Communication autocrine : Questions médicales fréquentes
Nom anglais: Autocrine Communication
Descriptor UI:D019898
Tree Number:G04.085.100
Termes MeSH sélectionnés :
Quadriceps Muscle
Questions fréquentes et termes MeSH associés
Diagnostic
5
#1
Comment diagnostiquer une communication autocrine ?
Le diagnostic repose sur des tests biologiques et des analyses de signalisation cellulaire.
Signalisation cellulaireBiomarqueurs
#2
Quels tests sont utilisés pour évaluer la communication autocrine ?
Des tests de culture cellulaire et des dosages de cytokines peuvent être utilisés.
CytokinesCulture cellulaire
#3
Y a-t-il des marqueurs spécifiques pour la communication autocrine ?
Oui, des marqueurs comme les récepteurs de cytokines peuvent indiquer une communication autocrine.
Récepteurs de cytokinesMarqueurs biologiques
#4
La communication autocrine est-elle visible par imagerie ?
Elle n'est généralement pas visible par imagerie, mais des techniques avancées peuvent aider.
Imagerie médicaleTechniques avancées
#5
Quels sont les signes d'une dérégulation autocrine ?
Des signes incluent une croissance cellulaire anormale ou une inflammation persistante.
InflammationCroissance cellulaire
Symptômes
5
#1
Quels symptômes indiquent une communication autocrine anormale ?
Des symptômes peuvent inclure des douleurs, des inflammations ou des tumeurs.
DouleurTumeurs
#2
La communication autocrine affecte-t-elle le métabolisme ?
Oui, elle peut influencer le métabolisme cellulaire et provoquer des déséquilibres.
MétabolismeDéséquilibres
#3
Y a-t-il des symptômes spécifiques liés à l'autocrine dans le cancer ?
Oui, des symptômes comme la fatigue et la perte de poids peuvent être présents.
CancerFatigue
#4
Comment la communication autocrine influence-t-elle l'immunité ?
Elle peut moduler la réponse immunitaire, entraînant une inflammation ou une immunosuppression.
ImmunitéInflammation
#5
Des symptômes neurologiques peuvent-ils être liés à l'autocrine ?
Oui, des troubles neurologiques peuvent survenir en raison de la signalisation autocrine.
Troubles neurologiquesSignalisation
Prévention
5
#1
Comment prévenir les dérégulations autocrines ?
Une alimentation équilibrée et un mode de vie sain peuvent aider à prévenir ces dérégulations.
AlimentationMode de vie sain
#2
Y a-t-il des mesures préventives spécifiques pour le cancer ?
Oui, éviter les carcinogènes et maintenir un poids santé sont des mesures préventives.
CarcinogènesPoids santé
#3
L'exercice physique aide-t-il à réguler l'autocrine ?
Oui, l'exercice régulier peut moduler la signalisation autocrine et améliorer la santé cellulaire.
Exercice physiqueSanté cellulaire
#4
Le stress influence-t-il la communication autocrine ?
Oui, le stress chronique peut perturber la communication autocrine et affecter la santé.
StressSanté
#5
Des compléments alimentaires peuvent-ils aider ?
Certains compléments, comme les oméga-3, peuvent moduler la communication autocrine.
Compléments alimentairesOméga-3
Traitements
5
#1
Quels traitements ciblent la communication autocrine ?
Des thérapies ciblées et des inhibiteurs de signalisation peuvent être utilisés.
Thérapies cibléesInhibiteurs
#2
Les médicaments peuvent-ils moduler la communication autocrine ?
Oui, certains médicaments peuvent inhiber ou stimuler la signalisation autocrine.
MédicamentsSignalisation
#3
Y a-t-il des traitements spécifiques pour le cancer liés à l'autocrine ?
Des traitements comme les anticorps monoclonaux ciblent souvent la communication autocrine dans le cancer.
Anticorps monoclonauxCancer
#4
Comment la thérapie génique influence-t-elle l'autocrine ?
La thérapie génique peut corriger des dérégulations dans la communication autocrine.
Thérapie géniqueDérégulations
#5
Les traitements hormonaux affectent-ils la communication autocrine ?
Oui, les traitements hormonaux peuvent influencer la signalisation autocrine dans certaines pathologies.
Traitements hormonauxPathologies
Complications
5
#1
Quelles complications peuvent résulter d'une communication autocrine anormale ?
Des complications incluent des cancers, des maladies auto-immunes et des inflammations chroniques.
CancersMaladies auto-immunes
#2
La communication autocrine peut-elle entraîner des troubles métaboliques ?
Oui, une dérégulation peut provoquer des troubles métaboliques comme le diabète.
Troubles métaboliquesDiabète
#3
Y a-t-il des risques d'inflammation chronique ?
Oui, une communication autocrine anormale peut entraîner une inflammation chronique.
Inflammation chroniqueRisques
#4
Comment la communication autocrine affecte-t-elle le cancer ?
Elle peut favoriser la croissance tumorale et la résistance aux traitements anticancéreux.
Croissance tumoraleRésistance aux traitements
#5
Des complications neurologiques sont-elles possibles ?
