questionsmedicales.fr
Procédures de chirurgie opératoire
Procédures orthopédiques
Allongement osseux
Technique d'Ilizarov
Technique d'Ilizarov : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Déformations osseuses
Imagerie par résonance magnétique
Longueur osseuse
Radiographie
Chirurgie orthopédique
Douleur
Symptômes
5
Infection osseuse
Chirurgie
Distraction osseuse
Douleur
Effets secondaires
Infection
Prévention
5
Prévention des fractures
Sport
Complications
Chirurgie orthopédique
Déformations osseuses
Croissance
Traitements
5
Technique d'Ilizarov
Régénération osseuse
Fractures
Déformations osseuses
Distraction osseuse
Allongement osseux
Soins post-opératoires
Réhabilitation
Durée du traitement
Technique d'Ilizarov
Complications
5
Douleur chronique
Réhabilitation
Non-consolidation
Circulation sanguine
Facteurs de risque
5
Médicaments
Cicatrisation
Antécédents médicaux
Complications
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Technique d'Ilizarov : Questions médicales les plus fréquentes",
"headline": "Technique d'Ilizarov : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Technique d'Ilizarov : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-01-16",
"dateModified": "2025-04-10",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Technique d'Ilizarov"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Allongement osseux",
"url": "https://questionsmedicales.fr/mesh/D001852",
"about": {
"@type": "MedicalCondition",
"name": "Allongement osseux",
"code": {
"@type": "MedicalCode",
"code": "D001852",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "E04.555.120"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Technique d'Ilizarov",
"alternateName": "Ilizarov Technique",
"code": {
"@type": "MedicalCode",
"code": "D018889",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Aihemaitijiang Yusufu",
"url": "https://questionsmedicales.fr/author/Aihemaitijiang%20Yusufu",
"affiliation": {
"@type": "Organization",
"name": "Department of Trauma and Microreconstructive Surgery, The First Affiliated Hospital of Xinjiang Medical University, 830054, Urumqi, Xinjiang, China. ahmatjang@163.com."
}
},
{
"@type": "Person",
"name": "Piotr Morasiewicz",
"url": "https://questionsmedicales.fr/author/Piotr%20Morasiewicz",
"affiliation": {
"@type": "Organization",
"name": "Department and Clinic of Orthopaedic and Traumatologic Surgery, Wroclaw Medical University, Borowska 213, 50-556, Wroclaw, Poland."
}
},
{
"@type": "Person",
"name": "Maimaiaili Yushan",
"url": "https://questionsmedicales.fr/author/Maimaiaili%20Yushan",
"affiliation": {
"@type": "Organization",
"name": "Department of Orthopedic Surgery, The Fourth Affiliated Hospital of Xinjiang Medical University, Traditional Chinese Medicine Hospital of Xinjiang Uyghur Autonomous Region, Ürümqi, Xinjiang, People's Republic of China. 424257832@qq.com."
}
},
{
"@type": "Person",
"name": "Sihe Qin",
"url": "https://questionsmedicales.fr/author/Sihe%20Qin",
"affiliation": {
"@type": "Organization",
"name": "Department of Orthopedics, Rehabilitation Hospital, National Research Center for Rehabilitation, Beijing, China."
