Oui, certains antidépresseurs peuvent améliorer les symptômes liés au tRNA-Trp.
AntidépresseursTraitement médicamenteux
#3
Y a-t-il des thérapies alternatives ?
Des thérapies comme la méditation peuvent aider à gérer les symptômes.
Thérapies alternativesMéditation
#4
Le suivi médical est-il nécessaire ?
Oui, un suivi régulier est essentiel pour ajuster le traitement.
Suivi médicalAjustement thérapeutique
#5
Des changements de mode de vie sont-ils recommandés ?
Oui, une alimentation équilibrée et l'exercice régulier sont conseillés.
Mode de vie sainExercice physique
Complications
5
#1
Quelles complications peuvent survenir avec une carence en tRNA-Trp ?
Des troubles mentaux et des problèmes de croissance peuvent se développer.
ComplicationsTroubles mentaux
#2
Le tRNA-Trp est-il lié à des maladies chroniques ?
Oui, des déséquilibres peuvent contribuer à des maladies comme la dépression.
Maladies chroniquesDépression
#3
Des troubles métaboliques peuvent-ils être causés ?
Oui, une carence peut entraîner des troubles métaboliques et endocriniens.
Troubles métaboliquesEndocrinologie
#4
Y a-t-il un risque accru de maladies cardiovasculaires ?
Oui, des déséquilibres en acides aminés peuvent affecter la santé cardiaque.
Maladies cardiovasculairesAcides aminés
#5
Les complications neurologiques sont-elles possibles ?
Oui, des troubles neurologiques peuvent survenir en cas de carence prolongée.
Complications neurologiquesCarence prolongée
Facteurs de risque
5
#1
Quels sont les facteurs de risque de carence en tryptophane ?
Une alimentation déséquilibrée et des troubles digestifs augmentent le risque.
Facteurs de risqueTroubles digestifs
#2
Les personnes âgées sont-elles plus à risque ?
Oui, elles peuvent avoir des besoins nutritionnels accrus et une absorption réduite.
Personnes âgéesBesoins nutritionnels
#3
Les végétariens courent-ils un risque accru ?
Oui, ils doivent veiller à consommer suffisamment de sources de tryptophane.
VégétariensSources alimentaires
#4
Les troubles alimentaires augmentent-ils le risque ?
Oui, ils peuvent entraîner des carences en nutriments essentiels comme le tryptophane.
Troubles alimentairesCarences nutritionnelles
#5
Le stress peut-il affecter le tRNA-Trp ?
Oui, le stress chronique peut perturber le métabolisme des acides aminés.
StressMétabolisme des acides aminés
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "ARN de transfert du tryptophane : Questions médicales les plus fréquentes",
"headline": "ARN de transfert du tryptophane : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les ARN de transfert du tryptophane : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-04-17",
"dateModified": "2025-04-12",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "ARN de transfert du tryptophane"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "ARN de transfert spécifiques des différents acides aminés",
"url": "https://questionsmedicales.fr/mesh/D012345",
"about": {
"@type": "MedicalCondition",
"name": "ARN de transfert spécifiques des différents acides aminés",
"code": {
"@type": "MedicalCode",
"code": "D012345",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D13.444.735.757.700"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "ARN de transfert du tryptophane",
"alternateName": "RNA, Transfer, Trp",
"code": {
"@type": "MedicalCode",
"code": "D012364",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Makoto Tominaga",
"url": "https://questionsmedicales.fr/author/Makoto%20Tominaga",
"affiliation": {
"@type": "Organization",
"name": "Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan; Thermal Biology Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Japan; Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Japan; Institute for Environmental and Gender-Specific Medicine, Juntendo University, Chiba, Japan. Electronic address: tominaga@nips.ac.jp."
}
},
{
"@type": "Person",
"name": "Sudhanva S Kashyap",
"url": "https://questionsmedicales.fr/author/Sudhanva%20S%20Kashyap",
"affiliation": {
"@type": "Organization",
"name": "Department of Biomedical Sciences, Iowa State University, Ames, IA, 50011, USA."
