TRP channels in thermosensation.

Sensory Receptor Cells TRPC Cation Channels / genetics TRPM Cation Channels / genetics TRPV Cation Channels Transient Receptor Potential Channels / genetics

Journal

Current opinion in neurobiology
ISSN: 1873-6882
Titre abrégé: Curr Opin Neurobiol
Pays: England
ID NLM: 9111376

Informations de publication

Date de publication:
08 2022
Historique:
received: 24 09 2021
revised: 18 05 2022
accepted: 20 05 2022
pubmed: 22 6 2022
medline: 26 7 2022
entrez: 21 6 2022
Statut: ppublish

Résumé

The ability to sense external temperature is assumed by somatosensory neurons, in which temperature information is converted to neural activity by afferent input to the central nervous system. Somatosensory neurons consist of various populations with specialized gene expression, including thermosensitive transient receptor potential ion channels (thermo-TRPs). Thermo-TRPs are responsible for thermal transduction at the peripheral ends of somatosensory neurons and over a wide range of temperatures. In this review, we focus on several thermo-TRPs expressed in sensory neurons: TRPV1, TRPV4, TRPM2, TRPM3, TRPM8, TRPC5, and TRPA1. TRPV3, TRPV4, and TRPC5 expressed in non-neuronal cells that are also involved in somatosensation are also discussed, whereas TRPM2 and TRPM8 are involved in thermosensation in the brain.

Identifiants

DOI: 10.1016/j.conb.2022.102591 PMID: 35728275
pubmed: 35728275
pii: S0959-4388(22)00085-X
doi: 10.1016/j.conb.2022.102591
pii:
doi:

Substances chimiques

TRPC Cation Channels 0
TRPM Cation Channels 0
TRPV Cation Channels 0
Transient Receptor Potential Channels 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102591

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest statement Nothing declared.

Auteurs

Makiko Kashio (M)

Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan; Thermal Biology Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Japan; Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Japan. Electronic address: mkashio@nips.ac.jp.

Makoto Tominaga (M)

Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan; Thermal Biology Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Japan; Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Japan; Institute for Environmental and Gender-Specific Medicine, Juntendo University, Chiba, Japan. Electronic address: tominaga@nips.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › TRP channels in thermosensation.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux cationiques TRP › Canaux cationiques TRPC › TRP channels in thermosensation.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux cationiques TRP › Canaux cationiques TRPM › TRP channels in thermosensation.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Canaux cationiques TRPV › TRP channels in thermosensation.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux cationiques TRP › TRP channels in thermosensation.