}
},
{
"@type": "Person",
"name": "Yanshi Liu",
"url": "https://questionsmedicales.fr/author/Yanshi%20Liu",
"affiliation": {
"@type": "Organization",
"name": "Department of Trauma and Microreconstructive Surgery, The First Affiliated Hospital of Xinjiang Medical University, 830054, Urumqi, Xinjiang, China."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "DNA methylation of ITGB2 contributes to allopurinol hypersensitivity.",
"datePublished": "2023-02-03",
"url": "https://questionsmedicales.fr/article/36738816",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.clim.2023.109250"
}
},
{
"@type": "ScholarlyArticle",
"name": "Optimizing adherence to allopurinol for gout: patients' perspectives.",
"datePublished": "2023-01-25",
"url": "https://questionsmedicales.fr/article/36607199",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1111/bcp.15657"
}
},
{
"@type": "ScholarlyArticle",
"name": "An allopurinol adherence tool using plasma oxypurinol concentrations.",
"datePublished": "2022-09-15",
"url": "https://questionsmedicales.fr/article/36036094",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1111/bcp.15516"
}
},
{
"@type": "ScholarlyArticle",
"name": "Treatment of Cutaneous Leishmaniasis with Allopurinol Plus Itraconazole in Iran.",
"datePublished": "2023-04-24",
"url": "https://questionsmedicales.fr/article/37094789",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.4269/ajtmh.22-0733"
}
},
{
"@type": "ScholarlyArticle",
"name": "[HLA-B58.01 and allopurinol hypersensitivity renal vasculitis in a Chinese patient].",
"datePublished": "2022-05-20",
"url": "https://questionsmedicales.fr/article/35606203",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.revmed.2022.04.018"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Procédures de chirurgie opératoire",
"item": "https://questionsmedicales.fr/mesh/D013514"
},
{
"@type": "ListItem",
"position": 3,
"name": "Procédures orthopédiques",
"item": "https://questionsmedicales.fr/mesh/D019637"
},
{
"@type": "ListItem",
"position": 4,
"name": "Allongement osseux",
"item": "https://questionsmedicales.fr/mesh/D001852"
},
{
"@type": "ListItem",
"position": 5,
"name": "Technique d'Ilizarov",
"item": "https://questionsmedicales.fr/mesh/D018889"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Technique d'Ilizarov - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Technique d'Ilizarov",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-09",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Technique d'Ilizarov",
"description": "Comment diagnostiquer une fracture complexe ?\nQuels tests sont utilisés pour évaluer les déformations osseuses ?\nQuels signes indiquent une nécrose osseuse ?\nComment évaluer la longueur des os ?\nQuels symptômes nécessitent une intervention chirurgicale ?",
"url": "https://questionsmedicales.fr/mesh/D018889?mesh_terms=Allopurinol#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Technique d'Ilizarov",
"description": "Quels sont les symptômes d'une fracture ?\nComment reconnaître une infection osseuse ?\nQuels signes indiquent une mauvaise cicatrisation ?\nQuels symptômes peuvent survenir après la distraction osseuse ?\nQuels sont les effets secondaires possibles de la technique ?",
"url": "https://questionsmedicales.fr/mesh/D018889?mesh_terms=Allopurinol#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Technique d'Ilizarov",
"description": "Comment prévenir les fractures chez les sportifs ?\nQuelles mesures prendre pour éviter les infections post-chirurgicales ?\nComment éviter les complications après une chirurgie osseuse ?\nQuels conseils pour une bonne cicatrisation osseuse ?\nComment prévenir les déformations osseuses chez les enfants ?",
"url": "https://questionsmedicales.fr/mesh/D018889?mesh_terms=Allopurinol#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Technique d'Ilizarov",
"description": "Comment fonctionne la technique d'Ilizarov ?\nQuels types de fractures sont traités par cette technique ?\nQuel est le rôle de la distraction osseuse ?\nQuels soins post-opératoires sont nécessaires ?\nCombien de temps dure le traitement avec la technique d'Ilizarov ?",
"url": "https://questionsmedicales.fr/mesh/D018889?mesh_terms=Allopurinol#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Technique d'Ilizarov",
"description": "Quelles sont les complications possibles de la technique d'Ilizarov ?\nComment gérer une infection après la chirurgie ?\nQuels signes indiquent une complication grave ?\nComment prévenir les douleurs chroniques après la chirurgie ?\nQuels sont les risques de non-consolidation osseuse ?",
"url": "https://questionsmedicales.fr/mesh/D018889?mesh_terms=Allopurinol#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Technique d'Ilizarov",
"description": "Quels facteurs augmentent le risque de fractures ?\nComment le tabagisme influence-t-il la cicatrisation osseuse ?\nQuels médicaments peuvent affecter la guérison osseuse ?\nComment l'alimentation influence-t-elle la santé osseuse ?\nQuels antécédents médicaux augmentent les risques de complications ?",
"url": "https://questionsmedicales.fr/mesh/D018889?mesh_terms=Allopurinol#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une fracture complexe ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un examen clinique et des imageries comme les radiographies sont nécessaires."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer les déformations osseuses ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des radiographies et des IRM peuvent être utilisés pour évaluer les déformations."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une nécrose osseuse ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Douleur persistante, gonflement et incapacité à utiliser le membre affecté."
}
},
{
"@type": "Question",
"name": "Comment évaluer la longueur des os ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des mesures radiographiques précises sont effectuées pour évaluer la longueur."