}
},
{
"@type": "Person",
"name": "Alan P Robertson",
"url": "https://questionsmedicales.fr/author/Alan%20P%20Robertson",
"affiliation": {
"@type": "Organization",
"name": "Department of Biomedical Sciences, Iowa State University, Ames, IA, 50011, USA."
}
},
{
"@type": "Person",
"name": "Richard J Martin",
"url": "https://questionsmedicales.fr/author/Richard%20J%20Martin",
"affiliation": {
"@type": "Organization",
"name": "Department of Biomedical Sciences, Iowa State University, Ames, IA, 50011, USA. rjmartin@iastate.edu."
}
},
{
"@type": "Person",
"name": "Lixia Yue",
"url": "https://questionsmedicales.fr/author/Lixia%20Yue",
"affiliation": {
"@type": "Organization",
"name": "Department of Cell Biology, Calhoun Cardiology Center, School of Medicine (UConn Health), University of Connecticut, Farmington, CT, 06030, USA. lyue@uchc.edu."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Associations between muscle morphology and spasticity in children with spastic cerebral palsy.",
"datePublished": "2023-01-10",
"url": "https://questionsmedicales.fr/article/36706682",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.ejpn.2023.01.007"
}
},
{
"@type": "ScholarlyArticle",
"name": "Efficacy of nabiximols oromucosal spray on spasticity in people with multiple sclerosis: Treatment effects on Spasticity Numeric Rating Scale, muscle spasm count, and spastic muscle tone in two randomized clinical trials.",
"datePublished": "2023-05-01",
"url": "https://questionsmedicales.fr/article/37209500",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.msard.2023.104745"
}
},
{
"@type": "ScholarlyArticle",
"name": "Rebalancing the Spastic Wrist by Transposition of Antagonistic Muscle-Tendon Complex.",
"datePublished": "2022-06-01",
"url": "https://questionsmedicales.fr/article/34711790",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1097/BTH.0000000000000371"
}
},
{
"@type": "ScholarlyArticle",
"name": "Methods of muscle spasticity assessment in children with cerebral palsy: a scoping review.",
"datePublished": "2024-07-11",
"url": "https://questionsmedicales.fr/article/38992701",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s13018-024-04894-7"
}
},
{
"@type": "ScholarlyArticle",
"name": "Focal muscle spasticity has little impact on muscle power for walking in people with Traumatic Brain Injury.",
"datePublished": "2023-05-03",
"url": "https://questionsmedicales.fr/article/37295342",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.clinbiomech.2023.105978"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Acides nucléiques, nucléotides et nucléosides",
"item": "https://questionsmedicales.fr/mesh/D009706"
},
{
"@type": "ListItem",
"position": 3,
"name": "Acides nucléiques",
"item": "https://questionsmedicales.fr/mesh/D009696"
},
{
"@type": "ListItem",
"position": 4,
"name": "ARN",
"item": "https://questionsmedicales.fr/mesh/D012313"
},
{
"@type": "ListItem",
"position": 5,
"name": "ARN de transfert",
"item": "https://questionsmedicales.fr/mesh/D012343"
},
{
"@type": "ListItem",
"position": 6,
"name": "ARN de transfert spécifiques des différents acides aminés",
"item": "https://questionsmedicales.fr/mesh/D012345"
},
{
"@type": "ListItem",
"position": 7,
"name": "ARN de transfert du tryptophane",
"item": "https://questionsmedicales.fr/mesh/D012364"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : ARN de transfert du tryptophane - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur ARN de transfert du tryptophane",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-05",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur ARN de transfert du tryptophane",
"description": "Comment diagnostiquer une anomalie du tRNA-Trp ?\nQuels tests sont utilisés pour évaluer le tRNA-Trp ?\nQuels symptômes peuvent indiquer un problème avec le tRNA-Trp ?\nLe dosage du tryptophane est-il utile ?\nPeut-on détecter des mutations dans le gène du tRNA-Trp ?",
"url": "https://questionsmedicales.fr/mesh/D012364?mesh_terms=Muscle+Spasticity#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur ARN de transfert du tryptophane",
