://questionsmedicales.fr/author/Katerina%20James", "affiliation": { "@type": "Organization", "name": "Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA; Department of Applied Sciences, Translational Bioscience, Northumbria University, Newcastle, UK." } }, { "@type": "Person", "name": "Albert Quintana", "url": "https://questionsmedicales.fr/author/Albert%20Quintana", "affiliation": { "@type": "Organization", "name": "Mitochondrial Neuropathology Laboratory, Institut de Neurociències and Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra, Spain." } }, { "@type": "Person", "name": "Philip G Morgan", "url": "https://questionsmedicales.fr/author/Philip%20G%20Morgan", "affiliation": { "@type": "Organization", "name": "Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA; Department of Anesthesiology and Pain Medicine, Seattle, WA, USA." } }, { "@type": "Person", "name": "Manuela Schubert Baldo", "url": "https://questionsmedicales.fr/author/Manuela%20Schubert%20Baldo", "affiliation": { "@type": "Organization", "name": "Research and Development Unit, Human Genetics Department, National Institute of Health Doutor Ricardo Jorge, 4000-053 Porto, Portugal." } } ], "citation": [ { "@type": "ScholarlyArticle", "name": "Exploring real-time functional magnetic resonance imaging neurofeedback in adolescents with disruptive behavior disorder and callous unemotional traits.", "datePublished": "2023-10-16", "url": "https://questionsmedicales.fr/article/37852585", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1016/j.jad.2023.10.036" } }, { "@type": "ScholarlyArticle", "name": "The conduct and oppositional defiant disorder scales (CODDS) for disruptive behaviour disorders.", "datePublished": "2022-07-23", "url": "https://questionsmedicales.fr/article/35961152", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1016/j.psychres.2022.114744" } }, { "@type": "ScholarlyArticle", "name": "Short-Term Impact of \"Amaka Amasanyufu\" Multiple Family Group Intervention on Mental Health Functioning of Children With Disruptive Behavior Disorders in Uganda.", "datePublished": "2023-03-08", "url": "https://questionsmedicales.fr/article/36898607", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1016/j.jaac.2022.12.028" } }, { "@type": "ScholarlyArticle", "name": "Some critical comments on the paper titled \"Some critical considerations in applying the construct of psychopathy to research and classification of childhood disruptive behavior disorders\".", "datePublished": "2022-10-21", "url": "https://questionsmedicales.fr/article/36328895", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1016/j.cpr.2022.102214" } }, { "@type": "ScholarlyArticle", "name": "Polygenic risk scores for antisocial behavior in relation to amygdala morphology across an attention deficit hyperactivity disorder case-control sample with and without disruptive behavior.", "datePublished": "2022-07-30", "url": "https://questionsmedicales.fr/article/35914510", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1016/j.euroneuro.2022.07.182" } } ], "breadcrumb": { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "questionsmedicales.fr", "item": "https://questionsmedicales.fr" }, { "@type": "ListItem", "position": 2, "name": "Maladies métaboliques et nutritionnelles", "item": "https://questionsmedicales.fr/mesh/D009750" }, { "@type": "ListItem", "position": 3, "name": "Maladies métaboliques", "item": "https://questionsmedicales.fr/mesh/D008659" }, { "@type": "ListItem", "position": 4, "name": "Maladies mitochondriales", "item": "https://questionsmedicales.fr/mesh/D028361" }, { "@type": "ListItem", "position": 5, "name": "Maladie de Leigh", "item": "https://questionsmedicales.fr/mesh/D007888" } ] } }, { "@type": "MedicalWebPage", "name": "Article complet : Maladie de Leigh - Questions et réponses", "headline": "Questions et réponses médicales fréquentes sur Maladie de Leigh", "description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.", "datePublished": "2025-05-12", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur Maladie de Leigh", "description": "Comment diagnostique-t-on la maladie de Leigh ?\nQuels examens sont recommandés pour le diagnostic ?\nLes symptômes peuvent-ils aider au diagnostic ?\nQuel rôle joue l'historique familial dans le diagnostic ?\nPeut-on diagnostiquer la maladie de Leigh à tout âge ?", "url": "https://questionsmedicales.fr/mesh/D007888?mesh_terms=Attention+Deficit+and+Disruptive+Behavior+Disorders&page=3#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Maladie de Leigh", "description": "Quels sont les symptômes principaux de la maladie de Leigh ?