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"name": "Comment diagnostiquer une anémie pendant la grossesse ?",
"position": 1,
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"text": "Un diagnostic d'anémie se fait par une prise de sang mesurant l'hémoglobine et l'hématocrite."
}
},
{
"@type": "Question",
"name": "Quels tests pour la thrombocytopénie chez la femme enceinte ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un hémogramme complet est nécessaire pour évaluer le nombre de plaquettes sanguines."
}
},
{
"@type": "Question",
"name": "Comment détecter un trouble de la coagulation ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests de coagulation comme le temps de prothrombine et le temps de thromboplastine partielle sont utilisés."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une complication hématologique ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes comme des saignements, des ecchymoses ou une fatigue excessive peuvent indiquer une complication."
}
},
{
"@type": "Question",
"name": "Quand faire un dépistage de la thalassémie ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le dépistage de la thalassémie est recommandé lors des consultations prénatales, surtout en cas d'antécédents familiaux."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes de l'anémie chez la femme enceinte ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent fatigue, pâleur, essoufflement et palpitations."
}
},
{
"@type": "Question",
"name": "Comment reconnaître une thrombocytopénie ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des saignements inhabituels, des ecchymoses et des saignements de nez fréquents peuvent indiquer une thrombocytopénie."
}
},
{
"@type": "Question",
"name": "Quels signes d'alerte pour les troubles de la coagulation ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des saignements prolongés après une coupure ou des hématomes fréquents peuvent être des signes d'alerte."
}
},
{
"@type": "Question",
"name": "Quels symptômes d'une carence en fer ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent fatigue, faiblesse, et parfois des envies de manger des substances non alimentaires."
}
},
{
"@type": "Question",
"name": "Comment se manifeste une hypercoagulabilité ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut se manifester par des douleurs dans les jambes, un gonflement ou des rougeurs."
}
},
{
"@type": "Question",
"name": "Comment prévenir l'anémie pendant la grossesse ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée riche en fer et des suppléments peuvent aider à prévenir l'anémie."
}
},
{
"@type": "Question",
"name": "Quelles mesures pour éviter la thrombocytopénie ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter les médicaments qui affectent les plaquettes et surveiller les infections peut aider."
}
},
{
"@type": "Question",
"name": "Comment réduire le risque de troubles de la coagulation ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Maintenir une activité physique régulière et éviter le tabagisme peut réduire le risque."
}
},
{
"@type": "Question",
"name": "Quels conseils nutritionnels pour prévenir les carences ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Consommer des aliments riches en fer, folates et vitamines est crucial pour prévenir les carences."
}
},
{
"@type": "Question",
"name": "Comment surveiller les facteurs de risque hématologiques ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un suivi médical régulier et des tests sanguins peuvent aider à surveiller les facteurs de risque."
}
},
{
"@type": "Question",
"name": "Quel traitement pour l'anémie pendant la grossesse ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement inclut des suppléments de fer et une alimentation riche en fer."
}
},
{
"@type": "Question",
"name": "Comment traiter la thrombocytopénie ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement dépend de la cause, mais peut inclure des transfusions de plaquettes si nécessaire."
}
},
{
"@type": "Question",
"name": "Quels médicaments pour les troubles de la coagulation ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anticoagulants peuvent être prescrits pour prévenir les complications thromboemboliques."
}
},
{
"@type": "Question",
"name": "Comment gérer une carence en vitamine B12 ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des injections de vitamine B12 ou des suppléments oraux peuvent être nécessaires."
}
},
{
"@type": "Question",
"name": "Quel suivi pour les femmes avec des troubles hématologiques ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un suivi régulier avec des tests sanguins est essentiel pour surveiller l'évolution."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec l'anémie ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'anémie peut entraîner des complications comme un faible poids à la naissance et une fatigue accrue."
}
},
{
"@type": "Question",
"name": "Quels risques associés à la thrombocytopénie ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "La thrombocytopénie peut augmenter le risque de saignements graves pendant l'accouchement."
}
},
{
"@type": "Question",
"name": "Comment les troubles de la coagulation affectent-ils la grossesse ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent entraîner des complications comme des thromboses veineuses profondes et des hémorragies."
}
},
{
"@type": "Question",
"name": "Quelles sont les conséquences d'une carence en fer ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une carence en fer peut causer des complications comme une fatigue extrême et des problèmes de développement fœtal."
}
},
{
"@type": "Question",
"name": "Quels impacts des troubles hématologiques sur le fœtus ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent affecter la croissance fœtale et augmenter le risque de prématurité."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque d'anémie ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent une alimentation pauvre en fer, des grossesses multiples et des antécédents d'anémie."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour la thrombocytopénie ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antécédents médicaux, certaines infections et des médicaments peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "Comment l'âge influence-t-il les complications hématologiques ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les femmes plus âgées peuvent avoir un risque accru de complications hématologiques pendant la grossesse."
