Comment diagnostiquer une déficience en oxydoréductases N-déméthylantes ?

Des tests enzymatiques et des analyses génétiques peuvent être effectués.

Quels tests sont utilisés pour évaluer l'activité enzymatique ?

Des tests de métabolisme des médicaments et des dosages enzymatiques sont utilisés.

Quels symptômes peuvent indiquer un dysfonctionnement enzymatique ?

Des symptômes tels que des réactions médicamenteuses inattendues peuvent survenir.

Peut-on utiliser des biomarqueurs pour le diagnostic ?

Oui, certains biomarqueurs peuvent indiquer une activité enzymatique altérée.

Les tests sanguins sont-ils utiles pour le diagnostic ?

Oui, des tests sanguins peuvent mesurer les niveaux de métabolites spécifiques.

Quels symptômes sont associés à une altération de la déméthylation ?

Des nausées, des vomissements et des réactions cutanées peuvent se manifester.

Les troubles neurologiques peuvent-ils être liés à ces enzymes ?

Oui, des troubles neurologiques peuvent survenir en raison d'une accumulation de toxines.

Comment les effets secondaires des médicaments sont-ils liés ?

Une déméthylation inefficace peut entraîner des effets secondaires imprévus.

Les symptômes varient-ils selon les individus ?

Oui, les symptômes peuvent varier en fonction de la génétique et de l'environnement.

Y a-t-il des symptômes spécifiques aux enfants ?

Les enfants peuvent présenter des symptômes plus aigus, comme des troubles de l'attention.

Comment prévenir les complications liées à la déméthylation ?

Éviter les médicaments connus pour interférer avec la déméthylation peut aider.

Y a-t-il des tests préventifs recommandés ?

Des tests génétiques peuvent être recommandés pour les personnes à risque.

L'éducation des patients est-elle importante ?

Oui, informer les patients sur les médicaments et leurs effets est crucial.

Les habitudes de vie peuvent-elles influencer la fonction enzymatique ?

Oui, des habitudes de vie saines peuvent améliorer la fonction enzymatique.

Des vaccinations peuvent-elles aider à prévenir des complications ?

Certaines vaccinations peuvent prévenir des infections qui compliquent les traitements.

Quels traitements sont disponibles pour les dysfonctionnements enzymatiques ?

Des traitements symptomatiques et des ajustements médicamenteux peuvent être nécessaires.

Peut-on utiliser des suppléments pour améliorer la fonction enzymatique ?

Des suppléments comme les antioxydants peuvent aider à soutenir la fonction enzymatique.

Les modifications alimentaires peuvent-elles aider ?

Oui, une alimentation équilibrée peut soutenir le métabolisme et la fonction enzymatique.

Des thérapies géniques sont-elles envisageables ?

La thérapie génique est une option potentielle pour corriger des déficiences enzymatiques.

Les médicaments peuvent-ils être ajustés pour éviter des effets indésirables ?

Oui, ajuster les doses ou changer de médicament peut réduire les effets indésirables.

Quelles complications peuvent survenir en cas de dysfonctionnement ?

Des complications comme des réactions médicamenteuses graves peuvent se produire.

Les complications sont-elles réversibles ?

Certaines complications peuvent être réversibles avec un traitement approprié.

Comment les complications affectent-elles la qualité de vie ?

Les complications peuvent réduire la qualité de vie en provoquant des symptômes chroniques.

Les complications peuvent-elles être prévenues ?

Oui, une surveillance régulière et des ajustements de traitement peuvent prévenir les complications.

Y a-t-il des complications spécifiques aux traitements ?

Oui, certains traitements peuvent entraîner des complications spécifiques, comme des allergies.

Quels sont les facteurs de risque pour les dysfonctionnements enzymatiques ?

Des facteurs génétiques, environnementaux et liés au mode de vie peuvent influencer le risque.

L'âge joue-t-il un rôle dans le risque de dysfonctionnement ?

Oui, le risque peut augmenter avec l'âge en raison de la diminution de la fonction enzymatique.

Les antécédents familiaux sont-ils un facteur de risque ?

Oui, des antécédents familiaux de troubles enzymatiques augmentent le risque.

L'exposition à des toxines peut-elle augmenter le risque ?

Oui, l'exposition à des toxines environnementales peut affecter la fonction enzymatique.

Le mode de vie influence-t-il le risque de complications ?

Oui, un mode de vie sain peut réduire le risque de complications liées à la déméthylation.

