questionsmedicales.fr
Acides aminés, peptides et protéines
Protéines
Protéines du sang
Immunoprotéines
Protéines du système du complément
Complément C3
Complément C3b
Complément C3c
Complément C3c : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Compléments
Tests de laboratoire
Compléments
Tests de laboratoire
Maladies auto-immunes
Inflammation
Marqueurs biologiques
Pathologies
Système du complément
Diagnostic
Symptômes
5
Système immunitaire
Symptômes
Prévention
5
Prévention
Maladies chroniques
Vaccins
Système immunitaire
Stress
Système immunitaire
Examens médicaux
Prévention
Traitements
5
Immunothérapie
Traitement
Médicaments immunosuppresseurs
Compléments
Suivi médical
Compléments
Alimentation
Système immunitaire
Transfusions sanguines
Compléments
Complications
5
Infections
Maladies auto-immunes
Complications
Inflammation
Maladies cardiovasculaires
Risques
Facteurs de risque
5
Facteurs de risque
Maladies auto-immunes
Antécédents familiaux
Maladies immunitaires
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"position": 12,
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"text": "Éviter le tabagisme et une mauvaise alimentation peut aider à maintenir un C3c normal."
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"name": "Le stress affecte-t-il le C3c ?",
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"name": "Les transfusions affectent-elles le C3c ?",
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"@type": "Question",
"name": "Un C3c élevé cause-t-il des complications ?",
"position": 22,
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}
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"@type": "Question",
"name": "Le C3c affecte-t-il la guérison des blessures ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux anormaux de C3c peuvent retarder la guérison en perturbant l'inflammation."
}
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"@type": "Question",
"name": "Y a-t-il des risques de thrombose liés au C3c ?",
"position": 24,
"acceptedAnswer": {
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"text": "Des niveaux élevés de C3c peuvent être associés à un risque accru de thrombose."
}
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"@type": "Question",
"name": "Le C3c influence-t-il les maladies cardiovasculaires ?",
"position": 25,
"acceptedAnswer": {
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"text": "Oui, des niveaux anormaux de C3c peuvent être liés à un risque accru de maladies cardiovasculaires."
}
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{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de C3c anormal ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les maladies auto-immunes, infections chroniques et certains médicaments augmentent le risque."
}
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{
"@type": "Question",
"name": "L'âge influence-t-il le C3c ?",
"position": 27,
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"@type": "Answer",
"text": "Oui, l'âge peut affecter les niveaux de C3c, souvent en raison de changements immunitaires."
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"@type": "Question",
"name": "Le sexe joue-t-il un rôle dans le C3c ?",
"position": 28,
"acceptedAnswer": {
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"text": "Oui, des différences hormonales peuvent influencer les niveaux de C3c entre les sexes."
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"@type": "Question",
"name": "Le mode de vie affecte-t-il le C3c ?",
"position": 29,
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"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation peuvent affecter le C3c."
}
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"@type": "Question",
"name": "Les antécédents familiaux influencent-ils le C3c ?",
"position": 30,
"acceptedAnswer": {
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"text": "Oui, des antécédents familiaux de maladies immunitaires peuvent augmenter le risque de C3c anormal."
}
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 31/03/2025
Contenu vérifié selon les dernières recommandations médicales
4 publications dans cette catégorie
Affiliations :
Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA. mdalakas@med.uoa.gr.
Neuroimmunology Unit, Department of Pathophysiology, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece. mdalakas@med.uoa.gr.
Publications dans "Complément C3c" :
4 publications dans cette catégorie
Affiliations :
Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Publications dans "Complément C3c" :
4 publications dans cette catégorie
Affiliations :
Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Publications dans "Complément C3c" :
3 publications dans cette catégorie
Affiliations :
Division of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Institute of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Hannover, Germany.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Institute of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Hannover, Germany.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Institute of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Hannover, Germany.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Institute for Laboratory Animal Science, Medical School Hannover, Hannover, Germany.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Institute of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Hannover, Germany.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Institute of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Hannover, Germany.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Department of Biomedicine, Aarhus University, Aarhus C, Denmark.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Translational Bio-Nanosciences Laboratory, Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado Anschutz Medical Center, Aurora, CO, USA; Colorado Center for Nanomedicine and Nanosafety, University of Colorado Anschutz Medical Center, Aurora, CO, USA.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Radboud Institute for Molecular Life Sciences, Department of Pediatric Nephrology, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, Netherlands.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Department of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway.
