{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Kringles : Questions médicales les plus fréquentes",
"headline": "Kringles : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Kringles : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-06-24",
"dateModified": "2025-03-21",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Kringles"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Éléments structuraux des protéines",
"url": "https://questionsmedicales.fr/mesh/D000072416",
"about": {
"@type": "MedicalCondition",
"name": "Éléments structuraux des protéines",
"code": {
"@type": "MedicalCode",
"code": "D000072416",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "G02.111.570.820.709.275"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Kringles",
"alternateName": "Kringles",
"code": {
"@type": "MedicalCode",
"code": "D018082",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Liujiao Bian",
"url": "https://questionsmedicales.fr/author/Liujiao%20Bian",
"affiliation": {
"@type": "Organization",
"name": "College of Life Science, Northwest University, Xi'an 710069, Shaanxi, China. Electronic address: bianliujiao@sohu.com."
}
},
{
"@type": "Person",
"name": "Byung Kwan Jin",
"url": "https://questionsmedicales.fr/author/Byung%20Kwan%20Jin",
"affiliation": {
"@type": "Organization",
"name": "4 Departments of Biochemistry and Molecular Biology, and Neuroscience Graduate School, School of Medicine, Kyung Hee University, Seoul, Korea."
}
},
{
"@type": "Person",
"name": "Jae Yeong Jeong",
"url": "https://questionsmedicales.fr/author/Jae%20Yeong%20Jeong",
"affiliation": {
"@type": "Organization",
"name": "3 Department of Predictive Model Research Center, Korea Institute of Toxicology, Korea Research Institute of Chemical Technology, Daejeon, Korea."
}
},
{
"@type": "Person",
"name": "Stefan Coassin",
"url": "https://questionsmedicales.fr/author/Stefan%20Coassin",
"affiliation": {
"@type": "Organization",
"name": "Institute of Genetic Epidemiology, Medical University of Innsbruck, Schoepfstrasse 41, 6020, Innsbruck, Austria. Electronic address: Stefan.Coassin@i-med.ac.at."
}
},
{
"@type": "Person",
"name": "Florian Kronenberg",
"url": "https://questionsmedicales.fr/author/Florian%20Kronenberg",
"affiliation": {
"@type": "Organization",
"name": "Institute of Genetic Epidemiology, Medical University of Innsbruck, Schoepfstrasse 41, 6020, Innsbruck, Austria."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Plasminogen and plasmin can bind to human T cells and generate truncated CCL21 that increases dendritic cell chemotactic responses.",
"datePublished": "2022-06-09",
"url": "https://questionsmedicales.fr/article/35690148",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.jbc.2022.102112"
}
},
{
"@type": "ScholarlyArticle",
"name": "Ligneous periodontitis exacerbated by Behçet's disease in a patient with plasminogen deficiency and a stop-gained variant PLG c.1468C > T: a case report.",
"datePublished": "2023-11-08",
"url": "https://questionsmedicales.fr/article/37940896",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s12903-023-03586-8"
}
},
{
"@type": "ScholarlyArticle",
"name": "Anakinra in hospitalized COVID-19 patients guided by baseline soluble urokinase plasminogen receptor plasma levels: A real world, retrospective cohort study.",
"datePublished": "2023-04-04",
"url": "https://questionsmedicales.fr/article/37014833",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1371/journal.pone.0273202"
}
},
{
"@type": "ScholarlyArticle",
"name": "Investigation of binding mechanism for human plasminogen Kringle 5 with its potential receptor vWA1 domain in Cochlin by bio-specific technologies and molecular dynamic simulation.",
"datePublished": "2022-06-27",
"url": "https://questionsmedicales.fr/article/35777236",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.bioorg.2022.105989"
}
},
{
"@type": "ScholarlyArticle",
"name": "Long-term follow-up in a pediatric patient with Ligneous Conjunctivitis due to PLG gene mutation in topical plasminogen treatment after successful use of ocular prosthesis for aesthetic rehabilitation: a case report.",
"datePublished": "2023-08-23",
"url": "https://questionsmedicales.fr/article/37612758",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s13052-023-01503-x"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Phénomènes chimiques",