Oui, des dérégulations peuvent entraîner des troubles neurologiques et cognitifs.
Troubles neurologiquesCognitifs
Facteurs de risque
5
#1
Quels sont les facteurs de risque de dérégulation autocrine ?
Les facteurs incluent l'âge, l'obésité, le tabagisme et l'exposition à des toxines.
ObésitéTabagisme
#2
L'alimentation influence-t-elle la communication autocrine ?
Oui, une alimentation riche en sucres et graisses peut perturber la signalisation autocrine.
AlimentationSucres
#3
Le stress est-il un facteur de risque ?
Oui, le stress chronique peut augmenter le risque de dérégulation autocrine.
StressRisque
#4
Y a-t-il des prédispositions génétiques ?
Certaines mutations génétiques peuvent prédisposer à des dérégulations autocrines.
Mutations génétiquesPrédispositions
#5
L'exposition à des produits chimiques est-elle un risque ?
Oui, l'exposition à des produits chimiques toxiques peut augmenter le risque de dérégulation.
Produits chimiquesToxiques
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},
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"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments peuvent inhiber ou stimuler la signalisation autocrine."
}
},
{
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"position": 18,
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},
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}
},
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"name": "Quelles complications peuvent résulter d'une communication autocrine anormale ?",
"position": 21,
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},
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"@type": "Question",
"name": "La communication autocrine peut-elle entraîner des troubles métaboliques ?",
"position": 22,
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"text": "Oui, une dérégulation peut provoquer des troubles métaboliques comme le diabète."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques d'inflammation chronique ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une communication autocrine anormale peut entraîner une inflammation chronique."
}
},
{
"@type": "Question",
"name": "Comment la communication autocrine affecte-t-elle le cancer ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut favoriser la croissance tumorale et la résistance aux traitements anticancéreux."
}
},
{
"@type": "Question",
"name": "Des complications neurologiques sont-elles possibles ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des dérégulations peuvent entraîner des troubles neurologiques et cognitifs."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque de dérégulation autocrine ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent l'âge, l'obésité, le tabagisme et l'exposition à des toxines."
}
},
{
"@type": "Question",
"name": "L'alimentation influence-t-elle la communication autocrine ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation riche en sucres et graisses peut perturber la signalisation autocrine."
}
},
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"name": "Le stress est-il un facteur de risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut augmenter le risque de dérégulation autocrine."
}
},
{
"@type": "Question",
"name": "Y a-t-il des prédispositions génétiques ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines mutations génétiques peuvent prédisposer à des dérégulations autocrines."
}
},
{
"@type": "Question",
"name": "L'exposition à des produits chimiques est-elle un risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à des produits chimiques toxiques peut augmenter le risque de dérégulation."
}
}
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}
Department of Dermatology and the USC-Norris Comprehensive Cancer Center, University of Southern California Keck Medical Centre, Los Angeles, CA, 90033, USA.
Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta, T2N 1N4, Canada. Electronic address: Habibi@ucalgary.ca.
Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology, Biology Department, Temple University, Philadelphia, PA, 19122, USA. pscalia@isoprog.org.
Istituto Somatogene Per la Ricerca Onco-Genomica, ISOPROG, Caltanissetta, 93100, Italy. pscalia@isoprog.org.
Somatolink Research Foundation, Philadelphia, PA, 19102, USA. pscalia@isoprog.org.
Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology, Biology Department, Temple University, Philadelphia, PA, 19122, USA.
Department of Medical Biotechnology, University of Siena, Siena, 53100, Italy.
Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology, Biology Department, Temple University, Philadelphia, PA, 19122, USA.
Istituto Somatogene Per la Ricerca Onco-Genomica, ISOPROG, Caltanissetta, 93100, Italy.
Somatolink Research Foundation, Philadelphia, PA, 19102, USA.
Point-of-care ultrasound can be used to assess muscle thickness. However, its reliability has not been fully evaluated....
This study aimed to assess the intrarater and inter-rater reliability of point-of-care ultrasound for the estimation of quadriceps and rectus femoris thickness in patients from a rehabilitation settin...
This is a cross-sectional study....
This study was conducted at the Department of Physical Medicine and Rehabilitation of a tertiary care hospital....
Twenty-nine inpatients consecutively selected after admission....
Four observers, two trained and two untrained, used point-of-care ultrasound to measure quadriceps femoris and rectus femoris thickness. Each observer performed two measurements followed by a second s...
Both intrarater and inter-rater ICC were higher than 0.888 for both quadriceps and rectus femoris measurements. Reliability was highest when ICC were calculated based on the average of two measurement...
These results suggest that point-of-care ultrasound is a reliable option to measure muscle thickness of knee extensors by the same or different observers....
Measuring knee extensors thickness may aid to adequately modulate treatment choices in patients with disability. This study suggests that quadriceps and rectus femoris muscle thickness measured after ...
To create an anatomical chart that indicates the probability of finding a motor point (MP) in different areas of the quadriceps muscle....