}
},
{
"@type": "Question",
"name": "Quels symptômes nécessitent une intervention chirurgicale ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Douleur intense, déformation sévère ou incapacité fonctionnelle persistante."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une fracture ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Douleur aiguë, gonflement, déformation et incapacité à bouger le membre."
}
},
{
"@type": "Question",
"name": "Comment reconnaître une infection osseuse ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Rougeur, chaleur, douleur et écoulement au site de la fracture ou de la chirurgie."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une mauvaise cicatrisation ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Douleur persistante, mobilité limitée et déformation visible de l'os."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent survenir après la distraction osseuse ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Douleur, gonflement et parfois des picotements au niveau du site de distraction."
}
},
{
"@type": "Question",
"name": "Quels sont les effets secondaires possibles de la technique ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Inconfort, infection, et parfois des problèmes de croissance osseuse."
}
},
{
"@type": "Question",
"name": "Comment prévenir les fractures chez les sportifs ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Renforcement musculaire, échauffement adéquat et utilisation d'équipements de protection."
}
},
{
"@type": "Question",
"name": "Quelles mesures prendre pour éviter les infections post-chirurgicales ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Maintenir une bonne hygiène, suivre les instructions médicales et surveiller les signes d'infection."
}
},
{
"@type": "Question",
"name": "Comment éviter les complications après une chirurgie osseuse ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Suivre les recommandations médicales, éviter les activités à risque et faire des contrôles réguliers."
}
},
{
"@type": "Question",
"name": "Quels conseils pour une bonne cicatrisation osseuse ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée, repos suffisant et éviter le tabac favorisent la cicatrisation."
}
},
{
"@type": "Question",
"name": "Comment prévenir les déformations osseuses chez les enfants ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Surveiller la croissance, encourager l'activité physique et consulter un médecin si nécessaire."
}
},
{
"@type": "Question",
"name": "Comment fonctionne la technique d'Ilizarov ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle utilise un cadre externe pour stabiliser l'os et favoriser la régénération."
}
},
{
"@type": "Question",
"name": "Quels types de fractures sont traités par cette technique ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fractures complexes, fractures non consolidées et déformations osseuses."
}
},
{
"@type": "Question",
"name": "Quel est le rôle de la distraction osseuse ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle permet d'allonger l'os progressivement en créant un nouvel os entre les segments."
}
},
{
"@type": "Question",
"name": "Quels soins post-opératoires sont nécessaires ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Surveillance des signes d'infection, gestion de la douleur et rééducation."
}
},
{
"@type": "Question",
"name": "Combien de temps dure le traitement avec la technique d'Ilizarov ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement peut durer de plusieurs semaines à plusieurs mois selon le cas."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles de la technique d'Ilizarov ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Infections, douleurs chroniques, et problèmes de consolidation osseuse."
}
},
{
"@type": "Question",
"name": "Comment gérer une infection après la chirurgie ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Antibiotiques et soins locaux sont nécessaires pour traiter l'infection efficacement."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une complication grave ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fièvre élevée, douleur intense et écoulement purulent au site opératoire."
}
},
{
"@type": "Question",
"name": "Comment prévenir les douleurs chroniques après la chirurgie ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une rééducation précoce et une gestion adéquate de la douleur sont essentielles."
}
},
{
"@type": "Question",
"name": "Quels sont les risques de non-consolidation osseuse ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Mauvaise circulation sanguine, infection ou mauvaise technique chirurgicale peuvent causer cela."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de fractures ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge avancé, l'ostéoporose et les activités sportives à risque augmentent ce risque."
}
},
{
"@type": "Question",
"name": "Comment le tabagisme influence-t-il la cicatrisation osseuse ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le tabagisme retarde la cicatrisation et augmente le risque d'infections post-opératoires."
}
},
{
"@type": "Question",
"name": "Quels médicaments peuvent affecter la guérison osseuse ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les corticostéroïdes et certains anti-inflammatoires peuvent retarder la guérison."
}
},
{
"@type": "Question",
"name": "Comment l'alimentation influence-t-elle la santé osseuse ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en calcium et vitamine D est essentielle pour la santé osseuse."
}
},
{
"@type": "Question",
"name": "Quels antécédents médicaux augmentent les risques de complications ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Antécédents de maladies osseuses, diabète ou troubles circulatoires augmentent les risques."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 10/04/2025
Contenu vérifié selon les dernières recommandations médicales
6 publications dans cette catégorie
Affiliations :
Department of Trauma and Microreconstructive Surgery, The First Affiliated Hospital of Xinjiang Medical University, 830054, Urumqi, Xinjiang, China. ahmatjang@163.com.
