Regulation of myogenic gene expression.
Skeletal muscle development and regeneration is governed by the combined action of Myf5, MyoD, Mrf4 and MyoG, also known as the myogenic regulatory factors (MRFs). These transcription factors are expr...
Lipoprotéines HDL : Questions médicales fréquentes
Questions fréquentes et termes MeSH associés
Diagnostic 5
#1
Comment mesurer le taux de HDL ?
Le taux de HDL se mesure par une analyse sanguine lipidique.
#2
Quel est le taux normal de HDL ?
Un taux de HDL supérieur à 1,0 g/L est considéré comme normal chez les hommes.
#3
Quels tests diagnostiques sont utilisés ?
Les tests incluent le profil lipidique et parfois des tests génétiques.
#4
Comment interpréter un faible taux de HDL ?
Un faible taux de HDL augmente le risque de maladies cardiovasculaires.
#5
Les lipoprotéines HDL sont-elles mesurables ?
Oui, elles sont mesurables par des tests sanguins spécifiques.
Symptômes 5
#1
Quels symptômes indiquent un faible HDL ?
Un faible HDL est souvent asymptomatique mais peut indiquer un risque accru de maladies cardiaques.
#2
Le faible HDL cause-t-il des douleurs ?
Non, un faible taux de HDL ne cause pas de douleurs directement.
#3
Y a-t-il des signes cliniques associés ?
Il n'y a pas de signes cliniques spécifiques liés uniquement au HDL.
#4
Un HDL bas peut-il affecter l'énergie ?
Un HDL bas n'affecte pas directement les niveaux d'énergie.
#5
Le HDL bas est-il lié à d'autres maladies ?
Oui, un HDL bas est souvent associé à des maladies métaboliques et cardiovasculaires.
Prévention 5
#1
Comment prévenir un faible taux de HDL ?
Maintenir un mode de vie actif et une alimentation équilibrée aide à prévenir un faible HDL.
#2
Le tabagisme affecte-t-il le HDL ?
Oui, le tabagisme réduit le taux de HDL, augmentant le risque cardiovasculaire.
#3
L'alcool influence-t-il le HDL ?
Une consommation modérée d'alcool peut augmenter le HDL, mais l'excès est nuisible.
#4
Le stress impacte-t-il le HDL ?
Le stress chronique peut affecter négativement le taux de HDL.
#5
Les examens réguliers sont-ils nécessaires ?
Oui, des examens réguliers aident à surveiller le taux de HDL et la santé cardiovasculaire.
Traitements 5
#1
Comment augmenter le taux de HDL ?
L'exercice régulier, une alimentation saine et l'arrêt du tabac peuvent augmenter le HDL.
#2
Les médicaments peuvent-ils aider ?
Oui, certains médicaments comme les statines peuvent aider à augmenter le HDL.
#3
Quels aliments favorisent le HDL ?
Les acides gras oméga-3, les noix et l'huile d'olive favorisent le HDL.
#4
Le HDL peut-il être traité par des suppléments ?
Certains suppléments comme les oméga-3 peuvent aider à augmenter le HDL.
#5
Les changements de mode de vie sont-ils efficaces ?
Oui, des changements de mode de vie peuvent significativement améliorer le taux de HDL.
Complications 5
#1
Quelles complications sont liées à un faible HDL ?
Un faible HDL est associé à un risque accru de maladies cardiaques et d'accidents vasculaires.
#2
Le HDL bas cause-t-il des AVC ?
Oui, un faible taux de HDL peut augmenter le risque d'accidents vasculaires cérébraux.
#3
Un faible HDL affecte-t-il la santé mentale ?
Des études suggèrent un lien entre un faible HDL et des troubles de l'humeur.
#4
Le HDL bas est-il lié au diabète ?
Oui, un faible HDL est souvent observé chez les personnes diabétiques.
#5
Le HDL bas peut-il entraîner des maladies rénales ?
Un faible HDL peut être associé à un risque accru de maladies rénales.
Facteurs de risque 5
#1
Quels sont les principaux facteurs de risque pour un faible HDL ?
L'obésité, le tabagisme, l'inactivité physique et une mauvaise alimentation sont des facteurs de risque.
#2
L'âge influence-t-il le taux de HDL ?
Oui, le taux de HDL tend à diminuer avec l'âge, surtout chez les femmes après la ménopause.
#3
Le sexe affecte-t-il le HDL ?
Oui, les femmes ont généralement des taux de HDL plus élevés que les hommes.
#4
Le stress est-il un facteur de risque ?