"description": "Quels sont les symptômes d'une carence en tryptophane ?\nLes troubles de l'humeur sont-ils liés au tRNA-Trp ?\nY a-t-il des signes neurologiques associés ?\nComment le tRNA-Trp affecte-t-il l'appétit ?\nDes problèmes de croissance peuvent-ils survenir ?",
"url": "https://questionsmedicales.fr/mesh/D012364?mesh_terms=Muscle+Spasticity#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur ARN de transfert du tryptophane",
"description": "Comment prévenir une carence en tryptophane ?\nLes tests génétiques peuvent-ils aider à la prévention ?\nY a-t-il des recommandations diététiques spécifiques ?\nL'éducation nutritionnelle est-elle importante ?\nLes suppléments sont-ils nécessaires pour tout le monde ?",
"url": "https://questionsmedicales.fr/mesh/D012364?mesh_terms=Muscle+Spasticity#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur ARN de transfert du tryptophane",
"description": "Comment traiter une carence en tryptophane ?\nLes médicaments peuvent-ils aider ?\nY a-t-il des thérapies alternatives ?\nLe suivi médical est-il nécessaire ?\nDes changements de mode de vie sont-ils recommandés ?",
"url": "https://questionsmedicales.fr/mesh/D012364?mesh_terms=Muscle+Spasticity#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur ARN de transfert du tryptophane",
"description": "Quelles complications peuvent survenir avec une carence en tRNA-Trp ?\nLe tRNA-Trp est-il lié à des maladies chroniques ?\nDes troubles métaboliques peuvent-ils être causés ?\nY a-t-il un risque accru de maladies cardiovasculaires ?\nLes complications neurologiques sont-elles possibles ?",
"url": "https://questionsmedicales.fr/mesh/D012364?mesh_terms=Muscle+Spasticity#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur ARN de transfert du tryptophane",
"description": "Quels sont les facteurs de risque de carence en tryptophane ?\nLes personnes âgées sont-elles plus à risque ?\nLes végétariens courent-ils un risque accru ?\nLes troubles alimentaires augmentent-ils le risque ?\nLe stress peut-il affecter le tRNA-Trp ?",
"url": "https://questionsmedicales.fr/mesh/D012364?mesh_terms=Muscle+Spasticity#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une anomalie du tRNA-Trp ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques et des analyses biochimiques peuvent être effectués."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer le tRNA-Trp ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'électrophorèse et la spectrométrie de masse sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème avec le tRNA-Trp ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des troubles neurologiques et des retards de développement peuvent survenir."
}
},
{
"@type": "Question",
"name": "Le dosage du tryptophane est-il utile ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il peut aider à évaluer la fonction du tRNA-Trp dans l'organisme."
}
},
{
"@type": "Question",
"name": "Peut-on détecter des mutations dans le gène du tRNA-Trp ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des techniques de séquençage peuvent identifier des mutations spécifiques."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une carence en tryptophane ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fatigue, dépression et troubles du sommeil peuvent se manifester."
}
},
{
"@type": "Question",
"name": "Les troubles de l'humeur sont-ils liés au tRNA-Trp ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une dysfonction du tRNA-Trp peut affecter la synthèse de neurotransmetteurs."
}
},
{
"@type": "Question",
"name": "Y a-t-il des signes neurologiques associés ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des convulsions et des troubles cognitifs peuvent être observés."
}
},
{
"@type": "Question",
"name": "Comment le tRNA-Trp affecte-t-il l'appétit ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il joue un rôle dans la régulation de la sérotonine, influençant l'appétit."
}
},
{
"@type": "Question",
"name": "Des problèmes de croissance peuvent-ils survenir ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une carence en tryptophane peut entraîner un retard de croissance."
}
},
{
"@type": "Question",
"name": "Comment prévenir une carence en tryptophane ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en protéines et en acides aminés essentiels est clé."