"item": "https://questionsmedicales.fr/mesh/D055598"
},
{
"@type": "ListItem",
"position": 3,
"name": "Phénomènes biochimiques",
"item": "https://questionsmedicales.fr/mesh/D001669"
},
{
"@type": "ListItem",
"position": 4,
"name": "Conformation moléculaire",
"item": "https://questionsmedicales.fr/mesh/D008968"
},
{
"@type": "ListItem",
"position": 5,
"name": "Conformation des protéines",
"item": "https://questionsmedicales.fr/mesh/D011487"
},
{
"@type": "ListItem",
"position": 6,
"name": "Éléments structuraux des protéines",
"item": "https://questionsmedicales.fr/mesh/D000072416"
},
{
"@type": "ListItem",
"position": 7,
"name": "Kringles",
"item": "https://questionsmedicales.fr/mesh/D018082"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Kringles - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Kringles",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-09",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Kringles",
"description": "Comment diagnostiquer une anomalie des Kringles ?\nQuels tests sont utilisés pour évaluer les Kringles ?\nLes Kringles peuvent-ils être visualisés par imagerie ?\nQuels marqueurs biologiques sont associés aux Kringles ?\nLes tests génétiques sont-ils fiables pour les Kringles ?",
"url": "https://questionsmedicales.fr/mesh/D018082?mesh_terms=Plasminogen&page=3#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Kringles",
"description": "Quels symptômes sont liés aux anomalies des Kringles ?\nLes anomalies des Kringles provoquent-elles des douleurs ?\nLes symptômes des Kringles sont-ils toujours visibles ?\nLes anomalies des Kringles affectent-elles la circulation sanguine ?\nLes symptômes des Kringles varient-ils selon les individus ?",
"url": "https://questionsmedicales.fr/mesh/D018082?mesh_terms=Plasminogen&page=3#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Kringles",
"description": "Comment prévenir les complications liées aux Kringles ?\nL'exercice physique aide-t-il à prévenir les problèmes de Kringles ?\nUne alimentation spécifique peut-elle aider ?\nLes anticoagulants préventifs sont-ils recommandés ?\nLe dépistage précoce est-il important ?",
"url": "https://questionsmedicales.fr/mesh/D018082?mesh_terms=Plasminogen&page=3#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Kringles",
"description": "Quels traitements sont disponibles pour les anomalies des Kringles ?\nLes transfusions sanguines sont-elles nécessaires ?\nLa chirurgie est-elle une option pour les anomalies des Kringles ?\nLes traitements sont-ils personnalisés pour chaque patient ?\nLes traitements des Kringles sont-ils efficaces ?",
"url": "https://questionsmedicales.fr/mesh/D018082?mesh_terms=Plasminogen&page=3#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Kringles",
"description": "Quelles sont les complications possibles des anomalies des Kringles ?\nLes complications peuvent-elles être mortelles ?\nComment gérer les complications des Kringles ?\nLes complications sont-elles prévisibles ?\nLes complications des Kringles nécessitent-elles une hospitalisation ?",
"url": "https://questionsmedicales.fr/mesh/D018082?mesh_terms=Plasminogen&page=3#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Kringles",
"description": "Quels sont les facteurs de risque des anomalies des Kringles ?\nL'âge influence-t-il le risque d'anomalies des Kringles ?\nLe mode de vie affecte-t-il le risque ?\nLes maladies chroniques sont-elles un facteur de risque ?\nLe stress a-t-il un impact sur le risque ?",
"url": "https://questionsmedicales.fr/mesh/D018082?mesh_terms=Plasminogen&page=3#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une anomalie des Kringles ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le diagnostic se fait par des tests génétiques et des analyses protéomiques."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer les Kringles ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests de coagulation et des dosages protéiques spécifiques sont utilisés."
}
},
{
"@type": "Question",
"name": "Les Kringles peuvent-ils être visualisés par imagerie ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, les Kringles ne sont pas visibles par imagerie, mais leurs effets peuvent l'être."