Oui, le stress chronique peut contribuer à un faible taux de HDL.
#5
Les antécédents familiaux influencent-ils le HDL ?
Oui, des antécédents familiaux de maladies cardiovasculaires peuvent augmenter le risque de faible HDL.
Contenu validé par Dr Olivier Menir
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 29/03/2025
Contenu vérifié selon les dernières recommandations médicales
Sous-catégories
4 au total
└─
Cholestérol HDL
Cholesterol, HDLD008076 -
D12.776.521.479.470
└─
Pré-bêta-lipoprotéines de haute densité
High-Density Lipoproteins, Pre-betaD053442 -
D12.776.521.479.602
└─
Lipoprotéines HDL2
Lipoproteins, HDL2D053439 -
D12.776.521.479.735
└─
Lipoprotéines HDL3
Lipoproteins, HDL3D053440 -
D12.776.521.479.867
Auteurs principaux
Kyung-Hyun Cho
5 publications dans cette catégorie
Affiliations :
- LipoLab, Yeungnam University, Gyeongsan 38541, Korea.
- Raydel Research Institute, Medical Innovation Complex, Daegu 41061, Korea.
Publications dans "Lipoprotéines HDL" :
-
The Current Status of Research on High-Density Lipoproteins (HDL): A Paradigm Shift from HDL Quantity to HDL Quality and HDL Functionality.
International journal of molecular sciences 2022-04-02
-
Human Serum Amyloid a Impaired Structural Stability of High-Density Lipoproteins (HDL) and Apolipoprotein (Apo) A-I and Exacerbated Glycation Susceptibility of ApoA-I and HDL.
Molecules (Basel, Switzerland) 2022-07-01
-
Long-Term Alcohol Consumption Caused a Significant Decrease in Serum High-Density Lipoprotein (HDL)-Cholesterol and Apolipoprotein A-I with the Atherogenic Changes of HDL in Middle-Aged Korean Women.
International journal of molecular sciences 2022-08-03
-
Native High-Density Lipoproteins (HDL) with Higher Paraoxonase Exerts a Potent Antiviral Effect against SARS-CoV-2 (COVID-19), While Glycated HDL Lost the Antiviral Activity.
Antioxidants (Basel, Switzerland) 2021-02-01
-
Enhancement of High-Density Lipoprotein (HDL) Quantity and Quality by Regular and Habitual Exercise in Middle-Aged Women with Improvements in Lipid and Apolipoprotein Profiles: Larger Particle Size and Higher Antioxidant Ability of HDL.
International journal of molecular sciences 2023-01-06
Anatol Kontush
5 publications dans cette catégorie
Affiliations :
- Unité de Recherche sur les Maladies Cardiovasculaires, Institut National de la Santé et de la Recherche Médicale (INSERM), le Métabolisme et la Nutrition, ICAN, Sorbonne Université, F-75013 Paris, France.
Publications dans "Lipoprotéines HDL" :
-
Mathematical Modelling of Material Transfer to High-Density Lipoprotein (HDL) upon Triglyceride Lipolysis by Lipoprotein Lipase: Relevance to Cardioprotective Role of HDL.
Metabolites 2022-07-06
-
High-density lipoproteins (HDL): Novel function and therapeutic applications.
Biochimica et biophysica acta. Molecular and cell biology of lipids 2021-10-05
-
Reciprocal Multifaceted Interaction Between HDL (High-Density Lipoprotein) and Myocardial Infarction.
Arteriosclerosis, thrombosis, and vascular biology 2019-06-13
-
Phospholipid transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis is directly correlated with HDL-cholesterol levels and is not associated with cardiovascular risk.
Atherosclerosis 2021-03-09
-
Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease.
European journal of preventive cardiology 2019-12-15
Fernando Brites
4 publications dans cette catégorie
Affiliations :
- Laboratory of Lipids and Atherosclerosis, Department of Clinical Biochemistry, INFIBIOC, University of Buenos Aires, CONICET. Buenos Aires, Argentina.
Publications dans "Lipoprotéines HDL" :
-
Phospholipid transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis is directly correlated with HDL-cholesterol levels and is not associated with cardiovascular risk.
Atherosclerosis 2021-03-09
-
Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease.
European journal of preventive cardiology 2019-12-15
-
Effect of Roux-en-Y Gastric Bypass on Lipoprotein Metabolism and Markers of HDL Functionality in Morbid Obese Patients.