Oxidoreductases, (N-demethylating) - Informations médicales vérifiées

Classification of Local Recurrence After Nipple-Sparing Mastectomy Based on Location: The Features of Nipple-Areolar Recurrence Differ from Those of Other Local Recurrences.

Mar 2023

DOI: 10.1245/s10434-022-12760-1 PMID: 36371582

Little information is available about the clinical and pathologic characteristics of local recurrence (LR) after nipple-sparing mastectomy according to the locations of LR.... This study classified 99 patients into the following two groups according to the location of LR after nipple-sparing mastectomy: nipple-areolar recurrence (NAR) group and other locations of LR (oLR) g... For about half of the patients (44.4 %) with NAR, the primary cancer was estrogen receptor (ER)-negative and human epidermal growth factor receptor 2 (HER2)-positive. Conversely, in most of the patien... This multi-institutional retrospective study demonstrated that the features of NAR, such as the characteristics of the primary and recurrent tumors and the prognostic factors after LR resection, were ...

Humans Female Breast Neoplasms Mastectomy Nipples +4 autres

Feasibility of local therapy for recurrent pancreatic cancer.

Sep 2022

DOI: 10.1016/j.pan.2022.05.004 PMID: 35641368

Despite advances in perioperative management, recurrence after curative pancreatectomy is a critical issue in the treatment of pancreatic ductal adenocarcinoma (PDAC). The significance of local therap... We reviewed the medical records of patients with PDAC who underwent curative resection at our institution between January 2009 and December 2019. We examined the patterns of relapse and assessed the c... A total of 246 patients with PDAC who underwent R0 or R1 resection were included in this study. The 3-year overall survival (OS) rate was 39.8%, and the 1-year recurrence-free survival rate was 51.2% ... Our results suggest that a multimodal approach may improve the clinical outcomes of patients with recurrent PDAC....

Adenocarcinoma Carcinoma, Pancreatic Ductal Feasibility Studies Humans Neoplasm Recurrence, Local +6 autres

Ultrasound Assessment of Skin Tumors Local Recurrence.

Oct 2023

DOI: 10.1002/jum.16255 PMID: 37195073

Skin cancer may recur at or around the surgical site despite wide excisions. Prompt clinical and sonographic detection of local recurrence is important since subjects with relapsing melanomas or nonme...

Humans Skin Neoplasms Skin Melanoma Ultrasonography +1 autres

Pathological determinants of outcome following resection of locally advanced or locally recurrent rectal cancer.

Nov 2023

DOI: 10.1016/j.ejso.2023.06.023 PMID: 37442715

Pathological factors that influence and predict survival following pelvic exenteration (PE) for locally advanced (LARC) or locally recurrent rectal cancer (LRRC), especially LRRC, remain poorly unders... A retrospective cohort study was performed for all patients undergoing a curative PE for LARC or LRRC between 2008 and 2021 at a tertiary referral UK specialist colorectal hospital. Cox regression ana... 388 patients were included in the analysis with 256 resections for LARC and 132 for LRRC. 62.4% of patients were male with a median age of 59 years (IQR 49-67). 247 (64%) partial pelvic exenterations ... A positive resection margin and poorly differentiated tumours are significant negative prognostic markers for survival and recurrence in LARC. The results of this study support the need to look for al...

Humans Male Middle Aged Aged Female +7 autres

Intraparenchymal metastases as a cause for local recurrence of pancreatic cancer.

Feb 2023

DOI: 10.1111/his.14839 PMID: 36371607

Using CODA, a technique for three-dimensional reconstruction of large tissues, Kiemen et al. report observation of a microscopic focus of pancreatic cancer found in the vasculature of grossly normal h...

Humans Pancreatic Neoplasms Pancreas Neoplasm Recurrence, Local Pancreatic Neoplasms

Does the Addition of Mutations of CTNNB1 S45F to Clinical Factors Allow Prediction of Local Recurrence in Patients With a Desmoid Tumor? A Local Recurrence Risk Model.

01 10 2023

DOI: 10.1097/CORR.0000000000002627 PMID: 37104792

The initial approach to the treatment of desmoid tumors has changed from surgical resection to watchful waiting. However, surgery is still sometimes considered for some patients, and it is likely that... We sought to explore whether a combined molecular and clinical prognostic model for relapse in patients with desmoid tumors treated with surgery would allow us to identify patients who might do well w... This was a retrospective, single-center study of 107 patients with desmoid tumors who were surgically treated between January 1980 and December 2015, with a median follow-up of 106 months (range 7 to ... The multivariable analysis showed that S45F mutations (hazard ratio 5.25 [95% confidence interval 2.27 to 12.15]; p < 0.001) and tumor in the extremities (HR 3.15 [95% CI 1.35 to 7.33]; p = 0.008) wer... CTNNB1 S45F mutations combined with other clinical variables are a potential prognostic biomarker associated with the risk of relapse in patients with desmoid tumors. The developed nomogram is simple ... Level III, therapeutic study....