}
},
{
"@type": "Question",
"name": "Quels marqueurs biologiques sont associés aux Kringles ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des marqueurs comme le fibrinogène et les facteurs de coagulation sont associés."
}
},
{
"@type": "Question",
"name": "Les tests génétiques sont-ils fiables pour les Kringles ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les tests génétiques sont fiables pour identifier les mutations liées aux Kringles."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont liés aux anomalies des Kringles ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent des troubles de la coagulation, des hémorragies ou des thromboses."
}
},
{
"@type": "Question",
"name": "Les anomalies des Kringles provoquent-elles des douleurs ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des douleurs peuvent survenir en raison de thromboses ou d'hémorragies."
}
},
{
"@type": "Question",
"name": "Les symptômes des Kringles sont-ils toujours visibles ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, certains symptômes peuvent être asymptomatiques et ne se manifester qu'à l'examen."
}
},
{
"@type": "Question",
"name": "Les anomalies des Kringles affectent-elles la circulation sanguine ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent entraîner des problèmes de circulation sanguine, comme des caillots."
}
},
{
"@type": "Question",
"name": "Les symptômes des Kringles varient-ils selon les individus ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes peuvent varier en fonction de la gravité et du type d'anomalie."
}
},
{
"@type": "Question",
"name": "Comment prévenir les complications liées aux Kringles ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention inclut un suivi médical régulier et un traitement préventif approprié."
}
},
{
"@type": "Question",
"name": "L'exercice physique aide-t-il à prévenir les problèmes de Kringles ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut améliorer la circulation et réduire les risques de thrombose."
}
},
{
"@type": "Question",
"name": "Une alimentation spécifique peut-elle aider ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée, riche en oméga-3, peut aider à la santé cardiovasculaire."
}
},
{
"@type": "Question",
"name": "Les anticoagulants préventifs sont-ils recommandés ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des anticoagulants peuvent être prescrits pour prévenir les complications thromboemboliques."
}
},
{
"@type": "Question",
"name": "Le dépistage précoce est-il important ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le dépistage précoce des anomalies peut aider à prévenir des complications graves."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour les anomalies des Kringles ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des anticoagulants et des thérapies ciblées selon le cas."
}
},
{
"@type": "Question",
"name": "Les transfusions sanguines sont-elles nécessaires ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, dans certains cas, des transfusions peuvent être nécessaires pour corriger les anomalies."
}
},
{
"@type": "Question",
"name": "La chirurgie est-elle une option pour les anomalies des Kringles ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "La chirurgie peut être envisagée dans des cas graves, comme des thromboses récurrentes."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils personnalisés pour chaque patient ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements sont souvent personnalisés en fonction des besoins individuels."
}
},
{
"@type": "Question",
"name": "Les traitements des Kringles sont-ils efficaces ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être très efficaces pour gérer les symptômes et prévenir les complications."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles des anomalies des Kringles ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des thromboses, des embolies et des hémorragies sévères."
}
},
{
"@type": "Question",
"name": "Les complications peuvent-elles être mortelles ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines complications, comme les embolies pulmonaires, peuvent être mortelles."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications des Kringles ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion inclut des traitements médicaux et parfois des interventions chirurgicales."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles prévisibles ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être prévisibles avec un suivi médical approprié."
}
},
{
"@type": "Question",
"name": "Les complications des Kringles nécessitent-elles une hospitalisation ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des complications graves peuvent nécessiter une hospitalisation pour traitement intensif."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque des anomalies des Kringles ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des antécédents familiaux, l'obésité et le tabagisme."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le risque d'anomalies des Kringles ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque augmente avec l'âge en raison de la dégradation des mécanismes de coagulation."
}
},
{
"@type": "Question",
"name": "Le mode de vie affecte-t-il le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque."
}
},
{
"@type": "Question",
"name": "Les maladies chroniques sont-elles un facteur de risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies comme le diabète et l'hypertension augmentent le risque d'anomalies."