Obesity surgery 2020-10-30
-
Increased Cholesteryl Ester Transfer Protein and Lipoprotein-Associated Phospholipase A2 Activities in Children and Adolescents Presenting High Triglyceride/High-Density Lipoprotein Cholesterol (TG/HDL-C) Ratio.
Indian journal of pediatrics 2021-06-07
Wilfried Le Goff
3 publications dans cette catégorie
Affiliations :
- Unité de Recherche sur les Maladies Cardiovasculaires, Institut National de la Santé et de la Recherche Médicale (INSERM), le Métabolisme et la Nutrition, ICAN, Sorbonne Université, F-75013 Paris, France.
Publications dans "Lipoprotéines HDL" :
-
Mathematical Modelling of Material Transfer to High-Density Lipoprotein (HDL) upon Triglyceride Lipolysis by Lipoprotein Lipase: Relevance to Cardioprotective Role of HDL.
Metabolites 2022-07-06
-
Phospholipid transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis is directly correlated with HDL-cholesterol levels and is not associated with cardiovascular risk.
Atherosclerosis 2021-03-09
-
Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease.
European journal of preventive cardiology 2019-12-15
Maryam Darabi
3 publications dans cette catégorie
Affiliations :
- National Institute for Health and Medical Research (INSERM), UMRS 1166 ICAN, Faculty of Medicine Pitié-Salpêtrière, Sorbonne University, Paris, France.
Publications dans "Lipoprotéines HDL" :
-
High-density lipoproteins (HDL): Novel function and therapeutic applications.
Biochimica et biophysica acta. Molecular and cell biology of lipids 2021-10-05
-
Phospholipid transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis is directly correlated with HDL-cholesterol levels and is not associated with cardiovascular risk.
Atherosclerosis 2021-03-09
-
Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease.
European journal of preventive cardiology 2019-12-15
Frank M Sacks
3 publications dans cette catégorie
Affiliations :
- Harvard T.H. Chan School of Public Health, Boston, MA (F.M.S.).
Publications dans "Lipoprotéines HDL" :
-
Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease.
Arteriosclerosis, thrombosis, and vascular biology 2019-10-10
-
Pharmacological Inhibition of CETP (Cholesteryl Ester Transfer Protein) Increases HDL (High-Density Lipoprotein) That Contains ApoC3 and Other HDL Subspecies Associated With Higher Risk of Coronary Heart Disease.
Arteriosclerosis, thrombosis, and vascular biology 2021-12-23
-
Effects of Replacing Dietary Monounsaturated Fat With Carbohydrate on HDL (High-Density Lipoprotein) Protein Metabolism and Proteome Composition in Humans.
Arteriosclerosis, thrombosis, and vascular biology 2019-09-26
Margery A Connelly
3 publications dans cette catégorie
Affiliations :
- Laboratory Corporation of America Holdings (LabCorp), Morrisville, NC (M.A.C.).
Publications dans "Lipoprotéines HDL" :
-
Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease.
Arteriosclerosis, thrombosis, and vascular biology 2019-10-10
-
Refinement of a published gene-physical activity interaction impacting HDL-cholesterol: role of sex and lipoprotein subfractions.
medRxiv : the preprint server for health sciences 2024-01-24
-
Triglyceride/HDL cholesterol ratio and lipoprotein insulin resistance Score: Associations with subclinical atherosclerosis and incident cardiovascular disease.
Clinica chimica acta; international journal of clinical chemistry 2023-12-22
Dan McConnell
2 publications dans cette catégorie
Affiliations :
- Central Ligand Assay Satellite Services Laboratories, University of Michigan, Ann Arbor (D.M.).
Publications dans "Lipoprotéines HDL" :
-
HDL (High-Density Lipoprotein) Subclasses, Lipid Content, and Function Trajectories Across the Menopause Transition: SWAN-HDL Study.
Arteriosclerosis, thrombosis, and vascular biology 2020-12-03
-
High-density lipoprotein over midlife and future cognition in women: The SWAN HDL ancillary study.
The Journal of clinical endocrinology and metabolism 2024-10-05
Daniel J Rader
2 publications dans cette catégorie
Affiliations :
- Perelman School of Medicine, University of Pennsylvania, Philadelphia (J.B., D.J.R.).
Publications dans "Lipoprotéines HDL" :
-
HDL (High-Density Lipoprotein) Subclasses, Lipid Content, and Function Trajectories Across the Menopause Transition: SWAN-HDL Study.
Arteriosclerosis, thrombosis, and vascular biology 2020-12-03
-
High-density lipoprotein metrics during midlife and future subclinical atherosclerosis in women: the SWAN HDL study.