6 publications dans cette catégorie
Affiliations :
Department and Clinic of Orthopaedic and Traumatologic Surgery, Wroclaw Medical University, Borowska 213, 50-556, Wroclaw, Poland.
Department of Orthopaedic and Trauma Surgery, University Hospital in Opole, Institute of Medical Sciences, University of Opole, Witosa 26, 41-405, Opole, Poland.
5 publications dans cette catégorie
Affiliations :
Department of Orthopedic Surgery, The Fourth Affiliated Hospital of Xinjiang Medical University, Traditional Chinese Medicine Hospital of Xinjiang Uyghur Autonomous Region, Ürümqi, Xinjiang, People's Republic of China. 424257832@qq.com.
Publications dans "Technique d'Ilizarov" :
4 publications dans cette catégorie
Affiliations :
Department of Orthopedics, Rehabilitation Hospital, National Research Center for Rehabilitation, Beijing, China.
Publications dans "Technique d'Ilizarov" :
4 publications dans cette catégorie
Affiliations :
Department of Trauma and Microreconstructive Surgery, The First Affiliated Hospital of Xinjiang Medical University, 830054, Urumqi, Xinjiang, China.
Publications dans "Technique d'Ilizarov" :
4 publications dans cette catégorie
Affiliations :
Department of Orthopedics and Musculoskeletal Traumatology, Medical University of Warsaw, Lindleya 4, 02-005, Warsaw, Poland. L.szelerski@gmail.com.
Publications dans "Technique d'Ilizarov" :
4 publications dans cette catégorie
Affiliations :
Department of Orthopedics and Musculoskeletal Traumatology, Medical University of Warsaw, Lindleya 4, 02-005, Warsaw, Poland.
Publications dans "Technique d'Ilizarov" :
4 publications dans cette catégorie
Affiliations :
Department of Physiotherapy in Motor Disorders and Dysfunctions, University School of Physical Education in Wroclaw, 51-612 Wroclaw, Poland.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Orthopaedic Department, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. hanpei_cn@163.com.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Trauma and Microreconstructive Surgery, The First Affiliated Hospital of Xinjiang Medical University, 830054, Urumqi, Xinjiang, China.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopedics and Musculoskeletal Traumatology, Medical University of Warsaw, Lindleya 4, 02-005, Warsaw, Poland.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopaedic Surgery, 920th Hospital of Joint Logistics Support Force, Kunming Yunnan, 650032, P.R.China.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopaedic Surgery, 920th Hospital of Joint Logistics Support Force, Kunming Yunnan, 650032, P.R.China.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopaedic Surgery, 920th Hospital of Joint Logistics Support Force, Kunming Yunnan, 650032, P.R.China.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopaedic Surgery, 920th Hospital of Joint Logistics Support Force, Kunming Yunnan, 650032, P.R.China.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Orthopaedic Surgery, 920th Hospital of Joint Logistics Support Force, Kunming Yunnan, 650032, P.R.China.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Microrepair and Reconstruction, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China. 8212682@qq.com.
Publications dans "Technique d'Ilizarov" :
3 publications dans cette catégorie
Affiliations :
Department of Massage and Physical Therapy, Faculty of Physiotherapy, Wroclaw University of Health and Sport Sciences, 51-612 Wrocław, Poland.
Publications dans "Technique d'Ilizarov" :
HLA-B*58:01 allele was strongly associated with allopurinol induced severe cutaneous adverse drug reaction (SCAR). However, HLA-B genotype is not sufficient to predict the occurrence of allopurinol-in...
To discover DNA methylation markers for allopurinol-induced SCAR which may improve the prediction accuracy of genetic testing....
The study was designed as a retrospective case-control clinical study in multicenter hospitals across Taiwan, Mainland China, Malaysia and Canada. 125 cases of allopurinol-induced SCAR patients and 13...
The results of genome-wide DNA methylation assay of 62 patients revealed that ITGB2 showed strong discriminative ability of allopurinol-induced SCAR in both HLA-B*58:01 positive and negative patients ...
Our study uncovers differentially methylated genes between allopurinol-induced SCAR patients and tolerant controls with positive or negative HLA-B*58:01 allele and provides the novel epigenetic marker...