\nLa maladie de Leigh provoque-t-elle des retards de développement ?\nY a-t-il des symptômes spécifiques à surveiller ?\nLes symptômes varient-ils d'un patient à l'autre ?\nLes symptômes peuvent-ils s'aggraver avec le temps ?", "url": "https://questionsmedicales.fr/mesh/D007888?mesh_terms=Attention+Deficit+and+Disruptive+Behavior+Disorders&page=3#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Maladie de Leigh", "description": "Peut-on prévenir la maladie de Leigh ?\nLe dépistage génétique est-il utile ?\nLes conseils génétiques sont-ils recommandés ?\nLes femmes enceintes peuvent-elles être testées ?\nY a-t-il des mesures préventives à prendre ?", "url": "https://questionsmedicales.fr/mesh/D007888?mesh_terms=Attention+Deficit+and+Disruptive+Behavior+Disorders&page=3#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Maladie de Leigh", "description": "Quels traitements sont disponibles pour la maladie de Leigh ?\nLes suppléments nutritionnels aident-ils ?\nLa physiothérapie est-elle recommandée ?\nY a-t-il des traitements expérimentaux ?\nLes traitements varient-ils selon l'âge ?", "url": "https://questionsmedicales.fr/mesh/D007888?mesh_terms=Attention+Deficit+and+Disruptive+Behavior+Disorders&page=3#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Maladie de Leigh", "description": "Quelles complications peuvent survenir avec la maladie de Leigh ?\nLa maladie de Leigh peut-elle entraîner des handicaps ?\nLes complications sont-elles réversibles ?\nLes patients sont-ils à risque d'autres maladies ?\nComment gérer les complications ?", "url": "https://questionsmedicales.fr/mesh/D007888?mesh_terms=Attention+Deficit+and+Disruptive+Behavior+Disorders&page=3#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Maladie de Leigh", "description": "Quels sont les facteurs de risque de la maladie de Leigh ?\nLa consanguinité augmente-t-elle le risque ?\nLes facteurs environnementaux jouent-ils un rôle ?\nLes hommes et les femmes sont-ils également affectés ?\nLes enfants sont-ils plus à risque ?", "url": "https://questionsmedicales.fr/mesh/D007888?mesh_terms=Attention+Deficit+and+Disruptive+Behavior+Disorders&page=3#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostique-t-on la maladie de Leigh ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Le diagnostic repose sur l'imagerie cérébrale, les tests génétiques et l'analyse du liquide céphalorachidien." } }, { "@type": "Question", "name": "Quels examens sont recommandés pour le diagnostic ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "L'IRM cérébrale et les tests biochimiques mitochondriaux sont souvent utilisés." } }, { "@type": "Question", "name": "Les symptômes peuvent-ils aider au diagnostic ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les symptômes neurologiques et métaboliques orientent vers un diagnostic de la maladie de Leigh." } }, { "@type": "Question", "name": "Quel rôle joue l'historique familial dans le diagnostic ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Un historique familial de maladies mitochondriales peut augmenter la suspicion de la maladie de Leigh." } }, { "@type": "Question", "name": "Peut-on diagnostiquer la maladie de Leigh à tout âge ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Bien que souvent diagnostiquée chez les enfants, elle peut apparaître à tout âge." } }, { "@type": "Question", "name": "Quels sont les symptômes principaux de la maladie de Leigh ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent des troubles neurologiques, des crises, et des problèmes respiratoires." } }, { "@type": "Question", "name": "La maladie de Leigh provoque-t-elle des retards de développement ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les enfants peuvent présenter des retards de développement moteur et cognitif." } }, { "@type": "Question", "name": "Y a-t-il des symptômes spécifiques à surveiller ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Surveillez les troubles de la coordination, la faiblesse musculaire et les crises épileptiques." } }, { "@type": "Question", "name": "Les symptômes varient-ils d'un patient à l'autre ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'expression des symptômes peut varier considérablement entre les individus." } }, { "@type": "Question", "name": "Les symptômes peuvent-ils s'aggraver avec le temps ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la maladie de Leigh est progressive et les symptômes peuvent