}
},
{
"@type": "Question",
"name": "Les tests génétiques peuvent-ils aider à la prévention ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent identifier les personnes à risque de troubles liés au tRNA-Trp."
}
},
{
"@type": "Question",
"name": "Y a-t-il des recommandations diététiques spécifiques ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Consommer des aliments riches en tryptophane comme les noix et les produits laitiers."
}
},
{
"@type": "Question",
"name": "L'éducation nutritionnelle est-elle importante ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle aide à comprendre l'importance des acides aminés dans l'alimentation."
}
},
{
"@type": "Question",
"name": "Les suppléments sont-ils nécessaires pour tout le monde ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, ils ne sont nécessaires que pour ceux qui ont des besoins accrus."
}
},
{
"@type": "Question",
"name": "Comment traiter une carence en tryptophane ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des suppléments de tryptophane et des modifications alimentaires sont recommandés."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils aider ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains antidépresseurs peuvent améliorer les symptômes liés au tRNA-Trp."
}
},
{
"@type": "Question",
"name": "Y a-t-il des thérapies alternatives ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des thérapies comme la méditation peuvent aider à gérer les symptômes."
}
},
{
"@type": "Question",
"name": "Le suivi médical est-il nécessaire ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un suivi régulier est essentiel pour ajuster le traitement."
}
},
{
"@type": "Question",
"name": "Des changements de mode de vie sont-ils recommandés ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation équilibrée et l'exercice régulier sont conseillés."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec une carence en tRNA-Trp ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des troubles mentaux et des problèmes de croissance peuvent se développer."
}
},
{
"@type": "Question",
"name": "Le tRNA-Trp est-il lié à des maladies chroniques ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des déséquilibres peuvent contribuer à des maladies comme la dépression."
}
},
{
"@type": "Question",
"name": "Des troubles métaboliques peuvent-ils être causés ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une carence peut entraîner des troubles métaboliques et endocriniens."
}
},
{
"@type": "Question",
"name": "Y a-t-il un risque accru de maladies cardiovasculaires ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des déséquilibres en acides aminés peuvent affecter la santé cardiaque."
}
},
{
"@type": "Question",
"name": "Les complications neurologiques sont-elles possibles ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles neurologiques peuvent survenir en cas de carence prolongée."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque de carence en tryptophane ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation déséquilibrée et des troubles digestifs augmentent le risque."
}
},
{
"@type": "Question",
"name": "Les personnes âgées sont-elles plus à risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent avoir des besoins nutritionnels accrus et une absorption réduite."
}
},
{
"@type": "Question",
"name": "Les végétariens courent-ils un risque accru ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils doivent veiller à consommer suffisamment de sources de tryptophane."
}
},
{
"@type": "Question",
"name": "Les troubles alimentaires augmentent-ils le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent entraîner des carences en nutriments essentiels comme le tryptophane."
}
},
{
"@type": "Question",
"name": "Le stress peut-il affecter le tRNA-Trp ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut perturber le métabolisme des acides aminés."
}
}
]
}
]
}
Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan; Thermal Biology Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Japan; Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Japan; Institute for Environmental and Gender-Specific Medicine, Juntendo University, Chiba, Japan. Electronic address: tominaga@nips.ac.jp.
Publications dans "ARN de transfert du tryptophane" :
Department of Cell Biology, Calhoun Cardiology Center, School of Medicine (UConn Health), University of Connecticut, Farmington, CT, 06030, USA. lyue@uchc.edu.
Publications dans "ARN de transfert du tryptophane" :
Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan; Thermal Biology Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Japan; Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Japan. Electronic address: mkashio@nips.ac.jp.
Publications dans "ARN de transfert du tryptophane" :
Department of Cell Biology, Calhoun Cardiology Center, School of Medicine (UConn Health), University of Connecticut, Farmington, CT, 06030, USA. zong@uchc.edu.