Menopause (New York, N.Y.) 2024-05-14
Samia Mora
2 publications dans cette catégorie
Affiliations :
- Center for Lipid Metabolomics, Divisions of Preventive and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.M.).
Publications dans "Lipoprotéines HDL" :
-
Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease.
Arteriosclerosis, thrombosis, and vascular biology 2019-10-10
-
Refinement of a published gene-physical activity interaction impacting HDL-cholesterol: role of sex and lipoprotein subfractions.
medRxiv : the preprint server for health sciences 2024-01-24
Angela M Zivkovic
2 publications dans cette catégorie
Affiliations :
- Department of Nutrition, University California Davis (A.M.Z.).
Publications dans "Lipoprotéines HDL" :
-
Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease.
Arteriosclerosis, thrombosis, and vascular biology 2019-10-10
-
Lipid-Based Nutrient Supplementation Increases High-Density Lipoprotein (HDL) Cholesterol Efflux Capacity and Is Associated with Changes in the HDL Glycoproteome in Children.
ACS omega 2021-11-18
Uwe J F Tietge
2 publications dans cette catégorie
Affiliations :
- Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden (U.J.F.T.).
- Clinical Chemistry, Karolinska University Laboratory, Karolinska University Hospital, Stockholm, Sweden (U.J.F.T.).
Publications dans "Lipoprotéines HDL" :
-
Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease.
Arteriosclerosis, thrombosis, and vascular biology 2019-10-10
-
HDL (High-Density Lipoprotein) Cholesterol Efflux Capacity Is Associated With Incident Cardiovascular Disease in the General Population.
Arteriosclerosis, thrombosis, and vascular biology 2019-07-18
Mary G Sorci-Thomas
2 publications dans cette catégorie
Affiliations :
- Division of Endocrinology (D.S., M.G.S.-T.), Medical College of Wisconsin, Milwaukee.
Publications dans "Lipoprotéines HDL" :
-
Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease.
Arteriosclerosis, thrombosis, and vascular biology 2019-10-10
-
Recombinant LCAT (Lecithin:Cholesterol Acyltransferase) Rescues Defective HDL (High-Density Lipoprotein)-Mediated Endothelial Protection in Acute Coronary Syndrome.
Arteriosclerosis, thrombosis, and vascular biology
Tomas Vaisar
2 publications dans cette catégorie
Affiliations :
- UW Medicine Diabetes Institute, University of Washington, Seattle (T.V.).
Publications dans "Lipoprotéines HDL" :
-
Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease.
Arteriosclerosis, thrombosis, and vascular biology 2019-10-10
-
Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes Drives Atherosclerosis.
Circulation research 2024-06-03
Giacomo Ruotolo
2 publications dans cette catégorie
Affiliations :
- Eli Lilly and Company, Indianapolis, IN (G.R.).
Publications dans "Lipoprotéines HDL" :
-
Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease.
Arteriosclerosis, thrombosis, and vascular biology 2019-10-10
-
Pharmacological Inhibition of CETP (Cholesteryl Ester Transfer Protein) Increases HDL (High-Density Lipoprotein) That Contains ApoC3 and Other HDL Subspecies Associated With Higher Risk of Coronary Heart Disease.
Arteriosclerosis, thrombosis, and vascular biology 2021-12-23
Vishal Kothari
2 publications dans cette catégorie
Affiliations :
- Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, UW Medicine Diabetes Institute (V.K., Y.H., F.K., M.S.-A., J.E.K., B.S., J.W.H., T.V., K.E.B.).
Publications dans "Lipoprotéines HDL" :
-
Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes Drives Atherosclerosis.
Circulation research 2024-06-03
-
Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques.
Arteriosclerosis, thrombosis, and vascular biology 2019-10-03
Yi He
2 publications dans cette catégorie
Affiliations :
- Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, UW Medicine Diabetes Institute (V.K., Y.H., F.K., M.S.-A., J.E.K., B.S., J.W.H., T.V., K.E.B.).
Publications dans "Lipoprotéines HDL" :
-
Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes Drives Atherosclerosis.
Circulation research 2024-06-03
-
Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques.
Arteriosclerosis, thrombosis, and vascular biology 2019-10-03
Jay W Heinecke
2 publications dans cette catégorie
Affiliations :
- Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, UW Medicine Diabetes Institute (V.K., Y.H., F.K., M.S.-A., J.E.K., B.S., J.W.H., T.V., K.E.B.).
Publications dans "Lipoprotéines HDL" :
-
Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes Drives Atherosclerosis.
Circulation research 2024-06-03
-
Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques.