s'aggraver avec le temps." } }, { "@type": "Question", "name": "Peut-on prévenir la maladie de Leigh ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Actuellement, il n'existe pas de méthode de prévention connue pour la maladie de Leigh." } }, { "@type": "Question", "name": "Le dépistage génétique est-il utile ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Le dépistage génétique peut aider à identifier les porteurs dans les familles à risque." } }, { "@type": "Question", "name": "Les conseils génétiques sont-ils recommandés ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les conseils génétiques sont conseillés pour les familles ayant des antécédents de maladies mitochondriales." } }, { "@type": "Question", "name": "Les femmes enceintes peuvent-elles être testées ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des tests peuvent être effectués pendant la grossesse pour détecter des anomalies génétiques." } }, { "@type": "Question", "name": "Y a-t-il des mesures préventives à prendre ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Éviter l'exposition à des toxines et maintenir une bonne santé générale peuvent être bénéfiques." } }, { "@type": "Question", "name": "Quels traitements sont disponibles pour la maladie de Leigh ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Il n'existe pas de traitement curatif, mais des soins symptomatiques et de soutien sont proposés." } }, { "@type": "Question", "name": "Les suppléments nutritionnels aident-ils ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Des suppléments comme la coenzyme Q10 peuvent être bénéfiques pour certains patients." } }, { "@type": "Question", "name": "La physiothérapie est-elle recommandée ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la physiothérapie peut aider à améliorer la mobilité et la qualité de vie des patients." } }, { "@type": "Question", "name": "Y a-t-il des traitements expérimentaux ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Des essais cliniques sur des thérapies géniques et des traitements ciblés sont en cours." } }, { "@type": "Question", "name": "Les traitements varient-ils selon l'âge ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les traitements peuvent être adaptés en fonction de l'âge et de la gravité des symptômes." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec la maladie de Leigh ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent des troubles respiratoires, des problèmes cardiaques et des infections." } }, { "@type": "Question", "name": "La maladie de Leigh peut-elle entraîner des handicaps ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elle peut causer des handicaps physiques et cognitifs significatifs chez les patients." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "La plupart des complications ne sont pas réversibles et nécessitent une gestion à long terme." } }, { "@type": "Question", "name": "Les patients sont-ils à risque d'autres maladies ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les patients peuvent être plus susceptibles de développer d'autres maladies métaboliques." } }, { "@type": "Question", "name": "Comment gérer les complications ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Une approche multidisciplinaire est nécessaire pour gérer les complications et améliorer la qualité de vie." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque de la maladie de Leigh ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent des antécédents familiaux de maladies mitochondriales et des mutations génétiques." } }, { "@type": "Question", "name": "La consanguinité augmente-t-elle le risque ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la consanguinité peut augmenter le risque de transmission de maladies génétiques comme la maladie de Leigh." } }, { "@type": "Question", "name": "Les facteurs environnementaux jouent-ils un rôle ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Des facteurs environnementaux peuvent influencer l'expression des maladies mitochondriales, mais leur rôle est encore étudié." } }, { "@type": "Question", "name": "Les hommes et les femmes sont-ils également affectés ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la maladie de Leigh affecte les deux sexes de manière égale, sans prédisposition spécifique." } }, { "@type": "Question", "name": "Les enfants sont-ils plus à risque ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Les enfants sont plus souvent diagnostiqués, mais la maladie peut également apparaître chez les adultes." } } ] } ] }