Linnaeus Centre for Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden.
Department of Chemistry and Biomedical Sciences, Linnaeus University, Kalmar, Sweden.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
BMT Unit, Hematology Department, G. Papanicolaou Hospital, Thessaloniki, Greece.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, United States.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Centre de Recherche des Cordeliers, Inserm UMR S1138, Paris, France.
Department of Nephrology Dialysis and Transplantation, University Hospital of Strasbourg, Strasbourg, France.
Publications dans "Complément C3c" :
2 publications dans cette catégorie
Affiliations :
Centre de Recherche des Cordeliers, Inserm UMR S1138, Paris, France.
Service d'Immunologie, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France.
Publications dans "Complément C3c" :
IgA Nephropathy (IgAN) is the most prevalent glomerular disease worldwide. Complement system activation is crucial in its pathogenesis. Few studies correlated serum C3 and C4 with disease activity and...
Complement activation after trauma promotes hemostasis but is associated with increased morbidity and mortality. However, the specific pathways and downstream mediators remain unclear. Recently, the a...
Blood was collected from injured patients at a single level I trauma center enrolled in the Control of Major Bleeding after Trauma (COMBAT) randomized clinical trial. Proteomic analyses were performed...
C4 activation occurred over the first 6 hours postinjury with peak activation 6 to 24 hours. Tissue hypoperfusion, defined as base deficit >10 mEq/L, and requirement for massive transfusion were assoc...
C4 activation has an important inflammatory role postinjury, and FFP has the potential to augment this complement activation during resuscitation....
Prognostic/epidemiological, level III....
To explore the relationship between immunoglobulin A (IgA), complement C4, and liver fibrosis (L.F.) progression (LFP) in patients with chronic hepatitis B (CHB)....
This is a retrospective cohort study of CHB patients who received liver biopsies. Relevant data, including demographics, clinical serum markers, and immunological results obtained during liver biopsie...
This study included 1,938 CHB patients, of whom 132 received two liver biopsies (group 1). Thirty (22.7%) of these patients were diagnosed with LFP (increase in L.F. stage (Scheuer score F ≥ 1)). IgA ...
The findings of this study suggest that serum IgA and C4 levels are independent risk factors for LFP that could serve as future targets for L.F. management and treatment....
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a small-vessel vasculitis affecting multiple organ systems, including the kidney. Small vessels in the kidney include small-s...
This study aimed to evaluate the risk factors for end-stage renal disease (ESRD) in microscopic polyangiitis (MPA). In total, 74 patients with MPA were enrolled, and we compared the baseline clinical ...
The activation of the complement system contributes essentially to the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis. We here aimed to directly compare levels...
Serum levels of complement components C3 and C4 were directly compared in association with clinical and outcome data in a retrospective cohort of ANCA-associated renal vasculitis....
As compared to poor outcome prediction by low levels of complement C3 (p = 0.0093), low levels of complement C4 did not associate with early requirement of kidney replacement therapy (KRT) or death (p...
While low levels of complement C3 were superior in predicting poor outcome in ANCA-associated renal vasculitis, a minor fraction with poor outcome had isolated C4 lowering not captured by serum C3 mea...
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a potentially life-threatening systemic small-vessel vasculitis that is characterized by pauci-immune glomerulonephritis in c...
Copy number variation of the C4 complement components, C4A and C4B, has been associated with systemic inflammatory autoimmune diseases. This study was undertaken to investigate whether C4 copy number ...
Using targeted DNA sequencing, we determined the copy number and genetic variants of C4 in 2,290 well-characterized Scandinavian patients with SLE, primary SS, or myositis and 1,251 healthy controls....
A prominent relationship was observed between C4A copy number and the presence of SSA/SSB autoantibodies, which was shared between the 3 diseases. The strongest association was detected in patients wi...
We show that a low C4A copy number is more strongly associated with the autoantibody repertoire than with the clinically defined disease entities. These findings may have implications for understandin...
Idiopathic inflammatory myopathies (IIM) are a group of autoimmune diseases characterised by myositis-related autoantibodies plus infiltration of leucocytes into muscles and/or the skin, leading to th...
We elucidated the gene copy number (GCN) variations of total...
The large study populations helped establish the distribution patterns of various...
Genetic deficiencies of early components of the classical complement activation pathway (especially C1q, r, s, and C4) are the strongest monogenic causal factors for the prototypic autoimmune disease ...