Poor adherence to allopurinol among people with gout contributes to suboptimal gout management. This study sought to understand the facilitators and barriers to allopurinol adherence across the three ...
Semi-structured interviews were conducted with 26 people with gout, previously or currently taking allopurinol. De-identified verbatim transcripts were thematically analysed using an inductive and ded...
Facilitators of adherence during allopurinol initiation were motivation to prevent gout flares and trust in the advice of their healthcare professionals (HCPs). Reluctance to commence long-term medica...
Patient perceptions of the effectiveness and necessity of allopurinol influenced intentional adherence during medication initiation, implementation and discontinuation. Strategies that inform patients...
This study aimed to develop and evaluate an allopurinol adherence tool based on steady-state oxypurinol plasma concentrations, allopurinol's active metabolite....
Plasma oxypurinol concentrations were simulated stochastically from an oxypurinol pharmacokinetic model for allopurinol doses of 100-800 mg daily, accounting for differences in renal function, diureti...
The allopurinol adherence tool produced S&S values for trough thresholds of 89-98% and 76-84%, respectively, and 90%-98% and 76-83% for peak thresholds. PPV and NPV were 79-84% and 88-94%, respectivel...
A tool to identify people with gout who require additional support to maintain adherence using plasma oxypurinol concentrations was developed and evaluated. The predictive performance of the tool is s...
Cutaneous leishmaniasis (CL) is a serious tropical disease and a neglected health challenge in Iran. Although limited data are available regarding anthroponotic CL, cases resistant to meglumine antimo...
Allopurinol, widely used in the treatment of hyperuricemia and gout, has been shown to cause severe cutaneous reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis, as well as s...
We report the observation of a 47-year-old Chinese patient, with no previous medical history, carrying the HLA-B*5801 allele, who developed an isolated allopurinol hypersensitivity necrotizing renal v...
. The identification of this allele should be proposed before prescribing allopurinol in patients originating from certain regions of Asia, and the imputability of allopurinol should be evoked in case...
ABCG2 is a gene that codes for the human breast cancer resistance protein (BCRP). It is established that rs2231142 G>T, a single nucleotide polymorphism of the ABCG2 gene, is associated with gout and ...
There were insufficient pieces of evidence regarding the effect of the two drugs (allopurinol and febuxostat) on patient survival in hemodialysis (HD) patients. Herein, we aimed to compare the efficac...
This study used data from a national HD quality assessment program and the claims data. Use of ULDs was defined as more than one prescription during the 6 months of each HD quality assessment period. ...
Kaplan-Meier curves showed that the survival rate was greatest in group 3 and worst in group 1 among the three groups. Multivariable analysis showed that group 2 had better patient survival compared t...
Our study showed that survival in patients receiving ULDs was not inferior to that of those not receiving ULDs. Patient survival between patients on HD receiving allopurinol and those receiving febuxo...
This study aimed to compare the risk of dementia between exposed to allopurinol and not exposed to allopurinol in persons who had gout and/or hyperuricemia....
The meta-analysis was conducted to select case-control research written in English through the help of PubMed and Web of Science. The pooled odds ratio (OR) with 95% confidence interval based on the f...
A total of 4 case-control studies relating the allopurinol exposure to the risk of dementia were identified. The study duration was from 9 to 14 years. The number of study persons was from 3148 to 137...
This is the first meta-analysis to report that there is a negative relationship between the allopurinol exposure and the risk of dementia. Although the results favor the hypothesis, currently it is un...
A 58-year-old woman was admitted for heart failure and concern for cardiogenic shock. The patient had been recently placed on colchicine and allopurinol, 4 months and 3 weeks, respectively, prior to a...
Gout is the most common form of inflammatory arthritis in men. Despite the availability of effective urate-lowering therapies (ULT), the management of gout is suboptimal due to poor persistence with U...
A 10% sample of the Australian Pharmaceutical Benefits Scheme dispensing claims database was used to identify individuals initiated on allopurinol between April 2014 and December 2019. The number of a...
The largest drop in persistence occurred immediately after initiation, with 34% of patients discontinuing allopurinol 300-mg therapy in the first month. Median persistence with allopurinol 300 mg was ...
Persistence with allopurinol was poor. More effective methods targeting prescribers, patients and systems are required to promote persistence with allopurinol. Improving persistence to allopurinol is ...