}
},
{
"@type": "Question",
"name": "Quels antécédents médicaux sont préoccupants ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des antécédents de troubles sanguins, comme la drépanocytose, augmentent le risque de complications."
}
},
{
"@type": "Question",
"name": "Quel rôle joue la génétique dans les complications hématologiques ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des antécédents familiaux de troubles sanguins peuvent prédisposer à des complications hématologiques."
}
}
]
}
]
}
Factor X (FX) is a vitamin K-dependent enzyme, which acts as an important coagulation factor of coagulation cascade. FX deficiency is an autosomal recessive inherited disease and is often demonstrated...
Hereditary factor X (FX) deficiency (FXD) is a rare autosomal recessive bleeding disorder. Plasma-derived FX (pdFX) is a high-purity FX concentrate approved in the United States and Europe for the tre...
To review pharmacokinetic dosing, efficacy, and safety data for pdFX as routine prophylaxis for HFXD....
Summary of the published pharmacokinetic and safety data from TEN01, TEN02, TEN05, and real-world publications of pdFX for prophylaxis....
Pharmacokinetic modelling data from the phase 3 TEN01 study supported administration of pdFX 25 IU/kg twice weekly for routine prophylaxis in adolescents/adults (aged ≥12 years). Results from nine pae...
pdFX was well tolerated in clinical studies, with no new safety signals identified during routine prophylactic use. Based on current evidence, it is recommended that routine prophylaxis with pdFX be i...
Autoimmune factor X (FX or F10) deficiency (AiF10D) is an extremely rare acquired haemorrhagic disorder characterized by a severe reduction in FX activity due to autoantibodies against FX....
Anti-FX autoantibodies were investigated in four patients with suspected AiF10D, and their properties were analysed....
Anti-FX auto antibodies in plasma were detected by ELISA with three of four cases. One case of anti-FX autoantibody negativity was later diagnosed as AL-amyloidosis. IgG1 and IgG3 coexisted in all ant...
Immunological anti-FX autoantibody detection is highly recommended to ensure that AiF10D cases are not overlooked, and to start necessary immunosuppressive therapies....
AL amyloidosis is associated with acquired factor X (FX) deficiency. Experience related to its management is limited to case reports and series using prothrombin complex concentrate, fresh frozen plas...
We report our experience with the perioperative use of FX concentrate (Coagadex) in two patients with AL amyloidosis-associated acquired FX deficiency requiring surgery, using their individual pharmac...
Both patients' plasma FX activity was successfully increased to provide perioperative hemostatic support. Monitoring FX activity post-surgery was also utilized to maintain FX activity levels to preven...
Pharmacokinetic studies have a useful role in tailoring preoperative FX repletion in patients with AL amyloidosis associated with acquired FX deficiency....
Coagulation factor X (FX) deficiency causes severe hemorrhagic symptoms. We herein report a 90-year-old man with hemorrhagic symptoms and prolongation of prothrombin time (PT) and activated partial th...
Multiple myeloma is one of the most common hematologic malignancies. Acquired factor X deficiencies are often observed in primary (AL) amyloidosis and rarely in multiple myeloma....
We report a case of an acquired factor X deficiency in a patient with a newly diagnosed IgA lambda multiple myeloma, without any evidence of concomitant amyloidosis....
We present the patient's medical history, clinical and physical examinations, laboratory analysis, and outcome....
A 76-year-old male presented at the emergency department with ongoing gingival bleeding. Several analytical problems with blood sample analysis arose, which eventually led to the diagnosis of a multip...
While coagulopathy is rarely observed in patients diagnosed with multiple myeloma, considering an acquired factor X deficiency becomes relevant when such patient present with bleeding diathesis....
In patients with severe congenital factor X deficiency, spontaneous intracranial hemorrhage (ICH) is particularly frequent in early childhood. We describe a case of fetal death at 26 weeks due to mass...
Factor X deficiency is a rare inherited bleeding disorder. To date, 181 variants are reported in the recently updated F10-gene variant database....
This study aimed to describe new F10 variants....
The F10 gene was analysed in 16 consecutive families with FX deficiency by a targeted high-throughput sequencing approach, including F10, F9, F8 genes, and 78 genes dedicated to haematological maligna...
We identified 19 variants (17 missense, one nonsense and one frameshift) and two copy number variations. Two patients presenting a combined FVII-FX deficiency showed a loss of one F10 gene copy (del13...
This study showed the feasibility and the interest of high-throughput sequencing approach for rare bleeding disorders, enabling the report of F10 gene screening in a 3-weeks delay, suitable for clinic...
Acquired factor X (FX) deficiency is a rare but well-documented clinical feature of AL amyloidosis. Patients with FX deficiency can present with clinically significant bleeding diathesis due to the ad...
Factor X (FX) deficiency is prevalent in light-chain (AL) amyloidosis but its clinical significance was not investigated deeply. We conducted a retrospective analysis of a consecutive cohort with 207 ...