Sources (10000 au total)

Exploring real-time functional magnetic resonance imaging neurofeedback in adolescents with disruptive behavior disorder and callous unemotional traits.

Adolescents with increased callous unemotional traits (CU traits) in the context of disruptive behavior disorder (DBD) show a persistent pattern of antisocial behavior with shallow affect and a lack o... In this explorative randomized controlled trial we randomly assigned twenty-seven adolescents with DBD to individualized real-time functional magnetic resonance neurofeedback (rtfMRI-NF) or behavioral... The rtfMRI-NF (n = 11) and TAU (n = 10) completers showed comparable and significant clinical improvement indicating neither superiority nor inferiority of rtfMRI-NF. The exploratory LMM revealed succ... This exploratory study demonstrated feasibility and suggests clinical efficacy of individualized rtfMRI-NF comparable to active TAU for adolescents with DBD and increased CU traits. Further studies ar...

The conduct and oppositional defiant disorder scales (CODDS) for disruptive behaviour disorders.

This study evaluates the clinical validity of a five-minute instrument, the Conduct and Oppositional Defiant Disorder Scales (CODDS), for assessing oppositional defiant disorder (ODD) and conduct diso...

Short-Term Impact of "Amaka Amasanyufu" Multiple Family Group Intervention on Mental Health Functioning of Children With Disruptive Behavior Disorders in Uganda.

We evaluate the mid-intervention (8 weeks) and short-term (16 weeks) impact of a culturally adapted multiple family group (MFG) intervention, "Amaka Amasanyufu," on the mental health of children with ... We analyzed data from the Strengthening mental health and research training in Sub-Saharan Africa (SMART) Africa-Uganda study. Schools were randomized to the following: a control group; an MFG facilit... There were significant group-by-time interactions for all outcomes, and differences were observed mid-intervention, with short-term effects at 16 weeks (end-intervention). MFG-PP and MFG-CHW children ... Amaka Amasanyufu MFG intervention is effective for reducing depressive symptoms and improving self-concept among children with DBDs while reducing parental stress and mental health problems among care... SMART Africa (Strengthening Mental Health Research and Training); https://clinicaltrials.gov/: NCT03081195....

Some critical comments on the paper titled "Some critical considerations in applying the construct of psychopathy to research and classification of childhood disruptive behavior disorders".

Frick (2022) presented a narrative review of some literature and made several critical comments regarding the extension of the full psychopathy construct to research and classification of childhood di...

Polygenic risk scores for antisocial behavior in relation to amygdala morphology across an attention deficit hyperactivity disorder case-control sample with and without disruptive behavior.

Antisocial and aggressive behaviors show considerable heritability and are central to disruptive behavior disorders (DBDs), but are also frequently observed in attention deficit hyperactivity disorder...

Differential Effects of Disruptive Mood Dysregulation Disorder Comorbidity in Attention Deficit Hyperactivity Disorder on Social Cognition and Empathy.

This study aimed to investigate social cognition and empathy properties in children among Disruptive Mood Dysregulation Disorder (DMDD) + Attention and Hyperactivity Disorder(ADHD); ADHD and healthy c... Twenty-two children with DMDD were compared to matched 30 children with ADHD and 60 healthy controls. We administered Affective Reactivity Index (ARI), KaSi Empathy Scale, Kiddie-SADS, and Reading Min... DMDD + ADHD group had lower performance in ToM skills and empathy than in two groups. The ARI scores were found to be statistically significantly higher in the DMDD group than in two groups. It was al... These results might be important to understand the difficulties in social functioning and interpersonal relationship in children with DMDD and ADHD. Children with DMDD may attend specific therapeutic ...

Language and reading in attention-deficit/hyperactivity disorder and comorbid attention-deficit/hyperactivity disorder + developmental language disorder.

The current study sought to examine whether psycholinguistic assessments could discriminate children and adolescents with developmental language disorder (DLD) from those with attention-deficit/hypera... The Clinical Evaluation of Language Fundamentals-Screening Test (CELFST; Wiig et al., 2013), the Comprehensive Test of Phonological Processing (... The presence of a language disorder (with or without ADHD) predicted poor performance across tasks. Children and adolescents with ADHD (combined vs. inattentive) only significantly differed in sight w... The combination of comorbid ADHD + DLD did not appear to be associated with lower language abilities, sight word reading, or phonemic decoding relative to DLD alone. Reading efficiency was effective i...

Sleep disturbance in children with attention-deficit hyperactivity disorder: relationship with melatonin and behavior.

To evaluate the prevalence and types of sleep problems and their correlations with melatonin content and behavior in Attention-Deficit Hyperactivity Disorder (ADHD) children.... Sleep in ADHD children and typically developing children (TD) aged 6-14 was assessed by the Sleep Disorders Scale for Children (SDSC) and actigraphy, salivary melatonin quantified by ELISA, and behavi... ADHD children showed a higher frequency of sleep disturbances, higher sleep latency, and lower sleep efficiency than in the TD group. The ADHD group presented lower melatonin nocturnal content compare... This study provides, for the first time, evidence that among the frequent sleep disturbances in ADHD, the disorders in initiating and maintaining sleep are associated with the low levels of melatonin ...