questionsmedicales.fr
Composés hétérocycliques
Composés hétérocycliques à cycles fusionnés
Composés hétérocycliques 3 noyaux
Xanthènes
Xanthènes : Questions médicales fréquentes
Termes MeSH sélectionnés :
Bulbo-Spinal Atrophy, X-Linked
Diagnostic
5
Intoxication
Tests de laboratoire
Chromatographie
Analyse chimique
Analyse d'urine
Détection
Historique médical
Exposition
Symptômes
5
Réaction allergique
Allergies
Système nerveux
Convulsions
Chimie organique
Variabilité des symptômes
Irritation cutanée
Dermatologie
Prévention
5
Prévention
Équipements de protection
Formation professionnelle
Sécurité au travail
Sécurité en laboratoire
Équipements de protection
Réglementation
Santé publique
Sensibilisation
Éducation à la santé
Traitements
5
Intoxication
Soins médicaux
Anticonvulsivants
Neurologie
Soins de soutien
Toxicologie
Médecine alternative
Efficacité des traitements
Complications
5
Maladies chroniques
Exposition prolongée
Effets à long terme
Santé cognitive
Santé reproductive
Toxicologie
Suivi médical
Traitements symptomatiques
Facteurs de risque
5
Travailleurs
Industrie chimique
Antécédents médicaux
Maladies respiratoires
Habitudes de vie
Tabagisme
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"@type": "Question",
"name": "Quels tests sont utilisés pour détecter les xanthènes ?",
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"@type": "Question",
"name": "Quels sont les symptômes courants d'une exposition aux xanthènes ?",
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"position": 8,
"acceptedAnswer": {
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"text": "Ils peuvent provoquer des troubles neurologiques comme des convulsions ou des tremblements."
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"name": "Les symptômes varient-ils selon le type de xanthène ?",
"position": 9,
"acceptedAnswer": {
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"text": "Oui, les symptômes peuvent varier selon la structure chimique des xanthènes."
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"@type": "Question",
"name": "Les xanthènes affectent-ils la peau ?",
"position": 10,
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"text": "Oui, une exposition cutanée peut entraîner des irritations ou des éruptions."
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"@type": "Question",
"name": "Comment prévenir l'exposition aux xanthènes ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Évitez les produits contenant des xanthènes et portez des équipements de protection."
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"@type": "Question",
"name": "Les travailleurs doivent-ils être formés sur les xanthènes ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une formation sur les risques et la manipulation sécurisée est essentielle."
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"@type": "Question",
"name": "Quelles mesures de sécurité doivent être prises en laboratoire ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Utilisez des hottes, des gants et des lunettes de protection lors de la manipulation."
}
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"@type": "Question",
"name": "Les xanthènes sont-ils réglementés ?",
"position": 14,
"acceptedAnswer": {
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"text": "Oui, leur utilisation est souvent réglementée pour protéger la santé publique."
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"name": "Comment informer le public sur les dangers des xanthènes ?",
"position": 15,
"acceptedAnswer": {
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"text": "Des campagnes de sensibilisation et des brochures d'information peuvent être utiles."
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"name": "Quel traitement est recommandé en cas d'intoxication aux xanthènes ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement inclut l'élimination de l'exposition et des soins symptomatiques."
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"@type": "Question",
"name": "Des antidotes existent-ils pour les xanthènes ?",
"position": 17,
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"text": "Actuellement, il n'existe pas d'antidote spécifique pour les xanthènes."
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"name": "Comment traiter les symptômes neurologiques causés par les xanthènes ?",
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"name": "Les soins de soutien sont-ils nécessaires ?",
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}
},
{
"@type": "Question",
"name": "Les xanthènes peuvent-ils causer des maladies chroniques ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une exposition prolongée peut augmenter le risque de maladies chroniques."
}
},
{
"@type": "Question",
"name": "Y a-t-il des effets à long terme des xanthènes ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des effets à long terme incluent des troubles cognitifs et des problèmes de santé."
}
},
{
"@type": "Question",
"name": "Les xanthènes peuvent-ils affecter la reproduction ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines études suggèrent qu'ils peuvent avoir des effets néfastes sur la reproduction."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications liées aux xanthènes ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un suivi médical régulier et des traitements symptomatiques sont recommandés."