Institute for the Brain and Cognitive Sciences, University of Connecticut, 337 Mansfield Road, Unit 1272, Storrs, CT, 06269, USA. zong@uchc.edu.
Publications dans "ARN de transfert du tryptophane" :
Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: vmb@pennmedicine.upenn.edu.
Publications dans "ARN de transfert du tryptophane" :
Ministry of Education Key Laboratory of Molecular Microbiology and Technology, Department of Microbiology, College of Life Science, Nankai University, Tianjin 300071, China.
Publications dans "ARN de transfert du tryptophane" :
Ministry of Education Key Laboratory of Molecular Microbiology and Technology, Department of Microbiology, College of Life Science, Nankai University, Tianjin 300071, China.
Publications dans "ARN de transfert du tryptophane" :
Ministry of Education Key Laboratory of Molecular Microbiology and Technology, Department of Microbiology, College of Life Science, Nankai University, Tianjin 300071, China.
Publications dans "ARN de transfert du tryptophane" :
Ministry of Education Key Laboratory of Molecular Microbiology and Technology, Department of Microbiology, College of Life Science, Nankai University, Tianjin 300071, China.
Publications dans "ARN de transfert du tryptophane" :
Due to the heterogeneous clinical presentation of spastic cerebral palsy (SCP), which makes spasticity treatment challenging, more insight into the complex interaction between spasticity and altered m...
We studied associations between spasticity and muscle morphology and compared muscle morphology between commonly observed spasticity patterns (i.e. different muscle activation patterns during passive ...
Spasticity and muscle morphology of the medial gastrocnemius (MG) and semitendinosus (ST) were defined in 74 children with SCP (median age 8 years 2 months, GMFCS I/II/III: 31/25/18, bilateral/unilate...
A moderate negative association (r = -0.624, p < 0.001) was found between spasticity and MG muscle volume, while other significant associations between spasticity and muscle morphology parameters were...
Higher spasticity levels were associated with smaller MG and ST volumes and shorter MG muscles. These muscle morphology alterations were more pronounced in muscles that activated during low-velocity s...
To provide a comprehensive assessment of the treatment effects of nabiximols oromucosal spray on multiple sclerosis spasticity in two clinical trials, GWSP0604 and SAVANT....
Both studies enriched for responders before randomization, defined by a ≥20% improvement in Spasticity 0-10 numeric rating scale (NRS) score. Additionally, SAVANT used randomized re-titration followin...
Mean change from baseline in average daily Spasticity NRS scores was significantly larger for nabiximols than placebo at all postbaseline timepoints, ranging from -0.36 to -0.89 in GWSP0604 and -0.52 ...
Nabiximols leads to improvement in spasticity that was sustained over the 12-week treatment period as measured by average daily Spasticity NRS scores, daily spasm counts, and MAS scores for combinatio...
Upper limb spasticity and spasticity-induced deformities after upper motor neuron lesions because of traumatic brain injury, encephalitis or cerebral palsy inhibit activities of daily living, result i...
Evaluating muscle spasticity in children with cerebral palsy (CP) is essential for determining the most effective treatment strategies. This scoping review assesses the current methods used to evaluat...
A search (to April 2024) used keywords such as muscle spasticity, cerebral palsy, and assessment methods. Selection criteria included articles involving CP children, assessing spasticity objectively/s...
From an initial pool of 1971 articles, 30 met our inclusion criteria. These studies collectively appraised a variety of techniques ranging from well-established clinical scales like the modified Ashwo...
The review discussed the strengths and limitations of each method and concluded that more reliable methods are needed to measure the level of muscle spasticity more accurately....
Spasticity is prevalent following Traumatic Brain Injury. 'Focal' muscle spasticity has been defined as spasticity affecting a localised muscle group, but it's impact on gait kinetics remains unclear....
Ninety-three participants attending physiotherapy for mobility limitations following Traumatic Brain Injury were invited to participate in the study. Participants underwent clinical gait analysis and ...
Hip extensor power generation at initial contact, hip flexor power generation at terminal stance, and knee extensor power absorption at terminal stance were all significantly increased, and ankle powe...