Humans Fibromatosis, Aggressive Retrospective Studies Neoplasm Recurrence, Local Mutation +2 autres

Risk Factors of Second Local Recurrence in Surgically Treated Recurrent Brain Metastases: An Exploratory Analysis.

Nov 2022

DOI: 10.1016/j.wneu.2022.08.066 PMID: 36028114

A first local recurrence is common after resection or radiotherapy for brain metastasis (BM). However, patients with BMs can develop multiple local recurrences over time. Published data on second loca... Patients were identified from a database at Brigham and Women's Hospital in Boston. Hazard ratios and 95% confidence intervals for predictors of a second local recurrence were computed using a Cox pro... Of 170 identified surgically treated first locally recurrent lesions, 74 (43.5%) progressed to second locally recurrent lesions at a median of 7 months after craniotomy. Subtotal resection of the firs... A second local recurrence occurred after 43.5% of craniotomies for first recurrent lesions. Subtotal resection and infratentorial location were the strongest risk factors for worse second local recurr...

Humans Female Neoplasm Recurrence, Local Prognosis Risk Factors +3 autres

Applying a neoscore in locally advanced rectal cancer is beneficial in predicting local recurrences after surgery.

2023

DOI: 10.1371/journal.pone.0285709 PMID: 37172066

The current study was undertaken to provide more detailed prognostic models for early prediction of local recurrences and local recurrence free survival (RFS) using different radiologic and pathologic... One hundred patients with locally advanced rectal carcinomas decided to receive neoadjuvant CRT were retrospectively recruited, Hazard ratios (HR) were determined in the two cox regression models and ... HR of 1st group of models: T+N, T+N+G, T+N+G+S, T+N+G+S+PNI, and T+N+G+S+PNI+R were summated and categorized into scores, these scores were significantly correlated with the risk of recurrence (Somer'... We propose that the addition of biologic factors to staging of rectal cancer provide precise stratification and association with local recurrences in patients received preoperative CRT....

Humans Retrospective Studies Prognosis Rectum Rectal Neoplasms +6 autres

Surgery of resectable local recurrence following colorectal cancer: Compartmental surgery improves local control.

Nov 2022

DOI: 10.1002/jso.26990 PMID: 35779039

This study aims to identify prognostic factors and define the best extent of surgery for optimizing treatment of local recurrence (LR) following colorectal cancer (CRC).... An institutional database of consecutive patients who underwent radical resection (R0/R1) of LR following CRC was analyzed prospectively from 2010 to 2021 at one tertiary cancer center.... In this study, 75 patients were included with LR following CRC and analyzed. Patients were categorized as compartmental resections (CompRe) (n = 47) if all adjacent organs were systematically removed,... Complete compartmental surgery is safe and improves local control. Optimal LR resection needs to remove all contiguous organs, with or without tumor involvement....

Colorectal Neoplasms Digestive System Surgical Procedures Humans Neoplasm Recurrence, Local Prognosis +3 autres

Recurrent RET fusions in fibrosarcoma-like neoplasms in adult viscera: expanding the clinicopathological and genetic spectrum.

Mar 2023

DOI: 10.1111/his.14847 PMID: 36443894

RET-fused mesenchymal neoplasms mostly affect the soft tissue of paediatric patients. Given their responsiveness to selective RET inhibitors, it remains critical to identify those extraordinary cases ... Clinicopathological features were assessed and partner agnostic targeted next-generation sequencing on clinically validated platforms were performed. The patients were 18, 53, and 55 years old and inc... Our study expands the clinicopathological and genetic spectrum of mesenchymal neoplasms associated with RET fusions....

Female Humans Male Adult Child +7 autres

Oxidoreductases, (N-demethylating) : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Sous-catégories

Aminopyrine N-demethylase

Dihydropteridine reductase

Dimethylglycine dehydrogenase

Ethylmorphine-N-demethylase

Histone Demethylases

Sarcosine dehydrogenase

Auteurs principaux

Sources (10000 au total)