Department of Health Services and Epidemiological Observatory, Regional Health Authority, Sicilian Region, Via Mario Vaccaro 5, 90145 Palermo, Italy. achille.cernigliaro@regione.sicilia.it.
Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Via del Vespro 131, 90127 Palermo, Italy. alessandra.casuccio@unipa.it.
Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Via del Vespro 131, 90127 Palermo, Italy. vincenzo.restivo@unipa.it.
Department of Health Promotion Sciences Maternal and Infant Care, Internal Medicine and Medical Specialities "G. D'Alessandro"-Hygiene Section, University of Palermo, Palermo, Italy.
Clinical Epidemiology Unit, Regional Reference Laboratory for Molecular Surveillance of Influenza, University Hospital "Paolo Giaccone", Palermo, Italy.
Department of Health Promotion Sciences Maternal and Infant Care, Internal Medicine and Medical Specialities "G. D'Alessandro"-Hygiene Section, University of Palermo, Palermo, Italy.
Clinical Epidemiology Unit, Regional Reference Laboratory for Molecular Surveillance of Influenza, University Hospital "Paolo Giaccone", Palermo, Italy.
Department of Health Promotion Sciences Maternal and Infant Care, Internal Medicine and Medical Specialities "G. D'Alessandro"-Hygiene Section, University of Palermo, Palermo, Italy.
Clinical Epidemiology Unit, Regional Reference Laboratory for Molecular Surveillance of Influenza, University Hospital "Paolo Giaccone", Palermo, Italy.
Department of Health Promotion Sciences Maternal and Infant Care, Internal Medicine and Medical Specialities "G. D'Alessandro"-Hygiene Section, University of Palermo, Palermo, Italy.
Tuberculosis (TB) is a major cause of ill health and one of the leading causes of death worldwide. The first step in developing strategies to reduce TB mortality is to identify the direct causes of de...
Data on patients with TB systemically collected from the National Surveillance System of South Korea from January 2019 to December 2020 were included in this study. We analyzed the clinical characteri...
Of the total of 12,340 patients with TB, 61% were males with a mean age of 61.3 years. During the follow-up period, the overall mortality rate was 10.6%, with TB-related deaths accounting for 21.3% of...
Patients with high-risk TB must be identified through cause-specific mortality analysis, and the mortality rate must be reduced through intensive monitoring of patients with a high TB burden and comor...
Breast tuberculosis (TB) is a rare extra-pulmonary presentation of tuberculosis. In the western world, this accounts for less than 0.1% of breast conditions (all breast conditions, not limited to TB o...
We report a case of a 54-year- old human immunodeficiency virus (HIV)-positive lady who presented with six months history of multiple masses on the left breast which were initially suspected to be can...
Presentation of TB can be non-specific and atypical in patients with HIV infection, especially when it presents in extra-pulmonary forms....
Elimination of tuberculosis (TB) is defined as reducing TB disease incidence in the United States to less than 1 case per million persons per year. In 2022, TB incidence in the United States was 2.5 T...
The 5-year period for which the most recent data were available for each of five indicators: 1) overall TB incidence (2018-2022), 2) TB incidence among non-U.S.-born persons (2018-2022), 3) percentage...
The National TB Indicators Project (NTIP) is a web-based performance monitoring tool that uses national TB surveillance data reported through the National TB Surveillance System and the Aggregate Repo...
During the 5-year period for which the most recent data were available, most TB programs had improvements in reducing overall TB incidence (71.2%) and increasing the percentage of contacts receiving a...
This report is the first to describe a 5-year relative change for TB program performance. These results suggest that TB programs are making improvements in activities that help identify persons with T...
Use of NTIP data from individual TB programs enables a more detailed examination of trends in program performance and identification of areas for program improvement. Assessing indicator trends by TB ...
We discuss the most recent literature to support the identification of children at risk for tuberculosis and optimal testing and treatment strategies....
The identification and management of children with tuberculosis has increased in complexity due to the recent severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) pandemic, greater use of immu...
The SARS-CoV-2 pandemic will likely have a negative impact on global tuberculosis control. It is important that countries maintain a comprehensive approach to the identification and management of chil...
Due to COVID-19 pandemic, the latest progress of the End Tuberculosis (TB) Strategy was far from optimal and services for TB needs to be quickly restored. Pregnancy is a unique opportunity to screen a...
The Center for Personalized Precision Medicine of Tuberculosis (cPMTb) was constructed to develop personalized pharmacotherapeutic systems for tuberculosis (TB). This study aimed to introduce the cPMT...
Until August 2021, 964, 167, and 95 patients with TB, NTM infection, and LTBI, respectively, were included. Clinical, laboratory, and radiographic data were collected. NAT2 and SLCO1B1 phenotypes were...
Patients with TB were older, had lower body mass index (BMI), higher diabetes rate, and higher male proportion than patients with LTBI. Patients with NTM infection were older, had lower BMI, lower dia...
Understanding disease characteristics and identifying pharmacokinetic traits are fundamental steps in optimizing treatment. Further longitudinal data are required for personalized precision medicine....
This study registered ClinicalTrials.gov NO. NCT05280886....
Extrapulmonary tuberculosis (TB) presents unique diagnostic and therapeutic challenges. The site of involvement can vary widely, with common sites including the lymph nodes, pleura, skin, ear, nose an...
Tuberculosis (TB) is a significant public health problem among the Saharia community, an underprivileged tribal group in the west-central part of India. There are several challenges for India's TB con...
Despite concerted efforts, Mycobacterium tuberculosis (M.tb), the pathogen that causes tuberculosis (TB), continues to be a burden on global health, regaining its dubious distinction in 2022 as the wo...
In this review, we discuss the application of a novel replicating RNA (repRNA)-based vaccine formulated and delivered in nanostructured lipids....
Our preclinical data are the first to report that RNA platforms are a viable system for TB vaccines and should be pursued with high-priority M.tb antigens containing cluster of differentiation (CD4+) ...
This RNA vaccine shows promise for use against intracellular bacteria such as M.tb as demonstrated by the feasibility of construction, enhanced induction of cell-mediated and humoral immune responses,...
Early and rapid diagnosis of Mycobacterium tuberculosis in clinical specimen is important for the treatment of patients and control of disease transmission to the community. The disease is largely pre...