Focal muscle spasticity had little association with abnormal gait kinetics in this cohort of independently ambulant people with Traumatic Brain Injury....
To investigate the influence of muscle position (relaxed vs stretched) on muscle mechanical properties and the ability of myotonometry to detect differences between sides, groups, and sites of testing...
Cross-sectional study....
Outpatient rehabilitation units including private and public centers....
Seventy-one participants (20 subacute stroke, 20 chronic stroke, 31 controls) were recruited (N=71)....
Muscle mechanical properties were measured bilaterally with a MyotonPRO at muscle belly and musculotendinous sites during 2 protocols (muscle relaxed or in maximal bearable stretched position)....
Muscle tone and stiffness of the biceps brachii and gastrocnemius. Poststroke spasticity was evaluated with the Modified Tardieu Scale (MTS). A mixed-model analysis of variance was used to detect diff...
The analysis of variance showed a significant effect of muscle position on muscle mechanical properties (higher tone and stiffness with the muscle assessed in stretched position). Measurements with th...
Myotonometry assessment of mechanical properties with the muscle stretched improves the ability of myotonometry to discriminate between sides in patients after stroke and between people with and witho...
In cerebral palsy (CP), spasticity is the dominant symptom and hip pain is one of the most common secondary conditions. Aetiology is not clear. Musculoskeletal ultrasound (MSUS) is a low-cost, non-inv...
A retrospective case-matched-control study. To investigate associated factors with painful spastic hip and to compare ultrasound findings (focusing on muscle thickness) in children with CP vs. typical...
Paediatric Rehabilitation Hospital in Mexico City, from August to November 2018....
21 children (13 male, 7 + 4.26 years) with CP, in Gross Motor Function Classification System (GMFCS) levels IV to V, with spastic hip diagnosis (cases) and 21 children age- and sex-matched (7 + 4.28 y...
Sociodemographic data, CP topography, degree of spasticity, mobility arch, contractures, Visual Analog Scale (VAS), GMFCS, measurements of the volumes of eight major muscles of the hip joint and MSUS ...
All children with CP group reported chronic hip pain. Associated factors for hip pain (high VAS hip pain score) were degree of hip displacement (percentage of migration), Ashworth Level, GMFCS level V...
Though possibly the most important issue with diminished muscle growth in CP children is the influence on their long-term function, it is likely that training routines that build muscle size may also ...
Botulinum neurotoxin-A (BoNT-A) injections are effective for focal spasticity. However, the impact on muscle strength is not established. This study aimed to investigate the effect of BoNT-A injection...
Although reduced gait asymmetry and trunk control are generally accepted outcomes in stroke patients after having a stroke, the number of studies examining the factors affecting gait symmetry and trun...
What are the effects of gastrocnemius muscle spasticity on trunk control and gait symmetry in chronic stroke patients?...
The sample of the study included 29 individuals aged 40-70 who were diagnosed with stroke at least six months ago. The sociodemographic information of the patients was collected using a descriptive in...
There was a numerical difference between the gait symmetry results of the patients who had a MAS score lower than 2 and those who had a MAS score of 2 or higher, where MAS scores corresponded to gastr...
According to the results of our study, to improve trunk control and gait in stroke survivors, the management of gastrocnemius muscle spasticity should be included in rehabilitation programs. We believ...
Evaluation the effects of dry needling on sonographic, biomechanical and functional parameters of spastic upper extremity muscles....
Twenty-four patients (35-65 years) with spastic hand were randomly allocated into two equal groups: intervention and sham-controlled groups. The treatment protocol was 12-sessions neurorehabilitation ...
The analysis showed that there was a significant reduction in muscle thickness, spasticity and reflex torque and a significant increment in motor function and dexterity in both groups after treatment ...
Dry needling plus neurorehabilitation could decrease muscle thickness, spasticity and reflex torque and improve upper-extremity motor performance and dexterity in chronic stroke patients. These change...