}
},
{
"@type": "Question",
"name": "Qui est le plus à risque d'exposition aux xanthènes ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les travailleurs dans l'industrie chimique et les laboratoires sont les plus à risque."
}
},
{
"@type": "Question",
"name": "Les enfants sont-ils plus vulnérables aux xanthènes ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les enfants peuvent être plus sensibles aux effets toxiques des xanthènes."
}
},
{
"@type": "Question",
"name": "Quels facteurs environnementaux augmentent le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "La pollution et l'exposition à des produits chimiques augmentent le risque."
}
},
{
"@type": "Question",
"name": "Les antécédents médicaux influencent-ils le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents de maladies respiratoires ou neurologiques augmentent le risque."
}
},
{
"@type": "Question",
"name": "Les habitudes de vie jouent-elles un rôle dans le risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des habitudes comme le tabagisme peuvent augmenter la vulnérabilité aux xanthènes."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 02/05/2025
Contenu vérifié selon les dernières recommandations médicales
3 publications dans cette catégorie
Affiliations :
Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, School of Chemistry and Materials Science, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China.
Publications dans "Xanthènes" :
3 publications dans cette catégorie
Affiliations :
Department of Chemistry, Mississippi State University, Mississippi State, Mississippi 39762, United States.
Publications dans "Xanthènes" :
3 publications dans cette catégorie
Affiliations :
Department of Chemistry, Mississippi State University, Mississippi State, Mississippi 39762, United States.
Publications dans "Xanthènes" :
3 publications dans cette catégorie
Affiliations :
Department of Advanced Organic Materials Engineering, Chungnam National University, 220 Gung-dong, Yuseong-gu, Daejeon, 305-764, South Korea.
Publications dans "Xanthènes" :
3 publications dans cette catégorie
Affiliations :
Department of Advanced Organic Materials Engineering, Chungnam National University, 220 Gung-dong, Yuseong-gu, Daejeon, 305-764, South Korea. yason@cnu.ac.kr.
Publications dans "Xanthènes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, University of Virginia, Charlottesville, VA, 22904, USA.
University of Virgnia Cancer Center, University of Virginia, Charlottesville, VA, 22904, USA.
Publications dans "Xanthènes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, University of California, Berkeley, CA, 94720, USA. evanwmiller@berkeley.edu.
Department of Molecular & Cell Biology, University of California, Berkeley, CA, 94720, USA.
Helen Wills Neuroscience Institute, University of California, Berkeley, CA, 94720, USA.
Publications dans "Xanthènes" :
2 publications dans cette catégorie
Affiliations :
Department of Medicinal Chemistry, State Key Laboratory of Bioactive Substance and Function of Natural Medicines & Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China.
Publications dans "Xanthènes" :
2 publications dans cette catégorie
Affiliations :
Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, School of Chemistry and Materials Science, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China.
Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004, P. R. China.
Publications dans "Xanthènes" :
2 publications dans cette catégorie
Affiliations :
Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, School of Chemistry and Materials Science, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China.
Publications dans "Xanthènes" :
2 publications dans cette catégorie
Affiliations :
University of Sarajevo, Faculty of Pharmacy, 71000Sarajevo, Bosnia and Herzegovina.
Publications dans "Xanthènes" :
2 publications dans cette catégorie
Affiliations :
University of Sarajevo, Faculty of Pharmacy, 71000Sarajevo, Bosnia and Herzegovina.
Publications dans "Xanthènes" :
2 publications dans cette catégorie
Affiliations :
University of Sarajevo, Faculty of Pharmacy, 71000Sarajevo, Bosnia and Herzegovina.
Publications dans "Xanthènes" :
2 publications dans cette catégorie
Affiliations :
University of Sarajevo, Faculty of Pharmacy, 71000Sarajevo, Bosnia and Herzegovina.
Publications dans "Xanthènes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, University of Virginia, Charlottesville, VA, USA.
Publications dans "Xanthènes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, Mississippi State University, Mississippi State, Mississippi 39762, United States.
Publications dans "Xanthènes" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Publications dans "Xanthènes" :
2 publications dans cette catégorie
Affiliations :
Masaryk University Faculty of Science: Masarykova univerzita Prirodovedecka Fakulta, Department of Chemistry, Kamenice 5, 62500, Brno, CZECH REPUBLIC.