}
},
{
"@type": "Question",
"name": "Le stress a-t-il un impact sur le risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut affecter la coagulation et augmenter le risque d'anomalies."
}
}
]
}
]
}
Plasmin is a broad-spectrum protease and therefore needs to be tightly regulated. Active plasmin is formed from plasminogen, which is found in high concentrations in the blood and is converted by the ...
Plasminogen serves as the precursor to plasmin, an essential element in the fibrinolytic process, and is synthesized primarily in the liver. Plasminogen activation occurs through the action of plasmin...
This case report depicts a patient diagnosed with ligneous gingivitis during childhood, originating from plasminogen deficiency and progressing to periodontitis. Genetic testing revealed a suspected a...
Collaborative efforts between medical and dental professionals are paramount in comprehensively evaluating and treating patients with intricate complications from rare diseases. Furthermore, the PLG c...
In patients with COVID-19 and baseline soluble urokinase plasminogen receptor plasma (suPAR) levels ≥ 6ng/mL, early administration of anakinra, a recombinant interleukin-1 receptor antagonist, may pre...
We conducted a monocenter, retrospective cohort study, including patients with SARS-CoV2 infection and respiratory failure. Patients treated with anakinra (anakinra group, AG) were compared to two con...
Between July, 2021 and January, 2022, 153 patients were included, among which 56 were treated with off-label anakinra, 49 retrospectively fulfilled prescriptive criteria for anakinra and were assigned...
This real-word, retrospective cohort study confirmed the safety and the efficacy of suPAR-guided, early use of anakinra in hospitalized COVID-19 patients with respiratory failure....
Given the significant clinical potential of human plasminogen Kringle 5 on tumours, it is crucial to seek its receptors for a thorough comprehension of its physiological functions and mechanism. Eleve...
Ligneous Conjunctivitis (LC) is the most common clinical manifestation of Type I Plasminogen deficiency (T1PD; OMIM# 217090), and it is characterized by the formation of pseudomembranes (due to deposi...
We present the case of a sixteen-year-old girl with LC with severe left eye involvement. We reported the clinical conditions of the patient before and after the use of topical plasminogen eye drops an...
The patient showed a progressive response to the topical plasminogen, with a complete absence of pseudomembrane formation at a twelve-year follow-up, despite using an ocular prosthesis....
The hemostatic and inflammatory systems work hand in hand to maintain homeostasis at mucosal barrier sites. Among the factors of the hemostatic system, fibrin is well recognized for its role in mucosa...
Chronic recurrent angioedema without wheals (CRA) with normal C1 inhibitor (C1-INH) that is unresponsive to antihistamines may involve patients with recurrent angioedema of unknown cause (ie, so-calle...
To identify patients with one of type of HAEnCI in a group of patients with CRA with normal C1-INH that was unresponsive to antihistamines....
A total of 132 patients with CRA and normal C1-INH that was unresponsive to antihistamines underwent mutational and clinical analysis. The presence of hereditary angioedema-specific mutations in Facto...
In 116 of 132 solitary patients with CRA (87.9%), none of the six HAEnCI-linked mutations could be found. Ten patients (7.6%) had the Factor XII mutation c.983C>A (p.T328K) and six (4.5%) the plasmino...
A search for HAEnCI-linked mutations in patients with solitary CRA may lead to the detection of patients and families with HAEnCI. This is important because family members can be identified who are at...
Cellular plasminogen (Pg) receptors (PgRs) are utilized to recruit Pg; stimulate its activation to the serine protease, plasmin (Pm); and sterically protect the surface Pm from inactivation by host in...
Fibrinolysis is a series of enzymatic reactions that degrade insoluble fibrin. Plasminogen activators convert the zymogen plasminogen to the active serine protease plasmin, which cleaves and solubiliz...
The subset of plasma extracellular vesicles (EVs) that coprecipitate with low-density lipoprotein (LDL-EVs) carry coagulation and fibrinolysis pathway proteins as cargo. We investigated the associatio...