On 31 healthy adults, the individual anatomy of the vastus medialis (VM), rectus femoris (RF) and vastus lateralis (VL) was determined using ultrasound. Thereafter, a 3 Hz neuromuscular electrical sti...
The heat-map displayed the two best 3x3cm areas, over VL and VM respectively, each with a probability greater than 50% of finding a MP and a higher probability compared to all other areas (p <.05). RF...
Large inter-individual variations in location, and number of MPs were found, but the heat-map displayed areas with higher probability of finding a MP and can be used to facilitate NMES-application....
Ultrasonographic quantitation of quadriceps muscle mass is increasingly used for assessment of sarcopenia, but its relationship with frailty in haemodialysis recipients is not known. This study explor...
This was an exploratory analysis of a subgroup of adult prevalent (≥3 months) haemodialysis recipients deeply phenotyped for frailty. Ultrasound assessment of BATT was obtained with participants at an...
In total 223 study participants had ultrasound measurements. Frailty ranged from 34% for FP to 58% for FI. BATT was associated with increasing frailty on simple linear regression by all frailty tools,...
Ultrasound measures of quadriceps thickness is variably associated with frailty in prevalent haemodialysis recipients, dependent upon the frailty tool used, but not independent of other variables. Fur...
Clinicaltrials.gov : NCT03071107 registered 06/03/2017....
The quadriceps muscle is one of the human body's largest and most clinically important muscles and is evaluated using mid-thigh computed tomography (CT); however, its relationship with motor function ...
A total of 472 middle-aged and older community dwellers (254 men and 218 women) aged ≥40 years (mean age: 62.3 years) were included in this study. The quantity and quality of the quadriceps muscle wer...
In men, CSA and CSA×CTV were significantly associated with seven of the eight motor functions (p<0.05), excluding only balance ability. BMI-corrected CSA was significantly correlated with all eight mo...
The present results showed that a single CT image of the quadriceps muscle at the mid-thigh is useful for diagnosing sarcopenic changes, such as loss of muscle mass, muscle weakness, and muscle functi...
The number of total knee arthroplasties (TKA) has increased steadily with the aging of the population. This surgical procedure is recognized for its success in pain relief and restoration of knee func...
Muscle biopsies (VM and VL muscles) were collected from patients previously submitted to TKA via the medial parapatellar route and undergoing TKA revision (main group, n = 9) and patients with osteoar...
The normal mosaic pattern of the medial and lateral knee muscles was observed in the main and control groups, with no evidence of peripheral nerve damage. Notably, 88.9 % of the patients exhibited mil...
The medial parapatellar incision for TKA surgical access does not generate definitive morphological changes in the VM and VL muscle fibers but may contribute to VL atrophy....
This study aimed to investigate the association of muscle thickness (MT) and echo intensity (EI) obtained at different regions along the muscle length with muscle volume (MV), intramuscular adipose ti...
A total of 135 community-dwelling adults (64 men and 71 women) participated in the study. Ultrasound scanning of the rectus femoris (RF) and vastus intermedius (VI) was performed at three locations (f...
The correlation between RF-MT and RF-MV weakened as scanning approached the distal thigh, and the difference between the coefficients for the scanning locations was significant for women. However, the...
The results of this study suggest that ultrasound measurements at the distal thigh can predict MV, IntraMAT, and muscle strength of the QF to the same degree as those at the mid-thigh....
Neuromuscular electrical stimulation (NMES) of the quadriceps (Q) may increase venous blood flow to reduce the risk of venous thromboembolism. This study assessed whether Q-NMES pants could increase p...
Vibration foam rolling (VFR) intervention has recently gained attention in sports and rehabilitation settings since the superimposed vibration with foam rolling can affect several physiological system...
As females have been hypothesized to have more fatigue resistant inspiratory muscles, this study aimed to compare the development of inspiratory and leg muscle fatigue between males and females follow...
Cross-sectional comparison....
17 healthy young males (27 ± 6 years, V̇O...
Time to exhaustion was similar between sexes (p = 0.270, 95% CI -2.4 - 0.7 min). MVC of the quadriceps was lower after cycling for males (83.9 ± 11.5% vs. 94.0 ± 12.0% of baseline for females, p = 0.0...
Females incur similar peripheral fatigue in the quadriceps and inspiratory muscles compared with men following high-intensity cycling, despite smaller reduction in voluntary force. This small differen...
To measure changes in muscle thickness and echogenicity, reflecting muscle bulk and quality, respectively, of quadriceps femoris (QF), in critically ill children....
This study was done on 58 children aged 1-18 y requiring mechanical ventilation, admitted in a pediatric intensive care unit (PICU) of a tertiary care hospital from January 2018 to June 2019. QF thick...
The median muscle thickness of QF was 1.58 cm, and vastus intermedius and rectus femoris echogenicity was 35.5 and 25.88 units, respectively in the present cohort, with median age of 6 y. Only 36 of t...
There was a significant change in rectus femoris echogenicity, but not in QF thickness. Echogenicity rather than muscle thickness may be a more sensitive marker for changes in muscle properties....