Arteriosclerosis, thrombosis, and vascular biology 2019-10-03
Karin E Bornfeldt
2 publications dans cette catégorie
Affiliations :
- Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, UW Medicine Diabetes Institute (V.K., Y.H., F.K., M.S.-A., J.E.K., B.S., J.W.H., T.V., K.E.B.).
- Department of Laboratory Medicine and Pathology, University of Washington, Seattle (K.E.B.).
Publications dans "Lipoprotéines HDL" :
-
Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes Drives Atherosclerosis.
Circulation research 2024-06-03
-
Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques.
Arteriosclerosis, thrombosis, and vascular biology 2019-10-03
Roberto Kalil Filho
2 publications dans cette catégorie
Affiliations :
- Instituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-900, Brazil.
Publications dans "Lipoprotéines HDL" :
-
Regular Practice of Physical Activity Improves Cholesterol Transfers to High-Density Lipoprotein (HDL) and Other HDL Metabolic Parameters in Older Adults.
Nutrients 2023-11-22
-
Disturbances of the transfer of cholesterol to high-density lipoprotein (HDL) in patients with peripheral artery disease with or without type 2 diabetes mellitus.
Vascular medicine (London, England) 2021-06-17
Sources (10000 au total)
Repetitive DNA regulates gene expression.
Short tandem repeats affect gene expression by binding regulatory proteins....
Regulation of Gene Expression in Cancer-An Overview.
Regulation of gene expression takes a central place in normal cells to maintain tissue homeostasis but also in cancer cells to respond to intra- and extra-cellular stimuli, such as therapeutic drugs [...
Factors and Methods for the Detection of Gene Expression Regulation.
Gene-expression regulation involves multiple processes and a range of regulatory factors. In this review, we describe the key factors that regulate gene expression, including transcription factors (TF...
Viral miRNA regulation of host gene expression.
Viruses have evolved a multitude of mechanisms to combat barriers to productive infection in the host cell. Virally-encoded miRNAs are one such means to regulate host gene expression in ways that bene...
Signaling pathways and regulation of gene expression in hematopoietic cells.
Cellular functions are regulated by signal transduction pathway networks consisting of protein-modifying enzymes that control the activity of many downstream proteins. Protein kinases and phosphatases...
Metaboepigenetic regulation of gene expression in obesity and insulin resistance.
Variation in DNA methylation (DNAm) in adipose tissue is associated with the pathogenesis of obesity and insulin resistance. The activity of enzymes involved in altering DNAm levels is dependent on se... To understand the role of metabolites as mechanistic regulators of epigenetic marks, we tested the association between selected plasma metabolites and DNAm levels in the adipose tissue of African Amer... In the AAGMEx cohort (N = 256), plasma levels of metabolites were measured by untargeted liquid chromatography-mass spectrometry; adipose tissue DNAm and transcript levels were measured by reduced rep... Among the 21 one-carbon metabolism pathway metabolites evaluated, six were associated with gluco-metabolic traits (P... Our study suggests that a subset of metabolites modulates the methylation levels of CpG sites in specific loci and, in turn, regulates the expression of transcripts involved in obesity and insulin res...
Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes.
Coronary artery disease (CAD) is the leading cause of death worldwide. Recent meta-analyses of genome-wide association studies have identified over 175 loci associated with CAD. The majority of these ... We measured gene expression in SMCs isolated from the ascending aortas of 151 heart transplant donors of various genetic ancestries in quiescent or proliferative conditions and calculated the associat... We identified 4910 expression and 4412 splicing quantitative trait loci (sQTLs) representing regions of the genome associated with transcript abundance and splicing. A total of 3660 expression quantit... Collectively, our results provide evidence for the molecular mechanisms of genetic susceptibility to CAD in distinct SMC phenotypes....
Identification of non-coding silencer elements and their regulation of gene expression.
Cell type- and differentiation-specific gene expression is precisely controlled by genomic non-coding regulatory elements (NCREs), which include promoters, enhancers, silencers and insulators. It is e...
Genetically regulated gene expression and proteins revealed discordant effects.
Although gene-expression (GE) and protein levels are typically strongly genetically regulated, their correlation is known to be low. Here we investigate this phenomenon by focusing on the genetic back... We performed locus-wide association studies of 92 protein levels measured in whole blood for 2,014 samples of European ancestry and found that 66 are genetically regulated. Three female- and one male-... While total GE and protein levels are only weakly correlated, we found high correlations between their genetically regulated components across multiple tissues. Of note, strong negative causal effects...