Publications dans "Xanthènes" :
2 publications dans cette catégorie
Affiliations :
Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, Pakistan.
Publications dans "Xanthènes" :
2 publications dans cette catégorie
Affiliations :
Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, Pakistan.
Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn, Germany.
Publications dans "Xanthènes" :
Spinal-bulbar muscular atrophy (SBMA) (Kennedy's disease) is a motor neuron disease. Kennedy's disease is nearly exclusively caused by mutations in the androgen receptor encoding gene (AR). The result...
Clinical investigations included thorough neurological and non-neurological examinations and testing. Genetic analysis was performed by exome sequencing using standard protocols. UBA1 mutations were m...
The clinical features of the patients are described in detail. A missense mutation in UBA1 (c.T1499C; p.Ile500Thr) was identified as the probable cause of the non-Kennedy SBMA in the pedigree. Like AR...
UBA1 was identified as a novel SBMA causative gene. The gene affects protein homeostasis which is one of most important components of the pathology of neurodegeneration. The contribution of this same ...
Patients with spinal and bulbar muscular atrophy (SBMA) often experience muscular weakness under cold exposure....
In our previously conducted observational study, we assessed nerve conduction and grip strength to examine the effect of cold exposure on motor function, based on which we conducted a randomized contr...
In the observational study, 51 consecutive patients with SBMA and 18 healthy controls (HCs) were enrolled. Of the patients with SBMA, 88.0% experienced cold paresis. Patients with SBMA exhibited great...
Cold paresis is common and associated with prolongation of distal latency in SBMA. The results of the phase II clinical trial revealed that mexiletine showed short-term safety, but it did not restore ...
This study aimed to develop a functional measurement that combines quantitative motor evaluation index of various body regions in patients with spinal and bulbar muscular atrophy (SBMA). We assessed s...
To assess the clinical and electrophysiologic features of female carriers and early-stage male patients with spinal and bulbar muscular atrophy (SBMA) to elucidate the early pathophysiologic changes o...
Female carriers, early-stage male patients with SBMA, and age-matched male and female healthy controls were recruited. The results of motor functional scales, motor unit number estimation, dual-energy...
We enrolled 21 female carriers and 11 early-stage male patients. Seventeen female and 14 male age-matched healthy controls were also enrolled. Female carriers experienced early-stage symptoms such as ...
The present study revealed that female carriers of SBMA manifest mild muscular weakness associated with changes in neurogenic biomarkers. Conversely, male patients showed neurogenic and myopathic chan...
Serum creatinine has been indicated as a potential marker of motor function in SBMA and results form previous longitudinal studies pointed to its decline over time. This is a longitudinal retrospectiv...
The clinical characteristics of SBMA, also known as Kennedy's disease (OMIM 313200), were initially documented by Dr. H Kawahara in the 18th century and a hundred years later by Dr. W. Kennedy. SBMA i...
Spinal and bulbar muscular atrophy (SBMA), or Kennedy's disease, is a rare X-linked neuromuscular disorder predominantly affecting males and caused by a mutation in the androgen receptor gene. The epi...
This study assessed patient-reported health-related quality of life (HRQoL) using two generic preference-based measures in Chinese patients with spinal and bulbar muscular atrophy (SBMA) and identifie...
This study used cross-sectional data of 212 Chinese patients with SBMA who completed both the EQ-5D and SF-6D. Association between response to EQ-5D and SF-6D dimensions was examined using Spearman's ...
The mean utility scores for the EQ-5D and SF-6D were 0.54 and 0.56, respectively. The hypothesized correlation between the EQ-5D and SF-6D dimensions ranged from 0.31 to 0.58, and the correlation betw...
This study is the first to investigate the HRQoL of patients with SBMA worldwide. The estimated health utility scores for EQ-5D and SF-6D can be utilized as baseline data for future cost-utility analy...
Spinal and bulbar muscular atrophy (SBMA) is a rare X-linked recessive neurodegenerative disorder caused by the excessive expansion of cytosine-adenine-guanine repeat sequences in the androgen recepto...
This study explores a novel therapeutic approach for spinal bulbar muscular atrophy (SBMA), a neurodegenerative disorder caused by a mutation in the Androgen Receptor (AR) gene. The aim is to investig...